Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | prostaglandin f synthase, putative | 0.0208 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0208 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Mycobacterium leprae | Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho | 0.0148 | 0.6108 | 0.5941 |
Echinococcus granulosus | hypothetical protein | 0.0208 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Trichomonas vaginalis | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9045 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.006 | 0.0411 | 0.0411 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0208 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0208 | 1 | 1 |
Leishmania major | adenosine kinase, putative | 0.0105 | 0.3328 | 0.3042 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0065 | 0.0714 | 0.0316 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0065 | 0.0714 | 0.0316 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.006 | 0.0411 | 0.0411 |
Echinococcus granulosus | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Loa Loa (eye worm) | oxidoreductase | 0.0208 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0113 | 0.3856 | 0.3856 |
Loa Loa (eye worm) | oxidoreductase | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0065 | 0.0714 | 0.0714 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0208 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0193 | 0.9045 | 0.9004 | |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Echinococcus multilocularis | aldo keto reductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0113 | 0.3856 | 0.3592 | |
Schistosoma mansoni | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Giardia lamblia | Aldose reductase | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.012 | 0.4267 | 0.4021 |
Loa Loa (eye worm) | thymidylate synthase | 0.0113 | 0.3856 | 0.3592 |
Mycobacterium ulcerans | thymidylate synthase | 0.0113 | 0.3856 | 0.3592 |
Echinococcus multilocularis | thymidylate synthase | 0.0113 | 0.3856 | 0.3592 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0093 | 0.2551 | 0.2231 | |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0065 | 0.0714 | 0.0316 |
Trypanosoma cruzi | aldo-keto reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0148 | 0.609 | 0.5922 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.6855 | 0.672 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0065 | 0.0714 | 0.0714 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.006 | 0.0411 | 0.0411 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0208 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.006 | 0.0411 | 0.0411 |
Echinococcus granulosus | adenosine kinase | 0.0105 | 0.3328 | 0.3042 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0159 | 0.6855 | 0.7463 |
Toxoplasma gondii | aldose reductase, putative | 0.0208 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0113 | 0.3856 | 0.3592 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.3328 | 0.3042 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.6855 | 0.6855 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Plasmodium vivax | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0208 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9045 |
Schistosoma mansoni | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Trypanosoma brucei | prostaglandin f synthase | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.012 | 0.4267 | 0.4021 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0065 | 0.0714 | 0.0316 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.3328 | 0.3328 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9045 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.3328 | 0.3042 |
Echinococcus multilocularis | aldo keto reductase | 0.0208 | 1 | 1 |
Brugia malayi | Adenosine kinase-like | 0.0105 | 0.3328 | 0.3328 |
Mycobacterium ulcerans | oxidoreductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0208 | 1 | 1 |
Leishmania major | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Echinococcus granulosus | aldo keto reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0113 | 0.3856 | 0.3592 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0065 | 0.0714 | 0.0316 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0113 | 0.3856 | 0.3592 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0086 | 0.2088 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.006 | 0.0411 | 0.0411 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0086 | 0.2088 | 0.2088 |
Echinococcus multilocularis | aldo keto reductase | 0.0208 | 1 | 1 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0086 | 0.2088 | 0.1748 |
Leishmania major | xanthine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.6855 | 0.7463 |
Brugia malayi | thymidylate synthase | 0.0113 | 0.3856 | 0.3856 |
Brugia malayi | Phosphoribosyl transferase domain containing protein | 0.0193 | 0.9045 | 0.9045 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0208 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.6855 | 0.672 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Toxoplasma gondii | hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT | 0.0193 | 0.9045 | 0.9004 |
Onchocerca volvulus | 0.0208 | 1 | 1 | |
Schistosoma mansoni | aldo-keto reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0208 | 1 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0105 | 0.3328 | 0.3042 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0208 | 1 | 1 |
Trypanosoma brucei | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9004 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0208 | 1 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0105 | 0.3328 | 0.3042 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0105 | 0.3328 | 0.3042 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0086 | 0.2088 | 0.5 |
Schistosoma mansoni | pol-related | 0.0208 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0208 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.006 | 0.0411 | 0.0411 |
Schistosoma mansoni | aldo-keto reductase | 0.0208 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0208 | 1 | 1 |
Echinococcus granulosus | hypoxanthine guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Giardia lamblia | Guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.8971 |
Echinococcus multilocularis | aldehyde reductase | 0.0148 | 0.609 | 0.5922 |
Plasmodium falciparum | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0148 | 0.609 | 0.5922 |
Echinococcus multilocularis | hypoxanthine guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Mycobacterium ulcerans | hypoxanthine-guanine phosphoribosyltransferase Hpt | 0.0193 | 0.9045 | 0.9004 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0065 | 0.0714 | 0.0316 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0086 | 0.2088 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.3328 | 0.3042 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.006 | 0.0411 | 0.0411 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.012 | 0.4267 | 0.4021 |
Trichomonas vaginalis | conserved hypothetical protein | 0.006 | 0.0411 | 0.0411 |
Loa Loa (eye worm) | oxidoreductase | 0.0208 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.0065 | 0.0714 | 0.0714 |
Schistosoma mansoni | hypoxanthine-guanine phosphoribosyltransferase | 0.0193 | 0.9045 | 0.9004 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9045 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0208 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0086 | 0.2088 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0105 | 0.3328 | 0.3042 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.6855 | 0.672 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.006 | 0.0411 | 0.0411 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0208 | 1 | 1 |
Mycobacterium tuberculosis | Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor | 0.0148 | 0.6108 | 0.6108 |
Trypanosoma cruzi | hypoxanthine-guanine phosphoribosyltransferase, putative | 0.0193 | 0.9045 | 0.9045 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0105 | 0.3328 | 0.3328 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k' (ADMET) | = 2.31 | Index of hydrophobicity (k') | ChEMBL. | 3012086 |
MPR (functional) | = 0.7 | Molar potency ratio (MPR) against A2 adenosine receptor of coronary artery | ChEMBL. | 3012086 |
pka (binding) | = 3.3 | Acidic dissociation constant(pKa) against A2 adenosine receptor of coronary artery | ChEMBL. | 3012086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.