Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | SET domain protein, putative | 0.003 | 0.0616 | 0.0873 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0211 | 0.8697 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0079 | 0.2817 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0079 | 0.2817 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0.2817 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0079 | 0.2817 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0079 | 0.2817 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1336 | 0.3272 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.1336 | 0.1536 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.2134 | 0.2085 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1336 | 0.3272 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2817 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0616 | 0.0221 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1336 | 0.3421 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0405 | 0.0466 |
Echinococcus granulosus | dihydrofolate reductase | 0.0079 | 0.2817 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0616 | 0.0254 |
Brugia malayi | RNA binding protein | 0.0064 | 0.2134 | 0.2454 |
Brugia malayi | Pre-SET motif family protein | 0.0211 | 0.8697 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0079 | 0.2817 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.2134 | 0.6897 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2817 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0079 | 0.2817 | 0.3239 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.2134 | 0.2454 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2817 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.1336 | 0.3272 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1336 | 0.3272 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.2134 | 0.2454 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.003 | 0.0616 | 0.0873 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2134 | 0.6897 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.1336 | 0.3272 |
Trichomonas vaginalis | set domain proteins, putative | 0.024 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0079 | 0.2817 | 0.2909 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.2134 | 0.2085 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2817 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.2134 | 0.6966 |
Brugia malayi | dihydrofolate reductase family protein | 0.0079 | 0.2817 | 0.3239 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0079 | 0.2817 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.1336 | 0.3421 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2134 | 0.6897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2134 | 0.6897 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0.2817 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.2134 | 0.2085 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.1336 | 0.1123 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2134 | 0.6897 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.2134 | 0.6897 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0616 | 0.0708 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 80000000 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
IC50 (binding) | = 0.000000008 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
Inhibition (binding) | = 23 % | Compound was tested for inhibitory activity against Dihydrofolate reductase of rat liver at 2000 M | ChEMBL. | 7035668 |
Inhibition (binding) | = 23 % | Compound was tested for inhibitory activity against Dihydrofolate reductase of rat liver at 2000 M | ChEMBL. | 7035668 |
Ratio (functional) | = 10 | Minimum inhibitory concentration of compound versus trimethoprim against Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (functional) | > 30 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (functional) | = 10 | Minimum inhibitory concentration of compound versus trimethoprim against Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (functional) | > 30 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (functional) | = 30 | Minimum inhibitory concentration of compound versus trimethoprim against Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.