Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 2 | 0.028 | 0.2815 | 0.2946 |
Onchocerca volvulus | 0.028 | 0.2815 | 0.2772 | |
Brugia malayi | hypothetical protein | 0.0326 | 0.3334 | 0.3566 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Echinococcus granulosus | protein jagged 1 | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0866 | 0.9348 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0587 | 0.5 |
Schistosoma mansoni | slit | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0102 | 0.0828 | 0.0886 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.0828 | 0.0748 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0087 | 0.0093 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0161 | 0.1494 | 0.152 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.0587 | 0.0504 |
Brugia malayi | Blistered cuticle protein 3 | 0.0866 | 0.9348 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0087 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Muscle positioning protein 4 | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Delta serrate ligand family protein | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Toxoplasma gondii | EGF family domain-containing protein | 0.028 | 0.2815 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.0587 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | cell polarity protein | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0129 | 0.1133 | 0.1212 |
Brugia malayi | hypothetical protein | 0.027 | 0.2701 | 0.289 |
Brugia malayi | hypothetical protein | 0.0866 | 0.9348 | 1 |
Onchocerca volvulus | 0.0326 | 0.3334 | 0.3346 | |
Echinococcus granulosus | delta-like protein 1 | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Echinococcus granulosus | slit 2 protein | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.028 | 0.2815 | 0.2752 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.028 | 0.2815 | 0.2772 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.0587 | 0.054 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0102 | 0.0828 | 0.0748 |
Echinococcus multilocularis | notch | 0.028 | 0.2815 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Echinococcus granulosus | geminin | 0.0376 | 0.3889 | 0.4106 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | geminin | 0.0376 | 0.3889 | 0.3835 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.028 | 0.2815 | 0.2752 |
Echinococcus granulosus | notch | 0.028 | 0.2815 | 0.2946 |
Brugia malayi | Peroxidasin | 0.0866 | 0.9348 | 1 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0587 | 0.054 |
Echinococcus multilocularis | protein jagged 1 | 0.028 | 0.2815 | 0.2752 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | laminin gamma-3 chain | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0326 | 0.3334 | 0.3566 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0087 | 0.0093 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0866 | 0.9348 | 1 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.031 | 0.024 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.0587 | 0.054 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0587 | 0.5 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.031 | 0.024 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | Notch2 | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | peroxidasin | 0.0866 | 0.9348 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.027 | 0.2701 | 0.2823 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0828 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.2701 | 0.289 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0866 | 0.9348 | 1 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Brugia malayi | Animal haem peroxidase family protein | 0.0866 | 0.9348 | 1 |
Onchocerca volvulus | 0.028 | 0.2815 | 0.2772 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0828 | 0.0801 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | neurogenic locus protein delta | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | septate junction protein | 0.028 | 0.2815 | 0.2946 |
Echinococcus granulosus | fibropellin Ia | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0129 | 0.1133 | 0.1212 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0866 | 0.9348 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Onchocerca volvulus | 0.0866 | 0.9348 | 1 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | Peroxidasin homolog | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1494 | 0.1599 |
Onchocerca volvulus | Slit protein homolog | 0.028 | 0.2815 | 0.2772 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.031 | 0.0331 |
Echinococcus multilocularis | peroxidasin | 0.0866 | 0.9348 | 0.9342 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.028 | 0.2815 | 0.2752 |
Echinococcus multilocularis | fibropellin Ia | 0.028 | 0.2815 | 0.2752 |
Schistosoma mansoni | notch | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | slit 2 protein | 0.028 | 0.2815 | 0.2752 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0587 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.093 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.054 | 0.0577 |
Echinococcus granulosus | protein jagged 2 | 0.028 | 0.2815 | 0.2946 |
Echinococcus granulosus | neurogenic locus notch protein | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.028 | 0.2815 | 0.2752 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.028 | 0.2815 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1494 | 0.1599 |
Schistosoma mansoni | hypothetical protein | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0087 | 0.0093 |
Onchocerca volvulus | Dual oxidase homolog | 0.0866 | 0.9348 | 1 |
Echinococcus granulosus | neurogenic locus notch protein | 0.028 | 0.2815 | 0.2946 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.0828 | 0.0801 |
Brugia malayi | Animal haem peroxidase family protein | 0.0866 | 0.9348 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.028 | 0.2815 | 0.2752 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0102 | 0.0828 | 0.0886 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0866 | 0.9348 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Animal haem peroxidase family protein | 0.0866 | 0.9348 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | GCC2 and GCC3 family protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | 0.028 | 0.2815 | 0.2772 | |
Echinococcus multilocularis | muscleblind protein 1 | 0.0161 | 0.1494 | 0.142 |
Echinococcus granulosus | neural cadherin | 0.028 | 0.2815 | 0.2946 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | Peroxidase homolog | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | 0.0866 | 0.9348 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Muscleblind-like protein | 0.0161 | 0.1494 | 0.1599 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | Cadherin domain containing protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.027 | 0.2701 | 0.2637 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Echinococcus multilocularis | protein jagged 2 | 0.028 | 0.2815 | 0.2752 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.093 | 0.0995 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | Peroxidase homolog | 0.0866 | 0.9348 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.3889 | 0.4106 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | peroxidasin | 0.0866 | 0.9348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0102 | 0.0828 | 0.0801 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.093 | 0.0995 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0102 | 0.0828 | 0.0801 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2815 | 0.3011 |
Schistosoma mansoni | hypothetical protein | 0.0376 | 0.3889 | 0.4106 |
Echinococcus multilocularis | muscleblind protein | 0.0161 | 0.1494 | 0.142 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.093 | 0.0995 |
Echinococcus granulosus | protein jagged 1 | 0.028 | 0.2815 | 0.2946 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.028 | 0.2815 | 0.2752 |
Onchocerca volvulus | 0.0866 | 0.9348 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0866 | 0.9348 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.0587 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0129 | 0.1133 | 0.1212 |
Onchocerca volvulus | 0.028 | 0.2815 | 0.2772 | |
Echinococcus multilocularis | protein jagged 1 | 0.028 | 0.2815 | 0.2752 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.054 | 0.0489 |
Loa Loa (eye worm) | notch protein | 0.028 | 0.2815 | 0.3011 |
Onchocerca volvulus | 0.028 | 0.2815 | 0.2772 | |
Echinococcus multilocularis | neural cadherin | 0.028 | 0.2815 | 0.2752 |
Brugia malayi | EGF-like domain containing protein | 0.028 | 0.2815 | 0.3011 |
Giardia lamblia | High cysteine protein | 0.028 | 0.2815 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0866 | 0.9348 | 1 |
Onchocerca volvulus | Putative cubilin | 0.028 | 0.2815 | 0.2772 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.054 | 0.0577 |
Brugia malayi | Animal haem peroxidase family protein | 0.0866 | 0.9348 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED100 (functional) | = 272 ug kg-1 | Antiemetic potency was tested against cisplatin-induced emetic latency period in ferret after oral administration | ChEMBL. | 1548679 |
ED50 (functional) | = 33 ug kg-1 | Antiemetic potency was tested against cisplatin-induced emetic episodes in ferret after oral administration | ChEMBL. | 1548679 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.