Detailed information for compound 30622

Basic information

Technical information
  • TDR Targets ID: 30622
  • Name: (2R)-2-[[6-(3-amino-5-chloroanilino)-9-propan -2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
  • MW: 403.909 | Formula: C19H26ClN7O
  • H donors: 4 H acceptors: 4 LogP: 3.61 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H](C(C)C)Nc1nc(Nc2cc(N)cc(c2)Cl)c2c(n1)n(cn2)C(C)C
  • InChi: 1S/C19H26ClN7O/c1-10(2)15(8-28)24-19-25-17(23-14-6-12(20)5-13(21)7-14)16-18(26-19)27(9-22-16)11(3)4/h5-7,9-11,15,28H,8,21H2,1-4H3,(H2,23,24,25,26)/t15-/m0/s1
  • InChiKey: RAMROQQYRRQPDL-HNNXBMFYSA-N  


Substructure search Similarity search

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Synonyms

  • (2R)-2-[[6-(3-amino-5-chloro-anilino)-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol
  • (2R)-2-[[6-(3-amino-5-chloroanilino)-9-isopropyl-2-purinyl]amino]-3-methyl-1-butanol
  • (2R)-2-[[6-[(3-azanyl-5-chloro-phenyl)amino]-9-propan-2-yl-purin-2-yl]amino]-3-methyl-butan-1-ol
  • aminopurvalanol A
  • (2R)-2-[[6-[(3-amino-5-chlorophenyl)amino]-9-propan-2-ylpurin-2-yl]amino]-3-methylbutan-1-ol
  • (2R)-2-[[6-[(3-amino-5-chloro-phenyl)amino]-9-isopropyl-purin-2-yl]amino]-3-methyl-butan-1-ol
  • (2R)-2-[[6-[(3-amino-5-chlorophenyl)amino]-9-isopropyl-2-purinyl]amino]-3-methylbutan-1-ol
  • (2R)-2-[[6-[(3-amino-5-chloro-phenyl)amino]-9-propan-2-yl-purin-2-yl]amino]-3-methyl-butan-1-ol
  • (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol
  • NG-97
  • HSCI1_000391
  • (2R)-2-({6-[(3-amino-5-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)-3-methylbutan-1-ol
  • CHEBI:38937
  • NCGC00025348-01
  • Tocris-2072

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References
Homo sapiens arachidonate 15-lipoxygenase, type B Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens cyclin B1 References
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus arachidonate 5 lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing Get druggable targets OG5_127482 All targets in OG5_127482
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni lipoxygenase Get druggable targets OG5_127482 All targets in OG5_127482
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative Get druggable targets OG5_127482 All targets in OG5_127482
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0354 0.0788
Plasmodium vivax protein kinase Crk2 0.0052 0.0354 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0354 0.0788
Trichomonas vaginalis cyclin D, putative 0.0064 0.0505 0.169
Trichomonas vaginalis cyclins, putative 0.0124 0.1245 1
Echinococcus granulosus para nitrobenzyl esterase 0.0065 0.052 0.0515
Brugia malayi Carboxylesterase family protein 0.0065 0.052 0.1156
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0354 0.035
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.052 0.0515
Echinococcus granulosus nAChR subunit 0.0031 0.0098 0.0093
Onchocerca volvulus 0.0065 0.052 0.4148
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0031 0.0098 0.0093
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Loa Loa (eye worm) carboxylesterase 0.0388 0.4496 1
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.2164 0.4813
Trichomonas vaginalis cyclin B, putative 0.0124 0.1245 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0031 0.0098 0.0093
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0354 0.035
Loa Loa (eye worm) hypothetical protein 0.0124 0.1245 0.277
Brugia malayi Carboxylesterase family protein 0.0388 0.4496 1
Onchocerca volvulus 0.0031 0.0098 0.0752
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1245 0.277
Echinococcus granulosus BC026374 protein S09 family 0.0065 0.052 0.0515
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0031 0.0098 0.0093
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0354 0.0788
Brugia malayi Carboxylesterase family protein 0.0388 0.4496 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0065 0.052 0.5
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0031 0.0098 0.0093
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0505 0.169
Giardia lamblia Cyclin A 0.0064 0.0505 0.169
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0284 0.3222 0.7168
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Onchocerca volvulus Putative nachr subunit 0.0031 0.0098 0.0752
Onchocerca volvulus 0.0031 0.0098 0.0752
Echinococcus multilocularis nAChR subunit 0.0031 0.0098 0.0093
Trypanosoma cruzi cyclin 6, putative 0.0124 0.1245 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.1245 0.277
Onchocerca volvulus 0.0065 0.052 0.4148
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0098 0.0219
Schistosoma mansoni BC026374 protein (S09 family) 0.0065 0.052 0.0515
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0065 0.052 0.1854
Echinococcus granulosus acetylcholinesterase 0.0388 0.4496 0.4493
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0011
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0031 0.0098 0.0219
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0031 0.0098 0.0219
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0354 0.2846
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0098 0.0093
Echinococcus multilocularis acetylcholinesterase 0.0388 0.4496 0.4493
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0354 0.2846
Trichomonas vaginalis cyclin A, putative 0.0124 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.4496 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0098 0.0093
Entamoeba histolytica cyclin family protein 0.0064 0.0505 0.169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Echinococcus multilocularis BC026374 protein (S09 family) 0.0065 0.052 0.0515
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0031 0.0098 0.0093
Schistosoma mansoni lipoxygenase 0.0142 0.147 0.1465
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.147 0.1465
Onchocerca volvulus 0.0031 0.0098 0.0752
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Trichomonas vaginalis cyclins, putative 0.0124 0.1245 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0354 0.2846
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0031 0.0098 0.0219
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0031 0.0098 0.0219
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0098 0.0219
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Brugia malayi Doublecortin family protein 0.0024 0.0005 0.0011
Echinococcus multilocularis para nitrobenzyl esterase 0.0065 0.052 0.0515
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Loa Loa (eye worm) ACC-1 protein 0.0031 0.0098 0.0219
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0098 0.0093
Schistosoma mansoni cyclin B3 0.0199 0.2164 0.216
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Trichomonas vaginalis cyclin B, putative 0.0124 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0348 0.0773
Brugia malayi Cation transporter family protein 0.0031 0.0098 0.0219
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0031 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0124 0.1245 0.277
Echinococcus granulosus cyclins 0.0064 0.0505 0.05
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Entamoeba histolytica cyclin, putative 0.0064 0.0505 0.169
Trichomonas vaginalis cyclins, putative 0.0124 0.1245 1
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.2164 0.4813
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0005 0.0011
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0451 0.1004
Echinococcus granulosus cyclins 0.0064 0.0505 0.05
Schistosoma mansoni cyclins 0.0064 0.0505 0.05
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0354 0.2846
Echinococcus granulosus cyclins 0.0064 0.0505 0.05
Brugia malayi cell division control protein 2 homolog 0.0052 0.0354 0.0788
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.1245 1
Entamoeba histolytica cyclin family protein 0.0064 0.0505 0.169
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0098 0.0219
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.1245 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Echinococcus granulosus cyclin b3 0.0064 0.0505 0.05
Trichomonas vaginalis cyclins, putative 0.0124 0.1245 1
Brugia malayi Cation transporter family protein 0.0031 0.0098 0.0219
Trichomonas vaginalis cyclins, putative 0.0064 0.0505 0.169
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0031 0.0098 0.0093
Trichomonas vaginalis spcc417.12 protein, putative 0.0065 0.052 0.1854
Loa Loa (eye worm) carboxylesterase 0.0065 0.052 0.1156
Brugia malayi Carboxylesterase family protein 0.0065 0.052 0.1156
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0065 0.052 0.0515
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0031 0.0098 0.0219
Onchocerca volvulus 0.0065 0.052 0.4148
