Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mercuric reductase, putative | 0.0073349 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0073349 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0211667 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0073349 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0211667 | 1 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0073349 | 0 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0211667 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0073349 | 0 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0211667 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0211667 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0211667 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0211667 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0073349 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073349 | 0 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0073349 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0211667 | 1 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0211667 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0211667 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073349 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0211667 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0211667 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0211667 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0073349 | 0 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0073349 | 0 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0211667 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0211667 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.73 uM | Antitrypanosomial activity against Trypanosoma cruzi epimastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 0.73 uM | Antitrypanosomial activity against Trypanosoma cruzi epimastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 1.3 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 1.3 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 3.3 uM | Antitrypanosomial activity against Trypanosoma cruzi amastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 3.3 uM | Antitrypanosomial activity against Trypanosoma cruzi amastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 6.4 uM | In vitro cell survival assay on cancer KB cell lines | ChEMBL. | 11300877 |
IC50 (functional) | = 12.5 uM | Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) | ChEMBL. | 11300877 |
IC50 (functional) | = 12.5 uM | Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) | ChEMBL. | 11300877 |
IC50 (functional) | = 15.1 uM | In vitro cytotoxicity against L6 cells | ChEMBL. | 11300877 |
IS (functional) | = 4.6 | Index of selectivity was determined in T. cruzi | ChEMBL. | 11300877 |
IS (functional) | = 12.6 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
IS (functional) | = 4.6 | Index of selectivity was determined in T. cruzi | ChEMBL. | 11300877 |
IS (functional) | = 12.6 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11300877 | |
Trypanosoma cruzi | ChEMBL23 | 11300877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.