Detailed information for compound 306817

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.545 | Formula: C18H34O5Si
  • H donors: 1 H acceptors: 1 LogP: 3.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[C@@H]1CCC[C@H]2C31OO[C@](O[C@@H]3OC)(C(C2)C[Si](C)(C)C)C
  • InChi: 1S/C18H34O5Si/c1-17-15(12-24(3,4)5)11-14-8-6-7-13(9-10-19)18(14,23-22-17)16(20-2)21-17/h13-16,19H,6-12H2,1-5H3/t13-,14+,15?,16-,17-,18?/m0/s1
  • InChiKey: OWRZJKGNIFIYSX-ZKUYNTJRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0822 0.1355
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0222 0.2609 0.6213
Loa Loa (eye worm) hypothetical protein 0.0491 0.6064 1
Echinococcus multilocularis FTZ F1 alpha 0.0222 0.2609 0.2609
Onchocerca volvulus 0.01 0.1036 0.1404
Brugia malayi nuclear hormone receptor family member odr-7 0.0105 0.1102 0.1817
Brugia malayi tailless protein 0.0105 0.1102 0.1817
Entamoeba histolytica hypothetical protein 0.0108 0.1147 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0222 0.2609 0.4644
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Echinococcus multilocularis thyroid hormone receptor alpha 0.0346 0.4199 0.4199
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0481 0.419
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0056 0.2546
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0222 0.2609 0.4302
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0374
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0132 0.0218
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Entamoeba histolytica hypothetical protein 0.0023 0.0056 0.0487
Loa Loa (eye worm) hypothetical protein 0.006 0.0527 0.087
Schistosoma mansoni hypothetical protein 0.005 0.0393 0.0935
Echinococcus multilocularis musashi 0.0055 0.0458 0.0458
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0105 0.1102 0.1522
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0527 0.1256
Brugia malayi Cytochrome P450 family protein 0.0031 0.0159 0.0263
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.022 0.0374
Onchocerca volvulus 0.0094 0.0964 0.1277
Brugia malayi PAS domain containing protein 0.0146 0.1636 0.2698
Brugia malayi follicle stimulating hormone receptor 0.023 0.2712 0.4473
Loa Loa (eye worm) hypothetical protein 0.0117 0.1263 0.2083
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0038 0.0245 0.0436
Echinococcus multilocularis expressed protein 0.0367 0.4472 0.4472
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0105 0.1102 0.1961
Entamoeba histolytica hypothetical protein 0.0108 0.1147 1
Brugia malayi ecdysteroid receptor 0.0222 0.2609 0.4302
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0206 0.034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0222 0.2609 0.6213
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0245 0.0417
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0038 0.0245 0.0404
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Onchocerca volvulus 0.0071 0.0671 0.0757
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0222 0.2609 0.4644
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1844 0.1844
Brugia malayi photoreceptor-specific nuclear receptor 0.0222 0.2609 0.4302
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0527 0.0527
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0481 0.0793
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0245 0.5091
Loa Loa (eye worm) hypothetical protein 0.0051 0.0414 0.0683
Loa Loa (eye worm) hypoxia-induced factor 1 0.0453 0.5575 0.9194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0222 0.2609 0.4302
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Echinococcus granulosus Nuclear hormone receptor HR96 0.0105 0.1102 0.1961
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0159 0.0263
Echinococcus granulosus geminin 0.0174 0.1993 0.3547
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0056 0.1162
Echinococcus multilocularis neuropeptide receptor A26 0.0456 0.5618 0.5618
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.022 0.8967
Echinococcus granulosus nuclear receptor nhr 48 0.0105 0.1102 0.1961
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0245 0.0417
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.022 0.8967
Brugia malayi orphan nuclear receptor NR2E1 0.0105 0.1102 0.1817
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1147 0.2731
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0245 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0105 0.1102 0.2624
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.0892 0.1587
Onchocerca volvulus 0.0149 0.1665 0.2522
Brugia malayi hypothetical protein 0.0117 0.1263 0.2083
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.034
Brugia malayi hypothetical protein 0.0149 0.1665 0.2746
Onchocerca volvulus 0.0083 0.0822 0.1024
Echinococcus multilocularis transfer RNA-Lys 0.0108 0.1148 0.1148
Schistosoma mansoni intermediate filament proteins 0.0055 0.0458 0.109
Loa Loa (eye worm) hypothetical protein 0.0122 0.1326 0.2187
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0222 0.2609 0.2609
Mycobacterium leprae Possible regulatory protein 0.0038 0.0245 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0222 0.2609 0.4302
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0245 0.0417
Brugia malayi nuclear receptor RXR 0.0117 0.1263 0.2083
Schistosoma mansoni RAR-like nuclear receptor 0.0222 0.2609 0.6213
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0105 0.1102 0.1102
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Brugia malayi nuclear receptor NHR-88 0.0105 0.1102 0.1817
Brugia malayi steroid hormone receptor 0.0222 0.2609 0.4302
