Detailed information for compound 307443

Basic information

Technical information
  • TDR Targets ID: 307443
  • Name: (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3 -hydroxyphenyl)methyl]oxolan-2-one
  • MW: 342.386 | Formula: C20H22O5
  • H donors: 1 H acceptors: 2 LogP: 3.62 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C[C@H]1COC(=O)[C@@H]1Cc1cccc(c1)O
  • InChi: 1S/C20H22O5/c1-23-18-7-6-14(11-19(18)24-2)8-15-12-25-20(22)17(15)10-13-4-3-5-16(21)9-13/h3-7,9,11,15,17,21H,8,10,12H2,1-2H3/t15-,17+/m0/s1
  • InChiKey: QMFLBQHSWVZOFI-DOTOQJQBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-hydroxyphenyl)methyl]tetrahydrofuran-2-one
  • (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(3-hydroxyphenyl)methyl]-2-tetrahydrofuranone
  • (3R,4R)-3-(3-hydroxybenzyl)-4-veratryl-tetrahydrofuran-2-one
  • (3R,4R)-4-(3,4-dimethoxybenzyl)-3-(3-hydroxybenzyl)tetrahydrofuran-2-one
  • 3-(3"",4""-Dimethoxybenzyl)-4-hydroxy-2-(3'-hydroxybenzyl)butyric acid, .gamma.-lactone
  • AIDS-028460
  • AIDS028460

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0017 0.0062
Brugia malayi Cytochrome P450 family protein 0.0023 0.001 0.0037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0169 0.0637
Brugia malayi G protein-coupled receptor F59B2.13 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0161
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Schistosoma mansoni alpha-1 adrenergic receptor 0.004 0.0048 0.0144
Schistosoma mansoni ap endonuclease 0.002 0.0001 0.0003
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0228 0.0228
Loa Loa (eye worm) nuclear receptor nhr-7B 0.003 0.0025 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0102 0.0387
Trypanosoma brucei Carboxypeptidase-like protein 0.0043 0.0054 0.02
Loa Loa (eye worm) hypothetical protein 0.0119 0.0228 0.0861
Loa Loa (eye worm) melatonin receptor type 1A 0.004 0.0048 0.018
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.009 0.0162 0.0613
Schistosoma mansoni smad1 5 8 and 0.0043 0.0054 0.0163
Echinococcus granulosus transcription factor eb 0.0112 0.0212 0.0639
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.004 0.0048 0.018
Echinococcus multilocularis dro:myosuppressin receptor 0.004 0.0048 0.0048
Trypanosoma cruzi histone deacetylase, putative 0.0038 0.0042 0.0157
Plasmodium vivax acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0036 0.0134
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.0295 0.1111
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0064 0.0102 0.0309
Leishmania major importin beta-1 subunit, putative 0.0023 0.0009 0.003
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0167
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0137
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0048 0.0144
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.004 0.0048 0.0144
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0075 0.0279
Leishmania major hypothetical protein, conserved 0.0035 0.0036 0.0134
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0048 0.0144
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0009 0.003
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0073 0.0219
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.01 0.0376
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0051 0.0154
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0665
Echinococcus granulosus neuropeptide receptor A26 0.004 0.0048 0.0144
Plasmodium vivax heat shock protein 86, putative 0.0065 0.0105 0.0394
Plasmodium falciparum histone deacetylase, putative 0.0125 0.0242 0.0913
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0138 0.0517
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0038 0.0043 0.0158
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0087 0.0326
Schistosoma mansoni hypothetical protein 0.1414 0.3182 0.9588
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0609 0.1346 0.509
Brugia malayi MH1 domain containing protein 0.0043 0.0054 0.0204
Schistosoma mansoni hypothetical protein 0.0043 0.0054 0.0162
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0036 0.0134
Trichomonas vaginalis adenosylhomocysteinase, putative 0.037 0.08 0.3023
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0021 0.0076
Trypanosoma cruzi histone deacetylase, putative 0.0038 0.0042 0.0157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0165 0.0498
Trypanosoma cruzi Carboxypeptidase-like protein 0.0043 0.0054 0.02
Trypanosoma cruzi DNA polymerase eta, putative 0.0057 0.0087 0.0326
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0075 0.0279
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus histone deacetylase 6 0.0125 0.0242 0.073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Loa Loa (eye worm) zinc carboxypeptidase 0.0043 0.0054 0.0204
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0054 0.0163
Schistosoma mansoni histone deacetylase 0.0132 0.0258 0.0776
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0107 0.0107
Echinococcus granulosus dna polymerase eta 0.0057 0.0087 0.0262
Trypanosoma brucei histone deacetylase 4 0.0125 0.0242 0.0913
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.1178 0.2644 1
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0102 0.0309
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus 7TM GPCR rhodopsin 0.004 0.0048 0.0144
Schistosoma mansoni peptide (allatostatin)-like receptor 0.004 0.0048 0.0144
Echinococcus granulosus g protein coupled receptor 0.004 0.0048 0.0144
Toxoplasma gondii propionate-CoA ligase 0.0038 0.0043 0.0158
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.003 0.0025 0.0025
Brugia malayi isocitrate dehydrogenase 0.0066 0.0107 0.0403
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Plasmodium vivax histone deacetylase, putative 0.0038 0.0042 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0102 0.0387
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.004 0.0048 0.0048
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0038 0.0043 0.0158
