Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor alpha | Starlite/ChEMBL | References |
Homo sapiens | peroxisome proliferator-activated receptor delta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Schistosoma japonicum | IPR008946,Nuclear receptor, ligand-binding,domain-containing | Get druggable targets OG5_137778 | All targets in OG5_137778 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor delta | 441 aa | 369 aa | 24.7 % |
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Brugia malayi | ecdysteroid receptor | peroxisome proliferator-activated receptor alpha | 468 aa | 397 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0273 | 0.5368 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0273 | 0.5368 | 1 |
Schistosoma mansoni | peroxidasin | 0.0273 | 0.5368 | 0.5368 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | 0.0273 | 0.5368 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | 0.0273 | 0.5368 | 1 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Echinococcus granulosus | peroxidasin | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0273 | 0.5368 | 1 |
Brugia malayi | Peroxidasin | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0273 | 0.5368 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0273 | 0.5368 | 1 |
Schistosoma mansoni | peroxidasin | 0.0273 | 0.5368 | 0.5368 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0273 | 0.5368 | 1 |
Giardia lamblia | High cysteine protein | 0.0088 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0273 | 0.5368 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0088 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Brugia malayi | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | 0.0273 | 0.5368 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0273 | 0.5368 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0273 | 0.5368 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 33 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR alpha receptor | ChEMBL. | 12617924 |
EC50 (functional) | = 33 nM | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR alpha receptor | ChEMBL. | 12617924 |
Inhibition (functional) | = 69 % | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR delta at 3 microM; Max % | ChEMBL. | 12617924 |
Inhibition (functional) | = 69 % | Agonistic activity was determined in COS1 cells transfected with GAL 4-PPAR delta at 3 microM; Max % | ChEMBL. | 12617924 |
Inhibition (functional) | = 72 % | Agonistic transcriptional activity in COS1 cells expressing GAL 4-PPAR gamma at 3 uM; Maximal percent | ChEMBL. | 12617924 |
Inhibition (functional) | = 72 % | Agonistic transcriptional activity in COS1 cells expressing GAL 4-PPAR gamma at 3 uM; Maximal percent | ChEMBL. | 12617924 |
Ki (binding) | = 156 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) | ChEMBL. | 12617924 |
Ki (binding) | = 156 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor delta (PPAR delta) | ChEMBL. | 12617924 |
Ki (binding) | = 305 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) | ChEMBL. | 12617924 |
Ki (binding) | = 305 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor alpha (PPAR alpha) | ChEMBL. | 12617924 |
Ki (binding) | = 616 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) | ChEMBL. | 12617924 |
Ki (binding) | = 616 nM | In vitro binding affinity towards human peroxisome proliferator activated receptor gamma (PPAR gamma) | ChEMBL. | 12617924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.