Detailed information for compound 306399

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 455.719 | Formula: C29H49N3O
  • H donors: 1 H acceptors: 1 LogP: 8.64 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCN(CCCCCC)CCCCCCNc1cc(OC)cc2c1nccc2C
  • InChi: 1S/C29H49N3O/c1-5-7-9-14-20-32(21-15-10-8-6-2)22-16-12-11-13-18-30-28-24-26(33-4)23-27-25(3)17-19-31-29(27)28/h17,19,23-24,30H,5-16,18,20-22H2,1-4H3
  • InChiKey: ULRCAPZWWOXBMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0012 0.0012
Loa Loa (eye worm) carboxylesterase 1.2805 1 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.0296
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Echinococcus multilocularis Niemann Pick C1 protein 0.0109 0.0075 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0003 0.0077
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0004 0.0469
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.0094 0.0544
Brugia malayi 6-phosphofructokinase 0.0121 0.0084 0.0084
Echinococcus multilocularis protein patched 0.0047 0.0027 0.0026
Echinococcus granulosus axis inhibition protein axin 0.002 0.0005 0.0005
Brugia malayi hypoxia-induced factor 1 0.0157 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.043
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0008 0.0864
Loa Loa (eye worm) carboxylesterase 0.2164 0.1681 0.1681
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0027 0.0026
Echinococcus granulosus lamin dm0 0.0028 0.0012 0.0012
Brugia malayi Carboxylesterase family protein 0.2164 0.1681 0.1681
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0084 1
Schistosoma mansoni single-minded 0.0051 0.0029 0.0029
Plasmodium falciparum glutathione reductase 0.0018 0.0004 0.0697
Brugia malayi hypothetical protein 0.0263 0.0195 0.0195
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0008 0.0732
Loa Loa (eye worm) hypothetical protein 0.0083 0.0055 0.0055
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0005 0.0005
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0027 0.0026
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0013 0 0.000005494
Brugia malayi jmjC domain containing protein 0.0059 0.0036 0.0035
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0291 0.0217 0.1271
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0012 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0263 0.0195 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0153 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Brugia malayi PXA domain containing protein 0.002 0.0005 0.0005
Trichomonas vaginalis set domain proteins, putative 0.0509 0.0388 0.2308
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0004 0.052
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Brugia malayi CHE-14 protein 0.0047 0.0027 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Echinococcus multilocularis lamin 0.0028 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.017 0.0123 0.0123
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0012 0.0012
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0005 0.0005
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0084 0.1769
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0012 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0002 0.0002
Toxoplasma gondii exonuclease III APE 0.0019 0.0004 0.0338
Schistosoma mansoni lamin 0.0028 0.0012 0.0012
Brugia malayi hypothetical protein 0.002 0.0005 0.0005
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi glutaminase DH11.1 0.0284 0.0212 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0012 0.0012
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0012 0.0012
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0595 0.0455 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0153 0.011 0.011
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0002 0.0069
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0012 0.0012
Plasmodium vivax JmjC domain containing protein 0.0016 0.0002 0.0126
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Schistosoma mansoni hypothetical protein 0.0045 0.0025 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0109 0.0075 0.0075
Echinococcus multilocularis geminin 0.0176 0.0128 0.0128
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0031 0.7624
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0077
Onchocerca volvulus 0.0083 0.0055 0.0324
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2164 0.1681 0.1681
Brugia malayi isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0055 0.0054
Trichomonas vaginalis glutaminase, putative 0.0284 0.0212 0.1261
Echinococcus multilocularis acetylcholinesterase 1.2805 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Brugia malayi Carboxylesterase family protein 0.2164 0.1681 0.1681
Schistosoma mansoni hypothetical protein 0.0054 0.0032 0.0032
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0291 0.0217 1
Echinococcus granulosus acetylcholinesterase 1.2805 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Schistosoma mansoni thyroid hormone receptor 0.0153 0.011 0.011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0004 0.052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0004 0.0245
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0013 0 0.000005494
Schistosoma mansoni hypothetical protein 0.0045 0.0025 0.0025
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0084 0.05
Loa Loa (eye worm) hypothetical protein 0.0263 0.0195 0.0195
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0595 0.0455 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0012 0.0012
Echinococcus granulosus survival motor neuron protein 1 0.0263 0.0195 0.0195
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0059 0.0036 0.0035
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0005
Echinococcus granulosus Niemann Pick C1 protein 0.0156 0.0112 0.0112
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0002 0.0002
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0002 0.0069
Onchocerca volvulus 0.0064 0.004 0.0237
Echinococcus multilocularis lamin dm0 0.0028 0.0012 0.0012
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.004 0.004
