Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0.1234 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0211 | 1 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0073 | 0.1234 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0073 | 0.1234 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0211 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073 | 0.1234 | 0.5 |
Leishmania major | trypanothione reductase | 0.0211 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0211 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0211 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0211 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0211 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0073 | 0.1234 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0211 | 1 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0073 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0073 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0073 | 0.1234 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0073 | 0.1234 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0211 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0073 | 0.1234 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0211 | 1 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0211 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0073 | 0.1234 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0211 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0211 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0073 | 0.1234 | 0.1234 |
Brugia malayi | Thioredoxin reductase | 0.0211 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Decrease in blood pressure (functional) | = 22.7 mmHg | Compound was tested for antihypertensive activity in rat after 24 hr postdose | ChEMBL. | 3712385 |
Decrease in blood pressure (functional) | = 31.3 mmHg | Compound was tested for antihypertensive activity in rat after 1 hr postdose | ChEMBL. | 3712385 |
Decrease in blood pressure (functional) | = 45 mmHg | Compound was tested for antihypertensive activity in rat after 4 hr postdose | ChEMBL. | 3712385 |
Diuretic activity (functional) | = 5 ml | Diuretic activity in rats at time intervals of 0-5 hours | ChEMBL. | 3712385 |
Diuretic activity (functional) | = 6.8 ml | Diuretic activity in rats at time intervals of 5-24 hours | ChEMBL. | 3712385 |
Diuretic activity (functional) | = 11.8 ml | Diuretic activity in rats at time intervals of 0-24 hours | ChEMBL. | 3712385 |
Ratio (functional) | = 1.13 | Saluretic activity in rats after 5-24 hours, as ratio of Na+/K+ ion concentration in urine | ChEMBL. | 3712385 |
Ratio (functional) | = 1.33 | Saluretic activity in rats after 0-24 hours, as ratio of Na+/K+ ion concentration in urine | ChEMBL. | 3712385 |
Ratio (functional) | = 1.74 | Saluretic activity in rats after 0-5 hours, as ratio of Na+/K+ ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 2.55 m equiv kg-1 | Saluretic activity in rats after 0-5 hours, as potassium ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 3.15 m equiv kg-1 | Saluretic activity in rats after 5-24 hours, as chloride ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 4.45 m equiv kg-1 | Saluretic activity in rats after 0-5 hours, as sodium ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 5.27 m equiv kg-1 | Saluretic activity in rats after 5-24 hours, as potassium ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 5.98 m equiv kg-1 | Saluretic activity in rats after 5-24 hours, as sodium ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 6.2 m equiv kg-1 | Saluretic activity in rats after 0-5 hours, as chloride ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 7.82 m equiv kg-1 | Saluretic activity in rats after 0-24 hours, as potassium ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 9.35000000000003 m equiv kg-1 | Saluretic activity in rats after 0-24 hours, as chloride ion concentration in urine | ChEMBL. | 3712385 |
Saluretic activity (functional) | = 10.43 m equiv kg-1 | Saluretic activity in rats after 0-24 hours, as sodium ion concentration in urine | ChEMBL. | 3712385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.