Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.87 uM site-1 | Tested for ability to inhibit the topical inflammatory response in the topical mouse ear(TME) model | ChEMBL. | 2308140 |
ED50 (functional) | = 0.87 uM site-1 | Tested for ability to inhibit the topical inflammatory response in the topical mouse ear(TME) model | ChEMBL. | 2308140 |
IC50 (functional) | = 8700 nM | Inhibitory activity against production of leukotriene B4 in isolated human polymorphonuclear leukocytes | ChEMBL. | 2308140 |
IC50 (functional) | = 8700 nM | Inhibitory activity against production of leukotriene B4 in isolated human polymorphonuclear leukocytes | ChEMBL. | 2308140 |
logP (ADMET) | = 2.9 | Partition coefficient (logP) | ChEMBL. | 2308140 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 2308140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.