TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 194.187 | Formula: C9H10N2O3
H donors: 1 H acceptors: 3 LogP: -0.59 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)/C=C/n1cc(C)c(=O)[nH]c1=O
InChi: 1S/C9H10N2O3/c1-6-5-11(4-3-7(2)12)9(14)10-8(6)13/h3-5H,1-2H3,(H,10,13,14)/b4-3+
InChiKey: KRGOZWZPQZMGPU-ONEGZZNKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.0909	0.0916
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Schistosoma mansoni	gliotactin	0.0092	0.0909	0.0916
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0324	0.3567
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0092	0.0909	0.0916
Schistosoma mansoni	serine/threonine protein kinase	0.0502	0.7603	0.7664
Brugia malayi	Protein kinase domain containing protein	0.0116	0.1309	0.1319
Loa Loa (eye worm)	carboxylesterase	0.0092	0.0909	0.0909
Entamoeba histolytica	hypothetical protein	0.0111	0.123	0.1617
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Echinococcus granulosus	cyclin dependent kinase 9	0.0116	0.1309	0.1319
Brugia malayi	cyclin-dependent kinase 7 homolog	0.0116	0.1309	0.1319
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Loa Loa (eye worm)	cuticular endochitinase	0.0081	0.0729	0.0729
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Brugia malayi	hypothetical protein	0.0119	0.1358	0.1368
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	acetylcholinesterase	0.0542	0.826	0.8326
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Echinococcus multilocularis	cyclin dependent kinase 9	0.0116	0.1309	0.1319
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0	0.5
Schistosoma mansoni	protein kinase	0.0116	0.1309	0.1319
Brugia malayi	Carboxylesterase family protein	0.0092	0.0909	0.0916
Trypanosoma brucei	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0502	0.7603	1
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Entamoeba histolytica	hypothetical protein	0.0097	0.1003	0.1319
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Loa Loa (eye worm)	microfilarial chitinase	0.0078	0.0694	0.0694
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Entamoeba histolytica	protein kinase domain containing protein	0.0116	0.1309	0.1721
Onchocerca volvulus		0.0092	0.0909	0.233
Echinococcus granulosus	Hepatocellular carcinoma associated antigen 59	0.0128	0.1501	0.1513
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus granulosus	serine:threonine protein kinase NLK	0.0116	0.1309	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0542	0.826	0.826
Echinococcus granulosus	dual specificity	0.0502	0.7603	0.7664
Schistosoma mansoni	serine/threonine kinase	0.0116	0.1309	0.1319
Echinococcus granulosus	mitogen activated protein kinase 15	0.0116	0.1309	0.1319
Loa Loa (eye worm)	haspin protein kinase	0.0644	0.9921	0.9921
Onchocerca volvulus		0.0092	0.0909	0.233
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0092	0.0909	0.1195
Trichomonas vaginalis	CMGC family protein kinase	0.0116	0.1309	0.1721
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0097	0.1003	0.1319
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0542	0.826	0.8326
Echinococcus granulosus	dual specificity	0.0502	0.7603	0.7664
Echinococcus granulosus	acetylcholinesterase	0.0542	0.826	0.8326
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0097	0.1003	0.1319
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.0263	0.0263
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.0909	0.0916
Echinococcus granulosus	dual specificity	0.0502	0.7603	0.7664
Entamoeba histolytica	cell division protein kinase 2, putative	0.0116	0.1309	0.1721
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0092	0.0909	1
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0324	0.0327
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0644	0.9921	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1501	0.1501
Onchocerca volvulus		0.0092	0.0909	0.233
Plasmodium vivax	hypothetical protein, conserved	0.0128	0.1501	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0535	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0542	0.826	0.826
Entamoeba histolytica	protein kinase, putative	0.0097	0.1003	0.1319
Brugia malayi	hypothetical protein	0.0092	0.0909	0.0916
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0092	0.0909	1
Echinococcus multilocularis	Cell division cycle 2 protein kinase	0.0116	0.1309	0.1319
Echinococcus granulosus	Cell division cycle 2 protein kinase	0.0116	0.1309	0.1319
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Brugia malayi	Carboxylesterase family protein	0.0092	0.0909	0.0916
Brugia malayi	Protein kinase domain containing protein	0.0097	0.1003	0.1011