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0354 0.035
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0354 0.035
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0031 0.0098 0.0093
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0354 0.035
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0031 0.0098 0.0219
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0354 0.2846
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0031 0.0098 0.0093
Brugia malayi hypothetical protein 0.0024 0.0005 0.0011
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0031 0.0098 0.0219
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0031 0.0098 0.0219
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0031 0.0098 0.0093
Echinococcus granulosus cyclins 0.0064 0.0505 0.05
Echinococcus multilocularis cyclin B 0.0124 0.1245 0.1241
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0031 0.0098 0.0219
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0031 0.0098 0.0093
Schistosoma mansoni lipoxygenase 0.01 0.094 0.0936
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.147 0.1465
Echinococcus granulosus cyclin B 0.0124 0.1245 0.1241
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Echinococcus multilocularis carboxylesterase 5A 0.0388 0.4496 0.4493
Echinococcus multilocularis glycine receptor subunit beta 0.0031 0.0098 0.0093
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0065 0.052 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trichomonas vaginalis cyclin B, putative 0.0124 0.1245 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.052 0.0515
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0031 0.0098 0.0219
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0098 0.0093
Echinococcus granulosus carboxylesterase 5A 0.0388 0.4496 0.4493
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0354 0.035
Echinococcus multilocularis cyclin b3 0.0064 0.0505 0.05
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.2164 0.216
Brugia malayi Carboxylesterase family protein 0.0065 0.052 0.1156
Echinococcus granulosus cyclin B3 1 0.0064 0.0505 0.05
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0031 0.0098 0.0219
Onchocerca volvulus 0.0124 0.1245 1
Brugia malayi hypothetical protein 0.0065 0.052 0.1156
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0354 0.2846
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0098 0.0093
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0031 0.0098 0.0093
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.2164 0.216
Loa Loa (eye worm) acetylcholinesterase 1 0.0388 0.4496 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.052 0.0515
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Brugia malayi follicle stimulating hormone receptor 0.0284 0.3222 0.7168
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) LGC-31 protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0354 0.2846
Trichomonas vaginalis cyclin B, putative 0.0064 0.0505 0.169
Echinococcus granulosus acetylcholinesterase 0.0388 0.4496 0.4493
Brugia malayi excitatory GABA receptor EXP-1A 0.0031 0.0098 0.0219
Onchocerca volvulus 0.0031 0.0098 0.0752
Schistosoma mansoni nAChR subunit 0.0031 0.0098 0.0093
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0354 0.2846
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Leishmania major cyclin 0.0124 0.1245 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0065 0.052 0.5
Plasmodium falciparum protein kinase 5 0.0052 0.0354 0.6988
Onchocerca volvulus 0.0065 0.052 0.4148
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) carboxylesterase 0.0065 0.052 0.1156
Brugia malayi hypothetical protein 0.0024 0.0005 0.0011
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0031 0.0098 0.0219
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Schistosoma mansoni gliotactin 0.0065 0.052 0.0515
Trichomonas vaginalis cyclin D, putative 0.0064 0.0505 0.169
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0031 0.0098 0.0093
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0354 0.035
Brugia malayi Protein kinase domain containing protein 0.0052 0.0354 0.0788
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0098 0.0093
Giardia lamblia Hypothetical protein 0.0064 0.0505 0.169
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0031 0.0098 0.0093
Echinococcus multilocularis cyclin B3 1 0.0064 0.0505 0.05
Schistosoma mansoni acetylcholinesterase 0.0065 0.052 0.0515
Brugia malayi Cation transporter family protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Loa Loa (eye worm) hypothetical protein 0.0024 0.0005 0.0011
Trichomonas vaginalis cyclins, putative 0.0075 0.0643 0.324
Brugia malayi Carboxylesterase family protein 0.0065 0.052 0.1156
Trichomonas vaginalis cyclin B3, putative 0.0064 0.0505 0.169
Brugia malayi Cytochrome P450 family protein 0.0036 0.0154 0.0342
Schistosoma mansoni cyclin B 0.0124 0.1245 0.1241
Echinococcus granulosus glycine receptor subunit beta 0.0031 0.0098 0.0093
Echinococcus granulosus cyclins 0.0064 0.0505 0.05
Schistosoma mansoni neuroligin 3 (S09 family) 0.0065 0.052 0.0515
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0354 0.035
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0354 0.035
Entamoeba histolytica cyclin, putative 0.0124 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Mycobacterium ulcerans carboxylesterase, LipT 0.0065 0.052 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0031 0.0098 0.0093
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0388 0.4496 0.4493
Trypanosoma cruzi cyclin, putative 0.0124 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0388 0.4496 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0031 0.0098 0.0093
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.1245 1
Echinococcus granulosus neuroligin 0.0065 0.052 0.0515
Echinococcus multilocularis cyclins 0.0064 0.0505 0.05
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0031 0.0098 0.0093
Onchocerca volvulus 0.0065 0.052 0.4148
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0219
Trypanosoma cruzi cyclin, putative 0.0124 0.1245 1
Plasmodium falciparum cyclin 0.0064 0.0505 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0065 0.052 0.0515
Echinococcus multilocularis neuroligin 0.0065 0.052 0.0515
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0354 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0031 0.0098 0.0219
Onchocerca volvulus 0.0031 0.0098 0.0752
Trypanosoma brucei mitotic cyclin 6 0.0124 0.1245 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0031 0.0098 0.0219
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0154 0.0342
Onchocerca volvulus 0.0031 0.0098 0.0752
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0354 0.035
Trichomonas vaginalis cyclin B, putative 0.0124 0.1245 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.052 0.1156
Echinococcus multilocularis acetylcholinesterase 0.0388 0.4496 0.4493

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.316227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.501187234 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
GI50 (functional) = 30 nM Inhibition of human KM12 cells ChEMBL. 18077363
GI50 (functional) = 30 nM Inhibition of human KM12 cells ChEMBL. 18077363
IC50 (binding) = 20 nM Inhibition of Cdk5/p35 (unknown origin) ChEMBL. 18077363
IC50 (binding) = 28 nM Inhibition of cdk2/cyclin E (unknown origin) ChEMBL. 18077363
IC50 (binding) = 33 nM In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes ChEMBL. 10753466
IC50 (binding) = 33 nM Inhibition of Cdk1/cyclin B (unknown origin) ChEMBL. 18077363
IC50 (binding) = 33 nM Inhibition Cdk2/cyclin A (unknown origin) ChEMBL. 18077363
IC50 (binding) = 33 nM In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes ChEMBL. 10753466
IC50 (binding) = 35 nM In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes ChEMBL. 10753466
IC50 (binding) = 35 nM In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes ChEMBL. 10753466
Potency (ADMET) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 19.9526 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (ADMET) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9. (Class of assay: confirmatory) [Related pubchem assays: 885, 884, 410 ] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference
