Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0211667 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0073349 | 0 | 0.5 |
Plasmodium falciparum | thioredoxin reductase | 0.0211667 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0211667 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0211667 | 1 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0211667 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0073349 | 0 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0073349 | 0 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0073349 | 0 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0211667 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0073349 | 0 | 0.5 |
Brugia malayi | glutathione reductase | 0.0211667 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0211667 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0211667 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0211667 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0211667 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0073349 | 0 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0211667 | 1 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0073349 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073349 | 0 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0211667 | 1 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0073349 | 0 | 0.5 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0073349 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0073349 | 0 | 0.5 |
Leishmania major | trypanothione reductase | 0.0211667 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0211667 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.34 uM | Antitrypanosomial activity against Trypanosoma cruzi epimastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 0.34 uM | Antitrypanosomial activity against Trypanosoma cruzi epimastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 0.39 uM | Antitrypanosomial activity against Trypanosoma cruzi amastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 0.39 uM | Antitrypanosomial activity against Trypanosoma cruzi amastigotes | ChEMBL. | 11300877 |
IC50 (functional) | = 0.48 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 0.48 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 6.8 uM | In vitro cytotoxicity against L6 cells | ChEMBL. | 11300877 |
IC50 (functional) | = 50 uM | Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) | ChEMBL. | 11300877 |
IC50 (functional) | = 50 uM | Antitrypanosomial activity against (T. cruzi) trypomastigotes (concentration of compound tested on trypomastigote motility) | ChEMBL. | 11300877 |
IS (functional) | = 14.4 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
IS (functional) | = 14.4 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
IS (functional) | = 17.4 | Index of selectivity was determined in T. cruzi | ChEMBL. | 11300877 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11300877 | |
Trypanosoma cruzi | ChEMBL23 | 11300877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.