Loa Loa (eye worm) hypothetical protein 1.2805 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0012 0.0012
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0036 0.0036
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0002 0.0002
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.2164 0.1681 0.1681
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0125 0.0088 0.0088
Brugia malayi hypothetical protein 0.0015 0.0001 0.0001
Plasmodium falciparum thioredoxin reductase 0.0018 0.0004 0.0697
Echinococcus granulosus family S9 non peptidase ue S09 family 0.2164 0.1681 0.1681
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0036 0.0035
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0092 0.0532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Brugia malayi 6-phosphofructokinase 0.0121 0.0084 0.0084
Brugia malayi PXA domain containing protein 0.002 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0291 0.0217 0.1278
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0084 0.1769
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0092 0.0524
Schistosoma mansoni neuroligin 3 (S09 family) 0.2164 0.1681 0.1681
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0004 0.0011
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0004 0.0291
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0008 1
Echinococcus multilocularis musashi 0.0028 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0054 0.0032 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0012 0.0012
Mycobacterium ulcerans 6-phosphofructokinase 0.0121 0.0084 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0012 0.0012
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0015 0.3579
Echinococcus granulosus nuclear receptor nhr 48 0.0013 0 0.000005494
Schistosoma mansoni coup transcription factor 0.0028 0.0012 0.0012
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0015 0.1536
Echinococcus granulosus carboxylesterase 5A 1.2805 1 1
Trypanosoma brucei trypanothione reductase 0.0053 0.0031 0.351
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0121 0.0084 0.3875
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0005 0.0005
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0012 0.0012
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0015 0.1536
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.043
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0005 0.0005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0005
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0005 0.1049
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 1.2805 1 1
Brugia malayi hypothetical protein 0.017 0.0123 0.0122
Toxoplasma gondii thioredoxin reductase 0.0053 0.0031 0.3255
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0002 0.0002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.2164 0.1681 1
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0005 0.0005
Onchocerca volvulus 0.0509 0.0388 0.2308
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0005 0.0005
Echinococcus granulosus para nitrobenzyl esterase 0.2164 0.1681 0.1681
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0007 0.0007
Mycobacterium ulcerans glutaminase 0.0284 0.0212 0.124
Echinococcus granulosus thyroid hormone receptor alpha 0.0013 0 0.000005494
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0007 0.0042
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0005 0.0005
Echinococcus granulosus phd:f box containing protein 0.0016 0.0002 0.0002
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0005 0.0005
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0015 0.0091
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0005 0.0005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0012 0.0069
Echinococcus multilocularis para nitrobenzyl esterase 0.2164 0.1681 0.1681
Leishmania major ATP-dependent phosphofructokinase 0.0121 0.0084 0.916
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0002 0.0002
Plasmodium vivax glutathione reductase, putative 0.0053 0.0031 0.7624
Echinococcus multilocularis expressed protein 0.0388 0.0293 0.0293
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0012 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0448 0.034 0.034
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0005 0.0005
Echinococcus granulosus axis inhibition protein axin 0.002 0.0005 0.0005
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0005 0.0005
Echinococcus multilocularis acetylcholinesterase 1.2805 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0 0.000005494
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0031 0.3659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0028 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0012 0.0012
Schistosoma mansoni survival motor neuron protein 0.0054 0.0032 0.0032
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0047 0.0027 0.0027
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0045 0.0025 0.0025
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0088 0.0088
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0004 0.1062
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0176 0.0128 0.0127
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0002 0.023
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0121 0.0084 0.1777
Schistosoma mansoni glutaminase 0.0284 0.0212 0.0212
Brugia malayi intermediate filament protein 0.0028 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0004 0.0476
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0038 0.0038
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0012 0.0069
Loa Loa (eye worm) RecQ helicase 0.0022 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.002 0.0005 0.0021
Brugia malayi nuclear receptor NHR-88 0.0028 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0176 0.0128 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0012 0.0012
Echinococcus granulosus Nuclear hormone receptor HR96 0.0013 0 0.000005494
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0005 0.0005
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Echinococcus multilocularis carboxylesterase 5A 1.2805 1 1