Residual Activity (binding) = -12 % Millipore: Percentage of residual kinase activity of CSNK1G2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = -2 % Millipore: Percentage of residual kinase activity of CLK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = -1 % Millipore: Percentage of residual kinase activity of LYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 0 % Millipore: Percentage of residual kinase activity of FYN at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 0 % Millipore: Percentage of residual kinase activity of YES1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 0 % Millipore: Percentage of residual kinase activity of NTRK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of CDK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of CLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of INSRR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of BLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of MAP3K9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of CSNK1G1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of SRPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore: Percentage of residual kinase activity of NTRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 1 % Millipore LITERATURE. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of AURKB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of CDK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of EPHB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of MERTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of FLT3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of RPS6KA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 2 % Millipore: Percentage of residual kinase activity of SRC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 3 % Millipore: Percentage of residual kinase activity of FGR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 3 % Millipore: Percentage of residual kinase activity of PTK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 3 % Millipore: Percentage of residual kinase activity of FLT4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 4 % Millipore: Percentage of residual kinase activity of FGFR1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 4 % Millipore: Percentage of residual kinase activity of RPS6KA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 4 % Millipore: Percentage of residual kinase activity of PAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 4 % Millipore LITERATURE. 23398362
Residual Activity (binding) = 5 % Millipore: Percentage of residual kinase activity of BTK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 5 % Millipore: Percentage of residual kinase activity of BMX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 5 % Millipore: Percentage of residual kinase activity of YES1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 5 % Millipore: Percentage of residual kinase activity of NTRK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 5 % Millipore: Percentage of residual kinase activity of PAK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of CDK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of CDK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of EPHB4 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of RPS6KA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 6 % Millipore: Percentage of residual kinase activity of RPS6KA6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 7 % Millipore: Percentage of residual kinase activity of CLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 7 % Millipore: Percentage of residual kinase activity of EPHB2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 7 % Millipore: Percentage of residual kinase activity of IRAK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 7 % Millipore: Percentage of residual kinase activity of MAP3K9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 7 % Millipore: Percentage of residual kinase activity of PTK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 8 % Millipore: Percentage of residual kinase activity of ABL2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 8 % Millipore: Percentage of residual kinase activity of ULK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 9 % Millipore: Percentage of residual kinase activity of FYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 9 % Millipore: Percentage of residual kinase activity of HCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 9 % Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 9 % Millipore: Percentage of residual kinase activity of LYN at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 9 % Millipore: Percentage of residual kinase activity of PLK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT ChEMBL. 23398362
Residual Activity (binding) = 10 % Millipore: Percentage of residual kinase activity of GRK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 10 % Millipore: Percentage of residual kinase activity of MUSK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 10 % Millipore: Percentage of residual kinase activity of FLT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 10 % Millipore: Percentage of residual kinase activity of NTRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 11 % Millipore: Percentage of residual kinase activity of EPHA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 11 % Millipore: Percentage of residual kinase activity of FLT4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 11 % Millipore: Percentage of residual kinase activity of FRK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 12 % Millipore: Percentage of residual kinase activity of SRPK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 12 % Millipore: Percentage of residual kinase activity of FES at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 12 % Millipore: Percentage of residual kinase activity of FLT3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 12 % Millipore: Percentage of residual kinase activity of PAK7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 13 % Millipore: Percentage of residual kinase activity of MET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 13 % Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 13 % Millipore: Percentage of residual kinase activity of TEC at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 13 % Millipore LITERATURE. 23398362
Residual Activity (binding) = 14 % Millipore: Percentage of residual kinase activity of AURKB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 14 % Millipore: Percentage of residual kinase activity of SRPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 15 % Millipore: Percentage of residual kinase activity of ABL1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of CSNK1G3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of GCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of MELK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of EPHA7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of CDK9 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 16 % Millipore: Percentage of residual kinase activity of ITK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 17 % Millipore: Percentage of residual kinase activity of STK10 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 17 % Millipore: Percentage of residual kinase activity of CSNK1G1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 17 % Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 17 % Millipore: Percentage of residual kinase activity of RAF1 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 17 % Millipore: Percentage of residual kinase activity of TXK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 18 % Millipore: Percentage of residual kinase activity of SIK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 18 % Millipore: Percentage of residual kinase activity of RPS6KA6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of CDK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of CLK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of ALK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of CSNK1G2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of CDK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 19 % Millipore: Percentage of residual kinase activity of RPS6KA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 20 % Millipore: Percentage of residual kinase activity of FGFR3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 20 % Millipore: Percentage of residual kinase activity of AXL at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 20 % Millipore: Percentage of residual kinase activity of CDK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 20 % Millipore: Percentage of residual kinase activity of CAMK2G at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 20 % Millipore: Percentage of residual kinase activity of GSG2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 21 % Millipore: Percentage of residual kinase activity of LCK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 21 % Millipore: Percentage of residual kinase activity of CSF1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 