Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 34 ug ml-1 | Inhibitory concentration against purified recombinant integrase by strand transfer 3D search (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 34 ug ml-1 | Inhibitory concentration against purified recombinant integrase by strand transfer 3D search (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 68 ug ml-1 | Inhibitory concentration against purified recombinant integrase by strand transfer 3D search (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 68 ug ml-1 | Inhibitory concentration against purified recombinant integrase by strand transfer 3D search (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 74 ug ml-1 | Inhibitory concentration against purified recombinant integrase by 3'-processing in 3D search (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 74 ug ml-1 | Inhibitory concentration against purified recombinant integrase by 3'-processing in 3D search (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 89 ug ml-1 | Inhibitory concentration against purified recombinant integrase by 3'-processing in 3D search (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 89 ug ml-1 | Inhibitory concentration against purified recombinant integrase by 3'-processing in 3D search (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 135 uM | Inhibitory concentration against purified recombinant integrase by strand transfer in vitro assay (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 135 uM | Inhibitory concentration against purified recombinant integrase by strand transfer in vitro assay (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 268 uM | Inhibitory concentration against purified recombinant integrase by strand transfer in vitro assay (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 268 uM | Inhibitory concentration against purified recombinant integrase by strand transfer in vitro assay (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 289 uM | Inhibitory concentration against purified recombinant integrase by 3'-processing in vitro assay (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 289 uM | Inhibitory concentration against purified recombinant integrase by 3'-processing in vitro assay (experiment 2) | ChEMBL. | 9083481 |
IC50 (binding) | = 350 uM | Inhibitory concentration against purified recombinant integrase by 3'-processing in vitro assay (experiment 1) | ChEMBL. | 9083481 |
IC50 (binding) | = 350 uM | Inhibitory concentration against purified recombinant integrase by 3'-processing in vitro assay (experiment 1) | ChEMBL. | 9083481 |
Inhibition (binding) | = 57.9 % | Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL | ChEMBL. | 9083481 |
Inhibition (binding) | = 57.9 % | Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by 3''-processing method at 100 micro g/mL | ChEMBL. | 9083481 |
Inhibition (binding) | = 65.6 % | Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL | ChEMBL. | 9083481 |
Inhibition (binding) | = 65.6 % | Percentage inhibition was obtained by performing in vitro assay on purified recombinant integrase by strand transfer method at 100 micro g/mL | ChEMBL. | 9083481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.