Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0037 | 0.0878 | 0.0878 |
Echinococcus multilocularis | fk506 binding protein | 0.027 | 1 | 1 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0018 | 0.0138 | 0.0138 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0028 | 0.054 | 0.054 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0441 | 0.0441 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0451 | 0.0451 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0037 | 0.0878 | 0.0878 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0232 | 0.8544 | 0.8544 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.027 | 1 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.027 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0037 | 0.0892 | 0.0892 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0037 | 0.0878 | 0.0878 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0044 | 0.1144 | 0.1144 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0037 | 0.0878 | 0.0878 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0035 | 0.0793 | 0.0793 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0037 | 0.0878 | 0.0878 |
Leishmania major | fk506-binding protein 1-like protein | 0.027 | 1 | 1 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0792 | 0.0792 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0792 | 0.0792 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0021 | 0.0237 | 0.0237 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0351 | 0.0351 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.1144 | 0.1144 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0037 | 0.0878 | 0.0878 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | 0.0037 | 0.0878 | 0.0878 | |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0352 | 0.0352 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0044 | 0.1144 | 0.0291 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0451 | 0.0451 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0792 | 0.0792 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0441 | 0.0441 |
Schistosoma mansoni | fk506 binding protein | 0.0037 | 0.0878 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0044 | 0.1144 | 0.1144 |
Schistosoma mansoni | immunophilin | 0.0232 | 0.8544 | 0.8544 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0352 | 0.0352 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0351 | 0.0351 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0792 | 0.0792 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.027 | 1 | 1 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.027 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0232 | 0.8544 | 0.8544 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0037 | 0.0878 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0451 | 0.0451 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0878 | 0.0878 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0037 | 0.0878 | 0.0878 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0035 | 0.0792 | 0.0792 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.027 | 1 | 1 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0035 | 0.0793 | 0.0793 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0037 | 0.0878 | 0.0878 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.027 | 1 | 1 |
Schistosoma mansoni | immunophilin | 0.027 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 0.0878 | 0.5 | |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0044 | 0.1144 | 0.1144 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0037 | 0.0878 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0044 | 0.1144 | 0.1144 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.027 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0037 | 0.0878 | 0.0878 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0037 | 0.0878 | 0.0878 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.027 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.027 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.027 | 1 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.027 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.027 | 1 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0037 | 0.0878 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.027 | 1 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0037 | 0.0878 | 0.5 |
Trypanosoma cruzi | macrophage infectivity potentiator, precursor, putative | 0.0037 | 0.0878 | 0.0878 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0035 | 0.0793 | 0.0793 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0037 | 0.0878 | 0.5 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0044 | 0.1144 | 0.0291 |
Schistosoma mansoni | immunophilin | 0.027 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.027 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0037 | 0.0878 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0878 | 0.0878 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0033 | 0.0703 | 0.0703 |
Giardia lamblia | GTOR | 0.0044 | 0.1144 | 0.0291 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0352 | 0.0352 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.027 | 1 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.027 | 1 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.027 | 1 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0037 | 0.0878 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0037 | 0.0878 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0037 | 0.0878 | 0.0878 |
Onchocerca volvulus | 0.0037 | 0.0878 | 0.5 | |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0037 | 0.0878 | 0.0878 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0351 | 0.0351 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.027 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0352 | 0.0352 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0044 | 0.1144 | 0.1144 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.8544 | 0.8544 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0044 | 0.1144 | 0.1144 |
Loa Loa (eye worm) | FKBP5 protein | 0.027 | 1 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.027 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.027 | 1 | 1 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0044 | 0.1144 | 0.1144 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.027 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0037 | 0.0878 | 0.5 |
Trichomonas vaginalis | immunophilin, putative | 0.027 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Reduction (functional) | < 30 % | Antisecretory activity was evaluated in adult mongrel dog after po administration of the compound at 8 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 75 % | Antisecretory activity was evaluated in adult mongrel dog after iv administration at 5 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 81 % | Antisecretory activity was evaluated in pylorus ligated rat after iv administration at 40 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.