Detailed information for compound 303838

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.291 | Formula: C10H12N4O5S
  • H donors: 3 H acceptors: 5 LogP: 0.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CN/N=N/S(=O)(=O)c1ccc(cc1)NC(=O)C
  • InChi: 1S/C10H12N4O5S/c1-7(15)12-8-2-4-9(5-3-8)20(18,19)14-13-11-6-10(16)17/h2-5H,6H2,1H3,(H,11,14)(H,12,15)(H,16,17)
  • InChiKey: FBZVYRZZDZCODD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Carboxylesterase family protein 0.0275 0.2779 0.2779
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.009 0.0357
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0362 1
Echinococcus multilocularis expressed protein 0.0385 0.3951 0.5488
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.1029 0.8837
Schistosoma mansoni lamin 0.0028 0.0139 0.0193
Onchocerca volvulus 0.0244 0.2451 1
Schistosoma mansoni hypothetical protein 0.002 0.0059 0.0082
Brugia malayi hypothetical protein 0.002 0.0053 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0362 0.1301
Echinococcus multilocularis musashi 0.0028 0.0139 0.0193
Echinococcus multilocularis carboxylesterase 5A 0.0275 0.2779 0.3861
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.002 0.0052 0.0201
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0139 0.0139
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0073
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0338 0.2773
Schistosoma mansoni protein kinase 0.0015 0.0003 0.0004
Echinococcus multilocularis glutamate receptor 2 0.0022 0.008 0.0111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0238 0.0319
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0362 0.0486
Schistosoma mansoni lipoxygenase 0.0057 0.0449 0.0624
Echinococcus multilocularis neuropeptide receptor 0.0023 0.009 0.0126
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0362 0.2985
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0053 0.0071
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.001 0.0033
Echinococcus granulosus neuropeptide receptor 0.0023 0.009 0.0121
Schistosoma mansoni tyrosine kinase 0.0015 0.0003 0.0004
Onchocerca volvulus 0.0046 0.0338 0.1369
Loa Loa (eye worm) hypothetical protein 0.0027 0.0133 0.0476
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.1111
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.006 0.0083
Echinococcus multilocularis conserved hypothetical protein 0.0689 0.7199 1
Echinococcus multilocularis nmda type glutamate receptor 0.0026 0.0115 0.016
Brugia malayi Doublecortin family protein 0.002 0.0059 0.0059
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.009 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.009 0.0121
Brugia malayi Carboxylesterase family protein 0.0046 0.0338 0.0338
Echinococcus granulosus RUN 0.002 0.0059 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0082
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.1339 0.186
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus geminin 0.0175 0.1707 0.2292
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi hypothetical protein 0.002 0.0059 0.0059
Brugia malayi hypothetical protein 0.002 0.0059 0.0059
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0035 0.0213 0.0765
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0362 0.0503
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.009 0.0121
Onchocerca volvulus 0.0046 0.0338 0.1369
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0031
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.1585
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0001 0.0002
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.009 0.0323
Schistosoma mansoni amine GPCR 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0053 0.0073
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.008 0.0107
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0153 0.1477 0.2052
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0001
Echinococcus granulosus hypothetical protein 0.0712 0.7447 1
Loa Loa (eye worm) carboxylesterase 0.0046 0.0338 0.1214
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Echinococcus multilocularis fmrfamide receptor 0.0023 0.009 0.0126
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0079
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.009 0.0121
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0022 0.5
Schistosoma mansoni adenoreceptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi AKH receptor 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0205 0.0205
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.009 0.0126
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.009 0.0126
Onchocerca volvulus 0.0023 0.009 0.0357
Plasmodium vivax SET domain protein, putative 0.0031 0.017 0.4358
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.1029 0.8837
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Onchocerca volvulus 0.0028 0.0139 0.0554
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.0003 0.0008
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.0003 0.0004
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.008 0.0107
Echinococcus granulosus expressed protein 0.0385 0.3951 0.5305
Onchocerca volvulus 0.0023 0.009 0.0357
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.006 0.1111
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.009 0.0323
Brugia malayi Carboxylesterase family protein 0.0046 0.0338 0.0338
Echinococcus granulosus orexin receptor type 2 0.0023 0.009 0.0121
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0053 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Loa Loa (eye worm) carboxylesterase 0.0275 0.2779 1
Schistosoma mansoni neuroligin 3 (S09 family) 0.0046 0.0338 0.047
