Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Antidepressant activity measured by potentiation of head twitching induced by 5-HTP in pargyline-pretreated rats after intraperitoneal administered;ND = No Data | ChEMBL. | 6602886 |
ED50 (functional) | = 4 mg kg-1 | Antidepressant activity by tetrabenazine ptosis prevention in mice after intraperitoneal administration | ChEMBL. | 6602886 |
ED50 (functional) | = 7.8 mg kg-1 | Potentiation of head twitching induced by 5-HTP in pargyline-pretreated rats following i.p. administration. | ChEMBL. | 6602886 |
ED50 (functional) | > 20 mg kg-1 | Inhibition of tetrabenazine ptosis in mice following i.p. administration. | ChEMBL. | 6602886 |
ED50 (functional) | > 20 mg kg-1 | Inhibition of tetrabenazine ptosis in mice following i.p. administration. | ChEMBL. | 6602886 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.