Giardia lamblia DINP protein human, muc B family 0.0019 0 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0527 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0146 0.1636 0.3897
Brugia malayi Cytochrome P450 family protein 0.0033 0.0181 0.0298
Trypanosoma brucei glucosidase, putative 0.0036 0.022 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.0892 0.0892
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0222 0.2609 0.6213
Brugia malayi intermediate filament protein 0.0055 0.0458 0.0755
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0222 0.2609 0.4198
Echinococcus granulosus lamin 0.0055 0.0458 0.0815
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0095 0.0169
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0414 0.0683
Loa Loa (eye worm) hypothetical protein 0.0054 0.0445 0.0734
Echinococcus multilocularis nuclear receptor nhr 48 0.0105 0.1102 0.1102
Schistosoma mansoni zinc finger protein 0.0105 0.1102 0.2624
Brugia malayi Nuclear hormone receptor E75 0.0105 0.1102 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0222 0.2609 0.4302
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0105 0.1102 0.1817
Echinococcus granulosus survival motor neuron protein 1 0.0243 0.2877 0.5121
Echinococcus multilocularis neuropeptide s receptor 0.0456 0.5618 0.5618
Brugia malayi Pre-SET motif family protein 0.0418 0.5132 0.8464
Echinococcus granulosus thyroid hormone receptor alpha 0.0105 0.1102 0.1961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0222 0.2609 0.4302
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Loa Loa (eye worm) hypothetical protein 0.0083 0.0822 0.1355
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.022 0.1915
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0056 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0222 0.2609 0.4302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0414 0.0683
Brugia malayi bHLH-PAS transcription factor 0.0108 0.1148 0.1893
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0117 0.1263 0.3008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0222 0.2609 0.2609
Schistosoma mansoni thyroid hormone receptor 0.0346 0.4199 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0245 1
Schistosoma mansoni single-minded 0.0146 0.1636 0.3897
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0222 0.2609 0.2609
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0105 0.1102 0.1522
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0481 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0245 0.0404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0222 0.2609 0.4302
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0374
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0222 0.2609 0.4302
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0132 0.0218
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0038 0.0245 0.0417
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1844 0.3283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0527 0.1256
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0159 0.6507
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0056 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0245 0.0417
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0527 0.0527
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.022 0.0374
Brugia malayi hypothetical protein 0.0122 0.1326 0.2187
Brugia malayi hypothetical protein 0.0108 0.1147 0.1891
Brugia malayi nuclear receptor NHR-67 0.0105 0.1102 0.1817
Entamoeba histolytica hypothetical protein 0.0108 0.1147 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0481 0.419
Loa Loa (eye worm) hypothetical protein 0.0117 0.1263 0.2083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0222 0.2609 0.4302
Onchocerca volvulus 0.01 0.1036 0.1404
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0222 0.2609 0.4644
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0105 0.1102 0.2624
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0527 0.1256
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.022 0.3471
Schistosoma mansoni survival motor neuron protein 0.005 0.0393 0.0935
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0374
Brugia malayi MH2 domain containing protein 0.0119 0.1286 0.2121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0222 0.2609 0.4644
Plasmodium vivax SET domain protein, putative 0.006 0.0527 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.1326 0.192
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0159 0.0263
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.022 0.0362
Loa Loa (eye worm) hypothetical protein 0.0117 0.1263 0.2083
Brugia malayi Nuclear hormone receptor-like 1 0.0222 0.2609 0.4302
Brugia malayi Pre-SET motif family protein 0.006 0.0527 0.087
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0056 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0222 0.2609 0.6213
Onchocerca volvulus 0.005 0.0393 0.0263
Echinococcus multilocularis survival motor neuron protein 1 0.0243 0.2877 0.2877
Echinococcus granulosus neuropeptide receptor A26 0.0456 0.5618 1
Brugia malayi hypothetical protein 0.01 0.1037 0.171
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0159 0.7256
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0105 0.1102 0.1102
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0245 0.0417
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0222 0.2609 0.4644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1147 0.2041
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0481 0.0856
Echinococcus granulosus single minded 2 0.0108 0.1148 0.2043
Schistosoma mansoni hypothetical protein 0.0108 0.1147 0.2731
Schistosoma mansoni thyroid hormone receptor 0.0346 0.4199 1