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0053 0.0073
Schistosoma mansoni hypothetical protein 0.0034 0.0205 0.0285
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0002
Echinococcus multilocularis tyrosine kinase 0.0015 0.0003 0.0004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Onchocerca volvulus 0.0023 0.009 0.0357
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.1162 1
Echinococcus multilocularis BC026374 protein (S09 family) 0.0046 0.0338 0.047
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.006 0.0083
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.009 0.0121
Schistosoma mansoni hypothetical protein 0.0023 0.009 0.0126
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2133 0.7672
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.006 0.0213
Brugia malayi glutathione reductase 0.0049 0.0362 0.0362
Entamoeba histolytica hypothetical protein 0.002 0.0053 0.212
Loa Loa (eye worm) glutamate receptor 0.0048 0.0352 0.1263
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.0003 0.0004
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.009 0.0121
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0139 0.0496
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.006 0.008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.009 0.0121
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.009 0.0121
Echinococcus granulosus neuroligin 0.0046 0.0338 0.0454
Brugia malayi Dopamine receptor protein 1 0.0023 0.009 0.009
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.009 0.0121
Echinococcus multilocularis glutamate receptor 2 0.0015 0.0003 0.0004
Echinococcus multilocularis para nitrobenzyl esterase 0.0046 0.0338 0.047
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0046 0.0338 0.2773
Loa Loa (eye worm) hypothetical protein 0.005 0.0373 0.134
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.1162 1
Schistosoma mansoni opsin-like receptor 0.0023 0.009 0.0126
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.006 0.0156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0022 0.003
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0053 0.0073
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.009 0.009
Schistosoma mansoni opsin-like receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Entamoeba histolytica hypothetical protein 0.0037 0.0238 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0003 0.0008
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0449 0.0624
Schistosoma mansoni amine GPCR 0.0023 0.009 0.0126
Echinococcus granulosus axis inhibition protein axin 0.002 0.0053 0.0071
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0053 0.0187
Echinococcus granulosus g protein coupled receptor 0.0023 0.009 0.0121
Plasmodium falciparum glutathione reductase 0.0049 0.0362 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.017 0.0237
Onchocerca volvulus 0.0046 0.0338 0.1369
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.0003 0.0004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.009 0.0126
Mycobacterium ulcerans carboxylesterase, LipT 0.0046 0.0338 1
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0053 0.0187
Echinococcus multilocularis neuropeptide receptor 0.0023 0.009 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.009 0.0121
Echinococcus granulosus GPCR family 3 C terminal 0.002 0.0052 0.007
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.009 0.0126
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.009 0.0126
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.0003 0.0004
Onchocerca volvulus 0.0046 0.0338 0.1369
Echinococcus multilocularis fmrfamide receptor 0.0023 0.009 0.0126
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.009 0.0121
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.009 0.0126
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0018 0.0038 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) RecQ helicase 0.002 0.006 0.0213
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.009 0.0126
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.061
Loa Loa (eye worm) acetylcholinesterase 1 0.0275 0.2779 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Loa Loa (eye worm) hypothetical protein 0.0275 0.2779 1
Onchocerca volvulus 0.0023 0.009 0.0357
Schistosoma mansoni hypothetical protein 0.0023 0.009 0.0126
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.008 0.0111
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0073
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0014
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus tyrosine kinase 0.0015 0.0003 0.0004
Echinococcus granulosus lamin 0.0028 0.0139 0.0186
Plasmodium vivax glutathione reductase, putative 0.0049 0.0362 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0018 0.0038 1
Loa Loa (eye worm) glutamate receptor 0.0125 0.1177 0.4234
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0003 0.0008
Echinococcus multilocularis lamin dm0 0.0028 0.0139 0.0193
Brugia malayi Carboxylesterase family protein 0.0275 0.2779 0.2779
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Brugia malayi Bloom's syndrome protein homolog 0.002 0.006 0.006
Schistosoma mansoni myosin xvIII 0.0023 0.009 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Schistosoma mansoni BC026374 protein (S09 family) 0.0046 0.0338 0.047
Toxoplasma gondii thioredoxin reductase 0.0049 0.0362 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0053 0.0073
Schistosoma mansoni biogenic amine receptor 0.0023 0.009 0.0126
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.009 0.0126
Onchocerca volvulus Poor gastrulation protein homolog 0.002 0.0052 0.0201
