Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3714 | 0.3714 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3714 | 0.3714 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3714 | 0.3714 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.003 | 0.2426 | 0.2426 |
Echinococcus granulosus | caspase 2 | 0.003 | 0.2424 | 0.2424 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.003 | 0.2424 | 0.2424 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.003 | 0.2426 | 0.2426 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3714 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3714 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2424 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3714 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.003 | 0.2424 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.2426 | 0.2426 |
Brugia malayi | Cell death protein 3 precursor | 0.003 | 0.2424 | 0.6527 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3714 | 0.3714 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.2424 | 0.6527 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2424 | 1 |
Echinococcus multilocularis | caspase 2 | 0.003 | 0.2424 | 0.2424 |
Onchocerca volvulus | 0.003 | 0.2424 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0035 | 0.3714 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.