Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-C motif) receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.7081 | 0.6633 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Echinococcus granulosus | tar DNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0065 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.1992 | 0.1992 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0034 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.3513 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.3513 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0034 | 0.3513 | 0.5 |
Leishmania major | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.3668 | 0.024 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.3513 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.3513 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0065 | 1 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.1329 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.7081 | 0.55 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.3513 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.3513 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3668 | 0.3668 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.3513 | 1 |
Brugia malayi | TAR-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.3513 | 0.2518 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Echinococcus multilocularis | tar DNA binding protein | 0.0065 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.3513 | 0.2518 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.3513 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0065 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0065 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.3668 | 0.2698 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.3513 | 0.3513 |
Leishmania major | pyruvate kinase | 0.0034 | 0.3513 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0034 | 0.3513 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.3513 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0034 | 0.3513 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.7081 | 0.55 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.7081 | 0.6633 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.9 nM | Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell | ChEMBL. | 15012999 |
IC50 (binding) | = 0.9 nM | Inhibitory concentration for displacement of [125I]-MIP-1 alpha from recombinant human CC chemokine receptor 5 (CCR5) expressed in CHO cell | ChEMBL. | 15012999 |
IC90 (functional) | = 0.4 nM | Antiviral activities in a cell culture HIV-1 infectivity inhibition assay using HeLa cells | ChEMBL. | 15012999 |
IC90 (functional) | = 0.4 nM | Antiviral activities in a cell culture HIV-1 infectivity inhibition assay using HeLa cells | ChEMBL. | 15012999 |
IC90 (functional) | = 100 nM | Antiviral activities in a cell culture HIV-1 infectivity inhibition assay using HeLa cells plus 50% normal human serum | ChEMBL. | 15012999 |
IC90 (functional) | = 100 nM | Antiviral activities in a cell culture HIV-1 infectivity inhibition assay using HeLa cells plus 50% normal human serum | ChEMBL. | 15012999 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.