Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0163 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0163 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0163 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0163 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 166 uM kg-1 | Anticonvulsant activity against audiogenic seizures in DBA/2 mice | ChEMBL. | 2909750 |
ED50 (functional) | = 166 uM kg-1 | Anticonvulsant activity against audiogenic seizures in DBA/2 mice | ChEMBL. | 2909750 |
ED50 (functional) | = 234.4 uM kg-1 | Anticonvulsant activity against maximal electroshock seizures(MES) in rats | ChEMBL. | 2909750 |
GI50 (functional) | -4.702 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.45 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.371 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.304 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.219 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
RM | = -0.033 | Relative lipophilicity | ChEMBL. | 2909750 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.