Detailed information for compound 305212

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 400.809 | Formula: C16H18ClF3N7-
  • H donors: 3 H acceptors: 3 LogP: 3.29 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCNc1nc(Nc2cccc(c2)C(F)(F)F)c2c(n1)n(CC)cn2.[Cl-]
  • InChi: 1S/C16H18F3N7.ClH/c1-2-26-9-22-12-13(24-15(21-7-6-20)25-14(12)26)23-11-5-3-4-10(8-11)16(17,18)19;/h3-5,8-9H,2,6-7,20H2,1H3,(H2,21,23,24,25);1H/p-1
  • InChiKey: XPUCBIWVODOLJD-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0179 0.0892 0.3468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0892 0.2337
Echinococcus granulosus RUN 0.008 0.0338 0.0334
Leishmania major pteridine reductase 1 0.0026 0.0031 0.1261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0069 0.0168
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0077 0.0322 0.0318
Loa Loa (eye worm) retinol dehydrogenase 12 0.0026 0.0031 0.0106
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0083 0.031
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0091 0.0438
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0026 0.0031 0.0085
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0091 0.0438
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0077 0.0322 0.1242
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0031 0.0106
Loa Loa (eye worm) hypothetical protein 0.0077 0.0322 0.1242
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0026 0.0031 0.0027
Schistosoma mansoni heat shock protein 0.0037 0.0097 0.0245
Loa Loa (eye worm) CYP4Cod1 0.0038 0.01 0.0376
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0573 0.0569
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0068 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.3803 0.3801
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0068 0.017
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0031 0.0135
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0159 0.7225
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0083 0.0181
Plasmodium vivax JmjC domain containing protein 0.0032 0.0068 0.0135
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0343
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0025 0.0068
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0026 0.0031 0.0135
Toxoplasma gondii cathepsin CPC1 0.0591 0.3201 1
Schistosoma mansoni polycystin 1-related 0.008 0.0338 0.0878
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0026 0.0031 0.0135
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0159 0.7225
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0159 0.8813
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0092 0.024
Echinococcus granulosus insulin receptor 0.0058 0.021 0.0206
Schistosoma mansoni tyrosine kinase 0.0058 0.021 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0057
Schistosoma mansoni hypothetical protein 0.0077 0.0322 0.0837
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0121 0.0566 0.0563
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0218 0.0215
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0025 0.003
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Schistosoma mansoni tyrosine kinase 0.0096 0.0425 0.1107
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Brugia malayi mbt repeat family protein 0.0103 0.0465 0.1802
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Schistosoma mansoni alpha-glucosidase 0.0142 0.0683 0.1787
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0121 0.0566 0.0563
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.048 0.2581 0.2578
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0238
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0591 0.3201 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0092 0.5034
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0628 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0092 0.024
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0465 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0103 0.0274
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0252
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.107
Schistosoma mansoni jumonji domain containing protein 0.0121 0.0566 0.148
Schistosoma mansoni rab6-interacting 0.008 0.0338 0.0878
Brugia malayi jmjC domain containing protein 0.0121 0.0566 0.2196
Trichomonas vaginalis glutaminase, putative 0.0276 0.1438 0.4464
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.018 0.0463
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0092 0.0277
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0465 0.1802
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0068 0.0064
Echinococcus granulosus Smad4 0.0032 0.007 0.0066
Mycobacterium ulcerans lipase LipD 0.0036 0.0091 0.0438
Brugia malayi Furin-like cysteine rich region family protein 0.018 0.0898 0.3492
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Trichomonas vaginalis hypothetical protein 0.0378 0.2008 0.6253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0103 0.0274
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.018 0.0176
Loa Loa (eye worm) latrophilin receptor protein 2 0.0077 0.0322 0.1242
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0091 0.0088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.0566 0.148
Brugia malayi jmjC domain containing protein 0.0032 0.0068 0.0252
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0083 0.0395
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0159 0.0605
Brugia malayi Doublecortin family protein 0.008 0.0338 0.1304
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.018 0.0514
Echinococcus granulosus heat shock protein 90 0.003 0.0054 0.005
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0591 0.3201 1
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0031 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0106
Loa Loa (eye worm) hypothetical protein 0.0052 0.0176 0.0674
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0026 0.0031 0.0085