Leishmania major trypanothione reductase 0.0053 0.0031 0.3352
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0008 0.5215
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0759
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.012 0.0083 0.0481
Schistosoma mansoni axis inhibition protein axin 0.002 0.0005 0.0005
Onchocerca volvulus 0.2164 0.1681 1
Mycobacterium ulcerans carboxylesterase, LipT 0.2164 0.1681 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.004 0.004
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0002 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0092 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0004 0.0009
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0055 0.0054
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0015 0.4605
Echinococcus granulosus expressed protein 0.0388 0.0293 0.0293
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0008 0.0366
Loa Loa (eye worm) hypothetical protein 0.0352 0.0265 0.0265
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0003 0.0305
Echinococcus granulosus geminin 0.0176 0.0128 0.0128
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0003 0.0218
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0012 0.0012
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0004 0.0291
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0007 0.0042
Brugia malayi jmjC domain containing protein 0.0016 0.0002 0.0002
Brugia malayi glutathione reductase 0.0053 0.0031 0.0031
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0088 0.0088
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.0077 0.0076
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0015 0.3579
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0005 0.0005
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0004 0.0004
Brugia malayi PAS domain containing protein 0.0051 0.0029 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0001 0.0001
Giardia lamblia Fructose-bisphosphate aldolase 0.0595 0.0455 1
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0019 0.009
Echinococcus granulosus neuroligin 0.2164 0.1681 0.1681
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0036 0.0036
Schistosoma mansoni lamin 0.0028 0.0012 0.0012
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0002 0.0002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0004 0.0649
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0013 0 0.000005494
Echinococcus multilocularis 6 phosphofructokinase 0.0121 0.0084 0.0084
Onchocerca volvulus 0.0028 0.0012 0.0069
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0005 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0012 0.0012
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0003 0.0003
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0005 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0007 0.0007
Onchocerca volvulus 0.2164 0.1681 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0 0.000005494
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0002 0.023
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0004 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus multilocularis neuroligin 0.2164 0.1681 0.1681
Leishmania major hypothetical protein, conserved 0.0016 0.0002 0.0211
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0008 0.073
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.012 0.0083 0.3841
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0005 0.0005
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0015 0.1536
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0036 0.0035
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.004 0.004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0001 0.0001
Brugia malayi jmjC domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0002 0.0002
Brugia malayi jmjC domain containing protein 0.0016 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.004 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0012 0.0012
Echinococcus granulosus bloom syndrome protein 0.0022 0.0007 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2164 0.1681 0.1681
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0008 0.1686
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0012 0.0012
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0005
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0002 0.0002
Treponema pallidum fructose-bisphosphate aldolase 0.0595 0.0455 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Echinococcus granulosus acetylcholinesterase 1.2805 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Brugia malayi Carboxylesterase family protein 1.2805 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0001 0.0001
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0005 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Schistosoma mansoni acetylcholinesterase 0.2164 0.1681 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0012 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Brugia malayi Carboxylesterase family protein 0.2164 0.1681 0.1681
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0003 0.0305
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0036 0.0036
Mycobacterium tuberculosis Probable dehydrogenase 0.012 0.0083 0.0481
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.004 0.004
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0012 0.0012
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0004 0.0469
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0004 0.0697
Brugia malayi Pre-SET motif family protein 0.0064 0.004 0.004
Mycobacterium tuberculosis Probable reductase 0.012 0.0083 0.0481
Brugia malayi nuclear hormone receptor 0.0028 0.0012 0.0012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.2164 0.1681 0.1681
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0005 0.0005
Onchocerca volvulus 0.2164 0.1681 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0005
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0012 0.0012
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.0094 0.0544
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0139
