Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1203 | 0.3755 | 0.8404 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1396 | 0.4404 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0192 | 0.0341 | 0.0774 |
Schistosoma mansoni | immunophilin | 0.1396 | 0.4404 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0192 | 0.0341 | 0.0774 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.0341 | 0.0774 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0192 | 0.0341 | 0.0774 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1396 | 0.4404 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0192 | 0.0341 | 0.0774 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0192 | 0.0341 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0192 | 0.0341 | 0.0774 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1396 | 0.4404 | 1 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1396 | 0.4404 | 1 |
Onchocerca volvulus | 0.0192 | 0.0341 | 1 | |
Giardia lamblia | Hypothetical protein | 0.0192 | 0.0341 | 0.0774 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1396 | 0.4404 | 1 |
Mycobacterium ulcerans | hydrolase/amidase | 0.0268 | 0.0597 | 0.1357 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1396 | 0.4404 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1396 | 0.4404 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0192 | 0.0341 | 0.5 |
Brugia malayi | hypothetical protein | 0.0512 | 0.142 | 0.142 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0192 | 0.0341 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1396 | 0.4404 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0192 | 0.0341 | 0.0774 |
Schistosoma mansoni | lipoxygenase | 0.0228 | 0.0461 | 0.0296 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1203 | 0.3755 | 0.8404 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0192 | 0.0341 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0192 | 0.0341 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0192 | 0.0341 | 0.0341 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1396 | 0.4404 | 1 |
Onchocerca volvulus | 0.0192 | 0.0341 | 1 | |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1396 | 0.4404 | 0.4404 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0192 | 0.0341 | 0.0341 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1396 | 0.4404 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1396 | 0.4404 | 1 |
Loa Loa (eye worm) | FKBP5 protein | 0.1396 | 0.4404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1293 | 0.4056 | 0.921 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0192 | 0.0341 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0192 | 0.0341 | 0.0774 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1396 | 0.4404 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0192 | 0.0341 | 0.0774 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0192 | 0.0341 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0192 | 0.0341 | 0.0774 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1396 | 0.4404 | 0.4404 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.0341 | 0.0774 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1396 | 0.4404 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1396 | 0.4404 | 1 |
Schistosoma mansoni | immunophilin | 0.1203 | 0.3755 | 0.8404 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1203 | 0.3755 | 0.8528 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0228 | 0.0461 | 0.0296 |
Leishmania major | fk506-binding protein 1-like protein | 0.1396 | 0.4404 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.1396 | 0.4404 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0192 | 0.0341 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0192 | 0.0341 | 0.0341 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.142 | 0.3225 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0192 | 0.0341 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0192 | 0.0341 | 0.0774 |
Schistosoma mansoni | immunophilin | 0.1396 | 0.4404 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1396 | 0.4404 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0192 | 0.0341 | 0.0774 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0228 | 0.0461 | 0.0296 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1396 | 0.4404 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.1396 | 0.4404 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1396 | 0.4404 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 14.8 nM | Binding affinity of the compound to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand | ChEMBL. | No reference |
Ki (binding) | = 20.1 nM | Binding affinity of the compound to 5-hydroxytryptamine 3 receptor in rat entorhinal cortex using [3H]-BRL 43694 as radioligand | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.