Detailed information for compound 305675

Basic information

Technical information
  • TDR Targets ID: 305675
  • Name: (6aR,11aS)-6-prop-2-enyl-5,6a,7,10,11,11a-hex ahydropyrazolo[3,4-b]phenanthridine
  • MW: 265.353 | Formula: C17H19N3
  • H donors: 1 H acceptors: 1 LogP: 2.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1Cc2ccccc2[C@H]2[C@H]1Cc1c[nH]nc1C2
  • InChi: 1S/C17H19N3/c1-2-7-20-11-12-5-3-4-6-14(12)15-9-16-13(8-17(15)20)10-18-19-16/h2-6,10,15,17H,1,7-9,11H2,(H,18,19)/t15-,17+/m0/s1
  • InChiKey: UGFPXXYUOKXTQN-DOTOQJQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6aR,11aS)-6-allyl-5,6a,7,10,11,11a-hexahydropyrazolo[3,4-b]phenanthridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.1074 0.1074
Brugia malayi Metabotropic glutamate receptor precursor. 0.0117 0.5363 0.5352
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.1074 0.1052
Brugia malayi PHD-finger family protein 0.0018 0.0298 0.0274
Plasmodium vivax thioredoxin reductase, putative 0.0208 1 1
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0019 0.0329 0.0706
Trypanosoma brucei protein kinase, putative 0.0034 0.1074 0.1052
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0072 0.3043 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Trypanosoma cruzi trypanothione reductase, putative 0.0072 0.3043 0.3026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.0193 0.0557
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0016 0.0193 0.0169
Echinococcus multilocularis FTZ F1 alpha 0.0014 0.0064 0.0064
Echinococcus granulosus caspase 0.0013 0.0024 0.0024
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0106 0.4798 0.4785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0014 0.0064 0.0064
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0333 0.031
Echinococcus granulosus apoptotic protease activating factor 1 0.003 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0019 0.0333 0.0333
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0333 0.0333
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0014 0.0064 0.0064
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0014 0.0064 0.0064
Trichomonas vaginalis apoptosis inducing factor, putative 0.0019 0.0333 0.1023
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0019 0.0333 0.0051
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0019 0.0333 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0072 0.3043 0.3026
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0064 0.004
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0014 0.0064 0.0064
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0144 0.6751 0.6751
Schistosoma mansoni hypothetical protein 0.0019 0.0329 0.0329
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0064 0.0064
Brugia malayi Bromodomain containing protein 0.0055 0.2195 0.2176
Loa Loa (eye worm) PHD-finger family protein 0.0015 0.0136 0.0136
Brugia malayi ecdysteroid receptor 0.0014 0.0064 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0309 0.0309
Echinococcus granulosus thioredoxin glutathione reductase 0.0208 1 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0072 0.3043 0.3026
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0019 0.0333 0.1023
Onchocerca volvulus Cell death protein 3 homolog 0.0043 0.1585 0.4046
Brugia malayi metabotropic glutamate receptor type 2 0.0057 0.2283 0.2264
Leishmania major cytochrome p450-like protein 0.0019 0.0319 0.0296
Echinococcus multilocularis SAM and MBT domain containing protein 0.0034 0.1094 0.1094
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0072 0.3043 0.3026
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0019 0.0333 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0072 0.3043 0.3026
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0319 0.0319
Brugia malayi photoreceptor-specific nuclear receptor 0.0014 0.0064 0.004
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0034 0.1094 0.274
Echinococcus multilocularis polycomb protein SCMH1 0.0034 0.1094 0.1094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0019 0.0333 0.0333
Schistosoma mansoni myelin transcription factor 1 myt1 0.0039 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0033 0.1037 0.1037
Plasmodium vivax ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Brugia malayi Cell death protein 3 precursor 0.0043 0.1585 0.1565
Brugia malayi Steroid receptor seven-up type 2 0.0014 0.0064 0.004
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.003 0.0897 0.0897
Schistosoma mansoni hypothetical protein 0.003 0.0915 0.0915
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0014 0.0064 0.0064
Loa Loa (eye worm) cytochrome P450 family protein 0.004 0.1392 0.1392
Loa Loa (eye worm) glutathione reductase 0.0208 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0014 0.0064 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0333 0.0051
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0019 0.0333 0.031
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0333 0.1023