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0004 0.0844
Schistosoma mansoni intermediate filament proteins 0.0028 0.0012 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0002 0.0002
Echinococcus granulosus single minded 2 0.0037 0.0019 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0031 0.0031
Echinococcus multilocularis BC026374 protein (S09 family) 0.2164 0.1681 0.1681
Echinococcus granulosus lamin 0.0028 0.0012 0.0012
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0005 0.0005
Onchocerca volvulus 0.0028 0.0012 0.0069
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0019 0.0019
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.012 0.0083 0.0481
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0031 0.0168
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0112 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0092 0.0524
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0012 0.0012
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0004 0.0697
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0026
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0012 0.0012
Brugia malayi Niemann-Pick C1 protein precursor 0.0109 0.0075 0.0075
Echinococcus granulosus intermediate filament protein 0.0028 0.0012 0.0012
Onchocerca volvulus 0.2164 0.1681 1
Loa Loa (eye worm) carboxylesterase 0.2164 0.1681 0.1681
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0121 0.0084 0.0486
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0092 0.0524
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0015 1
Loa Loa (eye worm) glutaminase 2 0.0284 0.0212 0.0212
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0008 0.0732
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0012 0.0012
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0008 0.208
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0012 0.0012
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0008 0.0088
Trichomonas vaginalis spcc417.12 protein, putative 0.2164 0.1681 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0012 0.0012
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0084 0.05
Echinococcus granulosus 6 phosphofructokinase 0.0121 0.0084 0.0084
Onchocerca volvulus 0.0054 0.0032 0.0188
Plasmodium vivax SET domain protein, putative 0.0064 0.004 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0036 0.0036
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0004 0.043
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0004 0.0469
Brugia malayi Pre-SET motif family protein 0.0448 0.034 0.034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0036 0.0035
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0084 0.05
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0012 0.0012
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0002 0.0002
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0004 0.043
Loa Loa (eye worm) hypothetical protein 0.0057 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0004 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0004 0.0245
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.004 0.4265
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0012 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0012 0.0012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0003 0.0139
Trichomonas vaginalis phosphofructokinase, putative 0.0121 0.0084 0.05
Echinococcus multilocularis nuclear receptor nhr 48 0.0013 0 0.000005494
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0004 0.0245
Schistosoma mansoni axis inhibition protein axin 0.002 0.0005 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0004 0.0023
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0005 0.0032
Brugia malayi Thioredoxin reductase 0.0053 0.0031 0.0031
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.2164 0.1681 1
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0027 0.0027
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0012 0.0012
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0092 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0004 0.0245
Loa Loa (eye worm) phosphofructokinase 0.0121 0.0084 0.0084
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0002 0.0002
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0012 0.0012
Brugia malayi hypothetical protein 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0004 0.0649
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Schistosoma mansoni hypothetical protein 0.0045 0.0025 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0005 0.0032
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0032 0.0032
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.000009889 0.000009889
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0003 0.0003
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0031 0.0031
Mycobacterium tuberculosis Putative ferredoxin reductase 0.012 0.0083 0.0481
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0015 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0012 0.0012
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0008 0.0024
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Echinococcus granulosus BC026374 protein S09 family 0.2164 0.1681 0.1681
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0003 0.029
Echinococcus multilocularis expressed conserved protein 0.0103 0.007 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0012 0.0012
Brugia malayi ecdysteroid receptor 0.0028 0.0012 0.0012
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0027 0.0026
Brugia malayi jmjC domain containing protein 0.0016 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0004 0.0469
Brugia malayi steroid hormone receptor 0.0028 0.0012 0.0012
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0092 0.0092
Onchocerca volvulus 0.2164 0.1681 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0005 0.0005
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0084 0.0084
Brugia malayi hypothetical protein 0.2164 0.1681 0.1681
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0004 0.0004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0012 0.0012
