TDR Targets

Basic information

Technical information

TDR Targets ID: 307042
Name: 10-(2-amino-6-oxo-3H-purin-9-yl)decylphosphon ic acid
MW: 371.372 | Formula: C15H26N5O4P
H donors: 4 H acceptors: 7 LogP: 1.39 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(O)c2c(n1)n(CCCCCCCCCCP(=O)(O)O)cn2
InChi: 1S/C15H26N5O4P/c16-15-18-13-12(14(21)19-15)17-11-20(13)9-7-5-3-1-2-4-6-8-10-25(22,23)24/h11H,1-10H2,(H2,22,23,24)(H3,16,18,19,21)
InChiKey: USQGLMQRKBGWGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

10-(2-azanyl-6-oxo-3H-purin-9-yl)decylphosphonic acid
10-(2-amino-6-keto-3H-purin-9-yl)decylphosphonic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purine nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	purine nucleoside phosphorylase	289 aa	255 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0153	0.5739	0.9969
Echinococcus granulosus	G protein coupled receptor 139	0.0153	0.5739	0.9969
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0153	0.5739	0.9969
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0153	0.5739	1
Brugia malayi	G-protein coupled receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0111	0.3624	0.6295
Onchocerca volvulus		0.0153	0.5739	0.9969
Echinococcus granulosus	neuropeptide receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0111	0.3624	0.6295
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	fmrfamide receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus granulosus	g protein coupled receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.5739	0.9969
Schistosoma mansoni	amine GPCR	0.0153	0.5739	0.5739
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0153	0.5739	0.9969
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Schistosoma mansoni	myosin xvIII	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0153	0.5739	0.5739
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0153	0.5739	0.5739
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.5739	0.5739
Echinococcus multilocularis	neuropeptide receptor A26	0.0153	0.5739	0.9969
Echinococcus granulosus	allatostatin A receptor	0.0153	0.5739	0.9969
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	neuropeptide receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	orexin receptor type 2	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	ORL1-like opioid receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.5739	0.5739
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.5739	0.9969
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0111	0.3624	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Onchocerca volvulus		0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	hypothetical protein	0.0153	0.5739	0.5739
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0154	0.5757	1
Echinococcus granulosus	neuropeptides capa receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	TYRA-2 protein	0.0153	0.5739	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.5739	0.9969
Schistosoma mansoni	neuropeptide receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	sulfakinin receptor protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0154	0.5757	1
Schistosoma mansoni	opsin-like receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0153	0.5739	0.9969
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Brugia malayi	G protein-coupled receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Brugia malayi	neuropeptide F receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4182	0.7265
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0153	0.5739	0.5739
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	0.3624	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0153	0.5739	0.9969
Echinococcus multilocularis	sex peptide receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Schistosoma mansoni	biogenic amine receptor	0.0153	0.5739	0.5739
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0154	0.5757	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Echinococcus granulosus	7tm_1 domain containing protein	0.0153	0.5739	0.9969
Echinococcus granulosus	neuropeptide receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	fmrfamide receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	neuropeptides capa receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus granulosus	serotonin receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	hypothetical protein	0.0153	0.5739	0.5739
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Leishmania major	xanthine phosphoribosyltransferase	0.0111	0.3624	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.5739	0.5739
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0153	0.5739	0.5739
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0153	0.5739	0.9969
Brugia malayi	larval opioid receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus granulosus	neuropeptide s receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	G protein coupled receptor 139	0.0153	0.5739	0.9969
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	orexin receptor type 2	0.0153	0.5739	0.9969
Brugia malayi	Dopamine receptor protein 1	0.0153	0.5739	0.9969
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.5739	0.9969
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0153	0.5739	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0111	0.3624	0.6295
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0111	0.3624	0.6295
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0154	0.5757	1
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	dro:myosuppressin receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0111	0.3624	0.6295
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Brugia malayi	neuropeptide F receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	amine GPCR	0.0153	0.5739	0.5739
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0153	0.5739	0.5739
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0153	0.5739	0.9969
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0154	0.5757	1
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0111	0.3624	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	neuropeptide receptor	0.0153	0.5739	0.5739
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0153	0.5739	0.9969
Echinococcus granulosus	g protein coupled receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	biogenic amine receptor	0.0153	0.5739	0.5739
Onchocerca volvulus		0.0153	0.5739	0.9969
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	Melatonin receptor type 1A	0.0153	0.5739	0.9969
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0153	0.5739	0.5739
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	hypothetical protein	0.0153	0.5739	0.5739
