Detailed information for compound 30539

Basic information

Technical information
  • TDR Targets ID: 30539
  • Name: 4-(4-chlorophenyl)-2-methyl-1,2,4-thiadiazoli dine-3,5-dione
  • MW: 242.682 | Formula: C9H7ClN2O2S
  • H donors: 0 H acceptors: 2 LogP: 2.21 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)n1c(=O)sn(c1=O)C
  • InChi: 1S/C9H7ClN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-6(10)3-5-7/h2-5H,1H3
  • InChiKey: XPFLDDSMNQTKFF-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(4-chlorophenyl)-2-methyl-1,2,4-thiadiazolidine-3,5-quinone
  • Thiadiazolidinone (TDZD) deriv. 15

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 alpha References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Leishmania major beta tubulin 0.005 0.1344 0.1344
Leishmania major proteasome alpha 1 subunit, putative 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit 0.0034 0.0666 0.0666
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.1386 0.1386
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0246 1 1
Trichomonas vaginalis tubulin gamma chain, putative 0.005 0.1344 0.1344
Echinococcus granulosus proteasome subunit alpha type 6 0.0034 0.0666 0.0666
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0246 1 1
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0034 0.0666 0.0666
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0034 0.0666 0.0666
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.431 0.431
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.0666 0.0666
Echinococcus multilocularis proteasome (prosome, macropain) 0.0246 1 1
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0034 0.0666 0.0666
Leishmania major proteasome beta 2 subunit, putative 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit beta type, putative 0.0246 1 1
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Brugia malayi cell division control protein 2 homolog 0.0051 0.1386 0.1386
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0034 0.0666 0.0666
Loa Loa (eye worm) tubulin beta chain 0.005 0.1344 0.1344
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0246 1 1
Plasmodium vivax proteasome subunit beta type-2, putative 0.0109 0.3976 0.3976
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0246 1 1
Echinococcus granulosus subfamily T1A non peptidase ue 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit alpha type, putative 0.0034 0.0666 0.0666
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0034 0.0666 0.0666
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Schistosoma mansoni kinase 0.0053 0.1496 0.1496
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0034 0.0666 0.0666
Brugia malayi 20S proteasome alpha5 subunit 0.0034 0.0666 0.0666
Loa Loa (eye worm) tubulin beta-4 chain 0.005 0.1344 0.1344
Plasmodium vivax protein kinase Crk2 0.0051 0.1386 0.1386
Toxoplasma gondii beta-1 tubulin, putative 0.005 0.1344 0.1344
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0034 0.0666 0.0666
Brugia malayi intracellular kinase 0.0117 0.431 0.431
Leishmania major proteasome alpha 2 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis cyclin dependent kinase 5 0.0051 0.1386 0.1386
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0117 0.431 0.431
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.0666 0.0666
Echinococcus multilocularis tubulin subunit beta 0.005 0.1344 0.1344
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0034 0.0666 0.0666
Loa Loa (eye worm) BEN-1 protein 0.005 0.1344 0.1344
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0034 0.0666 0.0666
Entamoeba histolytica tubulin family protein 0.005 0.1344 0.1344
Plasmodium vivax proteasome subunit beta type-5, putative 0.0246 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.1386 0.1386
Giardia lamblia 20S proteasome alpha subunit 5 0.0034 0.0666 0.0666
Trypanosoma cruzi cdc2-related kinase 3 0.0051 0.1386 0.1386
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0034 0.0666 0.0666
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0036 0.0754 0.0754
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0034 0.0666 0.0666
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0109 0.3976 0.3976
Plasmodium vivax proteasome subunit beta type-7, putative 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome subunit beta type 3 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0117 0.431 0.431
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.0666 0.0666
Trypanosoma brucei beta tubulin 0.005 0.1344 0.1344
Leishmania major beta tubulin 0.005 0.1344 0.1344
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0034 0.0666 0.0666
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Plasmodium falciparum proteasome subunit beta type-4 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Echinococcus granulosus cyclin dependent kinase 0.0051 0.1386 0.1386
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1386 0.1386
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0117 0.431 0.431
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.0666 0.0666
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.1344 0.1344
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0034 0.0666 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.431 0.431