Echinococcus multilocularis pyruvate kinase 0.0028 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.031
Loa Loa (eye worm) hypothetical protein 0.008 0.0338 0.1304
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0026 0.0031 0.0135
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0097 0.5286
Brugia malayi MH2 domain containing protein 0.0477 0.2564 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.0811 0.3155
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0218 0.0671
Loa Loa (eye worm) transcription factor SMAD2 0.0477 0.2564 1
Leishmania major hypothetical protein, conserved 0.0025 0.0025 0.1008
Echinococcus granulosus arachidonate 5 lipoxygenase 0.048 0.2581 0.2578
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Brugia malayi mbt repeat family protein 0.0103 0.0465 0.1802
Brugia malayi MH1 domain containing protein 0.0032 0.007 0.0257
Schistosoma mansoni hypothetical protein 0.0167 0.0826 0.2164
Schistosoma mansoni hypothetical protein 0.0108 0.0496 0.1296
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0097 0.0136
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0054 0.2344
Onchocerca volvulus 0.0036 0.0091 0.1396
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.0892 0.0888
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.4988
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Schistosoma mansoni heat shock protein 0.0037 0.0097 0.0245
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0026 0.0031 0.0135
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0068 0.0064
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0091 0.0343
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0068 0.0064
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1578 0.8741 0.8741
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0159 0.0449
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0068 0.0064
Echinococcus granulosus microtubule associated protein 2 0.0698 0.3803 0.3801
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0026 0.0031 0.1538
Loa Loa (eye worm) cytochrome P450 family protein 0.0095 0.0423 0.1637
Echinococcus multilocularis smad 0.0032 0.007 0.0066
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0465 0.0462
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0092 0.0346
Toxoplasma gondii ABC1 family protein 0.0036 0.0091 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0892 0.2337
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0083 0.031
Trichomonas vaginalis heat shock protein, putative 0.003 0.0054 0.012
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0068 0.0252
Plasmodium falciparum enoyl-acyl carrier reductase 0.0378 0.2008 0.6253
Echinococcus multilocularis endoplasmin 0.003 0.0054 0.005
Brugia malayi cell division control protein 2 homolog 0.0052 0.018 0.0687
Echinococcus multilocularis heat shock protein 90 0.003 0.0054 0.005
Brugia malayi heat shock protein 90 0.0037 0.0097 0.0363
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Mycobacterium ulcerans glutaminase 0.0276 0.1438 0.7156
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0378 0.2008 1
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0083 0.0211
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0465 0.1215
Loa Loa (eye worm) MBCTL1 0.0117 0.0545 0.2115
Echinococcus granulosus lysine specific demethylase 5A 0.0121 0.0566 0.0563
Echinococcus granulosus epidermal growth factor receptor 0.0097 0.043 0.0427
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0026 0.0031 0.0135
Plasmodium falciparum pyruvate kinase 0.0035 0.0083 0.0211
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.0892 0.0888
Mycobacterium leprae Probable lipase LipE 0.0036 0.0091 0.0438
Onchocerca volvulus 0.0036 0.0091 0.1396
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.018 0.0687
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0025 0.003
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0097 0.0363
Mycobacterium tuberculosis Probable oxidoreductase 0.0026 0.0031 0.0135
Trypanosoma brucei oxidoreductase-like protein 0.0026 0.0031 0.1717
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.018 0.8198
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0026 0.0031 0.1261
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Leishmania major oxidoreductase-like protein 0.0026 0.0031 0.1261
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0031 0.1261
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0026 0.0031 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Mycobacterium ulcerans hypothetical protein 0.0036 0.0091 0.0438
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0092 0.024
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0092 0.024
Brugia malayi beta-lactamase family protein 0.0036 0.0091 0.0343
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0438
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0031 0.0135
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.007 0.0173
Trypanosoma brucei pteridine reductase 1 0.0026 0.0031 0.1717
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0591 0.3201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0103 0.0274
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0245 0.1261 0.4909
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0465 1
Echinococcus granulosus geminin 0.053 0.2862 0.286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0063 0.015
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0092 0.0089
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0097 0.0291
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0097 0.0254
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0231
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0238
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0097 0.043 0.0427
Brugia malayi hypothetical protein 0.0108 0.0496 0.1923
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0026 0.0031 0.0135
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0054 0.005
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0083 0.1202
