Detailed information for compound 305675

Basic information

Technical information
  • TDR Targets ID: 305675
  • Name: (6aR,11aS)-6-prop-2-enyl-5,6a,7,10,11,11a-hex ahydropyrazolo[3,4-b]phenanthridine
  • MW: 265.353 | Formula: C17H19N3
  • H donors: 1 H acceptors: 1 LogP: 2.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1Cc2ccccc2[C@H]2[C@H]1Cc1c[nH]nc1C2
  • InChi: 1S/C17H19N3/c1-2-7-20-11-12-5-3-4-6-14(12)15-9-16-13(8-17(15)20)10-18-19-16/h2-6,10,15,17H,1,7-9,11H2,(H,18,19)/t15-,17+/m0/s1
  • InChiKey: UGFPXXYUOKXTQN-DOTOQJQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6aR,11aS)-6-allyl-5,6a,7,10,11,11a-hexahydropyrazolo[3,4-b]phenanthridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0064 0.0064
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0016 0.0193 0.0193
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0333 0.1023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0064 0.0064
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0064 0.0064
Brugia malayi Thioredoxin reductase 0.0208 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Brugia malayi nuclear receptor NHR-88 0.0014 0.0064 0.004
Schistosoma mansoni zinc finger protein 0.0014 0.0096 0.0096
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0333 0.031
Echinococcus granulosus histone acetyltransferase MYST2 0.0039 0.1335 0.1335
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0333 0.031
Plasmodium vivax glutathione reductase, putative 0.0208 1 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0072 0.3043 0.3026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0504 0.0504
Echinococcus granulosus metabotropic glutamate receptor 2 0.0098 0.4388 0.4388
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0075 0.0051
Echinococcus multilocularis histone acetyltransferase MYST2 0.0039 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0019 0.0333 0.0333
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0333 0.0333
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0333 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0064 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0033 0.1037 0.1037
Brugia malayi steroid hormone receptor 0.0014 0.0064 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0072 0.3043 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0034 0.1094 0.1094
Echinococcus granulosus metabotropic glutamate receptor 5 0.0144 0.6751 0.6751
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0333 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0072 0.3043 1
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0333 0.0051
Brugia malayi mbt repeat family protein 0.0034 0.1094 0.1073
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0193 0.0169
Loa Loa (eye worm) glutathione reductase 0.0208 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0333 0.1023
Echinococcus multilocularis GPCR, family 3, C terminal 0.0019 0.0329 0.0329
Plasmodium falciparum glutathione reductase 0.0208 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0193 0.0557
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.003 0.0897 0.0897
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0064 0.0064
Schistosoma mansoni caspase-3 (C14 family) 0.0013 0.0024 0.0024
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.3043 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0064 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0208 1 1
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0319 0.0319
Mycobacterium ulcerans dehydrogenase 0.0019 0.0333 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0333 0.031
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0106 0.4798 0.4785
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0333 0.0051
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0064 0.0064
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0333 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0064 0.0064
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0072 0.3043 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0064 0.004
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0333 0.031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0039 0.1335 0.1335
Schistosoma mansoni hypothetical protein 0.0019 0.0333 0.0333
Brugia malayi hypothetical protein 0.0087 0.3824 0.3809
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0333 0.0333
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.1392 0.1392
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Schistosoma mansoni coup transcription factor 0.0014 0.0064 0.0064
Echinococcus granulosus mitogen activated protein kinase 3 0.0034 0.1074 0.1074
Brugia malayi MAP kinase sur-1 0.0034 0.1074 0.1052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0033 0.1037 0.1015
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0333 0.0333
Brugia malayi PHD-finger family protein 0.0018 0.0298 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0333 0.0333
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0333 0.0333
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0134 0.6212 0.6212
Echinococcus granulosus fetal alzheimer antigen falz 0.0017 0.0208 0.0208
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3026
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0333 0.031
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0309 0.0285
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0072 0.3043 0.3026
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0333 0.031
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0333 0.0333
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0333 1
Toxoplasma gondii thioredoxin reductase 0.0208 1 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0034 0.1074 0.1074
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0072 0.3043 0.3026
