Detailed information for compound 304736

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 230.259 | Formula: C14H14O3
  • H donors: 1 H acceptors: 1 LogP: 3 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)COc1ccccc1)O
  • InChi: 1S/C14H14O3/c1-16-13-7-8-14(15)11(9-13)10-17-12-5-3-2-4-6-12/h2-9,15H,10H2,1H3
  • InChiKey: XQAYEDQPINZZQD-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0005 0.0099 0.0114
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0005 0.0099 0.0114
Schistosoma mansoni glutamate synthase 0.002 0.0715 0.0715
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0715 0.0827
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0715 0.0715
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0715 0.0715
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0715 0.2243
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0005 0.0099 0.0114
Brugia malayi nuclear hormone receptor 0.0005 0.0099 0.0114
Echinococcus granulosus cpg binding protein 0.0018 0.0661 0.0661
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Loa Loa (eye worm) CXXC zinc finger family protein 0.0017 0.062 0.0717
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0715 0.0827
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0005 0.0131 0.0131
Schistosoma mansoni sulfide quinone reductase 0.002 0.0715 0.0715
Schistosoma mansoni hypothetical protein 0.0009 0.0266 0.0266
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0004 0.0088 0.0088
Loa Loa (eye worm) steroid hormone receptor 0.0005 0.0099 0.0114
Plasmodium vivax glutathione reductase, putative 0.0214 0.8645 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0074 0.2938 0.2803
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0002 0.0011 0.0011
Onchocerca volvulus 0.0017 0.062 0.8673
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0715 0.2243
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0715 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0005 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.002 0.0715 0.0715
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0005 0.0099 0.0099
Brugia malayi Protein kinase domain containing protein 0.0009 0.0266 0.0308
Brugia malayi nuclear receptor RXR 0.0002 0.0011 0.0012
Loa Loa (eye worm) thioredoxin reductase 0.0214 0.8645 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0005 0.0099 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0005 0.0131 0.0131
Giardia lamblia NADH oxidase lateral transfer candidate 0.0074 0.2938 1
Plasmodium falciparum thioredoxin reductase 0.0214 0.8645 1
Brugia malayi F/Y-rich N-terminus family protein 0.0005 0.0128 0.0148
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0074 0.2938 0.3399
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0074 0.2938 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0074 0.2938 0.2803
Brugia malayi ecdysteroid receptor 0.0005 0.0099 0.0114
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0715 0.2243
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0005 0.0099 0.0099
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0715 0.0715
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0715 0.5
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0715 0.5
Brugia malayi hypothetical protein 0.0002 0.0011 0.0012
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0005 0.0099 0.0099
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0715 0.2243
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0074 0.2938 0.2938
Loa Loa (eye worm) hypothetical protein 0.0002 0.0011 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0005 0.0099 0.0114
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0074 0.2938 0.2938
Echinococcus granulosus geminin 0.0102 0.4091 0.4091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0099 0.0099
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0004 0.0088 0.0088
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0715 0.0715
Schistosoma mansoni retinoic acid receptor RXR 0.0005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0715 0.2243
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.2938 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0074 0.2938 0.2803
Schistosoma mansoni thyroid hormone receptor 0.0005 0.0099 0.0099
Plasmodium falciparum glutathione reductase 0.0214 0.8645 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0005 0.0099 0.0114
Echinococcus granulosus FTZ F1 alpha 0.0005 0.0099 0.0099
Brugia malayi hypothetical protein 0.0002 0.0011 0.0012
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Schistosoma mansoni cpg binding protein 0.0018 0.0661 0.0661
Brugia malayi Nuclear hormone receptor-like 1 0.0002 0.0011 0.0012
Echinococcus granulosus glutamate synthase 0.002 0.0715 0.0715
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0715 0.0715
Loa Loa (eye worm) glutathione reductase 0.0214 0.8645 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0002 0.0011 0.0011
Schistosoma mansoni cpg binding protein 0.0018 0.0661 0.0661
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0099 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0074 0.2938 0.2803
