TDR Targets

Basic information

Technical information

TDR Targets ID: 30539
Name: 4-(4-chlorophenyl)-2-methyl-1,2,4-thiadiazoli dine-3,5-dione
MW: 242.682 | Formula: C9H7ClN2O2S
H donors: 0 H acceptors: 2 LogP: 2.21 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)n1c(=O)sn(c1=O)C
InChi: 1S/C9H7ClN2O2S/c1-11-8(13)12(9(14)15-11)7-4-2-6(10)3-5-7/h2-5H,1H3
InChiKey: XPFLDDSMNQTKFF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(4-chlorophenyl)-2-methyl-1,2,4-thiadiazolidine-3,5-quinone
Thiadiazolidinone (TDZD) deriv. 15

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 alpha		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome subunit beta type 6	0.0034	0.0666	0.0666
Echinococcus granulosus	protein kinase shaggy	0.0117	0.431	0.431
Giardia lamblia	Proteasome subunit beta type 2	0.0109	0.3976	0.3976
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0051	0.1386	0.1386
Toxoplasma gondii	heat shock protein hslv, putative	0.0034	0.0666	0.0666
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.431	0.431
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.0666	0.0666
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0034	0.0666	0.0666
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0034	0.0666	0.0666
Echinococcus multilocularis	cyclin dependent kinase 5	0.0051	0.1386	0.1386
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0034	0.0666	0.0666
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0109	0.3976	0.3976
Trichomonas vaginalis	tubulin alpha chain, putative	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0109	0.3976	0.3976
Echinococcus multilocularis	cyclin dependent kinase 9	0.0053	0.1496	0.1496
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0246	1	1
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0666	0.0666
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0117	0.431	0.431
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0246	1	1
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0034	0.0666	0.0666
Giardia lamblia	Kinase, CMGC GSK	0.0117	0.431	0.431
Trichomonas vaginalis	tubulin beta chain, putative	0.005	0.1344	0.1344
Trichomonas vaginalis	tubulin gamma chain, putative	0.005	0.1344	0.1344
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0109	0.3976	0.3976
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0034	0.0666	0.0666
Entamoeba histolytica	protein kinase domain containing protein	0.0053	0.1496	0.1496
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0034	0.0666	0.0666
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0034	0.0666	0.0666
Giardia lamblia	Proteasome subunit beta type 3	0.0034	0.0666	0.0666
Entamoeba histolytica	cell division protein kinase 2, putative	0.0051	0.1386	0.1386
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	beta tubulin	0.005	0.1344	0.1344
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Brugia malayi	intracellular kinase	0.0117	0.431	0.431
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0051	0.1386	0.1386
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0034	0.0666	0.0666
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome beta 7 subunit	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Echinococcus multilocularis	Tubulin beta 2C chain	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome subunit beta t family	0.0034	0.0666	0.0666
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0117	0.431	0.431
Echinococcus granulosus	proteasome prosome macropain	0.0246	1	1
Trypanosoma cruzi	cdc2-related kinase 1	0.0051	0.1386	0.1386
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.005	0.1344	0.1344
Entamoeba histolytica	protein kinase, putative	0.0117	0.431	0.431
Giardia lamblia	20S proteasome alpha subunit 7	0.0034	0.0666	0.0666
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0051	0.1386	0.1386
Plasmodium falciparum	proteasome subunit beta type-5	0.0246	1	1
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0034	0.0666	0.0666
Leishmania major	proteasome beta 2 subunit, putative	0.0109	0.3976	0.3976
Plasmodium falciparum	glycogen synthase kinase 3	0.0117	0.431	0.431
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0034	0.0666	0.0666
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	proteasome subunit alpha type 2	0.0034	0.0666	0.0666
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0117	0.431	0.431
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome subunit beta type, putative	0.0246	1	1
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Echinococcus granulosus	Tubulin beta 2C chain	0.005	0.1344	0.1344
Giardia lamblia	Kinase, CMGC CDK	0.0051	0.1386	0.1386
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Echinococcus multilocularis	Tubulin beta 2C chain	0.005	0.1344	0.1344
Toxoplasma gondii	beta tubulin	0.005	0.1344	0.1344