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0206 0.0426 0.1608
Plasmodium falciparum histone deacetylase 1 0.0132 0.0258 0.0971
Echinococcus multilocularis G protein coupled receptor 139 0.004 0.0048 0.0048
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0048 0.0048
Onchocerca volvulus 0.0038 0.0043 0.0452
Loa Loa (eye worm) hypothetical protein 0.0062 0.0099 0.0374
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0038 0.0043 0.0158
Trypanosoma brucei histone deacetylase 2 0.0038 0.0042 0.0157
Echinococcus granulosus somatostatin receptor 0.004 0.0048 0.0144
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Echinococcus granulosus dnaJ subfamily B 0.0439 0.0957 0.2884
Echinococcus granulosus alpha 1A adrenergic receptor 0.004 0.0048 0.0144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0165 0.0625
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0043 0.0158
Echinococcus granulosus importin subunit beta 1 0.0028 0.0021 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.003 0.0025 0.0076
Loa Loa (eye worm) TYRA-2 protein 0.004 0.0048 0.018
Echinococcus granulosus neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus multilocularis histone deacetylase 0.0125 0.0242 0.0242
Schistosoma mansoni hypothetical protein 0.0439 0.0957 0.2884
Schistosoma mansoni hypothetical protein 0.0303 0.0647 0.1951
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0048 0.0048
Entamoeba histolytica acyl-coA synthetase, putative 0.0129 0.025 0.0942
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0138 0.0517
Onchocerca volvulus 0.0038 0.0043 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0064 0.0102 0.0387
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0119 0.0448
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Entamoeba histolytica histone deacetylase, putative 0.0132 0.0258 0.0971
Brugia malayi hypothetical protein 0.003 0.0025 0.0096
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0054 0.0163
Leishmania major DNA polymerase eta, putative 0.0057 0.0087 0.0326
Plasmodium falciparum adenosylhomocysteinase 0.1178 0.2644 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.004 0.0048 0.0144
Schistosoma mansoni opsin-like receptor 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.007 0.0116 0.0116
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0112 0.0212 0.0802
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0107 0.04
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Brugia malayi CHE-14 protein 0.0051 0.0073 0.0275
Loa Loa (eye worm) hypothetical protein 0.0088 0.0156 0.0591
Brugia malayi Importin beta-1 subunit 0.0028 0.0021 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0064 0.0102 0.0387
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0043 0.0158
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Brugia malayi nuclear receptor NHR-88 0.0064 0.0102 0.0387
Schistosoma mansoni hypothetical protein 0.0147 0.0293 0.0882
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0043 0.0158
Brugia malayi RNA binding protein 0.0202 0.0416 0.1575
Echinococcus multilocularis FTZ F1 alpha 0.0064 0.0102 0.0102
Echinococcus multilocularis histone deacetylase 8 0.0038 0.0042 0.0042
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0052 0.0075 0.0279
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0043 0.0054 0.02
Treponema pallidum heat shock protein 90 0.0052 0.0075 0.1138
Echinococcus granulosus g protein coupled receptor 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus neuropeptide FF receptor 2 0.004 0.0048 0.0144
Schistosoma mansoni cpg binding protein 0.0031 0.0027 0.008
Loa Loa (eye worm) hypothetical protein 0.0327 0.0702 0.2654
Echinococcus multilocularis histone deacetylase 6 0.0125 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0134
Echinococcus multilocularis g-protein coupled receptor 0.004 0.0048 0.0048
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Leishmania major hypothetical protein, conserved 0.0079 0.0138 0.0517
Trichomonas vaginalis endoplasmin, putative 0.004 0.0048 0.0176
Brugia malayi Serotonin receptor 0.004 0.0048 0.018
Echinococcus multilocularis transcription factor eb 0.0112 0.0212 0.0212
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0048 0.0144
Trypanosoma brucei unspecified product 0.0039 0.0047 0.0172
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Toxoplasma gondii ABC1 family protein 0.0035 0.0036 0.0134
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0129 0.025 0.0942
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.01 0.0302
Brugia malayi Histone deacetylase family protein 0.0125 0.0242 0.0916
Loa Loa (eye worm) heat shock protein 90 0.0065 0.0105 0.0397
Echinococcus multilocularis serotonin receptor 0.004 0.0048 0.0048
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus histone deacetylase 6 0.0125 0.0242 0.073
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0129 0.025 0.0942
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0036 0.0134
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0073 0.0073
Echinococcus granulosus FTZ F1 alpha 0.0064 0.0102 0.0309
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0064 0.0102 0.0102
Echinococcus multilocularis heat shock protein 0.0065 0.0105 0.0105
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.01 0.01
Brugia malayi histone deacetylase 11 0.0038 0.0042 0.016
Brugia malayi MH2 domain containing protein 0.0043 0.0054 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0047 0.0172
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0054 0.0054
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0087 0.0326
Schistosoma mansoni neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus granulosus GPCR family 2 0.01 0.0185 0.0556
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.0295 0.0991
Brugia malayi nuclear receptor RXR 0.003 0.0025 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0202 0.0416 0.1575
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0129 0.025 0.0946
