Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1478 | 1 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.02 | 0.1176 | 0.1197 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.02 | 0.1176 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.02 | 0.1176 | 0.5 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.02 | 0.1176 | 0.1197 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.02 | 0.1176 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.02 | 0.1176 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.1176 | 0.1197 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1478 | 1 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.02 | 0.1176 | 0.5 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.02 | 0.1176 | 0.1197 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1278 | 0.8619 | 0.8619 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.02 | 0.1176 | 0.1197 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.02 | 0.1176 | 0.1197 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1478 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1453 | 0.9827 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1453 | 0.9827 | 0.9827 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.02 | 0.1176 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1453 | 0.9827 | 0.9827 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.02 | 0.1176 | 0.1197 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.02 | 0.1176 | 0.1197 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.02 | 0.1176 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Echinococcus multilocularis | 0.02 | 0.1176 | 0.1176 | |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1453 | 0.9827 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.02 | 0.1176 | 0.1176 |
Loa Loa (eye worm) | FKBP5 protein | 0.1453 | 0.9827 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1453 | 0.9827 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.02 | 0.1176 | 0.1197 |
Schistosoma mansoni | hypothetical protein | 0.02 | 0.1176 | 0.1176 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0225 | 0.1349 | 0.1349 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1453 | 0.9827 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.02 | 0.1176 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1278 | 0.8619 | 0.8619 |
Loa Loa (eye worm) | hypothetical protein | 0.1258 | 0.8478 | 0.8627 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1453 | 0.9827 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.02 | 0.1176 | 0.1197 |
Onchocerca volvulus | 0.02 | 0.1176 | 0.974 | |
Schistosoma mansoni | fk506 binding protein | 0.02 | 0.1176 | 0.1176 |
Schistosoma mansoni | immunophilin | 0.1478 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.1453 | 0.9827 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1458 | 0.9859 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1453 | 0.9827 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.02 | 0.1176 | 0.1176 |
Echinococcus multilocularis | fk506 binding protein | 0.1453 | 0.9827 | 0.9827 |
Trypanosoma brucei | hypothetical protein, conserved | 0.02 | 0.1176 | 0.1197 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1453 | 0.9827 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.02 | 0.1176 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.1176 | 0.1197 |
Schistosoma mansoni | immunophilin | 0.1278 | 0.8619 | 0.8619 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.02 | 0.1176 | 0.1197 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.02 | 0.1176 | 0.1197 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1453 | 0.9827 | 1 |
Onchocerca volvulus | 0.0205 | 0.1208 | 1 | |
Schistosoma mansoni | immunophilin | 0.1478 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.02 | 0.1176 | 0.1197 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1453 | 0.9827 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.02 | 0.1176 | 0.1197 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1453 | 0.9827 | 0.9964 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1453 | 0.9827 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1453 | 0.9827 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.1453 | 0.9827 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = 0.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 2.5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 2.5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.4 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 1.25mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.4 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 1.25mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 10mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 10mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 4.6 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 20mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 4.6 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 20mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 8.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 40mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 8.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 40mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 12.6 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 80mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 12.6 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 80mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 17 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 160mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 17 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 160mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 24 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 320mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 24 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 320mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 34.4 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 640mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 34.4 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 640mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 3 | Antimalarial activity, administered as a single sc dose of 640mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 3 | Antimalarial activity, administered as a single sc dose of 640mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.