21 % Millipore: Percentage of residual kinase activity of RET at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 22 % Millipore: Percentage of residual kinase activity of MERTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM MOPS pH 7.0, 0.2 mM EDTA, 30 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 22 % Millipore: Percentage of residual kinase activity of FGFR2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 22 % Millipore: Percentage of residual kinase activity of RPS6KA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 23 % Millipore: Percentage of residual kinase activity of EPHA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 23 % Millipore: Percentage of residual kinase activity of FER at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 23 % Millipore: Percentage of residual kinase activity of PRKCQ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 24 % Millipore: Percentage of residual kinase activity of CAMK2D at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 26 % Millipore: Percentage of residual kinase activity of CSNK1D at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 26 % Millipore: Percentage of residual kinase activity of STK24 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 26 % Millipore: Percentage of residual kinase activity of SRPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 26 % Millipore: Percentage of residual kinase activity of PAK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 27 % Millipore: Percentage of residual kinase activity of BLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 28 % Millipore: Percentage of residual kinase activity of GSK3A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 28 % Millipore: Percentage of residual kinase activity of SRC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 29 % Millipore: Percentage of residual kinase activity of TNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 29 % Millipore: Percentage of residual kinase activity of MYLK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 29 % Millipore: Percentage of residual kinase activity of EPHA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 30 % Millipore: Percentage of residual kinase activity of CHEK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 30 % Millipore: Percentage of residual kinase activity of MAP3K7 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 32 % Millipore: Percentage of residual kinase activity of HIPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 32 % Millipore: Percentage of residual kinase activity of RPS6KA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 32 % Millipore: Percentage of residual kinase activity of PAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 33 % Millipore: Percentage of residual kinase activity of FGR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 33 % Millipore: Percentage of residual kinase activity of CAMK4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 34 % Millipore: Percentage of residual kinase activity of KDR at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 34 % Millipore: Percentage of residual kinase activity of SRPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 34 % Millipore: Percentage of residual kinase activity of PLK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 34 % Millipore: Percentage of residual kinase activity of ULK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 34 % Millipore LITERATURE. 23398362
Residual Activity (binding) = 37 % Millipore: Percentage of residual kinase activity of CAMK1D at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 37 % Millipore: Percentage of residual kinase activity of FGFR1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 37 % Millipore: Percentage of residual kinase activity of WNK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 38 % Millipore: Percentage of residual kinase activity of MARK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 39 % Millipore: Percentage of residual kinase activity of IRAK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 39 % Millipore: Percentage of residual kinase activity of RPS6KB1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 40 % Millipore: Percentage of residual kinase activity of SRPK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 40 % Millipore: Percentage of residual kinase activity of GRK6 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 40 % Millipore: Percentage of residual kinase activity of WNK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 41 % Millipore: Percentage of residual kinase activity of ULK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 42 % Millipore: Percentage of residual kinase activity of PTK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 43 % Millipore: Percentage of residual kinase activity of CDK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 43 % Millipore: Percentage of residual kinase activity of TBK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 44 % Millipore: Percentage of residual kinase activity of GRK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 44 % Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 45 % Millipore: Percentage of residual kinase activity of CDK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 45 % Millipore: Percentage of residual kinase activity of EPHB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 45 % Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP ChEMBL. 23398362
Residual Activity (binding) = 47 % Millipore: Percentage of residual kinase activity of STK4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 47 % Millipore: Percentage of residual kinase activity of AURKA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 48 % Millipore: Percentage of residual kinase activity of BTK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 48 % Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 48 % Millipore: Percentage of residual kinase activity of NEK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 48 % Millipore: Percentage of residual kinase activity of MARK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 49 % Millipore: Percentage of residual kinase activity of IRAK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 50 % Millipore: Percentage of residual kinase activity of HCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 50 % Millipore: Percentage of residual kinase activity of INSR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 50 % Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP ChEMBL. 23398362
Residual Activity (binding) = 50 % Millipore: Percentage of residual kinase activity of PLK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 20 mM DTT ChEMBL. 23398362
Residual Activity (binding) = 51 % Millipore: Percentage of residual kinase activity of BMX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 51 % Millipore: Percentage of residual kinase activity of RPS6KA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 51 % Millipore: Percentage of residual kinase activity of SGK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 52 % Millipore: Percentage of residual kinase activity of AURKC at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 52 % Millipore: Percentage of residual kinase activity of EPHA3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 52 % Millipore: Percentage of residual kinase activity of TEK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 52 % Millipore: Percentage of residual kinase activity of TAOK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 52 % Millipore: Percentage of residual kinase activity of ROCK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 53 % Millipore: Percentage of residual kinase activity of TYRO3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 53 % Millipore: Percentage of residual kinase activity of VRK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 54 % Millipore: Percentage of residual kinase activity of TAOK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 55 % Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 55 % Millipore: Percentage of residual kinase activity of CSF1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 56 % Millipore: Percentage of residual kinase activity of MAPKAPK5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 57 % Millipore: Percentage of residual kinase activity of STK10 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 57 % Millipore: Percentage of residual kinase activity of FES at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 57 % Millipore: Percentage of residual kinase activity of EPHB4 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 57 % Millipore: Percentage of residual kinase activity of GSG2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 57 % Millipore: Percentage of residual kinase activity of PAK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 58 % Millipore: Percentage of residual kinase activity of GRK7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 58 % Millipore: Percentage of residual kinase activity of CAMK2B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 59 % Millipore: Percentage of residual kinase activity of EPHA8 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 59 % Millipore: Percentage of residual kinase activity of RAF1 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 59 % Millipore: Percentage of residual kinase activity of PTK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 60 % Millipore: Percentage of residual kinase activity of STK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 60 % Millipore: Percentage of residual kinase activity of HIPK1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 61 % Millipore: Percentage of residual kinase activity of GCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 61 % Millipore: Percentage of residual kinase activity of TEC at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 62 % Millipore: Percentage of residual kinase activity of ABL2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 62 % Millipore: Percentage of residual kinase activity of MUSK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 62 % Millipore: Percentage of residual kinase activity of STK33 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 62 % Millipore: Percentage of residual kinase activity of MST1R at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 63 % Millipore: Percentage of residual kinase activity of EPHA4 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 63 % Millipore: Percentage of residual kinase activity of TXK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 66 % Millipore: Percentage of residual kinase activity of LCK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 66 % Millipore: Percentage of residual kinase activity of MAPK1 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 66 % Millipore: Percentage of residual kinase activity of TSSK1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 67 % Millipore: Percentage of residual kinase activity of MAPK10 at 10uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 67 % Millipore: Percentage of residual kinase activity of MELK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 67 % Millipore: Percentage of residual kinase activity of CHEK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 68 % Millipore: Percentage of residual kinase activity of CDK9 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 68 % Millipore: Percentage of residual kinase activity of PDPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 69 % Millipore: Percentage of residual kinase activity of ALK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 69 % Millipore: Percentage of residual kinase activity of FLT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 69 % Millipore: Percentage of residual kinase activity of CDK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 70 % Millipore: Percentage of residual kinase activity of AURKA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 70 % Millipore: Percentage of residual kinase activity of GSK3B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 70 % Millipore: Percentage of residual kinase activity of NEK3 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 71 % Millipore: Percentage of residual kinase activity of EPHA7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 71 % Millipore: Percentage of residual kinase activity of CAMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 72 % Millipore: Percentage of residual kinase activity of STK11 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 72 % Millipore: Percentage of residual kinase activity of FRK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 72 % Millipore: Percentage of residual kinase activity of PRKCD at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 72 % Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of MINK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of CSK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of HIPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of TLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of SYK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 73 % Millipore: Percentage of residual kinase activity of TAOK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 74 % Millipore: Percentage of residual kinase activity of CSNK1D at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 74 % Millipore: Percentage of residual kinase activity of MET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 74 % Millipore: Percentage of residual kinase activity of DYRK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 74 % Millipore: Percentage of residual kinase activity of CHEK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of NLK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of MKNK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of BRSK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM Na3VO4, 5 mM Na-?-glycerophosphate ChEMBL. 23398362
Residual Activity (binding) = 75 % Millipore: Percentage of residual kinase activity of CSNK1G3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 76 % Millipore: Percentage of residual kinase activity of INSRR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 76 % Millipore: Percentage of residual kinase activity of CAMK2G at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 76 % Millipore: Percentage of residual kinase activity of NEK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 76 % Millipore: Percentage of residual kinase activity of RPS6KA5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 77 % Millipore: Percentage of residual kinase activity of PRKCQ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 77 % Millipore: Percentage of residual kinase activity of PLK3 at 10uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 77 % Millipore: Percentage of residual kinase activity of RIPK2 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 78 % Millipore: Percentage of residual kinase activity of STK24 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 78 % Millipore: Percentage of residual kinase activity of MAP2K6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA ChEMBL. 23398362
Residual Activity (binding) = 79 % Millipore: Percentage of residual kinase activity of CDK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 79 % Millipore: Percentage of residual kinase activity of ITK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 79 % Millipore: Percentage of residual kinase activity of PLK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of DAPK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of AXL at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of GSK3A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of CAMK2D at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of PRKG1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of PRKCG at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 80 % Millipore: Percentage of residual kinase activity of PKN2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 81 % Millipore: Percentage of residual kinase activity of PAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 81 % Millipore: Percentage of residual kinase activity of PRKD1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 82 % Millipore: Percentage of residual kinase activity of MAPK10 at 1uM relative to control. Control inhibitor: JAK Inhibitor I at 30.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 82 % Millipore: Percentage of residual kinase activity of STK4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 82 % Millipore: Percentage of residual kinase activity of MYLK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 82 % Millipore: Percentage of residual kinase activity of MAPK3 at 10uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 83 % Millipore: Percentage of residual kinase activity of PTK6 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 83 % Millipore: Percentage of residual kinase activity of PRKCA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 83 % Millipore: Percentage of residual kinase activity of ULK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 83 % Millipore: Percentage of residual kinase activity of MTOR at 10uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 ChEMBL. 23398362
