Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | 0.017 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.017 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | 0.017 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.017 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.017 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | 0.017 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.017 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.017 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.017 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta MST (functional) | = -0.1 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 1.25mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = -0.1 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 1.25mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 2.5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 0.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 2.5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 1.9 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 1.9 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 5mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 2.1 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 10mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 2.1 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 10mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 5.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 20mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 5.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 20mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 9.3 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 40mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 9.3 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 40mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 11.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 80mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 11.5 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 80mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 21.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 320mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 21.2 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 320mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 21.7 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 160mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 21.7 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 160mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 25 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 640mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
Delta MST (functional) | = 25 day | Delta MST, difference in mean survival time of the control mice (an average of 6.2 days) from the mean survival time of the treated mice after a single sc dose of 640mg/kg, 72-h postinfection | ChEMBL. | 3712383 |
ED30 (functional) | = 89 mg kg-1 | Antimalarial activity in the initial screen | ChEMBL. | 3712383 |
ED30 (functional) | = 89 mg kg-1 | Antimalarial activity in the initial screen | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 1 | Antimalarial activity, administered as a single sc dose of 80mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 2 | Antimalarial activity, administered as a single sc dose of 640mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 1 | Antimalarial activity, administered as a single sc dose of 320mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 1 | Antimalarial activity administered as a single sc dose of 160mg/kg, 72-h post Plasmodium berghei infection, measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 1 | Antimalarial activity, administered as a single sc dose of 80mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
No. of mice cured (functional) | = 2 | Antimalarial activity, administered as a single sc dose of 640mg/kg, 72-h postinfection measured as number of mice surviving at 60 days postinfection | ChEMBL. | 3712383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.