Onchocerca volvulus 0.0023 0.009 0.0357
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Schistosoma mansoni hypothetical protein 0.002 0.0052 0.0072
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0449 0.0603
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.009 0.0323
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.017 0.0237
Brugia malayi Carboxylesterase family protein 0.0046 0.0338 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.0003 0.0004
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0031
Onchocerca volvulus 0.0023 0.009 0.0357
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1228 0.1705
Echinococcus multilocularis orexin receptor type 2 0.0023 0.009 0.0126
Brugia malayi sulfakinin receptor protein 0.0023 0.009 0.009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0053 0.0187
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.009 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.009 0.0126
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0138 0.1316 0.1828
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0053 0.0073
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0046 0.0338 0.047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.009 0.0121
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.009 0.009
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.7199 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.006
Echinococcus granulosus neuropeptide receptor A26 0.0023 0.009 0.0121
Echinococcus granulosus para nitrobenzyl esterase 0.0046 0.0338 0.0454
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0053 0.0071
Schistosoma mansoni amine GPCR 0.0023 0.009 0.0126
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.006
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0014
Entamoeba histolytica hypothetical protein 0.002 0.0053 0.212
Brugia malayi ORL1-like opioid receptor 0.0023 0.009 0.009
Echinococcus granulosus glutamate receptor 2 0.0022 0.008 0.0107
Echinococcus granulosus fmrfamide receptor 0.0023 0.009 0.0121
Echinococcus granulosus acetylcholinesterase 0.0275 0.2779 0.3732
Schistosoma mansoni hypothetical protein 0.0023 0.009 0.0126
Trypanosoma brucei trypanothione reductase 0.0049 0.0362 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.009 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.009 0.0126
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0373 0.0373
Mycobacterium tuberculosis Probable reductase 0.0111 0.1029 0.8837
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Onchocerca volvulus 0.0023 0.009 0.0357
Brugia malayi G-protein coupled receptor 0.0023 0.009 0.009
Echinococcus granulosus allatostatin A receptor 0.0023 0.009 0.0121
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.006 0.008
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0059 0.1078
Schistosoma mansoni biogenic amine receptor 0.0023 0.009 0.0126
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0053 0.0071
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0053 0.0187
Brugia malayi neuropeptide F receptor 0.0023 0.009 0.009
Brugia malayi Thioredoxin reductase 0.0049 0.0362 0.0362
Brugia malayi putative neuropeptide receptor 0.0023 0.009 0.009
Echinococcus multilocularis g protein coupled receptor 0.0023 0.009 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0338 0.047
Loa Loa (eye worm) follicle stimulating hormone receptor 0.026 0.2623 0.9435
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.009 0.0121
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0073
Echinococcus multilocularis acetylcholinesterase 0.0275 0.2779 0.3861
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0018 0.0038 0.0518
Schistosoma mansoni neuropeptide receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0373 0.134
Echinococcus granulosus serotonin receptor 0.0023 0.009 0.0121
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0022 0.008 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.009 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.009 0.0126
Onchocerca volvulus 0.002 0.0059 0.0228
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.009 0.0323
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0022 0.008 0.0107
Schistosoma mansoni acetylcholinesterase 0.0046 0.0338 0.047
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0046 0.0338 0.0454
Chlamydia trachomatis glutamine binding protein 0.0018 0.0038 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Onchocerca volvulus 0.0023 0.009 0.0357
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Onchocerca volvulus 0.0023 0.009 0.0357
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.011 0.1016 0.1016
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0238 0.033
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0053 0.0053
Leishmania major trypanothione reductase 0.0049 0.0362 1
Entamoeba histolytica recQ family helicase, putative 0.002 0.006 0.2425
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.001 0.0033
Schistosoma mansoni opsin-like receptor 0.0023 0.009 0.0126
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.009 0.0121
Brugia malayi Melatonin receptor type 1A 0.0023 0.009 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.017 0.0237
Onchocerca volvulus 0.0023 0.009 0.0357
Echinococcus multilocularis sex peptide receptor 0.0023 0.009 0.0126
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.009 0.0121
Onchocerca volvulus 0.0023 0.009 0.0357
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis GPCR, family 2 0.0016 0.001 0.0014
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.0003 0.0003
Echinococcus multilocularis geminin 0.0175 0.1707 0.2371
