TDR Targets

Basic information

Technical information

TDR Targets ID: 304984
Name: 5,7-diphenyl-1H-pyrrolo[2,3-d]pyrimidin-4-one
MW: 287.315 | Formula: C18H13N3O
H donors: 1 H acceptors: 1 LogP: 3.06 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]cnc2c1c(cn2c1ccccc1)c1ccccc1
InChi: 1S/C18H13N3O/c22-18-16-15(13-7-3-1-4-8-13)11-21(17(16)19-12-20-18)14-9-5-2-6-10-14/h1-12H,(H,19,20,22)
InChiKey: YTLWLZPZXNOVGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5,7-di(phenyl)-1H-pyrrolo[3,2-e]pyrimidin-4-one
ZINC03866115
ZINC02455205

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Gallus gallus	Tyrosine-protein kinase SRC	Starlite/ChEMBL	References
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.1 %
Onchocerca volvulus		Tyrosine-protein kinase SRC	533 aa	435 aa	27.4 %
Echinococcus multilocularis	tyrosine protein kinase Abl	Tyrosine-protein kinase SRC	533 aa	506 aa	36.6 %
Echinococcus multilocularis	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.9 %
Schistosoma mansoni	serine/threonine protein kinase	Tyrosine-protein kinase SRC	533 aa	473 aa	24.5 %
Echinococcus granulosus	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Onchocerca volvulus	Cyclin-H homolog	Tyrosine-protein kinase SRC	533 aa	453 aa	44.8 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Brugia malayi	Tyrosine-protein kinase abl-1	Tyrosine-protein kinase SRC	533 aa	455 aa	44.4 %
Schistosoma mansoni	tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	501 aa	35.3 %
Echinococcus multilocularis	tyrosine protein kinase Btk29A	Tyrosine-protein kinase SRC	533 aa	500 aa	35.0 %
Echinococcus granulosus	c src tyrosine kinase	Tyrosine-protein kinase SRC	533 aa	513 aa	33.7 %
Echinococcus granulosus	tyrosine protein kinase ABL1	Tyrosine-protein kinase SRC	533 aa	473 aa	39.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0018	0.0476	0.0796
Echinococcus granulosus	7TM GPCR rhodopsin	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0021	0.0669	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	NCK adaptor protein	0.0018	0.0476	0.0796
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Brugia malayi	Melatonin receptor type 1A	0.0061	0.3717	0.3717
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	c src tyrosine kinase	0.0021	0.0669	0.1118
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3717	0.6212
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0021	0.0669	0.1118
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3717	0.6212
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4894	0.8179
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3717	0.6212
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Onchocerca volvulus		0.002	0.0666	0.1792
Loa Loa (eye worm)	TK/ROR protein kinase	0.0023	0.0859	0.0859
Onchocerca volvulus		0.0061	0.3717	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4894	0.8179
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3717	0.6212
Entamoeba histolytica	protein kinase, putative	0.0073	0.4628	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0018	0.0476	0.0796
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0061	0.3717	0.3717
Brugia malayi	Dopamine receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	orexin receptor type 2	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0082	0.5314	0.8882
Schistosoma mansoni	hypothetical protein	0.0061	0.3717	0.6212
Brugia malayi	RE15519p	0.0061	0.3717	0.3717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	tissue type plasminogen activator	0.002	0.0666	0.1113
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0061	0.3717	0.6212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.008	0.5121	0.856
Schistosoma mansoni	growth factor receptor-bound protein	0.0018	0.0476	0.0796
Echinococcus granulosus	serotonin receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0061	0.3717	0.6212
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0091	0.5983	1
Schistosoma mansoni	tyrosine kinase	0.0091	0.5983	1
Echinococcus granulosus	tar DNA binding protein	0.0076	0.4894	0.8179
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0091	0.5983	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0061	0.3717	0.6212
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0061	0.3717	0.3717
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0061	0.3717	0.3717
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.3717	0.6212
Brugia malayi	AKH receptor	0.0061	0.3717	0.3717
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.3717	0.6212
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4894	0.8179
Loa Loa (eye worm)	SRC-1	0.0091	0.5983	0.5983
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Echinococcus granulosus	neuropeptide receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	neuropeptide FF receptor 2	0.0061	0.3717	0.6212
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0091	0.5983	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.4894	0.4894
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.4894	0.4894
Brugia malayi	sulfakinin receptor protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	opsin-like receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3717	0.6212
Brugia malayi	Protein kinase domain containing protein	0.0023	0.0859	0.0859
Schistosoma mansoni	myosin xvIII	0.0061	0.3717	0.6212
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0476	0.0476
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0091	0.5983	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0021	0.0669	0.0669
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3717	0.6212
Echinococcus multilocularis	g-protein coupled receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0061	0.3717	0.6212
Brugia malayi	G protein-coupled receptor	0.0061	0.3717	0.3717
Echinococcus multilocularis	neuropeptide receptor A26	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0666	0.0666
Brugia malayi	Dopamine receptor protein 2	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0061	0.3717	0.3717
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	1	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	larval opioid receptor	0.0061	0.3717	0.3717
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0091	0.5983	1
Brugia malayi	Serotonin receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	hypothetical protein	0.0061	0.3717	0.6212
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	serotonin receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0073	0.4628	0.7735
Echinococcus granulosus	G protein coupled receptor 139	0.0061	0.3717	0.6212
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0061	0.3717	0.6212
Echinococcus granulosus	neuropeptides capa receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0018	0.0476	0.0476
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0061	0.3717	0.6212
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	growth factor receptor-bound protein	0.0018	0.0476	0.0796
Brugia malayi	protein-tyrosine kinase	0.0082	0.5314	0.5314
Schistosoma mansoni	opsin-like receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	TYRA-2 protein	0.0061	0.3717	0.3717
Schistosoma mansoni	hypothetical protein	0.002	0.0666	0.1113
Loa Loa (eye worm)	RNA binding protein	0.0076	0.4894	0.4894
Echinococcus granulosus	sex peptide receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	neuropeptide s receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	neuropeptide Y receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	tyrosine kinase	0.0091	0.5983	1
Onchocerca volvulus		0.0061	0.3717	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0091	0.5983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0061	0.3717	0.6212
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.4894	0.8179
Echinococcus multilocularis	somatostatin receptor	0.0061	0.3717	0.6212
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	hypothetical protein	0.0061	0.3717	0.6212
Schistosoma mansoni	tyrosine kinase	0.0021	0.0669	0.1118
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0082	0.5314	0.8882
Schistosoma mansoni	neuropeptide f receptor 76f	0.0061	0.3717	0.6212