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	neuropeptides capa receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	g protein coupled receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Echinococcus granulosus	neuropeptide Y receptor	0.0153	0.5739	0.9969
Brugia malayi	G protein-coupled receptor F59B2.13	0.0153	0.5739	0.9969
Trypanosoma brucei	RNA helicase, putative	0.024	1	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0153	0.5739	0.9969
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0111	0.3624	0.6295
Echinococcus granulosus	neuropeptide FF receptor 2	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Brugia malayi	AKH receptor	0.0153	0.5739	0.9969
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0111	0.3624	0.5
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4182	0.7265
Echinococcus granulosus	hypothetical protein	0.0153	0.5739	0.9969
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0111	0.3624	0.5
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.5757	0.5757
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	somatostatin receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0153	0.5739	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Echinococcus multilocularis	neuropeptides capa receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	amine GPCR	0.0153	0.5739	0.5739
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	0.3624	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0153	0.5739	0.9969
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0153	0.5739	0.9969
Echinococcus multilocularis	neuropeptide s receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	follicle stimulating hormone receptor	0.0153	0.5739	0.9969
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0154	0.5757	1
Brugia malayi	putative neuropeptide receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0153	0.5739	0.5739
Echinococcus granulosus	tm gpcr rhodopsin	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0153	0.5739	0.5739
Schistosoma mansoni	amine GPCR	0.0153	0.5739	0.5739
Echinococcus multilocularis	fmrfamide receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0153	0.5739	0.5739
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Brugia malayi	Serotonin receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	biogenic amine receptor	0.0153	0.5739	0.5739
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0111	0.3624	0.3624
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0153	0.5739	0.5739
Brugia malayi	RE15519p	0.0153	0.5739	0.9969
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	0.3624	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0153	0.5739	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0153	0.5739	0.9969
Echinococcus granulosus	g-protein coupled receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	allatostatin A receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	neuropeptide receptor A26	0.0153	0.5739	0.9969
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0153	0.5739	0.5739
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0153	0.5739	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0153	0.5739	1
Echinococcus multilocularis	serotonin receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Echinococcus granulosus	biogenic amine 5HT receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	adenoreceptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0122	0.4182	0.7288
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0153	0.5739	0.9969
Echinococcus multilocularis	neuropeptide Y receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	g-protein coupled receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	opsin-like receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0153	0.5739	0.5739
Onchocerca volvulus		0.0153	0.5739	0.9969
Brugia malayi	G-protein coupled receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	dro:myosuppressin receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	neuropeptide receptor	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	0.3624	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Loa Loa (eye worm)	G-protein coupled receptor	0.0153	0.5739	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0153	0.5739	0.9969
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Loa Loa (eye worm)	neuropeptide F receptor	0.0153	0.5739	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Schistosoma mansoni	neuropeptide receptor	0.0153	0.5739	0.5739
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0122	0.4182	0.7265
Brugia malayi	Serotonin receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	opsin-like receptor	0.0153	0.5739	0.5739
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0153	0.5739	0.5739
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0153	0.5739	0.9969
Echinococcus granulosus	sex peptide receptor	0.0153	0.5739	0.9969
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Brugia malayi	hypothetical protein	0.0153	0.5739	0.9969
Onchocerca volvulus		0.0153	0.5739	0.9969
Schistosoma mansoni	neuropeptide f receptor 76f	0.0153	0.5739	0.5739
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0153	0.5739	0.9969
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0153	0.5739	0.9969
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	g protein coupled receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	amine GPCR	0.0153	0.5739	0.5739
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0111	0.3624	0.5
Brugia malayi	GnHR receptor homolog	0.0153	0.5739	0.9969
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.5757	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	hypothetical protein	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.5757	0.5757
Echinococcus granulosus	rhodopsin orphan GPCR	0.0153	0.5739	0.9969
Brugia malayi	Dopamine receptor protein 2	0.0153	0.5739	0.9969
Schistosoma mansoni	neuropeptide receptor	0.0153	0.5739	0.5739
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0153	0.5739	0.9969
Echinococcus granulosus	somatostatin receptor	0.0153	0.5739	0.9969
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Echinococcus multilocularis	serotonin receptor	0.0153	0.5739	0.9969
Brugia malayi	Dopamine receptor	0.0153	0.5739	0.9969
Loa Loa (eye worm)	hypothetical protein	0.0153	0.5739	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0153	0.5739	0.5739
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0153	0.5739	1
Schistosoma mansoni	histamine h1 receptor	0.0153	0.5739	0.5739
Brugia malayi	putative neuropeptide receptor NPR1	0.0153	0.5739	0.9969

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.6 uM	In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.	ChEMBL.	8632418
Ki (binding)	= 1.6 uM	In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.	ChEMBL.	8632418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10690588

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 307042