Echinococcus granulosus	cyclin dependent kinase 9	0.0053	0.1496	0.1496
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0246	1	1
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0034	0.0666	0.0666
Echinococcus multilocularis	tubulin subunit beta	0.005	0.1344	0.1344
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	proteasome subunit alpha type 6	0.0034	0.0666	0.0666
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0051	0.1386	0.1386
Echinococcus granulosus	cyclin dependent kinase 1	0.0051	0.1386	0.1386
Brugia malayi	proteasome subunit alpha type 4	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0246	1	1
Trypanosoma brucei	cdc2-related kinase 3	0.0051	0.1386	0.1386
Trypanosoma brucei	cdc2-related kinase 1	0.0051	0.1386	0.1386
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Brugia malayi	Tubulin beta-1 chain	0.005	0.1344	0.1344
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	tubulin beta 1 chain	0.005	0.1344	0.1344
Echinococcus granulosus	Tubulin beta 2C chain	0.005	0.1344	0.1344
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0246	1	1
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0034	0.0666	0.0666
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	proteasome beta-1 subunit, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0117	0.431	0.431
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0034	0.0666	0.0666
Trypanosoma cruzi	cdc2-related kinase 3	0.0051	0.1386	0.1386
Echinococcus multilocularis	cyclin dependent kinase 1	0.0051	0.1386	0.1386
Giardia lamblia	Kinase, CMGC GSK	0.0117	0.431	0.431
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Loa Loa (eye worm)	tubulin beta-4 chain	0.005	0.1344	0.1344
Loa Loa (eye worm)	beta-tubulin	0.005	0.1344	0.1344
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0117	0.431	0.431
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.0666	0.0666
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0034	0.0666	0.0666
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0034	0.0666	0.0666
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.1496	0.1496
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	beta tubulin	0.005	0.1344	0.1344
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit beta type 1	0.0034	0.0666	0.0666
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0051	0.1386	0.1386
Brugia malayi	Proteasome subunit alpha type 7-1	0.0034	0.0666	0.0666
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0666	0.0666
Plasmodium falciparum	proteasome subunit beta type-4	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0034	0.0666	0.0666
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0246	1	1
Entamoeba histolytica	tubulin family protein	0.005	0.1344	0.1344
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Loa Loa (eye worm)	BEN-1 protein	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	Tubulin beta 2C chain	0.005	0.1344	0.1344
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Echinococcus granulosus	Tubulin beta 2C chain	0.005	0.1344	0.1344
Giardia lamblia	Beta tubulin	0.005	0.1344	0.1344
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1386	0.1386
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0246	1	1
Trypanosoma cruzi	20S proteasome subunit	0.0109	0.3976	0.3976
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0246	1	1
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0034	0.0666	0.0666
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1386	0.1386
Trypanosoma brucei	beta tubulin	0.005	0.1344	0.1344
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1386	0.1386
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0246	1	1
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0034	0.0666	0.0666
Leishmania major	proteasome beta 7 subunit, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0117	0.431	0.431
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.0666	0.0666
Giardia lamblia	Beta tubulin	0.005	0.1344	0.1344
Schistosoma mansoni	kinase	0.0053	0.1496	0.1496
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0109	0.3976	0.3976
Plasmodium vivax	tubulin beta chain, putative	0.005	0.1344	0.1344
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome subunit beta type 6	0.0034	0.0666	0.0666
Giardia lamblia	20S proteasome alpha subunit 6	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0034	0.0666	0.0666
Brugia malayi	20S proteasome alpha5 subunit	0.0034	0.0666	0.0666
Giardia lamblia	20S proteasome alpha subunit 4	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit alpha type 2	0.0034	0.0666	0.0666
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit alpha type 6	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0034	0.0666	0.0666
Giardia lamblia	Kinase, CMGC CDK	0.0051	0.1386	0.1386