Schistosoma mansoni nuclear hormone receptor 0.0105 0.1102 0.2624
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1844 0.3041
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Brugia malayi M-phase phosphoprotein, mpp8 0.01 0.1036 0.1708
Onchocerca volvulus Bile acid receptor homolog 0.0222 0.2609 0.4198
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0038 0.0245 0.0245
Onchocerca volvulus 0.0105 0.1102 0.1522
Loa Loa (eye worm) hypothetical protein 0.0026 0.0095 0.0156
Schistosoma mansoni nuclear hormone receptor 0.0222 0.2609 0.6213
Leishmania major protein kinase, putative 0.0038 0.0245 0.5091
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0056 0.0487
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0822 0.1463
Loa Loa (eye worm) hypothetical protein 0.01 0.1036 0.1708
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0458 0.0755
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0135
Schistosoma mansoni coup transcription factor 0.0222 0.2609 0.6213
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.1286 0.2121
Brugia malayi Cytochrome P450 family protein 0.0031 0.0159 0.0263
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0458 0.0755
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0222 0.2609 0.2609
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0105 0.1102 0.1817
Loa Loa (eye worm) hypothetical protein 0.01 0.1037 0.171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0222 0.2609 0.4302
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0222 0.2609 0.2609
Brugia malayi hypoxia-induced factor 1 0.0453 0.5575 0.9194
Brugia malayi hypothetical protein 0.0105 0.1102 0.1817
Echinococcus multilocularis lamin dm0 0.0055 0.0458 0.0458
Onchocerca volvulus 0.0222 0.2609 0.4198
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0222 0.2609 0.6213
Schistosoma mansoni retinoic acid receptor RXR 0.0222 0.2609 0.6213
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1844 0.3041
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0432 0.0713
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0527 0.0939
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.022 0.1915
Onchocerca volvulus Protein ultraspiracle homolog 0.0222 0.2609 0.4198
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0892 0.2123
Onchocerca volvulus 0.0476 0.5876 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0117 0.1263 0.1263
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0222 0.2609 0.4302
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0181 0.0298
Echinococcus granulosus FTZ F1 alpha 0.0222 0.2609 0.4644
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.022 0.022
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0245 1
Echinococcus granulosus intermediate filament protein 0.0055 0.0458 0.0815
Loa Loa (eye worm) nuclear receptor NHR-67 0.0105 0.1102 0.1817
Echinococcus multilocularis ecdysone induced protein 78C 0.0222 0.2609 0.2609
Entamoeba histolytica hypothetical protein 0.0108 0.1147 1
Echinococcus granulosus lamin dm0 0.0055 0.0458 0.0815
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Echinococcus multilocularis aryl hydrocarbon receptor 0.0038 0.0245 0.0245
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0105 0.1102 0.1102
Schistosoma mansoni hypothetical protein 0.0035 0.0206 0.0491
Echinococcus granulosus ecdysone induced protein 78C 0.0222 0.2609 0.4644
Brugia malayi Steroid receptor seven-up type 2 0.0222 0.2609 0.4302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0055 0.0458 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0222 0.2609 0.4302
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0822 0.1957
Schistosoma mansoni hypothetical protein 0.0174 0.1993 0.4745
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0038 0.0245 0.0417
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0159 0.6507
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0222 0.2609 0.2609
Loa Loa (eye worm) hypothetical protein 0.0149 0.1665 0.2746
Onchocerca volvulus 0.0105 0.1102 0.1522
Brugia malayi ecdysone receptor 0.0105 0.1102 0.1817
Onchocerca volvulus 0.0055 0.0458 0.0378
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.2712 0.4473
Loa Loa (eye worm) nuclear hormone receptor 0.0105 0.1102 0.1817
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.0671 0.1599
Schistosoma mansoni steroid hormone receptor ad4bp 0.0222 0.2609 0.6213
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.5132 0.8464
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0222 0.2609 0.4302
Echinococcus granulosus Nuclear hormone receptor HR96 0.0105 0.1102 0.1961
Brugia malayi hypothetical protein 0.0105 0.1102 0.1817
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.022 0.0374
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.022 0.0374
Echinococcus granulosus expressed protein 0.0367 0.4472 0.7959
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0222 0.2609 0.4644
Schistosoma mansoni nuclear receptor nhr-48 0.0105 0.1102 0.2624
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0686 0.0686
Echinococcus granulosus neuropeptide s receptor 0.0456 0.5618 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0222 0.2609 0.4302
Schistosoma mansoni nuclear receptor 0.0105 0.1102 0.2624
Onchocerca volvulus 0.0108 0.1148 0.1603
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.022 0.0362
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1844 0.1844
Schistosoma mansoni hypothetical protein 0.0174 0.1993 0.4745
Schistosoma mansoni hypothetical protein 0.0124 0.1347 0.3207
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0245 0.0417
Loa Loa (eye worm) DR-78 0.0105 0.1102 0.1817