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.1074 0.1052
Leishmania major cytochrome p450-like protein 0.0019 0.0319 0.0296
Brugia malayi Cytochrome P450 family protein 0.0019 0.0319 0.0296
Giardia lamblia NADH oxidase lateral transfer candidate 0.0072 0.3043 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0808 0.0808
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Echinococcus multilocularis caspase 0.0013 0.0024 0.0024
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0013 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0064 0.0064
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0144 0.6751 0.6751
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0072 0.3043 0.3026
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0072 0.3043 0.3026
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0053 0.2064 0.2045
Leishmania major hypothetical protein, conserved 0.0019 0.0309 0.0285
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0333 0.031
Onchocerca volvulus Huntingtin homolog 0.0087 0.3824 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0034 0.1074 0.1074
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0333 0.1023
Mycobacterium ulcerans hypothetical protein 0.0019 0.0333 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Echinococcus granulosus GPCR family 3 C terminal 0.0019 0.0329 0.0329
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0133 0.6186 0.6186
Schistosoma mansoni caspase-7 (C14 family) 0.0043 0.1585 0.1585
Brugia malayi glutamate synthase 0.0019 0.0333 0.031
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0064 0.0064
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0072 0.3043 0.3026
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0333 0.1023
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0072 0.3043 0.3026
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0715 0.0715
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.3043 1
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0333 0.0051
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0333 0.031
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0333 0.031
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0144 0.6751 0.6751
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0319 0.0319
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0333 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0064 0.0064
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0333 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3026
Loa Loa (eye worm) hypothetical protein 0.003 0.0915 0.0915
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0019 0.0329 0.0706
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0134 0.6212 0.6212
Brugia malayi Bromodomain containing protein 0.0028 0.0805 0.0783
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0333 0.0333
Brugia malayi Cell death protein 3 precursor 0.0043 0.1585 0.1565
Onchocerca volvulus Huntingtin homolog 0.0087 0.3824 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0064 0.0064
Plasmodium vivax thioredoxin reductase, putative 0.0208 1 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0333 0.0333
Trypanosoma brucei trypanothione reductase 0.0208 1 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0017 0.0208 0.0208
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0053 0.2064 0.2045
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.1094 0.1094
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0064 0.0064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0064 0.004
Giardia lamblia Kinase, CMGC MAPK 0.0034 0.1074 0.2735
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0072 0.3043 0.2803
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0333 0.0051
Schistosoma mansoni caspase-7 (C14 family) 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0329
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0333 0.0051
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0333 0.1023
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.1094 0.1094
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0072 0.3043 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0039 0.1335 0.1335
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0064 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0333 0.0333
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0333 0.0333
Echinococcus multilocularis glutamate synthase 0.0019 0.0333 0.0333
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.1616 0.1616
Onchocerca volvulus Cell death protein 3 homolog 0.0043 0.1585 0.4046
Echinococcus granulosus zinc finger protein 0.0014 0.0096 0.0096
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0072 0.3043 0.2803
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0064 0.004
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0064 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.003 0.0915 0.0915
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0064 0.004
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0915 0.0915
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0333 0.031
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.003 0.0894 0.0894
Toxoplasma gondii FATC domain-containing protein 0.0016 0.0193 0.0169
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0064 0.0064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0064 0.0064
Toxoplasma gondii selenide, water dikinase 0.0019 0.0333 0.031
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0333 1
Onchocerca volvulus 0.0019 0.0333 0.0716
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0319 0.0296
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0333 0.031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0939 0.0917