Schistosoma mansoni alpha-glucosidase 0.0142 0.0683 0.1787
Echinococcus granulosus neuropeptide receptor A26 0.1802 1 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0438
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.1192 0.593
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.01 0.5473
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0092 0.024
Schistosoma mansoni dihydropteridine reductase 0.0026 0.0031 0.0071
Giardia lamblia Pyruvate kinase 0.0035 0.0083 0.0092
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0591 0.3201 0.8417
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0159 0.8838
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0058 0.021 0.0206
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.018 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0091 0.0208
Echinococcus multilocularis pyruvate kinase 0.0035 0.0083 0.0079
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0218 0.0215
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Schistosoma mansoni hypothetical protein 0.0122 0.0573 0.1497
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0591 0.3201 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0591 0.3201 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.0566 0.2196
Loa Loa (eye worm) hypothetical protein 0.0117 0.0545 0.2115
Brugia malayi jmjC domain containing protein 0.0032 0.0068 0.0252
Trypanosoma brucei glucosidase, putative 0.0037 0.0092 0.5139
Loa Loa (eye worm) doublecortin family protein 0.008 0.0338 0.1304
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0091 0.4988
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0378 0.2008 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0058 0.021 0.0206
Loa Loa (eye worm) endoplasmin 0.0037 0.0097 0.0363
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.003 0.0054 0.0251
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Brugia malayi Protein kinase domain containing protein 0.0052 0.018 0.0687
Schistosoma mansoni glutaminase 0.0276 0.1438 0.3775
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0159 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Schistosoma mansoni tyrosine kinase 0.0097 0.043 0.1122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.107
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0465 0.1215
Schistosoma mansoni smad1 5 8 and 0.0032 0.007 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0119 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0077 0.0322 0.0318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0103 0.0274
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.018 0.8198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0179 0.0892 0.0888
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Echinococcus multilocularis Polycystic kidney disease protein 0.008 0.0338 0.0334
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0811 0.0808
Loa Loa (eye worm) glutaminase 2 0.0276 0.1438 0.5601
Plasmodium falciparum protein kinase 5 0.0052 0.018 0.0514
Echinococcus granulosus endoplasmin 0.003 0.0054 0.005
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0159 0.0408
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0092 0.1451
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0026 0.0031 0.0149
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.018 1
Onchocerca volvulus 0.0095 0.0422 0.8998
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.007 0.0066
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0026 0.0031 0.0047
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0406 0.2165 0.2162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0097 0.5286
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.018 0.055
Schistosoma mansoni hypothetical protein 0.0626 0.3401 0.8943
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0026 0.0031 0.1261
Brugia malayi Calcitonin receptor-like protein seb-1 0.0245 0.1261 0.4909
Onchocerca volvulus 0.0036 0.0091 0.1396
Loa Loa (eye worm) TK/INSR protein kinase 0.0058 0.021 0.0806
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0083 0.0248
Schistosoma mansoni smad1 5 8 and 0.0032 0.007 0.0173
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0628 0.1642
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Echinococcus multilocularis neuropeptide s receptor 0.1802 1 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0083 0.031
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Mycobacterium ulcerans beta-lactamase 0.0036 0.0091 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0159 0.0449
Mycobacterium tuberculosis Conserved protein 0.0036 0.0091 0.0438
Echinococcus granulosus lipoxygenase domain containing protein 0.008 0.0338 0.0334
Mycobacterium ulcerans heat shock protein 90 0.003 0.0054 0.0251
Schistosoma mansoni lipoxygenase 0.048 0.2581 0.6784
Loa Loa (eye worm) hypothetical protein 0.0025 0.0025 0.0084
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0465 0.0462
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Brugia malayi Cytochrome P450 family protein 0.0038 0.01 0.0376
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0496 0.0492
Echinococcus granulosus pyruvate kinase 0.0035 0.0083 0.0079
Trichomonas vaginalis esterase, putative 0.0036 0.0091 0.0238
Schistosoma mansoni endoplasmin 0.0037 0.0097 0.0245
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0091 0.0438
Leishmania major hypothetical protein, conserved 0.0036 0.0091 0.4089
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0238
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0406 0.2165 0.2162
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0068 0.3666
Plasmodium falciparum LCCL domain-containing protein 0.008 0.0338 0.101
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Loa Loa (eye worm) hypothetical protein 0.0026 0.0031 0.0106
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0016 0.087
Echinococcus multilocularis GPCR, family 2 0.0077 0.0322 0.0318
Plasmodium falciparum heat shock protein 90 0.0037 0.0097 0.0254