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0109 0.3976 0.3976
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0034 0.0666 0.0666
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0117 0.431 0.431
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.1386 0.1386
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0109 0.3976 0.3976
Giardia lamblia Proteasome subunit beta type 3 0.0034 0.0666 0.0666
Trichomonas vaginalis tubulin beta chain, putative 0.005 0.1344 0.1344
Echinococcus multilocularis tubulin, beta 4A class IVa 0.005 0.1344 0.1344
Echinococcus multilocularis proteasome subunit alpha type 2 0.0034 0.0666 0.0666
Echinococcus granulosus cyclin dependent kinase 1 0.0051 0.1386 0.1386
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0034 0.0666 0.0666
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0117 0.431 0.431
Plasmodium falciparum proteasome subunit beta type-5 0.0246 1 1
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis cyclin dependent kinase 9 0.0053 0.1496 0.1496
Trichomonas vaginalis tubulin alpha chain, putative 0.005 0.1344 0.1344
Onchocerca volvulus 0.0117 0.431 1
Trypanosoma brucei proteasome beta 6 subunit 0.0034 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0049 0.1298 0.1298
Trypanosoma brucei proteasome beta 7 subunit 0.0034 0.0666 0.0666
Giardia lamblia Kinase, CMGC GSK 0.0117 0.431 0.431
Giardia lamblia Proteasome subunit beta type 1 0.0034 0.0666 0.0666
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0034 0.0666 0.5
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0034 0.0666 0.0666
Echinococcus granulosus cyclin dependent kinase 9 0.0053 0.1496 0.1496
Echinococcus granulosus beta tubulin 0.005 0.1344 0.1344
Echinococcus multilocularis tubulin beta 1 chain 0.005 0.1344 0.1344
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0034 0.0666 0.0666
Leishmania major proteasome alpha 3 subunit, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0109 0.3976 0.3976
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0034 0.0666 0.0666
Giardia lamblia Beta tubulin 0.005 0.1344 0.1344
Loa Loa (eye worm) PAS-3 protein 0.0034 0.0666 0.0666
Giardia lamblia 20S proteasome alpha subunit 4 0.0034 0.0666 0.0666
Echinococcus granulosus protein kinase shaggy 0.0117 0.431 0.431
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0034 0.0666 0.0666
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.431 0.431
Echinococcus granulosus tubulin beta 4A class IVa 0.005 0.1344 0.1344
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0246 1 1
Trypanosoma cruzi 20S proteasome subunit 0.0109 0.3976 0.3976
Loa Loa (eye worm) proteasome subunit beta type 2 0.0109 0.3976 0.3976
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0034 0.0666 0.0666
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0034 0.0666 0.0666
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0034 0.0666 0.0666
Plasmodium falciparum protein kinase 5 0.0051 0.1386 0.1386
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1386 0.1386
Brugia malayi proteasome subunit beta type 1 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0034 0.0666 0.0666
Echinococcus multilocularis cyclin dependent kinase 0.0051 0.1386 0.1386
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0034 0.0666 0.0666
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.0666 0.0666
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0034 0.0666 0.0666
Leishmania major proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis beta tubulin 0.005 0.1344 0.1344
Leishmania major proteasome beta-1 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.1386 0.1386
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Loa Loa (eye worm) beta-tubulin 0.005 0.1344 0.1344
Brugia malayi proteasome subunit alpha type 2 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.0666 0.0666
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0034 0.0666 0.0666
Giardia lamblia 20S proteasome alpha subunit 6 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome alpha 7 subunit 0.0034 0.0666 0.0666
Echinococcus granulosus proteasome prosome macropain 0.0246 1 1
Toxoplasma gondii proteasome subunit alpha1, putative 0.0034 0.0666 0.0666
Entamoeba histolytica cell division protein kinase 2, putative 0.0051 0.1386 0.1386
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.1344 0.1344
Brugia malayi Proteasome subunit alpha type 7-1 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome subunit beta type 1 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi cdc2-related kinase 1 0.0051 0.1386 0.1386
Toxoplasma gondii beta-tubulin, putative 0.005 0.1344 0.1344
Trypanosoma brucei cdc2-related kinase 3 0.0051 0.1386 0.1386
Giardia lamblia Beta tubulin 0.005 0.1344 0.1344
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0034 0.0666 0.0666
Echinococcus granulosus proteasome subunit beta t family 0.0034 0.0666 0.0666
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.1344 0.1344
Giardia lamblia 20S proteasome alpha subunit 3 0.0034 0.0666 0.0666
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1386 0.1386
Leishmania major proteasome beta 7 subunit, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0034 0.0666 0.0666