Residual Activity (binding) = 83 % Millipore: Percentage of residual kinase activity of RET at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of NEK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of ERBB4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of FGFR2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of TYRO3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of DAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 84 % Millipore: Percentage of residual kinase activity of ROCK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 85 % Millipore: Percentage of residual kinase activity of LIMK1 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 85 % Millipore: Percentage of residual kinase activity of NEK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 85 % Millipore: Percentage of residual kinase activity of RIPK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 85 % Millipore: Percentage of residual kinase activity of MAP3K7 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of EPHA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of PAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of HIPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of TSSK1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of RPS6KB1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 86 % Millipore: Percentage of residual kinase activity of PIM1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of KDR at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of DMPK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of JAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of PRKACA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of AKT3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 87 % Millipore: Percentage of residual kinase activity of WNK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of FGFR4 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of FER at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of IKBKB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of DDR2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of EPHA2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of WNK3 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of PRKX at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of TAOK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 88 % Millipore: Percentage of residual kinase activity of ROS1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 89 % Millipore: Percentage of residual kinase activity of GRK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 89 % Millipore: Percentage of residual kinase activity of MAPKAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 89 % Millipore: Percentage of residual kinase activity of PRKCI at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 89 % Millipore: Percentage of residual kinase activity of KIT at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 90 % Millipore: Percentage of residual kinase activity of INSR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 90 % Millipore: Percentage of residual kinase activity of GRK6 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 90 % Millipore: Percentage of residual kinase activity of DMPK at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 90 % Millipore: Percentage of residual kinase activity of CDC42BPB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 90 % Millipore: Percentage of residual kinase activity of TSSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of AURKC at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl, 0.1% v/v Triton-X-100 ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of BRSK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of MAPK3 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of TSSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of ROCK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 91 % Millipore: Percentage of residual kinase activity of TGFBR1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of MARK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of DAPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of IGF1R at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of EPHB2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of EPHB3 at 1uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of PRKAA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 200 uM AMP ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of CAMK2B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of FGFR3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of MAPKAPK5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of TAOK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 50 mM NaCl ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of PDGFRB at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 92 % Millipore: Percentage of residual kinase activity of SGK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of CSNK2A1 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of EPHA8 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of MAP2K6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4, 1 mg/mL BSA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of EPHA3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of PRKACA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of MARK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of PRKCD at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 93 % Millipore: Percentage of residual kinase activity of TAOK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 200 mM NaCl, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of DCLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of IRAK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of MKNK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of DYRK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of JAK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of PRKCB at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 94 % Millipore: Percentage of residual kinase activity of PRKCG at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of DCLK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of DDR2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of MAP2K7 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of EPHA1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of TLK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of DAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of PRKX at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of MAPK14 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of SGK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 95 % Millipore: Percentage of residual kinase activity of PIM1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of CSNK2A2 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of PTK6 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of CAMK4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 40 mM HEPES pH 7.4, 5 mM CaCl2, 30 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of CAMK1D at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of STK33 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of PRKD2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 96 % Millipore: Percentage of residual kinase activity of MST1R at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of DAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of PRKCA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of MAPK14 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of PHKG2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of TBK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 97 % Millipore: Percentage of residual kinase activity of PRKCH at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of HIPK1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of ZAP70 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of ZAP70 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of EEF2K at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: PI-103 at 30.