Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.3513 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.003 | 0.1992 | 0.1992 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.3513 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0038 | 0.3513 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.3513 | 0.2518 |
Mycobacterium ulcerans | pyruvate kinase | 0.0038 | 0.3513 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.7081 | 0.6633 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0027 | 0.1329 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.3513 | 0.2518 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0038 | 0.3513 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.0038 | 0.3513 | 0.5 |
Plasmodium falciparum | pyruvate kinase | 0.0038 | 0.3513 | 1 |
Leishmania major | pyruvate kinase | 0.0038 | 0.3513 | 0.5 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0038 | 0.3513 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.7081 | 0.55 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.3513 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.3668 | 0.024 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0038 | 0.3513 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.3668 | 0.2698 |
Leishmania major | pyruvate kinase | 0.0038 | 0.3513 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0038 | 0.3513 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.3668 | 0.3668 |
Giardia lamblia | Pyruvate kinase | 0.0038 | 0.3513 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.3513 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3513 | 0.2518 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0038 | 0.3513 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.7081 | 0.6633 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.7081 | 0.55 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0038 | 0.3513 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0038 | 0.3513 | 0.5 |
Schistosoma mansoni | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 1 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.0038 | 0.3513 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0038 | 0.3513 | 0.2518 |
Echinococcus granulosus | pyruvate kinase | 0.0038 | 0.3513 | 0.3513 |
Brugia malayi | TAR-binding protein | 0.0073 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 62 % | Percent plasma glucose concentration of drug treated mice (ob/ob) relative to vehicle control animals | ChEMBL. | 1548684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.