Echinococcus multilocularis Smad4 0.0032 0.007 0.0066
Schistosoma mansoni tyrosine kinase 0.0096 0.0425 0.1107
Leishmania major pyruvate kinase 0.0035 0.0083 0.3696
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0117 0.0545 0.0542
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.018 0.0514
Brugia malayi Endoplasmin precursor 0.0037 0.0097 0.0363
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0083 0.4624
Loa Loa (eye worm) hypothetical protein 0.0103 0.0465 0.1802
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0031 0.1538
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0218 0.0564
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0091 0.0438
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0091 0.0438
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.1229
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.018 0.0176
Echinococcus granulosus GPCR family 2 0.0077 0.0322 0.0318
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0077 0.0322 0.0318
Echinococcus granulosus phd:f box containing protein 0.0032 0.0068 0.0064
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0378 0.2008 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0083 0.0395
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0025 0.1229
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0092 0.4127
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0103 0.4645
Schistosoma mansoni pyruvate kinase 0.0035 0.0083 0.0209
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.018 0.0687
Echinococcus multilocularis heat shock protein 0.0037 0.0097 0.0093
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0097 0.5286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0057
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0026 0.0031 0.0027
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0068 0.017
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0083 0.031
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0068 0.3666
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0091 0.0438
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.01 0.0376
Brugia malayi hypothetical protein 0.0025 0.0025 0.0084
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0068 0.3801
Echinococcus granulosus cyclin dependent kinase 0.0052 0.018 0.0176
Brugia malayi MH2 domain containing protein 0.0032 0.007 0.0257
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.018 0.0176
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0103 0.5666
Echinococcus granulosus heat shock protein 90 0.0037 0.0097 0.0093
Schistosoma mansoni hypothetical protein 0.0077 0.0322 0.0837
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0068 0.0252
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0083 0.4624
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0092 0.1451
Giardia lamblia GTOR 0.0048 0.0159 0.0333
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0465 0.0462
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0056
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0378 0.2008 0.6242
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Schistosoma mansoni tyrosine kinase 0.0096 0.0425 0.1107
Schistosoma mansoni tyrosine kinase 0.018 0.0898 0.2353
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0378 0.2008 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0083 0.1202
Echinococcus multilocularis epidermal growth factor receptor 0.0097 0.043 0.0427
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0068 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0628 0.1642
Echinococcus multilocularis epidermal growth factor receptor 0.018 0.0898 0.0894
Loa Loa (eye worm) Smad1 0.0032 0.007 0.0257
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0097 0.0291
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0026 0.0031 0.1717
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.01 0.048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0159 0.8813
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0092 0.5034
Brugia malayi jmjC domain containing protein 0.0121 0.0566 0.2196
Echinococcus granulosus smad 0.0032 0.007 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0092 0.024
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0083 0.4508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0083 0.4508
Brugia malayi MH2 domain containing protein 0.0032 0.007 0.0257
Loa Loa (eye worm) TK/EGFR protein kinase 0.018 0.0898 0.3492
Onchocerca volvulus 0.008 0.0338 0.706
Echinococcus multilocularis heat shock protein 90 0.0037 0.0097 0.0093
Echinococcus granulosus lipoxygenase domain containing protein 0.008 0.0338 0.0334
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0031 0.0135
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0068 0.017
Brugia malayi glutaminase DH11.1 0.0276 0.1438 0.5601
Schistosoma mansoni smad1 5 8 and 0.0032 0.007 0.0173
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0004 0.0212
Schistosoma mansoni loxhd1 0.008 0.0338 0.0878
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0097 0.1545
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.018 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.0811 0.3155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Treponema pallidum heat shock protein 90 0.003 0.0054 0.5
Schistosoma mansoni hypothetical protein 0.0077 0.0322 0.0837
Trypanosoma brucei cytochrome P450, putative 0.0038 0.01 0.5568
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0573 0.0569
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0068 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.008 0.0338 0.0334
Schistosoma mansoni smad 0.0032 0.007 0.0173
Brugia malayi latrophilin 2 splice variant baaae 0.0167 0.0826 0.3212
Loa Loa (eye worm) MH2 domain-containing protein 0.0477 0.2564 1
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0097 0.1545
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.01 0.5473
Schistosoma mansoni hypothetical protein 0.008 0.0338 0.0878
Brugia malayi jmjC domain containing protein 0.0032 0.0068 0.0252