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0715 0.5
Trichomonas vaginalis mercuric reductase, putative 0.0074 0.2938 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0099 0.0114
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Trypanosoma cruzi trypanothione reductase, putative 0.0074 0.2938 0.2803
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0002 0.0011 0.0012
Schistosoma mansoni sulfide quinone reductase 0.002 0.0715 0.0715
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0715 0.5
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0099 0.0099
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0099 0.0114
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0074 0.2938 0.2803
Echinococcus granulosus thioredoxin glutathione reductase 0.0214 0.8645 0.8645
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0005 0.0099 0.0114
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0074 0.2938 1
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0099 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0074 0.2938 0.2803
Brugia malayi nuclear receptor NHR-88 0.0005 0.0099 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0005 0.0099 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0005 0.0099 0.0114
Plasmodium falciparum thioredoxin reductase 0.0074 0.2938 0.2803
Brugia malayi glutathione reductase 0.0214 0.8645 1
Schistosoma mansoni hypothetical protein 0.0102 0.4091 0.4091
Echinococcus granulosus ecdysone induced protein 78C 0.0005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0009 0.0269 0.0312
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0074 0.2938 0.2938
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0074 0.2938 0.2803
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0715 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0005 0.0099 0.0099
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0074 0.2938 0.2803
Echinococcus multilocularis FTZ F1 alpha 0.0005 0.0099 0.0099
Echinococcus multilocularis ecdysone induced protein 78C 0.0005 0.0099 0.0099
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0074 0.2938 0.2803
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0005 0.0099 0.0114
Schistosoma mansoni hypothetical protein 0.0102 0.4091 0.4091
Schistosoma mansoni netrin receptor unc5 0.0009 0.0266 0.0266
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0074 0.2938 0.2803
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0074 0.2938 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0099 0.0099
Trichomonas vaginalis glutathione reductase, putative 0.0074 0.2938 1
Brugia malayi steroid hormone receptor 0.0005 0.0099 0.0114
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0009 0.0266 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0005 0.0099 0.0114
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0715 0.0715
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.2938 1
Echinococcus multilocularis netrin receptor unc 5 0.0009 0.0266 0.0266
Onchocerca volvulus 0.0005 0.0099 0.1381
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.2938 0.2803
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0004 0.0088 0.0088
Echinococcus granulosus death domain containing protein 0.0009 0.0266 0.0266
Schistosoma mansoni cpg binding protein 0.0017 0.062 0.062
Brugia malayi Death domain containing protein 0.0009 0.0266 0.0308
Echinococcus granulosus mixed lineage leukemia protein mll 0.0004 0.0088 0.0088
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0715 0.2243
Treponema pallidum NADH oxidase 0.0074 0.2938 1
Schistosoma mansoni glutamate synthase 0.002 0.0715 0.0715
Loa Loa (eye worm) hypothetical protein 0.0002 0.0011 0.0012
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0715 0.0827
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0005 0.0099 0.0099
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0005 0.0099 0.0099
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0074 0.2938 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0002 0.0011 0.0012
Schistosoma mansoni coup transcription factor 0.0005 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0005 0.0099 0.0114
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0715 0.0715
Plasmodium falciparum glutathione reductase 0.0074 0.2938 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0074 0.2938 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0088 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0005 0.0099 0.0099
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0715 0.0715
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0009 0.0266 0.0308
Onchocerca volvulus Protein ultraspiracle homolog 0.0005 0.0099 0.1381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0005 0.0099 0.0114
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0074 0.2938 0.2803
Onchocerca volvulus Bile acid receptor homolog 0.0005 0.0099 0.1381
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0715 0.0827
Echinococcus granulosus Ankyrin 0.0009 0.0269 0.0269
Schistosoma mansoni glutamate synthase 0.002 0.0715 0.0715
Echinococcus multilocularis thyroid hormone receptor alpha 0.0005 0.0099 0.0099
