Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Human immunodeficiency virus type 1 reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0124 | 0.0121 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.1732 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0004 | 0.0004 |
Brugia malayi | hypothetical protein | 0.021 | 0.108 | 0.108 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0874 | 0.0871 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.0571 | 0.0571 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0442 | 0.2438 | 0.1686 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0874 | 0.0871 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0124 | 0.0121 |
Echinococcus granulosus | dihydrofolate reductase | 0.018 | 0.0904 | 0.09 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1732 | 1 | 1 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.1732 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0121 |
Trypanosoma brucei | ribonuclease H1 | 0.0027 | 0.0004 | 0.0004 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0017 | 0.0017 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.3494 | 0.3494 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.1732 | 1 | 1 |
Plasmodium falciparum | adenosylhomocysteinase | 0.1732 | 1 | 1 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0004 | 0.0004 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.3494 | 0.3494 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.1732 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1732 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.018 | 0.0904 | 0.09 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0121 |
Mycobacterium ulcerans | thymidylate synthase | 0.0442 | 0.2438 | 0.1686 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0027 | 0.0004 | 0.0004 |
Echinococcus multilocularis | dihydrofolate reductase | 0.018 | 0.0904 | 0.09 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1072 | 0.613 | 0.6129 |
Loa Loa (eye worm) | thymidylate synthase | 0.0442 | 0.2438 | 0.2438 |
Trypanosoma brucei | RNA helicase, putative | 0.01 | 0.0433 | 0.0433 |
Echinococcus granulosus | geminin | 0.0175 | 0.0874 | 0.0871 |
Toxoplasma gondii | ribonuclease HI protein | 0.0027 | 0.0004 | 0.0004 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0544 | 0.3034 | 0.3032 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0433 | 0.043 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.3494 | 0.3494 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0065 | 0.0062 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0027 | 0.0004 | 0.0004 |
Brugia malayi | dihydrofolate reductase family protein | 0.018 | 0.0904 | 0.0904 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0065 | 0.0062 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.1732 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0124 | 0.0121 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0124 | 0.0124 |
Trichomonas vaginalis | conserved hypothetical protein | 0.021 | 0.108 | 0.1076 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.3494 | 0.3494 |
Echinococcus multilocularis | geminin | 0.0175 | 0.0874 | 0.0871 |
Mycobacterium tuberculosis | Hypothetical protein | 0.021 | 0.108 | 0.0194 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0029 | 0.0017 | 0.0017 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.1732 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0442 | 0.2438 | 0.1686 |
Onchocerca volvulus | 0.0442 | 0.2438 | 1 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.018 | 0.0904 | 0.0904 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0622 | 0.3494 | 0.3494 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0029 | 0.0017 | 0.0017 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1072 | 0.613 | 0.6129 |
Brugia malayi | thymidylate synthase | 0.0442 | 0.2438 | 0.2438 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1732 | 1 | 1 |
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.1732 | 1 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.1732 | 1 | 1 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.1732 | 1 | 1 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.1732 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.0571 | 0.0571 |
Echinococcus granulosus | thymidylate synthase | 0.0442 | 0.2438 | 0.2435 |
Leishmania major | ribonuclease H1, putative | 0.0027 | 0.0004 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0065 | 0.0062 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0029 | 0.0017 | 0.0017 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0027 | 0.0004 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0124 | 0.0124 |
Brugia malayi | Dihydrofolate reductase | 0.018 | 0.0904 | 0.0904 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.1732 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1072 | 0.613 | 0.6129 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.1732 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0124 | 0.0121 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.1732 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0124 | 0.0121 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0065 | 0.0065 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.1732 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0029 | 0.0017 | 0.0017 |
Giardia lamblia | Ribonuclease H | 0.0027 | 0.0004 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0442 | 0.2438 | 0.2435 |
Schistosoma mansoni | adenosylhomocysteinase | 0.1072 | 0.613 | 0.6129 |
Chlamydia trachomatis | dihydrofolate reductase | 0.018 | 0.0904 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.021 | 0.108 | 0.108 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0065 | 0.0062 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0622 | 0.3494 | 0.3494 |
Echinococcus multilocularis | thymidylate synthase | 0.0442 | 0.2438 | 0.2435 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0027 | 0.0004 | 0.5 |
Brugia malayi | RNase H family protein | 0.0027 | 0.0004 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.85 uM | Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template) | ChEMBL. | 7683054 |
IC50 (binding) | = 1.85 uM | Tested for inhibition against HIV-1 RT (used (poly)rC-(oligo)dG as the template) | ChEMBL. | 7683054 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.