Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.008 | 0.5 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.5 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.5 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 220000000 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
IC50 (binding) | = 0.000000022 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
Inhibition (binding) | = 38 % | Compound was tested for inhibitory activity against Dihydrofolate reductase of rat liver at 40000 M | ChEMBL. | 7035668 |
Inhibition (binding) | = 3800000000 % | Compound was tested for inhibitory activity against Dihydrofolate reductase of rat liver at 40000 M | ChEMBL. | 7035668 |
Ratio (binding) | > 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (binding) | > 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (binding) | > 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | > 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 300 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.