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.018 0.3299
Onchocerca volvulus 0.0103 0.0465 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.018 0.3299
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Mycobacterium ulcerans oxidoreductase 0.0026 0.0031 0.0135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0078
Schistosoma mansoni hypothetical protein 0.053 0.2862 0.7524
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0103 0.0274
Schistosoma mansoni endoplasmin 0.0037 0.0097 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0057
Schistosoma mansoni lipoxygenase 0.0336 0.177 0.465
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0091 0.0238
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0097 0.5386
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0091 0.0438
Leishmania major cytochrome p450-like protein 0.0038 0.01 0.4487
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0091 0.0438
Schistosoma mansoni hypothetical protein 0.0077 0.0322 0.0837
Schistosoma mansoni tyrosine kinase 0.0058 0.021 0.0543
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0026 0.0031 0.0071
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.007 0.0066
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0159 0.2857
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0091 0.0438
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0092 0.024
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0089 0.0267
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0026 0.0031 0.1538
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0591 0.3201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Plasmodium vivax multidomain scavenger receptor, putative 0.008 0.0338 0.0983
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0091 0.0231
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.007 0.0257
Echinococcus granulosus pyruvate kinase 0.0035 0.0083 0.0079
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0031 0.0135
Echinococcus multilocularis RUN 0.008 0.0338 0.0334
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0092 0.024
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0068 0.017
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Loa Loa (eye worm) hypothetical protein 0.0167 0.0826 0.3212
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.007 0.0066
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0092 0.0089
Toxoplasma gondii preprocathepsin c precursor, putative 0.0591 0.3201 1
Trichomonas vaginalis heat shock protein, putative 0.003 0.0054 0.012
Onchocerca volvulus 0.008 0.0338 0.706
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0026 0.0031 0.0135
Schistosoma mansoni alpha glucosidase 0.0037 0.0092 0.0233
Brugia malayi jmjC domain containing protein 0.0032 0.0068 0.0252
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0083 0.1202
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0068 0.0252
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0068 0.017
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0091 0.5094
Schistosoma mansoni Smad4 0.0032 0.007 0.0173
Giardia lamblia Kinase, CMGC CDK 0.0052 0.018 0.0399
Echinococcus multilocularis histone acetyltransferase MYST2 0.0117 0.0545 0.0542
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0097 0.5386
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.018 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.0566 0.148
Schistosoma mansoni pyruvate kinase 0.0035 0.0083 0.0209
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0031 0.0135
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0117 0.0545 0.0542
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0068 0.0165
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Loa Loa (eye worm) oxidoreductase 0.0026 0.0031 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0106
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.007 0.0257
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0252
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0378 0.2008 1
Echinococcus multilocularis neuropeptide receptor A26 0.1802 1 1
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.018 0.0176
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0179 0.0892 0.0888
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0245 0.1261 0.4909
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0378 0.2008 0.6267
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0092 0.024
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0092 0.0346
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0159 0.0449
Echinococcus multilocularis lipoxygenase domain containing protein 0.008 0.0338 0.0334
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0054 0.2859
Plasmodium vivax endoplasmin, putative 0.0037 0.0097 0.0225
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0496 0.1296
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0465 0.0462
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.018 0.0176
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0179 0.0892 0.3468
Echinococcus granulosus epidermal growth factor receptor 0.018 0.0898 0.0894
Loa Loa (eye worm) beta-lactamase 0.0036 0.0091 0.0343
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0179 0.0892 0.2337
Brugia malayi Latrophilin receptor protein 2 0.0077 0.0322 0.1242
Trichomonas vaginalis heat shock protein, putative 0.003 0.0054 0.012
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0026 0.0031 0.0135
Brugia malayi hypothetical protein 0.008 0.0338 0.1304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0056
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0068 0.0064
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.018 0.0687
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.018 0.0514
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0097 0.5286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0101
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.0811 0.0808
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0218 0.107
