Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | immunophilin | 0.1533 | 0.862 | 0.862 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1748 | 0.9853 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0241 | 0.1206 | 0.1224 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0241 | 0.1206 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1753 | 0.988 | 1 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0241 | 0.1206 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0241 | 0.1206 | 0.1224 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0241 | 0.1206 | 0.5 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1748 | 0.9853 | 0.9853 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.1774 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0241 | 0.1206 | 0.1206 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1748 | 0.9853 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1748 | 0.9853 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1748 | 0.9853 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0241 | 0.1206 | 0.5 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1748 | 0.9853 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1748 | 0.9853 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.1774 | 1 | 1 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0241 | 0.1206 | 0.1224 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0241 | 0.1206 | 0.1224 |
Schistosoma mansoni | fk506 binding protein | 0.0241 | 0.1206 | 0.1206 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1748 | 0.9853 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1748 | 0.9853 | 0.9853 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1748 | 0.9853 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.1206 | 0.1224 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0241 | 0.1206 | 0.1224 |
Loa Loa (eye worm) | FKBP5 protein | 0.1748 | 0.9853 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0241 | 0.1206 | 0.5 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0241 | 0.1206 | 0.1224 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0241 | 0.1206 | 0.1224 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.1748 | 0.9853 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1748 | 0.9853 | 0.9969 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1774 | 1 | 1 |
Onchocerca volvulus | 0.0245 | 0.1233 | 1 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0241 | 0.1206 | 0.1224 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1533 | 0.862 | 0.862 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0241 | 0.1206 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0241 | 0.1206 | 0.5 |
Onchocerca volvulus | 0.0241 | 0.1206 | 0.9782 | |
Trichomonas vaginalis | immunophilin, putative | 0.1748 | 0.9853 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1748 | 0.9853 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Schistosoma mansoni | immunophilin | 0.1774 | 1 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0241 | 0.1206 | 0.1224 |
Loa Loa (eye worm) | hypothetical protein | 0.1512 | 0.85 | 0.8627 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0241 | 0.1206 | 0.1224 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0241 | 0.1206 | 0.1224 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1748 | 0.9853 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0241 | 0.1206 | 0.5 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0241 | 0.1206 | 0.1224 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0241 | 0.1206 | 0.5 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1748 | 0.9853 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0241 | 0.1206 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.1206 | 0.1206 |
Schistosoma mansoni | immunophilin | 0.1774 | 1 | 1 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0266 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0241 | 0.1206 | 0.1224 |
Echinococcus multilocularis | 0.0241 | 0.1206 | 0.1206 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0241 | 0.1206 | 0.1224 |
Echinococcus multilocularis | fk506 binding protein | 0.1748 | 0.9853 | 0.9853 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1533 | 0.862 | 0.862 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0241 | 0.1206 | 0.1224 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 11 % | Compound was tested for inhibitory activity against Cholesteryl ester transfer protein at 50 uM | ChEMBL. | No reference |
Inhibition (binding) | = 11 % | Compound was tested for inhibitory activity against Cholesteryl ester transfer protein at 50 uM | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.