Echinococcus multilocularis allatostatin A receptor 0.0023 0.009 0.0126
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.017 0.4358
Loa Loa (eye worm) carboxylesterase 0.0046 0.0338 0.1214
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0046 0.0338 0.1302
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Echinococcus multilocularis bloom syndrome protein 0.002 0.006 0.0083
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.008 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis g protein coupled receptor 0.0023 0.009 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Schistosoma mansoni hypothetical protein 0.0175 0.1707 0.2371
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.009 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Schistosoma mansoni hypothetical protein 0.0037 0.0238 0.033
Echinococcus granulosus metabotropic glutamate receptor 5 0.0153 0.1477 0.1983
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0238 0.033
Schistosoma mansoni thyroid hormone receptor 0.014 0.1339 0.186
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.009 0.0323
Echinococcus multilocularis neuroligin 0.0046 0.0338 0.047
Plasmodium falciparum thioredoxin reductase 0.0049 0.0362 1
Echinococcus granulosus g-protein coupled receptor 0.0023 0.009 0.0121
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.009 0.0126
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.009 0.0126
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.1111
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.006 0.1111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.009 0.0323
Loa Loa (eye worm) glutathione reductase 0.0049 0.0362 0.1301
Brugia malayi hypothetical protein 0.0037 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni intermediate filament proteins 0.0028 0.0139 0.0193
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi G protein-coupled receptor 0.0023 0.009 0.009
Schistosoma mansoni DNA helicase recq1 0.002 0.006 0.0083
Brugia malayi hypothetical protein 0.002 0.0053 0.0053
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.009 0.0126
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.006 1
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.006 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0373 0.0373
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.009 0.0323
Brugia malayi PXA domain containing protein 0.002 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0026 0.0115 0.016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Onchocerca volvulus 0.0023 0.009 0.0357
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.009 0.0126
Schistosoma mansoni loxhd1 0.002 0.0059 0.0082
Schistosoma mansoni axis inhibition protein axin 0.002 0.0053 0.0073
Entamoeba histolytica hypothetical protein 0.0037 0.0238 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0053 0.0071
Echinococcus multilocularis GPCR, family 3, C terminal 0.002 0.0052 0.0072
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.009 0.0121
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0053 0.0073
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.009 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0275 0.2779 0.3861
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.0003 0.0003
Echinococcus granulosus bloom syndrome protein 0.002 0.006 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni amine GPCR 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0275 0.2779 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Brugia malayi hypothetical protein 0.0046 0.0338 0.0338
Entamoeba histolytica hypothetical protein 0.0037 0.0238 1
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0082
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0059 0.1078
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0073
Brugia malayi Dopamine receptor protein 2 0.0023 0.009 0.009
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0053 0.0073
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0185
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0053 0.0053
Schistosoma mansoni metabotropic glutamate receptor 0.0105 0.0967 0.1343
Loa Loa (eye worm) hypothetical protein 0.002 0.006 0.0213
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0053 0.0053
Brugia malayi follicle stimulating hormone receptor 0.026 0.2623 0.2623
Schistosoma mansoni biogenic amine receptor 0.0023 0.009 0.0126
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0053 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Loa Loa (eye worm) hypothetical protein 0.0028 0.0139 0.0496
Brugia malayi G-protein coupled receptor 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0053 0.0187
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0053 0.0071
Brugia malayi Pre-SET motif family protein 0.0031 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0015 0.0003 0.0008
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.1029 0.8837
Echinococcus granulosus GPCR family 2 0.0016 0.001 0.0013
Schistosoma mansoni hypothetical protein 0.0023 0.009 0.0126
Brugia malayi Serotonin receptor 0.0023 0.009 0.009
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0022 0.0533
Onchocerca volvulus 0.0028 0.0139 0.0554
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.006 0.0156
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Echinococcus multilocularis g protein coupled receptor 0.0023 0.009 0.0126
Brugia malayi metabotropic glutamate receptor type 2 0.0063 0.0513 0.0513
Echinococcus granulosus neuropeptide receptor 0.0023 0.009 0.0121
Echinococcus granulosus carboxylesterase 5A 0.0275 0.2779 0.3732
Echinococcus multilocularis somatostatin receptor 0.0023 0.009 0.0126
