Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3026 | 1 |
Echinococcus multilocularis | cyclin B3 1 | 0.0053 | 0.0832 | 0.0832 |
Trichomonas vaginalis | cyclins, putative | 0.0053 | 0.0832 | 0.169 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3026 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0102 | 0.4924 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0079 | 0.3026 | 0.5 |
Onchocerca volvulus | 0.0102 | 0.4924 | 0.5 | |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.4924 | 0.4924 |
Trichomonas vaginalis | cyclin B3, putative | 0.0053 | 0.0832 | 0.169 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0079 | 0.3026 | 0.3026 |
Entamoeba histolytica | cyclin, putative | 0.0053 | 0.0832 | 0.169 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0102 | 0.4924 | 0.4924 |
Echinococcus granulosus | cyclins | 0.0053 | 0.0832 | 0.0832 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0102 | 0.4924 | 1 |
Echinococcus granulosus | cyclins | 0.0053 | 0.0832 | 0.0832 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Plasmodium falciparum | cyclin | 0.0053 | 0.0832 | 0.275 |
Trichomonas vaginalis | cyclins, putative | 0.0102 | 0.4924 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3026 | 0.6145 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0102 | 0.4924 | 1 |
Echinococcus granulosus | cyclins | 0.0053 | 0.0832 | 0.0832 |
Trichomonas vaginalis | cyclins, putative | 0.0102 | 0.4924 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0053 | 0.0832 | 0.169 |
Trichomonas vaginalis | cyclin B, putative | 0.0102 | 0.4924 | 1 |
Trypanosoma cruzi | cyclin 6, putative | 0.0102 | 0.4924 | 1 |
Giardia lamblia | Hypothetical protein | 0.0053 | 0.0832 | 0.169 |
Trichomonas vaginalis | cyclins, putative | 0.0102 | 0.4924 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0163 | 1 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0102 | 0.4924 | 0.4924 |
Trichomonas vaginalis | cyclins, putative | 0.0102 | 0.4924 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0079 | 0.3026 | 0.5 |
Echinococcus granulosus | cyclin B3 1 | 0.0053 | 0.0832 | 0.0832 |
Brugia malayi | dihydrofolate reductase family protein | 0.0079 | 0.3026 | 0.3026 |
Brugia malayi | Dihydrofolate reductase | 0.0079 | 0.3026 | 0.3026 |
Entamoeba histolytica | cyclin family protein | 0.0053 | 0.0832 | 0.169 |
Trichomonas vaginalis | cyclin B, putative | 0.0102 | 0.4924 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.3026 | 1 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0079 | 0.3026 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0079 | 0.3026 | 0.3026 |
Echinococcus granulosus | cyclins | 0.0053 | 0.0832 | 0.0832 |
Echinococcus multilocularis | cyclin b3 | 0.0053 | 0.0832 | 0.0832 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0163 | 1 | 1 |
Giardia lamblia | Cyclin A | 0.0053 | 0.0832 | 0.169 |
Trypanosoma cruzi | cyclin, putative | 0.0102 | 0.4924 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0102 | 0.4924 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.4924 | 0.4924 |
Leishmania major | cyclin | 0.0102 | 0.4924 | 1 |
Schistosoma mansoni | cyclins | 0.0053 | 0.0832 | 0.0832 |
Echinococcus granulosus | cyclin b3 | 0.0053 | 0.0832 | 0.0832 |
Trichomonas vaginalis | cyclin B, putative | 0.0102 | 0.4924 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0053 | 0.0832 | 0.169 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0163 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0053 | 0.0832 | 0.169 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3026 | 0.6145 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0079 | 0.3026 | 0.3026 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.3026 | 0.6145 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0102 | 0.4924 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0079 | 0.3026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0537 | 0.0537 |
Trichomonas vaginalis | cyclin D, putative | 0.0053 | 0.0832 | 0.169 |
Echinococcus granulosus | cyclins | 0.0053 | 0.0832 | 0.0832 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Trichomonas vaginalis | cyclins, putative | 0.0062 | 0.1595 | 0.324 |
Trichomonas vaginalis | cyclin A, putative | 0.0102 | 0.4924 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0053 | 0.0832 | 0.169 |
Schistosoma mansoni | dihydrofolate reductase | 0.0079 | 0.3026 | 0.3026 |
Schistosoma mansoni | cyclin B | 0.0102 | 0.4924 | 0.4924 |
Echinococcus multilocularis | cyclin B | 0.0102 | 0.4924 | 0.4924 |
Schistosoma mansoni | cyclin B3 | 0.0163 | 1 | 1 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0102 | 0.4924 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0102 | 0.4924 | 1 |
Echinococcus granulosus | cyclin B | 0.0102 | 0.4924 | 0.4924 |
Echinococcus multilocularis | cyclins | 0.0053 | 0.0832 | 0.0832 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 220000000 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
I50 (binding) | > 4000000000000 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
IC50 (binding) | = 0.000000022 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
IC50 (binding) | > 0.0004 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.