Schistosoma mansoni RAR-like nuclear receptor 0.0014 0.0064 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0939 0.0939
Leishmania major hypothetical protein, conserved 0.0019 0.0309 0.0285
Mycobacterium ulcerans hypothetical protein 0.0019 0.0333 0.0051
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Giardia lamblia NADH oxidase lateral transfer candidate 0.0072 0.3043 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0072 0.3043 0.3026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0014 0.0064 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0064 0.004
Echinococcus granulosus histone acetyltransferase MYST2 0.0039 0.1335 0.1335
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0072 0.3043 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0333 0.031
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0013 0.0024 0.0024
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0019 0.0333 0.031
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0019 0.0333 0.0333
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0019 0.0333 0.0333
Trypanosoma cruzi trypanothione reductase, putative 0.0208 1 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0072 0.3043 0.3026
Treponema pallidum NADH oxidase 0.0072 0.3043 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0144 0.6751 0.6751
Schistosoma mansoni hypothetical protein 0.0022 0.0504 0.0504
Trypanosoma brucei cytochrome P450, putative 0.0019 0.0319 0.0296
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0034 0.1094 0.1094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.3043 0.3026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0014 0.0064 0.0064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3026
Loa Loa (eye worm) hypothetical protein 0.003 0.0915 0.0915
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Echinococcus multilocularis serine protein kinase ATM 0.0016 0.0193 0.0193
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0019 0.0333 0.0333
Trypanosoma brucei trypanothione reductase 0.0208 1 1
Loa Loa (eye worm) hypothetical protein 0.0144 0.6751 0.6751
Echinococcus multilocularis glutamate synthase 0.0019 0.0333 0.0333
Plasmodium vivax glutathione reductase, putative 0.0208 1 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0072 0.3043 1
Brugia malayi hypothetical protein 0.003 0.0915 0.0893
Echinococcus granulosus caspase 8 0.0013 0.0024 0.0024
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0333 0.0333
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0016 0.0193 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0064 0.004
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0019 0.0333 0.031
Trichomonas vaginalis glutathione reductase, putative 0.0072 0.3043 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0031 0.0939 0.0917
Brugia malayi MAP kinase sur-1 0.0034 0.1074 0.1052
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0014 0.0064 0.0064
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0333 0.031
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0022 0.0504 0.0504
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0019 0.0333 0.0051
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0019 0.0333 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0014 0.0064 0.004
Brugia malayi hypothetical protein 0.0087 0.3824 0.3809
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0019 0.0333 0.0333
Echinococcus granulosus metabotropic glutamate receptor 2 0.0098 0.4388 0.4388
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0064 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Echinococcus granulosus zinc finger protein 0.0014 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0015 0.0136 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0031 0.0939 0.0939
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0019 0.0333 0.0051
Plasmodium falciparum thioredoxin reductase 0.0072 0.3043 0.3026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0014 0.0064 0.004
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0019 0.0333 0.031
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0044 0.1616 0.1616
Brugia malayi mbt repeat family protein 0.0034 0.1094 0.1073
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0072 0.3043 0.3026
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0319 0.0296
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.1094 0.1094
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0013 0.0024 0.0024
Echinococcus multilocularis zinc finger protein 0.0014 0.0096 0.0096
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0014 0.0064 0.0064
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0034 0.1074 0.1052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0014 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.003 0.0894 0.0894
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0072 0.3043 0.3026
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0333 1
Brugia malayi glutamate synthase 0.0019 0.0333 0.031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0064 0.0064
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0014 0.0064 0.004