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0246 1 1
Giardia lamblia 20S proteasome alpha subunit 2 0.0034 0.0666 0.0666
Entamoeba histolytica tubulin family protein 0.005 0.1344 0.1344
Brugia malayi Tubulin beta-1 chain 0.005 0.1344 0.1344
Leishmania major beta tubulin 0.005 0.1344 0.1344
Echinococcus multilocularis cyclin dependent kinase 1 0.0051 0.1386 0.1386
Echinococcus granulosus proteasome subunit beta type 6 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0034 0.0666 0.0666
Brugia malayi Protein kinase domain containing protein 0.0051 0.1386 0.1386
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Giardia lamblia 20S proteasome alpha subunit 7 0.0034 0.0666 0.0666
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0034 0.0666 0.0666
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.1344 0.1344
Echinococcus granulosus tubulin subunit beta 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0246 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0109 0.3976 0.3976
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0034 0.0666 0.0666
Giardia lamblia Proteasome subunit beta type 2 0.0109 0.3976 0.3976
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis proteasome subunit beta type 7 0.0034 0.0666 0.0666
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0053 0.1496 0.1496
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome beta subunit 0.0034 0.0666 0.0666
Plasmodium vivax proteasome subunit beta type-3, putative 0.0034 0.0666 0.0666
Entamoeba histolytica cell division protein kinase 2, putative 0.006 0.1783 0.1783
Plasmodium vivax tubulin beta chain, putative 0.005 0.1344 0.1344
Trypanosoma cruzi beta tubulin, putative 0.005 0.1344 0.1344
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0034 0.0666 0.0666
Leishmania major proteasome beta 2 subunit, putative 0.0109 0.3976 0.3976
Brugia malayi proteasome subunit beta type 3 0.0034 0.0666 0.0666
Brugia malayi Proteasome subunit alpha type 1 0.0034 0.0666 0.0666
Echinococcus granulosus proteasome subunit beta type 7 0.0034 0.0666 0.0666
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0034 0.0666 0.0666
Brugia malayi beta-tubulin, identical 0.005 0.1344 0.1344
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0034 0.0666 0.0666
Brugia malayi proteasome subunit alpha type 4 0.0034 0.0666 0.0666
Leishmania major proteasome alpha 1 subunit, putative 0.0034 0.0666 0.0666
Mycobacterium ulcerans proteasome PrcB 0.0246 1 1
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Trypanosoma brucei beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0109 0.3976 0.3976
Trypanosoma brucei beta tubulin 0.005 0.1344 0.1344
Leishmania major beta tubulin 0.005 0.1344 0.1344
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0051 0.1386 0.1386
Leishmania major proteasome beta 3 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0034 0.0666 0.0666
Plasmodium vivax proteasome subunit beta type-4, putative 0.0034 0.0666 0.0666
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0051 0.1386 0.1386
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0051 0.1386 0.1386
Echinococcus multilocularis protein kinase shaggy 0.0117 0.431 0.431
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Trypanosoma brucei beta tubulin 0.005 0.1344 0.1344
Plasmodium vivax proteasome subunit beta type-1, putative 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0034 0.0666 0.0666
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0051 0.1386 0.1386
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Echinococcus granulosus cyclin dependent kinase 9 0.0062 0.1893 0.1893
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0034 0.0666 0.0666
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1386 0.1386
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0109 0.3976 0.3976
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0034 0.0666 0.0666
Toxoplasma gondii heat shock protein hslv, putative 0.0034 0.0666 0.0666
Leishmania major proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Trypanosoma brucei cdc2-related kinase 1 0.0051 0.1386 0.1386
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0117 0.431 0.431
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1386 0.1386
Plasmodium vivax glycogen synthase kinase 3, putative 0.0117 0.431 0.431
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Loa Loa (eye worm) BEN-1 protein 0.005 0.1344 0.1344
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.431 0.431
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis proteasome subunit beta type 6 0.0034 0.0666 0.0666
Brugia malayi cyclin-dependent kinase 9 0.0053 0.1496 0.1496
Entamoeba histolytica protein kinase domain containing protein 0.0053 0.1496 0.1496
Loa Loa (eye worm) tubulin beta-2A chain 0.005 0.1344 0.1344
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.1496 0.1496
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0109 0.3976 0.3976
Leishmania major beta tubulin 0.005 0.1344 0.1344
Leishmania major beta tubulin 0.005 0.1344 0.1344
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.1344 0.1344
Echinococcus multilocularis cyclin dependent kinase 9 0.0062 0.1893 0.1893