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0333 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0939 0.0939
Trichomonas vaginalis mercuric reductase, putative 0.0072 0.3043 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0208 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.1074 0.1074
Toxoplasma gondii NADPH-glutathione reductase 0.0072 0.3043 0.3026
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0894 0.0872
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0017 0.0208 0.0208
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0072 0.3043 0.2803
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0064 0.0064
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.1094 0.274
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0333 0.031
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0064 0.004
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.3043 0.3026
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0333 0.031
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0064 0.0064
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0333 0.031
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0064 0.0064
Brugia malayi mbt repeat family protein 0.0034 0.1094 0.1073
Trichomonas vaginalis glutathione reductase, putative 0.0072 0.3043 1
Onchocerca volvulus 0.003 0.0915 0.2263
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0333 0.0333
Brugia malayi ecdysteroid receptor 0.0014 0.0064 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Echinococcus multilocularis mitogen activated protein kinase 0.0034 0.1074 0.1074
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.1074 0.1052
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0333 0.0333
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) thioredoxin reductase 0.0208 1 1
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0329 0.0306
Echinococcus multilocularis caspase 2 0.0043 0.1585 0.1585
Echinococcus granulosus glutamate synthase 0.0019 0.0333 0.0333
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0064 0.0064
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0319 0.0296
Schistosoma mansoni hypothetical protein 0.0019 0.0329 0.0329
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.1094 0.1094
Onchocerca volvulus 0.0034 0.1094 0.274
Loa Loa (eye worm) MBCTL1 0.0039 0.1335 0.1335
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.1094 0.1094
Schistosoma mansoni hypothetical protein 0.0022 0.0504 0.0504
Schistosoma mansoni metabotropic glutamate receptor 0.0057 0.2283 0.2283
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0064 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0064 0.0064
Brugia malayi Cytochrome P450 family protein 0.0019 0.0319 0.0296
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0333 0.0051
Loa Loa (eye worm) glutamate receptor 0.0046 0.1718 0.1718
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0034 0.1074 0.1052
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0072 0.3043 0.3026
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0333 0.031
Mycobacterium tuberculosis Probable oxidoreductase 0.0072 0.3043 0.2803
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.1616 0.1616
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0333 0.0333
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0064 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0309 0.0285
Mycobacterium ulcerans monoxygenase 0.0019 0.0333 0.0051
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0333 0.031
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0064 0.004
Echinococcus granulosus caspase 0.0013 0.0024 0.0024
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0023 0.0023
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Loa Loa (eye worm) hypothetical protein 0.0087 0.3824 0.3824
Brugia malayi nuclear hormone receptor 0.0014 0.0064 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0333 0.031
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0033 0.1037 0.1015
Leishmania major trypanothione reductase 0.0208 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0064 0.004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Loa Loa (eye worm) hypothetical protein 0.0033 0.1037 0.1037
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0072 0.3043 0.3026
Loa Loa (eye worm) hypothetical protein 0.0039 0.1335 0.1335
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0064 0.004
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0333 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0039 0.1335 0.1314
Brugia malayi Cytochrome P450 family protein 0.004 0.1392 0.1371
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0333 1
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0319 0.0296
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0064 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0064 0.0064
Echinococcus granulosus caspase 2 0.0043 0.1585 0.1585
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0072 0.3043 1
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0064 0.0064
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0309 0.0309
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0064 0.004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0039 0.1335 0.1335
Echinococcus granulosus serine protein kinase ATM 0.0016 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0064 0.004
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0915 0.0915
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.1094 0.1094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0064 0.0064
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0208 1 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0333 0.0333
Echinococcus multilocularis caspase 8 0.0013 0.0024 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0064 0.0064