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.009 0.0121
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0053 0.0053
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.0003 0.0003
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.7199 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.009 0.0126
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0059 0.0079
Schistosoma mansoni rab6-interacting 0.002 0.0059 0.0082
Schistosoma mansoni hypothetical protein 0.0016 0.001 0.0014
Brugia malayi hypothetical protein 0.0015 0.0003 0.0003
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0053 0.0071
Schistosoma mansoni hypothetical protein 0.0175 0.1707 0.2371
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.1029 0.8837
Schistosoma mansoni axis inhibition protein axin 0.002 0.0053 0.0073
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0053 0.0073
Echinococcus multilocularis lamin 0.0028 0.0139 0.0193
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus granulosus nmda type glutamate receptor 0.0026 0.0115 0.0155
Onchocerca volvulus 0.002 0.0059 0.0228
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0053 0.0053
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.009 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.017 0.0237
Schistosoma mansoni regulator of G protein signaling 0.002 0.0053 0.0073
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.009 0.009
Schistosoma mansoni DNA helicase recq5 0.002 0.006 0.0083
Onchocerca volvulus 0.0046 0.0338 0.1369
Brugia malayi neuropeptide F receptor 0.0023 0.009 0.009
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.009 0.0126
Schistosoma mansoni glutamate receptor NMDA 0.0022 0.008 0.0111
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0059 0.0082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.017 0.0237
Schistosoma mansoni hypothetical protein 0.013 0.1228 0.1705
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.009 0.0126
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Schistosoma mansoni thyroid hormone receptor 0.014 0.1339 0.186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.017 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Echinococcus granulosus metabotropic glutamate receptor 2 0.0105 0.0967 0.1298
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.009 0.0121
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0053 0.0073
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0053 0.0073
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0022 0.008 0.0107
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi Pre-SET motif family protein 0.0215 0.2133 0.2133
Schistosoma mansoni gliotactin 0.0046 0.0338 0.047
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0053 0.0071
Schistosoma mansoni neuropeptide receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0153 0.1477 0.5312
Schistosoma mansoni histamine h1 receptor 0.0023 0.009 0.0126
Brugia malayi intermediate filament protein 0.0028 0.0139 0.0139
Brugia malayi metabotropic GABA-B receptor subtype 2 0.002 0.0052 0.0052
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.009 0.0126
Schistosoma mansoni metabotropic glutamate receptor 0.0063 0.0513 0.0713
Echinococcus multilocularis serotonin receptor 0.0023 0.009 0.0126
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0053 0.0073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0037 0.0238 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni lamin 0.0028 0.0139 0.0193
Echinococcus multilocularis Ankyrin 0.0015 0.0001 0.0002
Brugia malayi Metabotropic glutamate receptor precursor. 0.0125 0.1177 0.1177
Echinococcus granulosus microtubule associated protein 2 0.0689 0.7199 0.9666
Loa Loa (eye worm) doublecortin family protein 0.002 0.0059 0.0209
Schistosoma mansoni polycystin 1-related 0.002 0.0059 0.0082
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Onchocerca volvulus 0.0023 0.009 0.0357
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.009 0.0126
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0105 0.0967 0.1343
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Echinococcus multilocularis serotonin receptor 0.0023 0.009 0.0126
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0053 0.0071
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0022 0.0533
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.009 0.0126
Schistosoma mansoni tyrosine kinase 0.0015 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0209
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Brugia malayi hypothetical protein 0.0023 0.009 0.009
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.009 0.0357
Echinococcus granulosus BC026374 protein S09 family 0.0046 0.0338 0.0454
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0035 0.0213 0.0765
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0022 0.008 0.0111
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.0213 0.0213
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.0003 0.0004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0022 0.0533
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.009 0.009
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.009 0.0121
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.009 0.0126
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0053 0.0073
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.009 0.0126
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.001 0.0014
Echinococcus granulosus intermediate filament protein 0.0028 0.0139 0.0186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0533
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0022 0.0533
