Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.069 | 0.0476 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.0725 | 0.0725 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0226 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0226 | 0.0002 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0286 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0239 | 0.8243 | 0.8105 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0286 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0286 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0286 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0286 | 1 | 1 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.0048 | 0.1062 | 0.0398 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.032 | 0.0097 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.069 | 0.0476 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0023 | 0.0105 | 0.0105 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.069 | 0.0476 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0246 | 0.852 | 0.8404 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0039 | 0.0725 | 1 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0725 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0039 | 0.0725 | 0.5 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.1062 | 0.0856 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0286 | 1 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0039 | 0.0725 | 0.0725 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.0048 | 0.1062 | 0.0398 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0286 | 1 | 1 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0286 | 1 | 1 |
Onchocerca volvulus | 0.0039 | 0.0725 | 0.5 | |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0286 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0226 | 0.0002 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0039 | 0.0725 | 0.0512 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0039 | 0.0725 | 0.5 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0039 | 0.0725 | 0.0512 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0286 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0239 | 0.8243 | 0.8105 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0286 | 1 | 1 |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.0048 | 0.1062 | 0.0363 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0239 | 0.8243 | 0.8105 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0331 | 0.0109 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0286 | 1 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0039 | 0.0725 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0031 | 0.0425 | 0.0204 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0331 | 0.0109 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.069 | 0.0476 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0039 | 0.0725 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0026 | 0.0226 | 0.0002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0039 | 0.0725 | 0.5 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0286 | 1 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0048 | 0.1062 | 0.0363 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.032 | 0.0097 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0093 | 0.2751 | 0.2212 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0239 | 0.8243 | 0.8105 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.0048 | 0.1062 | 0.1062 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0029 | 0.0331 | 0.0109 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.0048 | 0.1062 | 0.0398 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.1062 | 0.0856 |
Onchocerca volvulus | 0.0039 | 0.0725 | 0.5 | |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0039 | 0.0725 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0286 | 1 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0725 | 0.0512 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0286 | 1 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0286 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0286 | 1 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Loa Loa (eye worm) | FKBP5 protein | 0.0286 | 1 | 1 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0036 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0286 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0039 | 0.0725 | 0.5 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0048 | 0.1062 | 0.0363 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0041 | 0.0796 | 0.0585 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0048 | 0.1062 | 0.0363 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0246 | 0.852 | 0.8404 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0032 | 0.0464 | 0.0245 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0286 | 1 | 1 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.0048 | 0.1062 | 0.1062 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0286 | 1 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0048 | 0.1062 | 0.0363 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0048 | 0.1062 | 0.0856 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0039 | 0.0725 | 0.0512 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0239 | 0.8243 | 0.8105 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.0048 | 0.1062 | 0.0398 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0039 | 0.0725 | 0.0725 |
Echinococcus multilocularis | fk506 binding protein | 0.0286 | 1 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0039 | 0.0725 | 0.0036 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0036 | 0.0597 | 0.038 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0039 | 0.0725 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0286 | 1 | 1 |
Trypanosoma cruzi | macrophage infectivity potentiator, precursor, putative | 0.0039 | 0.0725 | 0.0036 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0038 | 0.0692 | 0.0692 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0048 | 0.1062 | 0.0363 |
Leishmania major | fk506-binding protein 1-like protein | 0.0286 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0093 | 0.2751 | 0.2212 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0725 | 0.0512 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0038 | 0.069 | 0.0476 |
Giardia lamblia | GTOR | 0.0048 | 0.1062 | 0.0363 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0093 | 0.2751 | 0.2751 |
Schistosoma mansoni | immunophilin | 0.0246 | 0.852 | 0.8404 |
Schistosoma mansoni | immunophilin | 0.0286 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.852 | 0.8404 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.0048 | 0.1062 | 0.0363 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0286 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 57 mg kg-1 | Antibacterial activity againist E. coli 120 infected NMRI mice after peroral administration | ChEMBL. | 6379179 |
ED50 (functional) | = 57 mg kg-1 | Antibacterial activity againist E. coli 120 infected NMRI mice after peroral administration | ChEMBL. | 6379179 |
MIC (functional) | > 8 ug ml-1 | Minimum inhibitory concentration of compound against Neisseria gonorrhoeae AS 7720 | ChEMBL. | 6379179 |
MIC (functional) | > 8 ug ml-1 | Minimum inhibitory concentration of compound against Neisseria gonorrhoeae W2 | ChEMBL. | 6379179 |
MIC (functional) | = 12.5 ug ml-1 | Minimum inhibitory concentration of compound against Klebsiella pneumoniae delta 217 | ChEMBL. | 6379179 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration of compound against Escherichia coli delta 120 | ChEMBL. | 6379179 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration of compound against E. aerogenes delta 220 | ChEMBL. | 6379179 |
MIC (functional) | = 50 ug ml-1 | Minimum inhibitory concentration of compound against Salmonella typhimurium delta 119 | ChEMBL. | 6379179 |
MIC (functional) | = 50 ug ml-1 | Minimum inhibitory concentration against Proteus mirabilis delta 89 | ChEMBL. | 6379179 |
MIC (functional) | > 50 ug ml-1 | Minimum inhibitory concentration of compound against Escherichia coli delta 120 | ChEMBL. | 6379179 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.