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0117	0.431	0.431
Brugia malayi	Proteasome subunit alpha type 1	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0034	0.0666	0.0666
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0666	0.0666
Trypanosoma cruzi	cdc2-related kinase 3	0.0051	0.1386	0.1386
Brugia malayi	proteasome subunit beta type 3	0.0034	0.0666	0.0666
Plasmodium falciparum	tubulin beta chain	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	cell division protein kinase 2, putative	0.006	0.1783	0.1783
Echinococcus multilocularis	Tubulin beta 2C chain	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	Proteasome subunit alpha beta	0.0034	0.0666	0.0666
Echinococcus multilocularis	protein kinase shaggy	0.0117	0.431	0.431
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1386	0.1386
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Plasmodium vivax	protein kinase Crk2	0.0051	0.1386	0.1386
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0246	1	1
Plasmodium falciparum	protein kinase 5	0.0051	0.1386	0.1386
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome alpha 7 subunit	0.0034	0.0666	0.0666
Onchocerca volvulus		0.0117	0.431	1
Leishmania major	proteasome alpha 3 subunit, putative	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0109	0.3976	0.3976
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome beta subunit	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Brugia malayi	beta-tubulin, identical	0.005	0.1344	0.1344
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0034	0.0666	0.0666
Echinococcus multilocularis	Tubulin beta 2C chain	0.005	0.1344	0.1344
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0034	0.0666	0.0666
Giardia lamblia	20S proteasome alpha subunit 3	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0034	0.0666	0.0666
Echinococcus granulosus	Tubulin beta 2C chain	0.005	0.1344	0.1344
Leishmania major	proteasome alpha 2 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	proteasome beta 3 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	proteasome beta 5 subunit, putative	0.0246	1	1
Echinococcus granulosus	beta tubulin	0.005	0.1344	0.1344
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	beta tubulin, putative	0.005	0.1344	0.1344
Trypanosoma brucei	proteasome beta 6 subunit	0.0034	0.0666	0.0666
Echinococcus multilocularis	beta tubulin	0.005	0.1344	0.1344
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0034	0.0666	0.0666
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	beta tubulin	0.005	0.1344	0.1344
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0036	0.0754	0.0754
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit alpha type 3	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0034	0.0666	0.0666
Trichomonas vaginalis	tubulin epsilon chain, putative	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome subunit beta type 7	0.0034	0.0666	0.0666
Trichomonas vaginalis	tubulin, putative	0.005	0.1344	0.1344
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0109	0.3976	0.3976
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0034	0.0666	0.0666
Trypanosoma brucei	protein kinase, putative	0.0117	0.431	0.431
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0051	0.1386	0.1386
Giardia lamblia	20S proteasome alpha subunit 1	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0246	1	1
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	tubulin subunit beta	0.005	0.1344	0.1344
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0109	0.3976	0.3976
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	tubulin beta 1 chain	0.005	0.1344	0.1344
Mycobacterium ulcerans	proteasome PrcB	0.0246	1	1
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0034	0.0666	0.0666
Trypanosoma cruzi	cdc2-related kinase 1	0.0051	0.1386	0.1386
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0117	0.431	0.431
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0109	0.3976	0.3976
Loa Loa (eye worm)	tubulin beta-1 chain	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0034	0.0666	0.0666
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0034	0.0666	0.0666
Loa Loa (eye worm)	tubulin beta chain	0.005	0.1344	0.1344
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Toxoplasma gondii	beta-1 tubulin, putative	0.005	0.1344	0.1344
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit alpha type 1	0.0034	0.0666	0.0666
Echinococcus granulosus	cyclin dependent kinase 5	0.0051	0.1386	0.1386
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Giardia lamblia	Proteasome subunit beta type 1	0.0034	0.0666	0.0666
Trypanosoma brucei	beta tubulin	0.005	0.1344	0.1344
Giardia lamblia	Beta tubulin	0.005	0.1344	0.1344
Echinococcus multilocularis	cyclin dependent kinase	0.0051	0.1386	0.1386