Schistosoma mansoni caspase-7 (C14 family) 0.0013 0.0024 0.0024
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0333 0.031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0014 0.0064 0.0064
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0939 0.0939
Echinococcus multilocularis GPCR, family 3, C terminal 0.0019 0.0329 0.0329
Brugia malayi mbt repeat family protein 0.0034 0.1094 0.1073
Onchocerca volvulus 0.0034 0.1094 0.274
Brugia malayi nuclear hormone receptor 0.0014 0.0064 0.004
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0019 0.0333 0.031
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0019 0.0333 0.1023
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0072 0.3043 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0014 0.0064 0.0064
Echinococcus multilocularis caspase 2 0.0043 0.1585 0.1585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0014 0.0064 0.0064
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0019 0.0333 0.031
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0039 0.1335 0.1335
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0333 0.0333
Brugia malayi nuclear receptor NHR-88 0.0014 0.0064 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0014 0.0064 0.0064
Toxoplasma gondii FATC domain-containing protein 0.0016 0.0193 0.0169
Echinococcus multilocularis thyroid hormone receptor alpha 0.0014 0.0064 0.0064
Plasmodium vivax ferrodoxin reductase, putative 0.0019 0.0333 0.031
Schistosoma mansoni bromodomain containing protein 0.0047 0.1751 0.1751
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.003 0.0894 0.0894
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0333 0.1023
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Schistosoma mansoni caspase-3 (C14 family) 0.0013 0.0024 0.0024
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0072 0.3043 0.2803
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0208 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0715 0.0715
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0014 0.0064 0.0064
Schistosoma mansoni metabotropic glutamate receptor 0.0098 0.4388 0.4388
Plasmodium falciparum ferrodoxin reductase-like protein 0.0019 0.0333 0.031
Brugia malayi steroid hormone receptor 0.0014 0.0064 0.004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0319 0.0319
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0072 0.3043 0.3026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Trypanosoma brucei PAB1-binding protein , putative 0.0019 0.0309 0.0285
Loa Loa (eye worm) hypothetical protein 0.0014 0.0075 0.0075
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0072 0.3043 0.2803
Echinococcus granulosus mitogen activated protein kinase 3 0.0034 0.1074 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0014 0.0064 0.004
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0019 0.0333 0.031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0031 0.0939 0.0939
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0014 0.0064 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0033 0.1037 0.1015
Schistosoma mansoni hypothetical protein 0.0206 0.9934 0.9934
Loa Loa (eye worm) hypothetical protein 0.0039 0.1335 0.1335
Entamoeba histolytica thioredoxin reductase, putative 0.0019 0.0333 1
Brugia malayi latrophilin 2 splice variant baaae 0.0022 0.0504 0.0481
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0019 0.0333 0.1023
Echinococcus granulosus caspase 2 0.0043 0.1585 0.1585
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0019 0.0333 0.0333
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0072 0.3043 0.3026
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0023 0.0023
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0133 0.6186 0.6186
Loa Loa (eye worm) thioredoxin reductase 0.0208 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0019 0.0333 0.1023
Schistosoma mansoni zinc finger protein 0.0014 0.0096 0.0096
Brugia malayi Bromodomain containing protein 0.0028 0.0805 0.0783
Schistosoma mansoni sulfide quinone reductase 0.0019 0.0333 0.0333
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0072 0.3043 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0014 0.0064 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0031 0.0939 0.0939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0333 0.031
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0319 0.0319
Loa Loa (eye worm) MBCTL1 0.0039 0.1335 0.1335
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0016 0.0193 0.0169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Echinococcus multilocularis histone acetyltransferase MYST2 0.0039 0.1335 0.1335
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0044 0.1616 0.1616
Echinococcus multilocularis apoptotic protease activating factor 1 0.003 0.0915 0.0915
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0019 0.0333 0.0333
Brugia malayi Cytochrome P450 family protein 0.0019 0.0319 0.0296
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0019 0.0333 1