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0034 0.0666 0.0666
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Giardia lamblia 20S proteasome alpha subunit 1 0.0034 0.0666 0.0666
Leishmania major proteasome beta 5 subunit, putative 0.0246 1 1
Brugia malayi proteasome subunit alpha type 1 0.0034 0.0666 0.0666
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0034 0.0666 0.0666
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.431 0.431
Loa Loa (eye worm) tubulin beta-1 chain 0.005 0.1344 0.1344
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0034 0.0666 0.0666
Brugia malayi proteasome subunit alpha type 6 0.0034 0.0666 0.0666
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis tubulin, putative 0.005 0.1344 0.1344
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0034 0.0666 0.0666
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0246 1 1
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0051 0.1386 0.1386
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0109 0.3976 0.3976
Trypanosoma brucei protein kinase, putative 0.0117 0.431 0.431
Echinococcus granulosus Proteasome subunit alpha type 7 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0034 0.0666 0.0666
Toxoplasma gondii peptidase, T1 family protein 0.0034 0.0666 0.0666
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0034 0.0666 0.0666
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0034 0.0666 0.0666
Giardia lamblia Kinase, CMGC GSK 0.0117 0.431 0.431
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0034 0.0666 0.0666
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Echinococcus granulosus cyclin dependent kinase 5 0.0051 0.1386 0.1386
Leishmania major beta tubulin 0.005 0.1344 0.1344
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.0666 0.0666
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0034 0.0666 0.0666
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0034 0.0666 0.0666
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0034 0.0666 0.0666
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0034 0.0666 0.0666
Echinococcus granulosus tubulin beta 1 chain 0.005 0.1344 0.1344
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.1344 0.1344
Giardia lamblia Kinase, CMGC CDK 0.0051 0.1386 0.1386
Giardia lamblia Kinase, CMGC CDK 0.0051 0.1386 0.1386
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0034 0.0666 0.0666
Echinococcus granulosus Tubulin beta 2C chain 0.005 0.1344 0.1344
Schistosoma mansoni tubulin subunit beta 0.005 0.1344 0.1344
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.0666 0.0666
Echinococcus multilocularis proteasome subunit alpha type 6 0.0034 0.0666 0.0666
Leishmania major beta tubulin 0.005 0.1344 0.1344
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0246 1 1
Plasmodium falciparum glycogen synthase kinase 3 0.0117 0.431 0.431
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0246 1 1
Echinococcus granulosus proteasome subunit alpha type 2 0.0034 0.0666 0.0666
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Plasmodium vivax proteasome subunit beta type-6, putative 0.0034 0.0666 0.0666
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0034 0.0666 0.0666
Entamoeba histolytica protein kinase, putative 0.0117 0.431 0.431
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.431 0.431
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0109 0.3976 0.3976
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0034 0.0666 0.0666
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0034 0.0666 0.0666
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.0666 0.0666
Echinococcus granulosus beta tubulin 0.005 0.1344 0.1344
Brugia malayi proteasome subunit alpha type 3 0.0034 0.0666 0.0666
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0034 0.0666 0.0666
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0034 0.0666 0.0666
Brugia malayi proteasome subunit beta type 2 0.0109 0.3976 0.3976
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.1344 0.1344
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.0666 0.0666
Echinococcus multilocularis Tubulin beta 2C chain 0.005 0.1344 0.1344
Plasmodium falciparum tubulin beta chain 0.005 0.1344 0.1344
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0051 0.1386 0.1386
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.0666 0.0666
Toxoplasma gondii beta tubulin 0.005 0.1344 0.1344
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0034 0.0666 0.0666
Giardia lamblia Beta tubulin 0.005 0.1344 0.1344
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0109 0.3976 0.3976
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0034 0.0666 0.0666
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.0666 0.0666
Echinococcus granulosus Proteasome subunit alpha beta 0.0034 0.0666 0.0666

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 uM Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta ChEMBL. 11881998
IC50 (binding) = 4 uM Inhibition of rabbit GSK3 ChEMBL. 16279768
IC50 (binding) = 4 uM Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta ChEMBL. 11881998
IC50 (binding) = 4 uM Inhibition of rabbit GSK3 ChEMBL. 16279768

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.