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20 ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of PRKCE at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of SGK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 98 % Millipore: Percentage of residual kinase activity of TGFBR1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 1 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of CHUK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of MAP2K1 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of DAPK2 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of PRKCH at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of PRKD1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of PLK3 at 1uM relative to control. Control inhibitor: Wortmannin at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of PRKD2 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of KIT at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 99 % Millipore: Percentage of residual kinase activity of MAPK11 at 10uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 100 % Millipore: Percentage of residual kinase activity of CDC42BPB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 100 % Millipore: Percentage of residual kinase activity of MAPKAPK3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 100 % Millipore: Percentage of residual kinase activity of TEK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 100 % Millipore: Percentage of residual kinase activity of PRKCE at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 100 % Millipore: Percentage of residual kinase activity of PRKCZ at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of NLK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of CAMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.5 mM CaCl2, 16 ug/mL calmodulin ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of CHEK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of JAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of AKT3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of PRKCB at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100, 0.1 mM CaCl2, 0.1 mg/mL phosphatidylserine, 10 ug/mL diacylglycerol ChEMBL. 23398362
Residual Activity (binding) = 101 % Millipore: Percentage of residual kinase activity of PIM2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of CDK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of EGFR at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of MAPK8 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of PIM3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of MAPK12 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of PKN2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of PASK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 102 % Millipore: Percentage of residual kinase activity of ROS1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 103 % Millipore: Percentage of residual kinase activity of MAP2K1 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 50 mM Tris pH 7.5, 0.2 mM EGTA, 0.1% ?-mercaptoethanol, 0.01% Brij-35 ChEMBL. 23398362
Residual Activity (binding) = 103 % Millipore: Percentage of residual kinase activity of PIM3 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 103 % Millipore: Percentage of residual kinase activity of PRKCI at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 20 mM HEPES pH 7.4, 0.03% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 103 % Millipore: Percentage of residual kinase activity of AKT2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of CHUK at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of CSNK2A1 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of MAP2K7 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol, 0.1 mM Na3VO4 ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of STK17A at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 104 % Millipore: Percentage of residual kinase activity of SYK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 105 % Millipore: Percentage of residual kinase activity of STK11 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.1% v/v Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 105 % Millipore: Percentage of residual kinase activity of MAPK9 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 105 % Millipore: Percentage of residual kinase activity of PDPK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Tris pH 7.5, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 106 % Millipore: Percentage of residual kinase activity of STK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 106 % Millipore: Percentage of residual kinase activity of SIK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 106 % Millipore: Percentage of residual kinase activity of PRKG1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 uM cGMP ChEMBL. 23398362
Residual Activity (binding) = 106 % Millipore: Percentage of residual kinase activity of MAPK12 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 106 % Millipore: Percentage of residual kinase activity of PDGFRB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of NEK7 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of MINK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of STK17A at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of ERBB4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 2.5 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of NEK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 107 % Millipore: Percentage of residual kinase activity of EPHA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 108 % Millipore: Percentage of residual kinase activity of NEK7 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 108 % Millipore: Percentage of residual kinase activity of RPS6KA4 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 108 % Millipore: Percentage of residual kinase activity of MAPK9 at 10uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 109 % Millipore: Percentage of residual kinase activity of EGFR at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 109 % Millipore: Percentage of residual kinase activity of ROCK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 110 % Millipore: Percentage of residual kinase activity of HIPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 110 % Millipore: Percentage of residual kinase activity of AKT2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 110 % Millipore: Percentage of residual kinase activity of MAPK13 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 110 % Millipore: Percentage of residual kinase activity of PDGFRA at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 110 % Millipore: Percentage of residual kinase activity of PRKCZ at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of LIMK1 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of CSK at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of CDC42BPA at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of MAPK1 at 1uM relative to control. Control inhibitor: ERK Inhibitor II at 30.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of AKT1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 111 % Millipore: Percentage of residual kinase activity of AKT1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 112 % Millipore: Percentage of residual kinase activity of FGFR4 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 112 % Millipore: Percentage of residual kinase activity of IKBKB at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 112 % Millipore: Percentage of residual kinase activity of JAK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 112 % Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 112 % Millipore: Percentage of residual kinase activity of MTOR at 1uM relative to control. Control inhibitor: Rapamycin at 10.0uM. Buffer: 50 mM HEPES pH 7.5, 1 mM EGTA, 0.01% Tween 20, 10 uM FKBP12 ChEMBL. 23398362
Residual Activity (binding) = 113 % Millipore: Percentage of residual kinase activity of PAK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 113 % Millipore: Percentage of residual kinase activity of BRSK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 113 % Millipore: Percentage of residual kinase activity of EEF2K at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 113 % Millipore: Percentage of residual kinase activity of VRK2 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 114 % Millipore: Percentage of residual kinase activity of MAPK8 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1% ? -mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 114 % Millipore: Percentage of residual kinase activity of MAPKAPK3 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 114 % Millipore: Percentage of residual kinase activity of MAPK13 at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 114 % Millipore: Percentage of residual kinase activity of SGK1 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 115 % Millipore: Percentage of residual kinase activity of NEK6 at 10uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 115 % Millipore: Percentage of residual kinase activity of GSK3B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 115 % Millipore: Percentage of residual kinase activity of NEK6 at 1uM relative to control. Control inhibitor: Phosphoric acid* at 0.3uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 115 % Millipore: Percentage of residual kinase activity of SGK1 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 116 % Millipore: Percentage of residual kinase activity of EPHB3 at 10uM relative to control. Control inhibitor: PP2 at 30.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA, 10 mM MnCl2 ChEMBL. 23398362