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0026 0.0031 0.0106
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0097 0.0225
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.3803 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0091 0.0438
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0083 0.0211
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0159 0.2857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0034 0.0056
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0117 0.0545 0.2115
Leishmania major pyruvate kinase 0.0035 0.0083 0.3696
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0089 0.023
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Brugia malayi Smad1 0.0032 0.007 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0049 0.0106
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.018 0.0176
Echinococcus granulosus histone acetyltransferase MYST2 0.0117 0.0545 0.0542
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0218 0.107
Echinococcus multilocularis pyruvate kinase 0.0035 0.0083 0.0079
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0091 0.0343
Brugia malayi beta-lactamase 0.0036 0.0091 0.0343
Echinococcus multilocularis geminin 0.053 0.2862 0.286
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0026 0.0031 0.0017
Brugia malayi MH1 domain containing protein 0.0032 0.007 0.0257
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0024 0.0078
Echinococcus multilocularis insulin receptor 0.0058 0.021 0.0206
Brugia malayi Protein kinase domain containing protein 0.0058 0.021 0.0806
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0159 0.8838
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0054 0.0251
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0068 0.0202
Leishmania major hypothetical protein, conserved 0.0032 0.0068 0.3006
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0083 0.0395
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0218 0.0564
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0026 0.0031 0.0135
Mycobacterium tuberculosis Possible oxidoreductase 0.0026 0.0031 0.0135
Echinococcus multilocularis 0.0056 0.02 0.0196
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0068 0.0064
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0218 1
Schistosoma mansoni hypothetical protein 0.053 0.2862 0.7524
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0252
Loa Loa (eye worm) hypothetical protein 0.0036 0.0091 0.0343
Schistosoma mansoni myelin transcription factor 1 myt1 0.0117 0.0545 0.1425
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0097 0.5386
Brugia malayi Cytochrome P450 family protein 0.0038 0.01 0.0376
Plasmodium vivax protein kinase Crk2 0.0052 0.018 0.0486
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0159 0.0605
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0103 0.5757
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.0811 0.0808
Loa Loa (eye worm) hypothetical protein 0.008 0.0338 0.1304
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.007 0.0066
Entamoeba histolytica hypothetical protein 0.0108 0.0496 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0097 0.5286
Giardia lamblia Kinase, CMGC CDK 0.0052 0.018 0.0399
Trypanosoma brucei heat shock protein, putative 0.0037 0.0097 0.5386
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0054 0.2859
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0091 0.0088
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0026 0.0031 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0101
Schistosoma mansoni rab6-interacting 0.008 0.0338 0.0878
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Echinococcus granulosus heat shock protein 0.0037 0.0097 0.0093
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0068 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0091 0.0238
Echinococcus multilocularis lysine specific demethylase 5A 0.0121 0.0566 0.0563
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Loa Loa (eye worm) glutaminase 0.0276 0.1438 0.5601
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0011 0.0403
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.018 1
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0083 0.031
Chlamydia trachomatis pyruvate kinase 0.0035 0.0083 0.0264
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.018 0.0176
Schistosoma mansoni tyrosine kinase 0.0097 0.043 0.1122
Mycobacterium ulcerans short chain dehydrogenase 0.0026 0.0031 0.0135
Brugia malayi Cytochrome P450 family protein 0.0095 0.0423 0.1637
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0077 0.0322 0.0318
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.018 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0025 0.1415
Loa Loa (eye worm) hypothetical protein 0.0245 0.1261 0.4909
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.018 0.0463
Echinococcus granulosus Polycystic kidney disease protein 0.008 0.0338 0.0334
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.003 0.0054 0.0117
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.01 0.0376
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0159 0.0155
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0026 0.0031 0.0085
Brugia malayi hypothetical protein 0.008 0.0338 0.1304
Leishmania major heat shock protein 83-1 0.0037 0.0097 0.4334
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0496 0.0492

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 uM Inhibitory activity of the compound against cyclin-dependent kinase 1 (CDK1) was determined ChEMBL. 9990463
IC50 (functional) = 6.08 uM Inhibition of human bladder carcinoma T24 cell proliferation ChEMBL. 9990463
IC50 (binding) > 10 uM Inhibit of epidermal growth factor receptor (EGFR) ChEMBL. 9990463
IC50 (binding) = 50 uM Inhibition of Protein kinase C alpha ChEMBL. 9990463
IC50 (binding) = 500 uM Inhibition of Protein kinase A ChEMBL. 9990463

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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