Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | smad | 0.0009 | 0.0183 | 0.0716 |
Loa Loa (eye worm) | ICD-1 protein | 0.0041 | 0.255 | 0.255 |
Schistosoma mansoni | smad | 0.0009 | 0.0183 | 0.0716 |
Brugia malayi | beta-NAC-like protein | 0.0041 | 0.255 | 0.255 |
Brugia malayi | Smad1 | 0.0009 | 0.0183 | 0.0183 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0183 | 0.0716 |
Schistosoma mansoni | Smad4 | 0.0009 | 0.0183 | 0.0716 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0041 | 0.255 | 0.5 |
Onchocerca volvulus | 0.0007 | 0 | 0.5 | |
Echinococcus multilocularis | smad | 0.0009 | 0.0183 | 0.0716 |
Echinococcus multilocularis | transcription factor btf3 | 0.0041 | 0.255 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0041 | 0.255 | 0.5 |
Echinococcus granulosus | transcription factor btf3 | 0.0041 | 0.255 | 1 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0009 | 0.0183 | 0.0716 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0183 | 0.0716 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0009 | 0.0183 | 0.0716 |
Loa Loa (eye worm) | Smad1 | 0.0009 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 1 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0183 | 0.0183 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0009 | 0.0183 | 0.0716 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0041 | 0.255 | 0.5 |
Echinococcus multilocularis | Smad4 | 0.0009 | 0.0183 | 0.0716 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0183 | 0.0183 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.255 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.255 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.255 | 0.5 |
Schistosoma mansoni | transcription factor btf3 | 0.0041 | 0.255 | 1 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0041 | 0.255 | 0.5 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0009 | 0.0183 | 0.0183 |
Brugia malayi | MH1 domain containing protein | 0.0009 | 0.0183 | 0.0183 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0009 | 0.0183 | 0.0716 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0041 | 0.255 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | Smad4 | 0.0009 | 0.0183 | 0.0716 |
Schistosoma mansoni | smad1 5 8 and | 0.0009 | 0.0183 | 0.0716 |
Brugia malayi | MH2 domain containing protein | 0.0009 | 0.0183 | 0.0183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.255 | 0.5 |
Leishmania major | basic transcription factor 3a, putative | 0.0041 | 0.255 | 0.5 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0041 | 0.255 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0007 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0009 | 0.0183 | 0.0183 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0007 | 0 | 0.5 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0009 | 0.0183 | 0.0716 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0041 | 0.255 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K app (functional) | = 0.00002 | Binding constant of the compound were determined from viscometric titrations with calf thymus DNA | ChEMBL. | 4009616 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.