Brugia malayi	cell division control protein 2 homolog	0.0051	0.1386	0.1386
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0051	0.1386	0.1386
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	BEN-1 protein	0.005	0.1344	0.1344
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0109	0.3976	0.3976
Leishmania major	proteasome beta 2 subunit, putative	0.0034	0.0666	0.0666
Brugia malayi	proteasome subunit beta type 2	0.0109	0.3976	0.3976
Toxoplasma gondii	proteasome subunit	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0034	0.0666	0.0666
Brugia malayi	Protein kinase domain containing protein	0.0051	0.1386	0.1386
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0109	0.3976	0.3976
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0034	0.0666	0.0666
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Trichomonas vaginalis	CMGC family protein kinase	0.0117	0.431	0.431
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0246	1	1
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.0666	0.0666
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0109	0.3976	0.3976
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Toxoplasma gondii	beta-tubulin, putative	0.005	0.1344	0.1344
Trypanosoma brucei	beta tubulin	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.0666	0.0666
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1386	0.1386
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.0666	0.0666
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.431	0.431
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	cyclin dependent kinase 9	0.0062	0.1893	0.1893
Giardia lamblia	20S proteasome alpha subunit 2	0.0034	0.0666	0.0666
Echinococcus granulosus	cyclin dependent kinase	0.0051	0.1386	0.1386
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0034	0.0666	0.5
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0034	0.0666	0.0666
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Echinococcus multilocularis	proteasome subunit beta type 7	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Toxoplasma gondii	peptidase, T1 family protein	0.0034	0.0666	0.0666
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.0666	0.0666
Trichomonas vaginalis	tubulin epsilon chain, putative	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.0666	0.0666
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.0666	0.0666
Giardia lamblia	20S proteasome alpha subunit 5	0.0034	0.0666	0.0666
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0109	0.3976	0.3976
Echinococcus multilocularis	cyclin dependent kinase 1	0.0051	0.1386	0.1386
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1298	0.1298
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0109	0.3976	0.3976
Loa Loa (eye worm)	tubulin beta-2A chain	0.005	0.1344	0.1344
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	tubulin family protein	0.005	0.1344	0.1344
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0034	0.0666	0.0666
Loa Loa (eye worm)	PAS-3 protein	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0034	0.0666	0.0666
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0034	0.0666	0.0666
Echinococcus granulosus	cyclin dependent kinase 9	0.0062	0.1893	0.1893
Echinococcus granulosus	tubulin beta 4A class IVa	0.005	0.1344	0.1344
Brugia malayi	cyclin-dependent kinase 9	0.0053	0.1496	0.1496
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.0666	0.0666
Leishmania major	beta tubulin	0.005	0.1344	0.1344
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.0666	0.0666
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0034	0.0666	0.0666
Entamoeba histolytica	protein kinase domain containing protein	0.0117	0.431	0.431
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0034	0.0666	0.0666
Echinococcus multilocularis	Tubulin beta 2C chain	0.005	0.1344	0.1344
Schistosoma mansoni	tubulin subunit beta	0.005	0.1344	0.1344
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0117	0.431	0.431
Loa Loa (eye worm)	CMGC/CDK/CDK9 protein kinase	0.0053	0.1496	0.1496
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0034	0.0666	0.0666
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.0666	0.0666
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.0666	0.0666

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 uM	Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta	ChEMBL.	11881998
IC50 (binding)	= 4 uM	Inhibition of rabbit GSK3	ChEMBL.	16279768
IC50 (binding)	= 4 uM	Inhibitory activity against recombinant rabbit Glycogen synthase kinase-3 beta	ChEMBL.	11881998
IC50 (binding)	= 4 uM	Inhibition of rabbit GSK3	ChEMBL.	16279768

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL24537
PubChem: 6539144

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 30539