Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.254 | 0.6226 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.091 | 0.234 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0019 | 0.0461 | 0.247 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.091 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0313 | 0.5 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.389 | 1 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.1886 | 0.4398 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable reductase | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.7773 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.091 | 0.234 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0017 | 0.0313 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.254 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.254 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.389 | 0.3692 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.254 | 0.6226 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0388 | 0.01 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.389 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0019 | 0.0461 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0017 | 0.0313 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.7773 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0313 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.389 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.091 | 0.1311 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.091 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.389 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0388 | 0.01 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.389 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.254 | 0.6064 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.389 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.254 | 0.653 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.7773 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0113 | 0.6906 | 0.8736 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.091 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0019 | 0.0461 | 0.0198 |
Leishmania major | trypanothione reductase | 0.0049 | 0.254 | 0.6226 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.091 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0388 | 0.01 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0113 | 0.6906 | 0.8837 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.091 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.091 | 0.1669 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.091 | 0.234 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.1886 | 0.4398 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.091 | 0.1669 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0019 | 0.0461 | 0.0662 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.091 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.7773 | 1 |
Onchocerca volvulus | 0.0026 | 0.091 | 0.5 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.091 | 1 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.389 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.254 | 0.653 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.254 | 0.2985 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.091 | 0.08 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.254 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.254 | 0.6226 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.091 | 0.1311 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.091 | 1 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.389 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.254 | 0.6226 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.091 | 0.1669 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0313 | 0.0806 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.254 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.091 | 0.08 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0313 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.389 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0018 | 0.0388 | 0.01 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0019 | 0.0461 | 0.0662 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.091 | 0.1311 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.254 | 0.6064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | <= 0.025 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa NCTC-10490 bacteria | ChEMBL. | No reference |
MIC (functional) | = 0.05 ug ml-1 | In vitro antibacterial activity against Pseudomonas aeruginosa ATCC-10145 bacteria | ChEMBL. | No reference |
MIC (functional) | = 0.1 ug ml-1 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2 bacteria | ChEMBL. | No reference |
MIC (functional) | = 0.1 ug ml-1 | In vitro antibacterial activity against Escherichia coli NIHJ JC-2 bacteria | ChEMBL. | No reference |
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus FDA 209P bacteria | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.