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Schistosoma mansoni lamin 0.0055 0.0458 0.109
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0822 0.0822
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1347 0.2397
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0499 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0222 0.2609 0.4302
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.1263 0.2083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0222 0.2609 0.4644
Leishmania major protein kinase, putative 0.0038 0.0245 0.5091
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0056 0.1162
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0159 0.0263
Brugia malayi nuclear receptor NHR-88 0.0222 0.2609 0.4302
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0393 0.0648
Loa Loa (eye worm) steroid hormone receptor 0.0222 0.2609 0.4302
Brugia malayi nuclear hormone receptor 0.0222 0.2609 0.4302
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0222 0.2609 0.4302
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0245 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0117 0.1263 0.2248
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0117 0.1263 0.2083
Brugia malayi hypothetical protein 0.0117 0.1263 0.2083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0082 0.0135
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.022 0.4565
Brugia malayi nuclear hormone receptor 0.0105 0.1102 0.1817
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0105 0.1102 0.1961
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Schistosoma mansoni nuclear receptor 0.0105 0.1102 0.2624
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0245 0.0417
Echinococcus multilocularis geminin 0.0174 0.1993 0.1993
Leishmania major cytochrome p450-like protein 0.0031 0.0159 0.3312
Trichomonas vaginalis set domain proteins, putative 0.0476 0.5875 1
Brugia malayi Nuclear hormone receptor-like 1 0.0117 0.1263 0.2083
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0105 0.1102 0.1102
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0222 0.2609 0.4302
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0105 0.1102 0.1102
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0686 0.1222
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0414 0.0683
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0374
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0222 0.2609 0.4302
Schistosoma mansoni nuclear hormone receptor 0.0105 0.1102 0.2624
Echinococcus multilocularis lamin 0.0055 0.0458 0.0458
Brugia malayi nuclear receptor RXR 0.0105 0.1102 0.1817
Onchocerca volvulus Huntingtin homolog 0.0122 0.1326 0.192
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0222 0.2609 0.4302
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Onchocerca volvulus 0.0055 0.0458 0.0378
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1347 0.1347
Loa Loa (eye worm) hypothetical protein 0.0105 0.1102 0.1817
Schistosoma mansoni alpha glucosidase 0.0036 0.022 0.0523
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0117 0.1263 0.3008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0222 0.2609 0.4302
Echinococcus granulosus aryl hydrocarbon receptor 0.0038 0.0245 0.0436
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0222 0.2609 0.6213
Loa Loa (eye worm) hypothetical protein 0.0117 0.1263 0.2083
Loa Loa (eye worm) hypothetical protein 0.0222 0.2609 0.4302
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.1286 0.2121
Schistosoma mansoni alpha-glucosidase 0.014 0.1553 0.3699
Brugia malayi hypothetical protein 0.0243 0.2877 0.4745
Brugia malayi conserved hypotetical protein 0.0105 0.1102 0.1817
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0038 0.0245 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0481 0.1145
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0892 0.2123
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0245 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0095 0.0095
Trichomonas vaginalis adenylate cyclase, putative 0.0038 0.0245 0.0417
Loa Loa (eye worm) hypothetical protein 0.0117 0.1263 0.2083
Schistosoma mansoni alpha-glucosidase 0.014 0.1553 0.3699
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.022 0.0391
Brugia malayi nuclear hormone receptor family member nhr-6 0.0105 0.1102 0.1817
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0245 0.0417
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0458 0.0755
Mycobacterium ulcerans putative regulatory protein 0.0108 0.1148 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0481 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0159 0.1388
Brugia malayi Nuclear hormone receptor E75 0.0105 0.1102 0.1817
Brugia malayi hypothetical protein 0.0491 0.6064 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.1326 0.2187
Schistosoma mansoni lamin 0.0055 0.0458 0.109
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.022 0.0374
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0481 0.0481
Loa Loa (eye worm) hypothetical protein 0.0243 0.2877 0.4745

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 240 nM in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes . ChEMBL. 9526569
IC50 (functional) = 240 nM in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes . ChEMBL. 9526569
IC50 (functional) > 2500 nM in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes ChEMBL. 9526569
IC50 (functional) > 2500 nM in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes ChEMBL. 9526569

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 9526569

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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