Loa Loa (eye worm) programmed cell death 8 0.002 0.0715 0.0827
Trypanosoma cruzi trypanothione reductase, putative 0.0214 0.8645 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0044 0.1728 0.1728
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0074 0.2938 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0044 0.1728 0.1728
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0005 0.0099 0.1381
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0054 0.2135 0.2469
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0002 0.0011 0.0011
Echinococcus multilocularis geminin 0.0102 0.4091 0.4091
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0715 0.0715
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0005 0.0099 0.0099
Brugia malayi Thioredoxin reductase 0.0214 0.8645 1
Onchocerca volvulus Netrin receptor homolog 0.0009 0.0266 0.3726
Echinococcus multilocularis Ankyrin 0.0009 0.0269 0.0269
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0074 0.2938 0.2803
Schistosoma mansoni ankyrin 23/unc44 0.0009 0.0266 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0005 0.0099 0.0114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0099 0.0099
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.1414 0.1414
Brugia malayi Uncoordinated protein 44 0.0009 0.0266 0.0308
Loa Loa (eye worm) hypothetical protein 0.0005 0.0099 0.0114
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0005 0.0099 0.0099
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0074 0.2938 0.2803
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0715 0.2243
Echinococcus multilocularis glutamate synthase 0.002 0.0715 0.0715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0074 0.2938 1
Loa Loa (eye worm) histone methyltransferase 0.0005 0.0131 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.1187 0.1187
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0715 0.0715
Onchocerca volvulus 0.002 0.0715 1
Echinococcus multilocularis dnaJ subfamily B 0.0247 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0002 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0005 0.0099 0.0114
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0715 0.0715
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0005 0.0099 0.0114
Leishmania major trypanothione reductase 0.0214 0.8645 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0074 0.2938 0.2803
Loa Loa (eye worm) hypothetical protein 0.0009 0.0266 0.0308
Brugia malayi photoreceptor-specific nuclear receptor 0.0005 0.0099 0.0114
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0074 0.2938 0.2803
Plasmodium vivax thioredoxin reductase, putative 0.0214 0.8645 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0266 0.0308
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0054 0.2135 0.2469
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0005 0.0099 0.0099
Brugia malayi CXXC zinc finger family protein 0.0017 0.062 0.0717
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.002 0.0715 0.0827
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0009 0.0266 0.0266
Toxoplasma gondii NADPH-glutathione reductase 0.0074 0.2938 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0005 0.0099 0.0114
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0715 0.2243
Schistosoma mansoni hypothetical protein 0.0247 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0002 0.0011 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0214 0.8645 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0005 0.0099 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0005 0.0099 0.0114
Brugia malayi glutamate synthase 0.002 0.0715 0.0827
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0009 0.0269 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0005 0.0099 0.0099
Toxoplasma gondii histone lysine methyltransferase SET1 0.0033 0.1254 0.0679
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0002 0.0011 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0099 0.0099
Echinococcus multilocularis thioredoxin glutathione reductase 0.0214 0.8645 0.8645
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0715 0.5
Echinococcus granulosus netrin receptor unc 5 0.0009 0.0266 0.0266
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0715 0.0715
Toxoplasma gondii thioredoxin reductase 0.0214 0.8645 1
Brugia malayi Nuclear hormone receptor-like 1 0.0002 0.0011 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0005 0.0099 0.0099
Echinococcus multilocularis cpg binding protein 0.0018 0.0661 0.0661
Trypanosoma brucei trypanothione reductase 0.0214 0.8645 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1400 nM Inhibitory activity against production of leukotriene B4 in isolated human polymorphonuclear leukocytes ChEMBL. 2308140
IC50 (functional) = 1400 nM Inhibitory activity against production of leukotriene B4 in isolated human polymorphonuclear leukocytes ChEMBL. 2308140
logP (ADMET) = 3.3 Partition coefficient (logP) ChEMBL. 2308140

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 2308140

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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