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0924	0.0924
Onchocerca volvulus		0.0092	0.0909	0.233
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Mycobacterium ulcerans	chitinase/cellulase	0.0069	0.0535	0.5888
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Brugia malayi	Carboxylesterase family protein	0.0542	0.826	0.8326
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0097	0.1003	0.1319
Echinococcus multilocularis	dual specificity	0.0502	0.7603	0.7664
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Brugia malayi	Cell division protein kinase 2	0.0116	0.1309	0.1319
Loa Loa (eye worm)	carboxylesterase	0.0542	0.826	0.826
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Brugia malayi	hypothetical protein	0.0644	0.9921	1
Onchocerca volvulus	Putative endochitinase	0.009	0.0887	0.2052
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.0324	0.0327
Entamoeba histolytica	protein kinase domain containing protein	0.0502	0.7603	1
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0116	0.1309	0.1721
Trichomonas vaginalis	protein kinase atmrk1, putative	0.0116	0.1309	0.1721
Echinococcus multilocularis	hypothetical protein	0.0111	0.123	0.1239
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Trypanosoma brucei	protein kinase, putative	0.0116	0.1309	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1358	0.1358
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0092	0.0909	0.0916
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0092	0.0909	0.0916
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0092	0.0909	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0092	0.0909	0.0916
Echinococcus granulosus	acetylcholinesterase	0.0542	0.826	0.8326
Brugia malayi	Carboxylesterase family protein	0.0092	0.0909	0.0916
Leishmania major	protein kinase, putative,dual-specificity protein kinase, putative	0.0502	0.7603	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0092	0.0909	0.0916
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus granulosus	dual specificity	0.0097	0.1003	0.1011
Echinococcus multilocularis	neuroligin	0.0092	0.0909	0.0916
Brugia malayi	GSG2	0.0644	0.9921	1
Trichomonas vaginalis	CMGC family protein kinase	0.0116	0.1309	0.1721
Echinococcus granulosus	BC026374 protein S09 family	0.0092	0.0909	0.0916
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Plasmodium falciparum	conserved protein, unknown function	0.0128	0.1501	1
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	dual specificity	0.0502	0.7603	0.7664
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trypanosoma cruzi	dual specificity tyrosine-phosphorylation-regulated kinase 2, putative	0.0502	0.7603	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.0324	0.0327
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	dual specificity	0.0502	0.7603	0.7664
Schistosoma mansoni	hypothetical protein	0.0644	0.9921	1
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0644	0.9921	1
Mycobacterium tuberculosis	Possible chitinase	0.0069	0.0535	0.3608
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Loa Loa (eye worm)	carboxylesterase	0.0092	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1501	0.1501
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0644	0.9921	1
Echinococcus multilocularis	serine:threonine protein kinase NLK	0.0116	0.1309	0.1319
Entamoeba histolytica	protein kinase, putative	0.0502	0.7603	1
Schistosoma mansoni	serine/threonine protein kinase	0.0116	0.1309	0.1319
Schistosoma mansoni	serine/threonine protein kinase	0.0097	0.1003	0.1011
Entamoeba histolytica	protein kinase domain containing protein	0.0097	0.1003	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Mycobacterium ulcerans	carboxylesterase, LipT	0.0092	0.0909	1
Schistosoma mansoni	hypothetical protein	0.0111	0.123	0.1239
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.0324	0.0327
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trypanosoma cruzi	Mitogen-activated protein kinase 10, putative	0.0116	0.1309	0.1721
Echinococcus granulosus	neuroligin	0.0092	0.0909	0.0916
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Brugia malayi	endochitinase	0.0081	0.0729	0.0734
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Brugia malayi	Carboxylesterase family protein	0.0092	0.0909	0.0916
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0092	0.0909	0.0916
Leishmania major	serine/threonine kinase-like protein, putative	0.0116	0.1309	0.1721
Trichomonas vaginalis	CMGC family protein kinase	0.0116	0.1309	0.1721
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.0324	0.3567
Giardia lamblia	Kinase, CMGC DYRK	0.0502	0.7603	1