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0333 0.0051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0034 0.1074 0.1052
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0333 0.1023
Loa Loa (eye worm) glutamate receptor 0.0117 0.5363 0.5363
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0333 0.1023
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Echinococcus multilocularis serine protein kinase ATM 0.0016 0.0193 0.0193
Schistosoma mansoni bromodomain containing protein 0.0047 0.1751 0.1751
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.003 0.0894 0.0894
Brugia malayi hypothetical protein 0.0019 0.0309 0.0285
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0333 0.0051
Loa Loa (eye worm) hypothetical protein 0.0031 0.097 0.097
Onchocerca volvulus Poor gastrulation protein homolog 0.0019 0.0329 0.0706
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.3043 0.3026
Brugia malayi hypothetical protein 0.003 0.0915 0.0893
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0939 0.0939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0939 0.0939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0034 0.1074 0.1052
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0013 0.0024 0.0024
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.3043 0.3026
Brugia malayi Bromodomain containing protein 0.0055 0.2195 0.2176
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.1094 0.1094
Loa Loa (eye worm) hypothetical protein 0.003 0.0894 0.0894
Plasmodium falciparum thioredoxin reductase 0.0208 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0064 0.004
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0309 0.0285
Trypanosoma brucei protein kinase, putative 0.0034 0.1074 0.1052
Schistosoma mansoni metabotropic glutamate receptor 0.0098 0.4388 0.4388
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0333 0.0333
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0072 0.3043 0.3026
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0064 0.0064
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0016 0.0193 0.0169
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0193 0.0169
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0034 0.1074 0.1052
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0333 0.031
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Plasmodium falciparum thioredoxin reductase 0.0072 0.3043 0.3026
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.1094 0.1094
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0309 0.0285
Plasmodium falciparum glutathione reductase 0.0072 0.3043 0.3026
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0034 0.1074 0.1052
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0319 0.0319
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0333 0.031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Echinococcus multilocularis zinc finger protein 0.0014 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Brugia malayi metabotropic glutamate receptor type 2 0.0057 0.2283 0.2264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0504 0.0481
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Loa Loa (eye worm) hypothetical protein 0.0043 0.1585 0.1585
Loa Loa (eye worm) hypothetical protein 0.0052 0.2033 0.2033
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0333 0.0333
Echinococcus granulosus mitogen activated protein kinase 0.0034 0.1074 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0064 0.004
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0013 0.0024 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0715 0.0715
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0098 0.4388 0.4388
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0064 0.0064
Echinococcus granulosus caspase 8 0.0013 0.0024 0.0024
Brugia malayi Metabotropic glutamate receptor precursor. 0.0117 0.5363 0.5352
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Leishmania major NADH dehydrogenase, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Treponema pallidum NADH oxidase 0.0072 0.3043 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0064 0.0064
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0333 0.0051
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.1094 0.1094
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0034 0.1074 0.1052
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0064 0.004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0939 0.0939
Loa Loa (eye worm) hypothetical protein 0.0087 0.3824 0.3824
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0206 0.9934 0.9934
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0939 0.0939
Trypanosoma cruzi trypanothione reductase, putative 0.0208 1 1

Activities

Activity type Activity value Assay description Source Reference
K 0.5 (binding) = 73.7 nM Affinity on C6 glioma cells transfected with Dopamine receptor D3 ChEMBL. 10072690
K 0.5 (binding) = 73.7 nM Affinity on C6 glioma cells transfected with Dopamine receptor D3 ChEMBL. 10072690
K 0.5 (binding) = 100 nM Inhibition of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 ChEMBL. 10072690
K 0.5 (binding) = 100 nM Inhibition of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 ChEMBL. 10072690
K 0.5 (binding) = 1880 nM Affinity on C6 glioma cells transfected with Dopamine receptor D2L ChEMBL. 10072690
K 0.5 (binding) = 1880 nM Affinity on C6 glioma cells transfected with Dopamine receptor D2L ChEMBL. 10072690
K 0.5 (binding) > 5 uM Inhibition of [3H]-SCH-23,390 binding to rat striatal membrane Dopamine receptor D1 ChEMBL. 10072690
K 0.5 (binding) > 5 uM Inhibition of [3H]-SCH-23,390 binding to rat striatal membrane Dopamine receptor D1 ChEMBL. 10072690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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