Residual Activity (binding) = 116 % Millipore: Percentage of residual kinase activity of PDGFRA at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 117 % Millipore: Percentage of residual kinase activity of ACVR1B at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 117 % Millipore: Percentage of residual kinase activity of MAPKAPK2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 50 mM Na-?-glycerophosphate pH 7.5, 0.1 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 117 % Millipore: Percentage of residual kinase activity of PASK at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 118 % Millipore: Percentage of residual kinase activity of IGF1R at 1uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 50 mM Tris pH 7.5, 0.1 mM EGTA, 0.1 mM Na3VO4, 0.1% ?-mercaptoethanol ChEMBL. 23398362
Residual Activity (binding) = 118 % Millipore: Percentage of residual kinase activity of RPS6KA5 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 119 % Millipore: Percentage of residual kinase activity of MAPK11 at 1uM relative to control. Control inhibitor: SB203580 at 100.0uM. Buffer: 25 mM Tris pH 7.5, 0.02 mM EGTA ChEMBL. 23398362
Residual Activity (binding) = 119 % Millipore: Percentage of residual kinase activity of PHKG2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 120 % Millipore: Percentage of residual kinase activity of CSNK2A2 at 1uM relative to control. Control inhibitor: Jnk Inhibitor II at 100.0uM. Buffer: 20 mM HEPES pH 7.6, 0.15 M NaCl, 0.1 mM EDTA, 5 mM DTT, 0.1% Triton X-100 ChEMBL. 23398362
Residual Activity (binding) = 122 % Millipore: Percentage of residual kinase activity of ACVR1B at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 122 % Millipore: Percentage of residual kinase activity of CDC42BPA at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 122 % Millipore: Percentage of residual kinase activity of BRSK2 at 1uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 123 % Millipore: Percentage of residual kinase activity of PAK3 at 10uM relative to control. Control inhibitor: Staurosporine at 100.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Residual Activity (binding) = 133 % Millipore: Percentage of residual kinase activity of PIM2 at 10uM relative to control. Control inhibitor: Staurosporine at 10.0uM. Buffer: 8 mM MOPS pH 7.0, 0.2 mM EDTA ChEMBL. 23398362
Thermal melting change (binding) Delta TM value showing the stabilisation of VRK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) Delta TM value showing the stabilisation of VRK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) Delta TM value showing the stabilisation of MST1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) Delta TM value showing the stabilisation of YSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) Delta TM value showing the stabilisation of PBK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of PAK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of PIM2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = -0.1 degrees C Delta TM value showing the stabilisation of RSK2a produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0 degrees C Delta TM value showing the stabilisation of NEK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of JAK1~B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of MEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.1 degrees C Delta TM value showing the stabilisation of PAK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of ERK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.2 degrees C Delta TM value showing the stabilisation of MPSK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of AMPKA2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of CAMK2D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.3 degrees C Delta TM value showing the stabilisation of PAK5 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.4 degrees C Delta TM value showing the stabilisation of CDK6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CAMK1G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CAMK2A produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.5 degrees C Delta TM value showing the stabilisation of CAMK2B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.6 degrees C Delta TM value showing the stabilisation of NDR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of CAMK1D produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 0.7 degrees C Delta TM value showing the stabilisation of GSK3B produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1 degrees C Delta TM value showing the stabilisation of PLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.1 degrees C Delta TM value showing the stabilisation of CK1G3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.2 degrees C Delta TM value showing the stabilisation of PIM1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.3 degrees C Delta TM value showing the stabilisation of CAMK2G produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.3 degrees C Delta TM value showing the stabilisation of MAP2K6 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.4 degrees C Delta TM value showing the stabilisation of PDK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.5 degrees C Delta TM value showing the stabilisation of ERK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.6 degrees C Delta TM value showing the stabilisation of DRAK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 1.8 degrees C Delta TM value showing the stabilisation of CK1G2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2 degrees C Delta TM value showing the stabilisation of CK1G1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2 degrees C Delta TM value showing the stabilisation of DMPK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.4 degrees C Delta TM value showing the stabilisation of ASK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.6 degrees C Delta TM value showing the stabilisation of OSR1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.7 degrees C Delta TM value showing the stabilisation of CDKL1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.7 degrees C Delta TM value showing the stabilisation of LOK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 2.8 degrees C Delta TM value showing the stabilisation of p38beta produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.3 degrees C Delta TM value showing the stabilisation of CAMKK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.3 degrees C Delta TM value showing the stabilisation of CDK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.4 degrees C Delta TM value showing the stabilisation of DAPK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.4 degrees C Delta TM value showing the stabilisation of RSK2b produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 3.5 degrees C Delta TM value showing the stabilisation of SLK produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 4.2 degrees C Delta TM value showing the stabilisation of CAMK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 4.3 degrees C Delta TM value showing the stabilisation of MST4(1) produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 4.5 degrees C Delta TM value showing the stabilisation of CLK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 4.5 degrees C Delta TM value showing the stabilisation of RIOK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 4.8 degrees C Delta TM value showing the stabilisation of NEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 5.5 degrees C Delta TM value showing the stabilisation of CLK1 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 6.1 degrees C Delta TM value showing the stabilisation of CLK3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 6.2 degrees C Delta TM value showing the stabilisation of PLK4 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 6.5 degrees C Delta TM value showing the stabilisation of PRKACA produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 6.7 degrees C Delta TM value showing the stabilisation of PIM3 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 7.5 degrees C Delta TM value showing the stabilisation of CHEK2 produced by compound binding ChEMBL. 18077363
Thermal melting change (binding) = 8.1 degrees C Delta TM value showing the stabilisation of PCTK1 produced by compound binding ChEMBL. 18077363

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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