Trichomonas vaginalis	G protein-coupled receptor kinase, putative	0.0116	0.1309	0.1721
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	CMGC family protein kinase	0.0502	0.7603	1
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus multilocularis	Hepatocellular carcinoma associated antigen 59	0.0128	0.1501	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Schistosoma mansoni	BC026374 protein (S09 family)	0.0092	0.0909	0.0916
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1358	0.8143
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0097	0.1003	0.1003
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Trichomonas vaginalis	serine/threonine kinase, putative	0.0116	0.1309	0.1721
Echinococcus multilocularis	serine:threonine protein kinase haspin	0.0644	0.9921	1
Echinococcus granulosus	carboxylesterase 5A	0.0542	0.826	0.8326
Brugia malayi	Hepatocellular carcinoma-associated antigen 59 family protein	0.0128	0.1501	0.1513
Echinococcus multilocularis	dual specificity	0.0097	0.1003	0.1011
Onchocerca volvulus		0.0128	0.1501	1
Onchocerca volvulus	Putative endochitinase	0.009	0.0887	0.2052
Loa Loa (eye worm)	AGC/PDK1 protein kinase	0.0116	0.1309	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0924	0.0924
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1358	0.8143
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.0324	0.0426
Echinococcus granulosus	serine:threonine protein kinase haspin	0.0644	0.9921	1
Brugia malayi	endochitinase	0.009	0.0887	0.0894
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Brugia malayi	Carboxylesterase family protein	0.0542	0.826	0.8326
Schistosoma mansoni	acetylcholinesterase	0.0092	0.0909	0.0916
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Echinococcus granulosus	Pfam-B_8186 domain containing protein	0.0111	0.123	0.1239
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Onchocerca volvulus		0.0128	0.1501	1
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Onchocerca volvulus	Putative endochitinase	0.009	0.0887	0.2052
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Loa Loa (eye worm)	CMGC/CDK/CRK7 protein kinase	0.0116	0.1309	0.1309
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Loa Loa (eye worm)	chitinase I	0.0081	0.0729	0.0729
Echinococcus multilocularis	acetylcholinesterase	0.0542	0.826	0.8326
Trichomonas vaginalis	spcc417.12 protein, putative	0.0092	0.0909	0.1195
Brugia malayi	Dual-specificity tyrosine-phosphorylation regulated kinase 2	0.0502	0.7603	0.7664
Toxoplasma gondii	cell-cycle-associated protein kinase DYRK2, putative	0.0502	0.7603	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0092	0.0909	0.0916
Schistosoma mansoni	hypothetical protein	0.0128	0.1501	0.1513
Leishmania major	mitogen-activated protein kinase, putative,map kinase-like protein	0.0116	0.1309	0.1721
Entamoeba histolytica	chitinase, putative	0.0081	0.0729	0.0958
Brugia malayi	Endochitinase	0.009	0.0887	0.0894
Mycobacterium ulcerans	chitinase/cellulase	0.0069	0.0535	0.5888
Toxoplasma gondii	hypothetical protein	0.0128	0.1501	0.1974
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0097	0.1003	0.1319
Trypanosoma brucei	Mitogen-activated protein kinase 10, putative	0.0116	0.1309	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0909	0.0909
Loa Loa (eye worm)	acetylcholinesterase 1	0.0542	0.826	0.826
Entamoeba histolytica	protein kinase, putative	0.0097	0.1003	0.1319
Trichomonas vaginalis	CMGC family protein kinase	0.0116	0.1309	0.1721
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0116	0.1309	0.1721
Echinococcus multilocularis	carboxylesterase 5A	0.0542	0.826	0.8326
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Onchocerca volvulus		0.0092	0.0909	0.233
Loa Loa (eye worm)	haspin protein kinase	0.0644	0.9921	0.9921
Trichomonas vaginalis	CAMK family protein kinase	0.0116	0.1309	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1358	0.1358
Loa Loa (eye worm)	CMGC/DYRK/DYRK2 protein kinase	0.0502	0.7603	0.7603
Leishmania major	chitinase	0.0081	0.0729	0.0958
Trichomonas vaginalis	AGC family protein kinase	0.0116	0.1309	0.1721

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA	ChEMBL.	6205151
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA	ChEMBL.	6205151
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein	ChEMBL.	6205151
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA	ChEMBL.	6205151
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA	ChEMBL.	6205151
IC50 (functional)	> 100 uM	Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein	ChEMBL.	6205151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 307222