Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Pneumocystis carinii | Dihydrofolate reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.14 uM | Compound was tested for inhibition activity against toxoplasma gondii (T. gondii) Dihydrofolate reductase | ChEMBL. | 9526565 |
IC50 (binding) | = 0.14 uM | Compound was tested for inhibition activity against toxoplasma gondii (T. gondii) Dihydrofolate reductase | ChEMBL. | 9526565 |
IC50 (binding) | = 0.22 uM | Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR). | ChEMBL. | 9526565 |
IC50 (binding) | = 0.22 uM | Compound was tested for inhibition activity against rat liver lipophilic Dihydrofolate reductase (DHFR). | ChEMBL. | 9526565 |
IC50 (binding) | = 1.3 uM | Compound was tested for inhibition activity against pneumocystis carinii (P. carinii) Dihydrofolate reductase | ChEMBL. | 9526565 |
IC50 (binding) | = 1.3 uM | Compound was tested for inhibition activity against pneumocystis carinii (P. carinii) Dihydrofolate reductase | ChEMBL. | 9526565 |
Selectivity ratio (binding) | = 0.17 | Selectivity ratio is the ratio between the IC50 values of rat liver and P. carinii | ChEMBL. | 9526565 |
Selectivity ratio (binding) | = 1.57 | Selectivity ratio is the ratio between the IC50 values of rat liver and T. gondii | ChEMBL. | 9526565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.