Schistosoma mansoni metabotropic glutamate receptor 0.0057 0.2283 0.2283
Echinococcus multilocularis caspase 0.0013 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.097 0.097
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0019 0.0333 0.031
Leishmania major hypothetical protein, conserved 0.0019 0.0333 0.031
Loa Loa (eye worm) hypothetical protein 0.0028 0.0808 0.0808
Loa Loa (eye worm) hypothetical protein 0.0013 0.0024 0.0024
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0064 0.0064
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.1074 0.1052
Onchocerca volvulus Huntingtin homolog 0.0087 0.3824 1
Echinococcus granulosus FTZ F1 alpha 0.0014 0.0064 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0014 0.0064 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0014 0.0064 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0072 0.3043 0.2803
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0019 0.0333 0.031
Schistosoma mansoni glutamate synthase 0.0019 0.0333 0.0333
Loa Loa (eye worm) glutamate receptor 0.0046 0.1718 0.1718
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Plasmodium falciparum glutathione reductase 0.0072 0.3043 0.3026
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0072 0.3043 0.3026
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0039 0.1335 0.1335
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0333 0.031
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.0319 0.0296
Loa Loa (eye worm) hypothetical protein 0.0043 0.1585 0.1585
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0014 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0014 0.0064 0.004
Mycobacterium ulcerans glutamate synthase subunit beta 0.0019 0.0333 0.0051
Brugia malayi Thioredoxin reductase 0.0208 1 1
Mycobacterium ulcerans monoxygenase 0.0019 0.0333 0.0051
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0019 0.0333 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0715 0.0715
Schistosoma mansoni disulfide oxidoreductase 0.0019 0.0333 0.0333
Brugia malayi Cytochrome P450 family protein 0.004 0.1392 0.1371
Echinococcus granulosus ecdysone induced protein 78C 0.0014 0.0064 0.0064
Leishmania major trypanothione reductase 0.0208 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0019 0.0309 0.0285
Loa Loa (eye worm) mbt repeat family protein 0.0034 0.1094 0.1094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0014 0.0064 0.004
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0019 0.0333 0.1023
Echinococcus granulosus mitogen activated protein kinase 0.0034 0.1074 0.1074
Loa Loa (eye worm) programmed cell death 8 0.0019 0.0333 0.0333
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0333 0.031
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0034 0.1074 0.1052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.3043 1
Echinococcus granulosus glutamate synthase 0.0019 0.0333 0.0333
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.0064
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0014 0.0064 0.0064
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0053 0.2064 0.2045
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0019 0.0333 0.031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3026
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0053 0.2064 0.2045
Loa Loa (eye worm) hypothetical protein 0.0052 0.2033 0.2033
Echinococcus granulosus SAM and MBT domain containing protein 0.0034 0.1094 0.1094
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0019 0.0333 0.0333
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0034 0.1074 0.1052
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0034 0.1074 0.1052
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0014 0.0064 0.0064
Echinococcus granulosus serine protein kinase ATM 0.0016 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0087 0.3824 0.3824
Echinococcus multilocularis ecdysone induced protein 78C 0.0014 0.0064 0.0064
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0039 0.1335 0.1314
Schistosoma mansoni caspase-7 (C14 family) 0.0043 0.1585 0.1585
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0034 0.1094 0.1094
Trypanosoma cruzi NADH dehydrogenase, putative 0.0019 0.0333 0.031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0031 0.0939 0.0939
Brugia malayi Receptor family ligand binding region containing protein 0.003 0.0894 0.0872
Trypanosoma brucei NADH dehydrogenase 0.0019 0.0333 0.031
Onchocerca volvulus 0.003 0.0915 0.2263
Loa Loa (eye worm) glutamate receptor 0.0117 0.5363 0.5363
Brugia malayi hypothetical protein 0.0019 0.0309 0.0285
Onchocerca volvulus Huntingtin homolog 0.0087 0.3824 1
Plasmodium falciparum thioredoxin reductase 0.0208 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0894 0.0894
Onchocerca volvulus Poor gastrulation protein homolog 0.0019 0.0329 0.0706
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0072 0.3043 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0019 0.0333 0.0051
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0075 0.0051