Mycobacterium tuberculosis Carboxylesterase LipT 0.0046 0.0338 0.2773
Onchocerca volvulus 0.0023 0.009 0.0357
Onchocerca volvulus 0.0023 0.009 0.0357
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.1029 0.8837
Brugia malayi Latrophilin receptor protein 2 0.0016 0.001 0.001
Echinococcus granulosus neuropeptide s receptor 0.0023 0.009 0.0121
Trichomonas vaginalis spcc417.12 protein, putative 0.0046 0.0338 0.1302
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0076 0.0652 0.0906
Echinococcus multilocularis neuropeptide receptor A26 0.0023 0.009 0.0126
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0022 0.5
Brugia malayi PXA domain containing protein 0.002 0.0053 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.009 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Echinococcus multilocularis neuropeptide s receptor 0.0023 0.009 0.0126
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.009 0.0121
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.009 0.0121
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.017 0.0229
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.006 0.1111
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.0059 0.0209
Echinococcus granulosus sex peptide receptor 0.0023 0.009 0.0121
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.009 0.0323
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.009 0.0126
Echinococcus granulosus lamin dm0 0.0028 0.0139 0.0186
Echinococcus granulosus g protein coupled receptor 0.0023 0.009 0.0121
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.009 0.0121
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.009 0.0126
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.009 0.0121
Entamoeba histolytica hypothetical protein 0.002 0.0053 0.212
Trichomonas vaginalis set domain proteins, putative 0.0244 0.2449 1
Echinococcus multilocularis RUN 0.002 0.0059 0.0082
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1228 0.1648
Brugia malayi Dopamine receptor 0.0023 0.009 0.009
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.009 0.0126
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0022 0.0533
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0018 0.0038 1
Echinococcus granulosus glutamate receptor 2 0.0015 0.0003 0.0004
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.006 0.1585
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0059 0.0082
Brugia malayi Carboxylesterase family protein 0.0046 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0213 0.0765
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.009 0.0121
Echinococcus granulosus acetylcholinesterase 0.0275 0.2779 0.3732
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.009 0.0323
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.009 0.0126
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.1162 1
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0362 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0338 0.047
Schistosoma mansoni neuropeptide receptor 0.0023 0.009 0.0126
Onchocerca volvulus 0.0023 0.009 0.0357
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.1162 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.009 0.0126
Onchocerca volvulus 0.0023 0.009 0.0357
Echinococcus granulosus g protein coupled receptor 0.0023 0.009 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.009 0.0126
Brugia malayi GnHR receptor homolog 0.0023 0.009 0.009
Onchocerca volvulus 0.0031 0.017 0.0684
Loa Loa (eye worm) RGS-3 protein 0.002 0.0053 0.0187
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.009 0.0126
Echinococcus multilocularis acetylcholinesterase 0.0275 0.2779 0.3861
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0046 0.0338 0.047
Brugia malayi larval opioid receptor 0.0023 0.009 0.009
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0139 0.0496
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0158 0.0212
Schistosoma mansoni lipoxygenase 0.002 0.0059 0.0082
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0053 0.0053
Schistosoma mansoni amine GPCR 0.0023 0.009 0.0126
Brugia malayi RE15519p 0.0023 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.0023 0.009 0.0323
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.009 0.0126
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.001 0.0013
Schistosoma mansoni neuropeptide receptor 0.0023 0.009 0.0126
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0018 0.0038 1
Echinococcus granulosus Ankyrin 0.0015 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0205 0.0735
Loa Loa (eye worm) hypothetical protein 0.0046 0.0338 0.1214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.009 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0053 0.0126
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0053 0.0073
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0059 0.0079
Echinococcus granulosus somatostatin receptor 0.0023 0.009 0.0121
Echinococcus granulosus nuclear factor of activated T cells 5 0.0076 0.0652 0.0876
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.009 0.009

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 200 uM Inhibitory concentration to inhibit HIV-1 integrase by 3' -processing method ChEMBL. 9083480
IC50 (binding) > 200 uM Inhibitory concentration against HIV-1 integrase by strand transfer method ChEMBL. 9083480
IC50 (binding) > 200 uM Inhibitory concentration to inhibit HIV-1 integrase by 3' -processing method ChEMBL. 9083480
IC50 (binding) > 200 uM Inhibitory concentration against HIV-1 integrase by strand transfer method ChEMBL. 9083480

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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