Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 457 aa | 21.0 % |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | Dopamine D2 receptor | 444 aa | 487 aa | 23.8 % |
Echinococcus granulosus | biogenic amine 5HT receptor | Dopamine D2 receptor | 444 aa | 429 aa | 31.7 % |
Onchocerca volvulus | RB1-inducible coiled-coil protein 1 homolog | Dopamine D2 receptor | 444 aa | 474 aa | 23.4 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine D2 receptor | 444 aa | 440 aa | 30.0 % |
Onchocerca volvulus | Glycoprotein hormone beta 5 homolog | Dopamine D2 receptor | 444 aa | 476 aa | 24.2 % |
Echinococcus multilocularis | g protein coupled receptor | Dopamine D2 receptor | 444 aa | 465 aa | 21.5 % |
Schistosoma mansoni | biogenic amine receptor | Dopamine D2 receptor | 444 aa | 452 aa | 30.1 % |
Schistosoma japonicum | ko:K04145 dopamine receptor D2, putative | Dopamine D2 receptor | 444 aa | 432 aa | 30.8 % |
Schistosoma japonicum | Octopamine receptor, putative | Dopamine D2 receptor | 444 aa | 456 aa | 29.4 % |
Schistosoma mansoni | biogenic amine (dopamine) receptor | Dopamine D2 receptor | 444 aa | 494 aa | 26.3 % |
Echinococcus multilocularis | serotonin receptor | Dopamine D2 receptor | 444 aa | 428 aa | 31.3 % |
Loa Loa (eye worm) | hypothetical protein | Dopamine D2 receptor | 444 aa | 433 aa | 21.2 % |
Onchocerca volvulus | Dopamine D2 receptor | 444 aa | 418 aa | 23.0 % | |
Schistosoma japonicum | ko:K04207 neuropeptide Y receptor Y5, putative | Dopamine D2 receptor | 444 aa | 386 aa | 19.7 % |
Schistosoma mansoni | amine GPCR | Dopamine D2 receptor | 444 aa | 424 aa | 32.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | trypanothione reductase | 0.0129 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.1234 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0129 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0045 | 0.1234 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0045 | 0.1234 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0129 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0045 | 0.1234 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0045 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0045 | 0.1234 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0129 | 1 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0129 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0129 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0129 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0129 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0129 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0129 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0045 | 0.1234 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0045 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0045 | 0.1234 | 0.5 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0045 | 0.1234 | 0.5 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0045 | 0.1234 | 0.1234 |
Brugia malayi | Thioredoxin reductase | 0.0129 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0129 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0129 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0045 | 0.1234 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0129 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 124 nM | Inhibition of [3H]-spiperone binding to rat striatal dopamine receptor D2 was determined in vitro | ChEMBL. | 1672158 |
IC50 (binding) | = 124 nM | Inhibition of [3H]-spiperone binding to rat striatal dopamine receptor D2 was determined in vitro | ChEMBL. | 1672158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.