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	amine GPCR	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	sex peptide receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	neuropeptides capa receptor	0.0061	0.3717	0.6212
Brugia malayi	ORL1-like opioid receptor	0.0061	0.3717	0.3717
Brugia malayi	Serotonin receptor	0.0061	0.3717	0.3717
Brugia malayi	Dopamine receptor protein 1	0.0061	0.3717	0.3717
Brugia malayi	G-protein coupled receptor	0.0061	0.3717	0.3717
Brugia malayi	Sex muscle abnormal protein 5	0.0018	0.0476	0.0476
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0061	0.3717	1
Loa Loa (eye worm)	TK protein kinase	0.0082	0.5314	0.5314
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0091	0.5983	1
Schistosoma mansoni	hypothetical protein	0.0061	0.3717	0.6212
Schistosoma mansoni	hypothetical protein	0.0061	0.3717	0.6212
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.002	0.0666	0.5
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0061	0.3717	0.6212
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0666	0.5
Brugia malayi	G protein-coupled receptor F59B2.13	0.0061	0.3717	0.3717
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0091	0.5983	1
Onchocerca volvulus		0.0061	0.3717	1
Schistosoma mansoni	adenoreceptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0021	0.0669	0.1118
Echinococcus multilocularis	orexin receptor type 2	0.0061	0.3717	0.6212
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0061	0.3717	0.6212
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0021	0.0669	0.1118
Schistosoma mansoni	tyrosine kinase	0.0021	0.0669	0.1118
Brugia malayi	SRC-1	0.0091	0.5983	0.5983
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	amine GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0091	0.5983	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0061	0.3717	0.3717
Echinococcus multilocularis	fmrfamide receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	biogenic amine receptor	0.0061	0.3717	0.6212
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0061	0.3717	0.3717
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0091	0.5983	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0082	0.5314	0.8882
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0091	0.5983	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0061	0.3717	0.6212
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	neuropeptide s receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	neuropeptide Y receptor	0.0061	0.3717	0.6212
Leishmania major	hypothetical protein, conserved	0.002	0.0666	0.5
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	opsin-like receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	allatostatin A receptor	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Onchocerca volvulus		0.0061	0.3717	1
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0476	0.0476
Echinococcus granulosus	tyrosine kinase	0.0082	0.5314	0.8882
Echinococcus granulosus	g-protein coupled receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0061	0.3717	0.6212
Brugia malayi	neuropeptide F receptor	0.0061	0.3717	0.3717
Brugia malayi	follicle stimulating hormone receptor	0.0061	0.3717	0.3717
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4894	0.8179
Onchocerca volvulus		0.0061	0.3717	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.008	0.5121	0.856
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	adapter molecule crk	0.0018	0.0476	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.3717	0.3717
Toxoplasma gondii	kringle domain-containing protein	0.002	0.0666	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0091	0.5983	1
Onchocerca volvulus		0.0061	0.3717	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	amine GPCR	0.0061	0.3717	0.6212
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0061	0.3717	0.3717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Schistosoma mansoni	neuropeptide F-like receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	amine GPCR	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	c src tyrosine kinase	0.0021	0.0669	0.1118
Brugia malayi	GnHR receptor homolog	0.0061	0.3717	0.3717
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0091	0.5983	1
Echinococcus granulosus	g protein coupled receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	TAR-binding protein	0.0076	0.4894	0.4894
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	neuropeptide receptor A26	0.0061	0.3717	0.6212
Echinococcus granulosus	fmrfamide receptor	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0082	0.5314	0.8882
Plasmodium falciparum	cysteine repeat modular protein 1	0.002	0.0666	0.5
Brugia malayi	Kringle domain containing protein	0.002	0.0666	0.0666
Loa Loa (eye worm)	TK protein kinase	0.0073	0.4628	0.4628
Schistosoma mansoni	amine GPCR	0.0061	0.3717	0.6212
Echinococcus granulosus	tm gpcr rhodopsin	0.0061	0.3717	0.6212
Echinococcus multilocularis	G protein coupled receptor 139	0.0061	0.3717	0.6212
Schistosoma mansoni	histamine h1 receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	neuropeptide receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tissue type plasminogen activator	0.002	0.0666	0.1113
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	G-protein coupled receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	melatonin receptor type 1A	0.0061	0.3717	0.3717
Echinococcus multilocularis	allatostatin A receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0018	0.0476	0.0476
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4894	0.8179
Echinococcus granulosus	biogenic amine 5HT receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0061	0.3717	0.6212
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.4894	0.4894
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	7tm_1 domain containing protein	0.0061	0.3717	0.6212
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0061	0.3717	0.3717
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3717	0.6212
Brugia malayi	Variant SH3 domain containing protein	0.0018	0.0476	0.0476
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0061	0.3717	0.3717
Echinococcus granulosus	tyrosine protein kinase HCK	0.0073	0.4628	0.7735
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0061	0.3717	0.3717
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0091	0.5983	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0091	0.5983	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Brugia malayi	putative neuropeptide receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus granulosus	somatostatin receptor	0.0061	0.3717	0.6212
Brugia malayi	putative neuropeptide receptor NPR1	0.0061	0.3717	0.3717
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0061	0.3717	0.6212
Onchocerca volvulus		0.0061	0.3717	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0091	0.5983	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0061	0.3717	0.6212
Brugia malayi	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Schistosoma mansoni	neuropeptide receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	NCK adaptor protein	0.0018	0.0476	0.0796
Brugia malayi	G-protein coupled receptor	0.0061	0.3717	0.3717
Brugia malayi	RNA binding protein	0.0076	0.4894	0.4894
Echinococcus multilocularis	serotonin receptor	0.0061	0.3717	0.6212
Echinococcus multilocularis	g protein coupled receptor	0.0061	0.3717	0.6212
Schistosoma mansoni	nck2/grb4	0.0018	0.0476	0.0796
Echinococcus granulosus	neuropeptide receptor	0.0061	0.3717	0.6212
Echinococcus granulosus	tyrosine protein kinase Blk	0.0082	0.5314	0.8882
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	neuropeptide F receptor	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0091	0.5983	1
Brugia malayi	neuropeptide F receptor	0.0061	0.3717	0.3717
Echinococcus granulosus	growth factor receptor bound protein 2	0.0018	0.0476	0.0796
Echinococcus granulosus	dro:myosuppressin receptor	0.0061	0.3717	0.6212
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717
Loa Loa (eye worm)	hypothetical protein	0.0061	0.3717	0.3717

