Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | No references |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | = 17 hr | Tested for total duration time(BP) after peroral administration of 30 mg/kg of dose in high renin rat | ChEMBL. | No reference |
Kd (binding) | = 7.9 | In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings | ChEMBL. | No reference |
Max drop (functional) | = 26 % | Tested for percent of maximal blood pressure drop in high renin rat after per oral administration of 30 mg/kg of dose | ChEMBL. | No reference |
Onset (functional) | = 1 hr | Tested for total onset time(BP) after peroral administration of 30 mg/kg of dose in high renin rat | ChEMBL. | No reference |
pA2 (binding) | = 7.9 | In vitro binding affinity against Angiotensin II receptor in rabbit aorta rings | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.