Detailed information for compound 304873

Basic information

Technical information
  • TDR Targets ID: 304873
  • Name: (3Z)-3-[(1-methylindol-3-yl)methylidene]-1H-p yrrolo[2,3-b]pyridin-2-one
  • MW: 275.305 | Formula: C17H13N3O
  • H donors: 1 H acceptors: 2 LogP: 2.24 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2c(/C/1=C/c1cn(c3c1cccc3)C)cccn2
  • InChi: 1S/C17H13N3O/c1-20-10-11(12-5-2-3-7-15(12)20)9-14-13-6-4-8-18-16(13)19-17(14)21/h2-10H,1H3,(H,18,19,21)/b14-9-
  • InChiKey: RJBBKRZRJMHITR-ZROIWOOFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3Z)-3-[(1-methylindol-3-yl)methylene]-1H-pyrrolo[2,3-b]pyridin-2-one
  • (3Z)-3-[(1-methyl-3-indolyl)methylene]-1H-pyrrolo[2,3-b]pyridin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis cyclin D, putative 0.0038 0.0933 0.2565
Entamoeba histolytica cyclin, putative 0.0038 0.0933 0.2565
Echinococcus granulosus cyclin B 0.009 0.3044 0.3044
Loa Loa (eye worm) thioredoxin reductase 0.0211 0.7909 0.7991
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0073 0.2365 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.152 0.1536
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Schistosoma mansoni cyclin B3 0.0038 0.0933 0.0933
Echinococcus multilocularis cyclin B 0.009 0.3044 0.3044
Trichomonas vaginalis cyclin B3, putative 0.0038 0.0933 0.2565
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0211 0.7909 1
Trichomonas vaginalis cyclins, putative 0.009 0.3044 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.152 0.152
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0205 0.0205
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0205 0.0205
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0073 0.2365 0.2803
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0205 0.0205
Trypanosoma cruzi trypanothione reductase, putative 0.0073 0.2365 0.2803
Trichomonas vaginalis cyclin B, putative 0.009 0.3044 1
Leishmania major cyclin 0.009 0.3044 0.3685
Brugia malayi Raf kinase 0.0254 0.9633 1
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.152 0.1708
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0073 0.2365 0.2803
Brugia malayi cell division control protein 2 homolog 0.0052 0.152 0.1578
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0205 0.0213
Entamoeba histolytica cyclin, putative 0.009 0.3044 1
Echinococcus granulosus cyclins 0.0038 0.0933 0.0933
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0205 0.0205
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0205 0.0213
Plasmodium vivax thioredoxin reductase, putative 0.0211 0.7909 1
Brugia malayi glutamate synthase 0.0019 0.0205 0.0213
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0205 0.0205
Trypanosoma cruzi trypanothione reductase, putative 0.0211 0.7909 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.1498 0.1513
Trichomonas vaginalis glutathione reductase, putative 0.0073 0.2365 0.7607
Trichomonas vaginalis cyclins, putative 0.009 0.3044 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0073 0.2365 0.2365
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0205 0.0205
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Echinococcus granulosus cyclins 0.0038 0.0933 0.0933
Toxoplasma gondii NADPH-glutathione reductase 0.0073 0.2365 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0073 0.2365 0.2803
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.152 0.1708
Trypanosoma brucei trypanothione reductase 0.0211 0.7909 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0211 0.7909 0.7909
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.152 0.152
Trichomonas vaginalis cyclins, putative 0.009 0.3044 1
Loa Loa (eye worm) raf kinase 0.026 0.9897 1
Trypanosoma cruzi cyclin 6, putative 0.009 0.3044 0.3685
Toxoplasma gondii hypothetical protein 0.0028 0.0569 0.0473
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.152 0.4634
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0073 0.2365 0.2803
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0073 0.2365 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.152 0.4634
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0073 0.2365 1
Onchocerca volvulus 0.009 0.3044 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0073 0.2365 1
Brugia malayi Thioredoxin reductase 0.0211 0.7909 0.821
Giardia lamblia Kinase, CMGC CDK 0.0052 0.152 0.4634
Echinococcus multilocularis glutamate synthase 0.0019 0.0205 0.0205
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.152 0.152
Giardia lamblia Kinase, CMGC CDK 0.0052 0.152 0.4634
Echinococcus granulosus cyclin b3 0.0038 0.0933 0.0933
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.015 0.5443 0.5499
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0073 0.2365 0.2803
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.3044 0.3685
Trichomonas vaginalis cyclin B, putative 0.0038 0.0933 0.2565
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0054 0.1584 0.1644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0073 0.2365 0.2803
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.152 0.1536
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0073 0.2365 0.2803
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0933 0.0933
Brugia malayi glutathione reductase 0.0211 0.7909 0.821
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Entamoeba histolytica cyclin family protein 0.0038 0.0933 0.2565
Echinococcus granulosus cyclins 0.0038 0.0933 0.0933
Plasmodium vivax glutathione reductase, putative 0.0211 0.7909 1
Leishmania major trypanothione reductase 0.0211 0.7909 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0073 0.2365 0.2365
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.152 0.1708
Loa Loa (eye worm) hypothetical protein 0.0019 0.0205 0.0207
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.152 0.152
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0205 0.0205
Echinococcus multilocularis raf serine:threonine protein kinase 0.0263 1 1
Trichomonas vaginalis cyclins, putative 0.009 0.3044 1
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Echinococcus granulosus cyclins 0.0038 0.0933 0.0933
Loa Loa (eye worm) hypothetical protein 0.009 0.3044 0.3075
Echinococcus multilocularis cyclin b3 0.0038 0.0933 0.0933
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0073 0.2365 0.2803
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0933 0.0943
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0205 0.0205