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 5	Inhibition of c-Src	ChEMBL.	18722033
IC50 (binding)	uM	Inhibition of EGF-receptor tyrosine kinase (Not determined)	ChEMBL.	10853665
IC50 (binding)	uM	Inhibition of serine/threonine kinase Cdc2 (Not determined)	ChEMBL.	10853665
IC50 (binding)	0 uM	Inhibition of EGF-receptor tyrosine kinase (Not determined)	ChEMBL.	10853665
IC50 (binding)	0 uM	Tested in vitro for inhibition of KDR-receptor tyrosine kinase; Not determined	ChEMBL.	10853665
IC50 (binding)	0 uM	Tested in vitro for inhibition of non-receptor tyrosine kinase v-Abl; Not determined	ChEMBL.	10853665
IC50 (binding)	0 uM	Inhibition of serine/threonine kinase Cdc2 (Not determined)	ChEMBL.	10853665
IC50 (binding)	= 10 uM	Tested for inhibition of protein tyrosine kinase c-Src phosphorylation	ChEMBL.	10853665
IC50 (binding)	= 10 uM	Tested for inhibition of protein tyrosine kinase c-Src phosphorylation	ChEMBL.	10853665
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Saccharomyces cerevisiae	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL173474
PubChem: 2049537

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 304984