Onchocerca volvulus 0.0028 0.0012 0.0069
Brugia malayi hypothetical protein 0.0135 0.0096 0.0095
Loa Loa (eye worm) glutaminase 0.0284 0.0212 0.0212
Loa Loa (eye worm) hypothetical protein 0.2164 0.1681 0.1681
Onchocerca volvulus 0.0037 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0015 0.4605
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0033 0.0015 0.025
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0012 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0012 0.0012
Brugia malayi Carboxylesterase family protein 0.2164 0.1681 0.1681
Echinococcus multilocularis Niemann Pick C1 protein 0.0156 0.0112 0.0112
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0001 0.0001
Loa Loa (eye worm) acetylcholinesterase 1 1.2805 1 1
Entamoeba histolytica hypothetical protein 0.0023 0.0008 0.0079
Echinococcus granulosus expressed conserved protein 0.0103 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0075 0.0075
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0012 0.0012
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0012 0.0069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0004 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0012 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0036 0.0036
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0004 0.0026
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.012 0.0083 0.0481
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0005 0.0005
Loa Loa (eye worm) 6-phosphofructokinase 0.0121 0.0084 0.0084
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0012 0.0012
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.0094 0.0544
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0005 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0004 0.0004
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0002 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0004 0.0003
Schistosoma mansoni gliotactin 0.2164 0.1681 0.1681
Plasmodium falciparum glutathione reductase 0.0053 0.0031 1
Schistosoma mansoni ap endonuclease 0.0019 0.0004 0.0004
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0013 0 0.000005494
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0109 0.0075 0.1572
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0013 0.000009889 0.000009889
Schistosoma mansoni patched 1 0.0047 0.0027 0.0026
Brugia malayi nuclear receptor RXR 0.0015 0.0001 0.0001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0008 0.0024
Loa Loa (eye worm) hypothetical protein 0.0064 0.004 0.004
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0004 0.2594
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0012 0.0012
Loa Loa (eye worm) glutathione reductase 0.0053 0.0031 0.0031
Echinococcus multilocularis protein dispatched 1 0.0054 0.0032 0.0032
Mycobacterium tuberculosis Carboxylesterase LipT 0.2164 0.1681 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 1.2805 1 1
Plasmodium falciparum thioredoxin reductase 0.0053 0.0031 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0055 0.0054
Schistosoma mansoni BC026374 protein (S09 family) 0.2164 0.1681 0.1681
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0002 0.0002
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0012 0.0012
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0013 0 0.000005494
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0027 0.0157
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Loa Loa (eye worm) hypothetical protein 0.0028 0.0012 0.0012
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0002 0.0002
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0121 0.0084 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0012 0.0012
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0013 0 0.000005494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0005 0.0005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0595 0.0455 0.2707
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0012 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0012 0.0012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.0094 0.4323
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0012 0.0012
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0008 0.0032
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0012 0.0012
Loa Loa (eye worm) RGS-3 protein 0.002 0.0005 0.0005
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0015 0.0091
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0005 0.0005
Schistosoma mansoni 6-phosphofructokinase 0.0121 0.0084 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0004 0.0004
Brugia malayi phosphofructokinase 0.0121 0.0084 0.0084
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0012 0.0012
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0055 0.0054
Loa Loa (eye worm) hypothetical protein 0.0015 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0012 0.0012
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.2164 0.1681 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0015 0.0241
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0005 0.0005
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0092 0.0092
Entamoeba histolytica phosphofructokinase, putative 0.0121 0.0084 0.1769
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0015 0.025

Activities

Activity type Activity value Assay description Source Reference
G Index (functional) 0 G index = SD90 for meglumine antimoniate / SD90 for the compound; NT = not tested ChEMBL. 7411553
Supression (functional) 0 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 13 mg/kg; NT = not tested ChEMBL. 7411553
Supression (functional) 0 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 0.81 mg/kg; NT = not tested ChEMBL. 7411553
Supression (functional) 0 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 0.2 mg/kg; NT = not tested ChEMBL. 7411553
Supression (functional) 0 % Antileishmanial activity against Leishmania donovani in hamsters at a concentration of 0.05 mg/kg; NT = not tested ChEMBL. 7411553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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