Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.3574 | 0.6035 |
Schistosoma mansoni | immunophilin | 0.0115 | 0.4796 | 0.8097 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0115 | 0.4796 | 0.4416 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.5922 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0115 | 0.4796 | 0.8097 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0115 | 0.4796 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0115 | 0.4796 | 0.8097 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0115 | 0.4796 | 0.5 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0115 | 0.4796 | 0.4416 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0115 | 0.4796 | 0.8097 |
Loa Loa (eye worm) | FKBP5 protein | 0.0115 | 0.4796 | 0.8097 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0115 | 0.4796 | 0.8097 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0115 | 0.4796 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0115 | 0.4796 | 0.8097 |
Trichomonas vaginalis | immunophilin, putative | 0.0115 | 0.4796 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0115 | 0.4796 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0115 | 0.4796 | 0.4416 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0053 | 0 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0115 | 0.4796 | 0.8097 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0115 | 0.4796 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0099 | 0.3574 | 0.6035 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0115 | 0.4796 | 1 |
Schistosoma mansoni | immunophilin | 0.0115 | 0.4796 | 0.8097 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.5922 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0115 | 0.4796 | 0.4416 |
Brugia malayi | thymidylate synthase | 0.013 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.5922 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0115 | 0.4796 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0099 | 0.3574 | 0.6035 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0115 | 0.4796 | 0.8097 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0115 | 0.4796 | 0.8097 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0115 | 0.4796 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0099 | 0.3574 | 0.6035 |
Onchocerca volvulus | 0.013 | 0.5922 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.5922 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0115 | 0.4796 | 0.8097 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.5922 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0062 | 0.068 | 0.1148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.