Detailed information for compound 306868

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.314 | Formula: C18H13N3O3
  • H donors: 2 H acceptors: 2 LogP: 3.09 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)O/N=C/1\c2ccccc2N=C1c1c(O)[nH]c2c1cccc2
  • InChi: 1S/C18H13N3O3/c1-10(22)24-21-16-12-7-3-5-9-14(12)19-17(16)15-11-6-2-4-8-13(11)20-18(15)23/h2-9,20,23H,1H3/b21-16+
  • InChiKey: SPLHCOMFUFSNNE-LTGZKZEYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 alpha References
Homo sapiens cyclin B3 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens cyclin B1 References
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References
Homo sapiens cyclin B2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_134175 All targets in OG5_134175
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) cyclin domain-containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum IPR002155,Thiolase,domain-containing Get druggable targets OG5_134175 All targets in OG5_134175
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis G2:mitotic specific cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_134175 All targets in OG5_134175
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni cyclin B3 Get druggable targets OG5_134175 All targets in OG5_134175
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AUR protein kinase 0.0207 0.1515 0.1235
Trichomonas vaginalis AGC family protein kinase 0.0207 0.1515 1
Trichomonas vaginalis cyclins, putative 0.0124 0.0564 0.372
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0501 0.119
Echinococcus granulosus protein kinase shaggy 0.0119 0.0501 0.0142
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0207 0.1515 0.1194
Trichomonas vaginalis cyclins, putative 0.0124 0.0564 0.372
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0564 0.0207
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0119 0.0501 0.0234
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0501 0.119
Trypanosoma cruzi CYC2-like cyclin, putative 0.0124 0.0564 0.0342
Trypanosoma brucei protein kinase, putative 0.0119 0.0501 0.0234
Entamoeba histolytica protein kinase domain containing protein 0.0207 0.1515 1
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0119 0.0501 0.0142
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0613 0.6207 1
Echinococcus granulosus dihydrofolate reductase 0.0941 1 1
Toxoplasma gondii aurora kinase 0.0207 0.1515 0.197
Brugia malayi Cyclin, N-terminal domain containing protein 0.0199 0.1423 0.1099
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0207 0.1515 1
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0501 0.3307
Loa Loa (eye worm) dihydrofolate reductase 0.0941 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0364 0.0047
Loa Loa (eye worm) hypothetical protein 0.0124 0.0564 0.0253
Schistosoma mansoni cyclin B 0.0124 0.0564 0.0207
Trichomonas vaginalis cyclin B, putative 0.0124 0.0564 0.372
Trypanosoma cruzi cyclin, putative 0.0124 0.0564 0.0342
Schistosoma mansoni protein kinase 0.0207 0.1515 0.1194
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0119 0.0501 0.0142
Trichomonas vaginalis AGC family protein kinase 0.0207 0.1515 1
Loa Loa (eye worm) AUR protein kinase 0.0207 0.1515 0.1235
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0119 0.0501 0.0142
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0364 0.2403
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0119 0.0501 0.0234
Trichomonas vaginalis cyclins, putative 0.0124 0.0564 0.372
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0207 0.1515 0.197
Trichomonas vaginalis CMGC family protein kinase 0.0119 0.0501 0.3307
Trypanosoma cruzi cyclin, putative 0.0124 0.0564 0.0342
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0107 0.0364 0.0047
Leishmania major protein kinase, putative 0.0207 0.1515 0.197
Brugia malayi serine/threonine-protein kinase 6 0.0207 0.1515 0.1194
Entamoeba histolytica protein kinase, putative 0.0207 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0837 0.0535
Schistosoma mansoni cyclin B3 0.0199 0.1423 0.1099
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.2699 0.2423
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0501 0.0188
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0119 0.0501 0.0234
Brugia malayi Dihydrofolate reductase 0.0941 1 1
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0207 0.1515 0.1194
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0613 0.6207 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0107 0.0364 0.0047
Plasmodium falciparum serine/threonine protein kinase, putative 0.0207 0.1515 0.197