Plasmodium falciparum glutathione reductase 0.0208 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0014 0.0064 0.0064
Toxoplasma gondii NADPH-glutathione reductase 0.0072 0.3043 0.3026
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0019 0.0333 0.0333
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0072 0.3043 0.3043
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0019 0.0333 0.0333
Toxoplasma gondii thioredoxin reductase 0.0208 1 1
Mycobacterium ulcerans NADH dehydrogenase 0.0019 0.0333 0.0051
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0033 0.1037 0.1037
Leishmania major NADH dehydrogenase, putative 0.0019 0.0333 0.031
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0034 0.1074 0.1052
Schistosoma mansoni sex comb on midleg homolog 0.0034 0.1094 0.1094
Schistosoma mansoni thyroid hormone receptor 0.0014 0.0064 0.0064
Mycobacterium ulcerans dehydrogenase 0.0019 0.0333 0.0051
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0017 0.0208 0.0208
Toxoplasma gondii LsmAD domain-containing protein 0.0019 0.0309 0.0285
Brugia malayi Calcitonin receptor-like protein seb-1 0.0033 0.1037 0.1015
Loa Loa (eye worm) steroid hormone receptor 0.0014 0.0064 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0014 0.0064 0.0064
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0019 0.0329 0.0306
Toxoplasma gondii selenide, water dikinase 0.0019 0.0333 0.031
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0019 0.0333 0.0333
Echinococcus multilocularis thioredoxin glutathione reductase 0.0208 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0034 0.1074 0.1052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0064 0.0064
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0019 0.0333 0.031
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0134 0.6212 0.6212
Echinococcus multilocularis mitogen activated protein kinase 0.0034 0.1074 0.1074
Loa Loa (eye worm) hypothetical protein 0.0087 0.3824 0.3824
Echinococcus multilocularis mitogen activated protein kinase 3 0.0034 0.1074 0.1074
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.1074 0.3478
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0019 0.0333 0.0333
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0134 0.6212 0.6212
Echinococcus granulosus fetal alzheimer antigen falz 0.0017 0.0208 0.0208
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0309 0.0285
Loa Loa (eye worm) hypothetical protein 0.0019 0.0329 0.0329
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0333 0.031
Schistosoma mansoni coup transcription factor 0.0014 0.0064 0.0064
Brugia malayi Cytochrome P450 family protein 0.0019 0.0319 0.0296
Echinococcus granulosus polycomb protein SCMH1 0.0034 0.1094 0.1094
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0019 0.0333 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0193 0.0169
Giardia lamblia Kinase, CMGC MAPK 0.0034 0.1074 0.2735
Echinococcus multilocularis caspase 8 0.0013 0.0024 0.0024
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0072 0.3043 0.3026
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0017 0.0208 0.0208
Trichomonas vaginalis mercuric reductase, putative 0.0072 0.3043 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0014 0.0064 0.0064
Onchocerca volvulus 0.0019 0.0333 0.0716
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0019 0.0333 0.031
Schistosoma mansoni retinoic acid receptor RXR 0.0014 0.0064 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0019 0.0309 0.0285
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0098 0.4388 0.4388
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0013 0.0024 0.0024
Mycobacterium ulcerans ferredoxin reductase 0.0019 0.0333 0.0051
Echinococcus granulosus GPCR family 3 C terminal 0.0019 0.0329 0.0329
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0034 0.1074 0.1074
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0072 0.3043 1
Entamoeba histolytica disulphide oxidoreductase, putative 0.0019 0.0333 1

Activities

Activity type Activity value Assay description Source Reference
K 0.5 (binding) = 73.7 nM Affinity on C6 glioma cells transfected with Dopamine receptor D3 ChEMBL. 10072690
K 0.5 (binding) = 73.7 nM Affinity on C6 glioma cells transfected with Dopamine receptor D3 ChEMBL. 10072690
K 0.5 (binding) = 100 nM Inhibition of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 ChEMBL. 10072690
K 0.5 (binding) = 100 nM Inhibition of [3H]-spiperone binding to rat striatal membrane Dopamine receptor D2 ChEMBL. 10072690
K 0.5 (binding) = 1880 nM Affinity on C6 glioma cells transfected with Dopamine receptor D2L ChEMBL. 10072690
K 0.5 (binding) = 1880 nM Affinity on C6 glioma cells transfected with Dopamine receptor D2L ChEMBL. 10072690
K 0.5 (binding) > 5 uM Inhibition of [3H]-SCH-23,390 binding to rat striatal membrane Dopamine receptor D1 ChEMBL. 10072690
K 0.5 (binding) > 5 uM Inhibition of [3H]-SCH-23,390 binding to rat striatal membrane Dopamine receptor D1 ChEMBL. 10072690

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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