Echinococcus granulosus glutamate synthase 0.0019 0.0205 0.0205
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0073 0.2365 0.2803
Mycobacterium tuberculosis Probable oxidoreductase 0.0073 0.2365 0.2803
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.152 0.1708
Plasmodium falciparum glutathione reductase 0.0211 0.7909 1
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0205 0.0207
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0073 0.2365 0.2803
Schistosoma mansoni cyclins 0.0038 0.0933 0.0933
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.152 0.4634
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0073 0.2365 0.2365
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0205 0.0205
Trichomonas vaginalis cyclin B, putative 0.009 0.3044 1
Toxoplasma gondii thioredoxin reductase 0.0211 0.7909 1
Schistosoma mansoni serine/threonine protein kinase 0.0263 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0073 0.2365 0.2803
Schistosoma mansoni cyclin B 0.009 0.3044 0.3044
Trypanosoma brucei mitotic cyclin 6 0.009 0.3044 0.3685
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0073 0.2365 1
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Trypanosoma cruzi cyclin, putative 0.009 0.3044 0.3685
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.152 0.4634
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.152 0.1708
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.152 0.1536
Plasmodium falciparum protein kinase 5 0.0052 0.152 0.1708
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0073 0.2365 0.2803
Trichomonas vaginalis cyclins, putative 0.0038 0.0933 0.2565
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.152 0.1708
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0205 0.0205
Treponema pallidum NADH oxidase 0.0073 0.2365 1
Echinococcus granulosus cyclin B3 1 0.0038 0.0933 0.0933
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0205 0.0205
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.152 0.1708
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.152 0.4634
Schistosoma mansoni glutamate synthase 0.0019 0.0205 0.0205
Schistosoma mansoni glutamate synthase 0.0019 0.0205 0.0205
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0205 0.0205
Trichomonas vaginalis cyclin D, putative 0.0038 0.0933 0.2565
Schistosoma mansoni hypothetical protein 0.0019 0.0205 0.0205
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0073 0.2365 0.2803
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0933 0.0933
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.152 0.152
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0073 0.2365 0.2455
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.3044 0.316
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0205 0.0207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0073 0.2365 0.2803
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.3044 1
Trichomonas vaginalis cyclins, putative 0.0062 0.1899 0.5968
Loa Loa (eye worm) glutathione reductase 0.0211 0.7909 0.7991
Schistosoma mansoni glutamate synthase 0.0019 0.0205 0.0205
Giardia lamblia Hypothetical protein 0.0038 0.0933 0.2565
Echinococcus granulosus thioredoxin glutathione reductase 0.0211 0.7909 0.7909
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0933 0.2565
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0205 0.0205
Plasmodium vivax protein kinase Crk2 0.0052 0.152 0.1708
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0073 0.2365 0.2803
Trypanosoma cruzi cyclin, putative 0.009 0.3044 0.3685
Entamoeba histolytica cyclin family protein 0.0038 0.0933 0.2565
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0205 0.0205
Onchocerca volvulus 0.0019 0.0205 0.0673
Echinococcus multilocularis cyclin B3 1 0.0038 0.0933 0.0933
Giardia lamblia NADH oxidase lateral transfer candidate 0.0073 0.2365 0.7607
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0933 0.0969
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.152 0.152
Trichomonas vaginalis cyclin B, putative 0.009 0.3044 1
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.152 0.152
Trichomonas vaginalis cyclin A, putative 0.009 0.3044 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0054 0.1584 0.1644
Loa Loa (eye worm) hypothetical protein 0.009 0.3044 0.3075
Brugia malayi Protein kinase domain containing protein 0.0052 0.152 0.1578
Plasmodium falciparum thioredoxin reductase 0.0073 0.2365 0.2803
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.152 0.1708
Echinococcus granulosus cyclins 0.0038 0.0933 0.0933
Echinococcus granulosus cyclin dependent kinase 0.0052 0.152 0.152
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0073 0.2365 1
Plasmodium falciparum glutathione reductase 0.0073 0.2365 0.2803
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.152 0.152
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0073 0.2365 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0073 0.2365 0.2803
Plasmodium falciparum thioredoxin reductase 0.0211 0.7909 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.152 0.152
Loa Loa (eye worm) hypothetical protein 0.0052 0.1535 0.1551
Trichomonas vaginalis mercuric reductase, putative 0.0073 0.2365 0.7607
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.3044 0.316
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0205 0.0205
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0205 0.0213
Plasmodium falciparum cyclin 0.0038 0.0933 0.0945
Trichomonas vaginalis cyclin B, putative 0.009 0.3044 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0073 0.2365 0.2803
Giardia lamblia Cyclin A 0.0038 0.0933 0.2565
Echinococcus multilocularis cyclins 0.0038 0.0933 0.0933
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.3044 0.3685
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.152 0.1708

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.012 uM Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor) ChEMBL. 15013000
IC50 (binding) = 0.012 uM Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor) ChEMBL. 15013000
IC50 (binding) > 6 uM Inhibition of Cyclin-dependent kinase 2 cyclin A ChEMBL. 15013000
IC50 (binding) > 6 uM Inhibition of Cyclin-dependent kinase 2 cyclin A ChEMBL. 15013000
IC50 (binding) = 7.2 uM Inhibition of c-Raf1 kinase ChEMBL. 15013000
IC50 (binding) = 7.2 uM Inhibition of c-Raf1 kinase ChEMBL. 15013000

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.