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0941 1 0.5
Echinococcus granulosus cyclin B 0.0124 0.0564 0.0207
Giardia lamblia Aurora kinase 0.0207 0.1515 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0837 0.0535
Schistosoma mansoni serine/threonine protein kinase 0.0207 0.1515 0.1194
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0199 0.1423 0.1099
Loa Loa (eye worm) cyclin domain-containing protein 0.0199 0.1423 0.114
Echinococcus multilocularis protein kinase shaggy 0.0119 0.0501 0.0142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0119 0.0501 0.0188
Schistosoma mansoni dihydrofolate reductase 0.0941 1 1
Echinococcus granulosus aurora kinase A 0.0207 0.1515 0.1194
Brugia malayi Cyclin, N-terminal domain containing protein 0.0124 0.0564 0.0207
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0613 0.6207 1
Trichomonas vaginalis cyclin B, putative 0.0124 0.0564 0.372
Echinococcus multilocularis dihydrofolate reductase 0.0941 1 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0613 0.6207 1
Entamoeba histolytica protein kinase domain containing protein 0.0119 0.0501 0.119
Trypanosoma brucei aurora B kinase 0.0207 0.1515 0.197
Entamoeba histolytica protein kinase, putative 0.0119 0.0501 0.119
Trichomonas vaginalis cyclins, putative 0.0124 0.0564 0.372
Plasmodium falciparum glycogen synthase kinase 3 0.0119 0.0501 0.0234
Entamoeba histolytica cyclin, putative 0.0124 0.0564 0.1734
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0207 0.1515 1
Brugia malayi intracellular kinase 0.0119 0.0501 0.0142
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.2699 0.2423
Trichomonas vaginalis AGC family protein kinase 0.0207 0.1515 1
Entamoeba histolytica protein kinase, putative 0.0207 0.1515 1
Leishmania major cyclin 0.0124 0.0564 0.0342
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0364 0.2403
Trypanosoma cruzi aurora B kinase, putative 0.0207 0.1515 0.197
Chlamydia trachomatis dihydrofolate reductase 0.0941 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0309 0.2699 0.2458
Brugia malayi serine/threonine kinase 12 0.0207 0.1515 0.1194
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0613 0.6207 1
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0207 0.1515 1
Entamoeba histolytica protein kinase , putative 0.0207 0.1515 1
Echinococcus multilocularis aurora kinase A 0.0207 0.1515 0.1194
Loa Loa (eye worm) hypothetical protein 0.0124 0.0564 0.0253
Giardia lamblia G2/mitotic-specific cyclin B 0.0124 0.0564 0.1734
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0124 0.0564 0.0342
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0199 0.1423 0.1099
Trichomonas vaginalis cyclin B, putative 0.0124 0.0564 0.372
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.2699 0.2423
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0613 0.6207 1
Loa Loa (eye worm) AUR protein kinase 0.0207 0.1515 0.1235
Trichomonas vaginalis CMGC family protein kinase 0.0107 0.0364 0.2403
Trichomonas vaginalis AGC family protein kinase 0.0207 0.1515 1
Trypanosoma brucei mitotic cyclin 6 0.0124 0.0564 0.0342
Trypanosoma cruzi cyclin 6, putative 0.0124 0.0564 0.0342
Trichomonas vaginalis cyclin A, putative 0.0124 0.0564 0.372
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0941 1 0.5
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0941 1 0.5
Trichomonas vaginalis cyclin B, putative 0.0124 0.0564 0.372
Onchocerca volvulus 0.0124 0.0564 1
Giardia lamblia Kinase, CMGC GSK 0.0119 0.0501 0.119
Plasmodium vivax glycogen synthase kinase 3, putative 0.0119 0.0501 0.0234
Brugia malayi hypothetical protein 0.0148 0.0837 0.0491
Brugia malayi serine/threonine protein kinase 6 0.0207 0.1515 0.1194
Echinococcus multilocularis cyclin B 0.0124 0.0564 0.0207

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.2 uM Inhibitory activity against GSK-3alpha/beta from porcine brain ChEMBL. 14761195
IC50 (binding) = 0.2 uM Inhibitory activity against GSK-3alpha/beta from porcine brain ChEMBL. 14761195
IC50 (binding) = 0.7 uM Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a ChEMBL. 14761195
IC50 (binding) = 0.7 uM Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a ChEMBL. 14761195
IC50 (binding) = 1.2 uM Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes ChEMBL. 14761195
IC50 (binding) = 1.2 uM Inhibitory activity against cyclin dependent kinase 1-cyclinB from starfish (Marthasterias glacialis) oocytes ChEMBL. 14761195
ID50 (functional) = 0.21 uM Antimicrobial activity against Toxoplasma gondii ChEMBL. 18824607

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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