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0044 0.0163
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0047 0.0172
Brugia malayi Serotonin receptor 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Trichomonas vaginalis STE family protein kinase 0.009 0.0162 0.061
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.0098 0.0295
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Schistosoma mansoni nuclear receptor nhr-48 0.003 0.0025 0.0076
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0129 0.025 0.0942
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0064 0.0102 0.0309
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Brugia malayi beta-lactamase 0.0035 0.0036 0.0137
Brugia malayi MH1 domain containing protein 0.0024 0.001 0.0039
Loa Loa (eye worm) hypothetical protein 0.01 0.0185 0.0699
Onchocerca volvulus 0.004 0.0048 0.0505
Loa Loa (eye worm) hypothetical protein 0.0024 0.001 0.0039
Brugia malayi Dihydrofolate reductase 0.0176 0.0359 0.1358
Brugia malayi RNA, U transporter 1 0.0081 0.014 0.0531
Loa Loa (eye worm) hypothetical protein 0.0038 0.0042 0.016
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0107 0.04
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0107 0.04
Schistosoma mansoni inositol transporter 0.0274 0.0581 0.175
Loa Loa (eye worm) MH2 domain-containing protein 0.0628 0.1388 0.5251
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0038 0.0043 0.0043
Brugia malayi ORL1-like opioid receptor 0.004 0.0048 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0036 0.0137
Onchocerca volvulus Cytosolic carboxypeptidase 1 homolog 0.0043 0.0054 0.0571
Echinococcus multilocularis g protein coupled receptor 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Echinococcus multilocularis neuropeptide receptor 0.004 0.0048 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0129 0.025 0.0946
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0132 0.0258 0.0971
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0129 0.025 0.0942
Trypanosoma cruzi histone deacetylase, putative 0.0125 0.0242 0.0913
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Leishmania major histone deacetylase, putative 0.0132 0.0258 0.0971
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0119 0.0448
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0034 0.0127
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni adenosylhomocysteinase 0.0729 0.162 0.4879
Brugia malayi beta-lactamase family protein 0.0035 0.0036 0.0137
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Schistosoma mansoni importin beta-1 0.0028 0.0021 0.0064
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0048 0.0144
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0043 0.0158
Plasmodium vivax histone deacetylase 1, putative 0.0132 0.0258 0.0971
Schistosoma mansoni hypothetical protein 0.0036 0.0038 0.0114
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0027 0.0101
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0027 0.0017 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0164 0.0616
Schistosoma mansoni growth hormone secretagogue receptor 0.004 0.0048 0.0144
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0119 0.0119
Entamoeba histolytica hypothetical protein 0.0023 0.0009 0.003
Onchocerca volvulus 0.0249 0.0525 0.5558
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0416 0.1255
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0102 0.0309
Toxoplasma gondii heat shock protein HSP90 0.0065 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.0098 0.0367
Brugia malayi histone deacetylase 3 (HD3) 0.0132 0.0258 0.0975
Brugia malayi AMP-binding enzyme family protein 0.0129 0.025 0.0946
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0064 0.0102 0.0387
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0034 0.0101
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0098 0.0367
Brugia malayi photoreceptor-specific nuclear receptor 0.0064 0.0102 0.0387
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.004 0.0048 0.0048
Onchocerca volvulus 0.0035 0.0036 0.0385
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0609 0.1346 0.509
Leishmania major histone deacetylase, putative 0.0132 0.0258 0.0971
Schistosoma mansoni hypothetical protein 0.01 0.0185 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Trypanosoma cruzi Heat shock protein 83, putative 0.0065 0.0105 0.0394
Schistosoma mansoni hypothetical protein 0.1414 0.3182 0.9588
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Plasmodium vivax glutathione reductase, putative 0.0041 0.005 0.0185
Brugia malayi hypothetical protein 0.0039 0.0045 0.0171
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0025 0.0025
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0038 0.0043 0.0161
Schistosoma mansoni cpg binding protein 0.0033 0.0031 0.0092
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0021 0.0076
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0038 0.0043 0.0024
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus granulosus thymidylate synthase 0.0433 0.0944 0.2843
Brugia malayi neuropeptide F receptor 0.004 0.0048 0.018
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0107 0.04
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0073 0.0275
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0043 0.0158
Echinococcus multilocularis tachykinin peptides receptor 99D 0.004 0.0048 0.0048
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0169 0.0637
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0087 0.0326
Loa Loa (eye worm) histone deacetylase 3 0.0132 0.0258 0.0975
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0048 0.018
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.01 0.0376
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Echinococcus multilocularis Nuclear hormone receptor HR96 0.003 0.0025 0.0025
Trypanosoma brucei trypanothione reductase 0.0041 0.005 0.0185
Echinococcus multilocularis biogenic amine (5HT) receptor 0.004 0.0048 0.0048
Loa Loa (eye worm) DR-78 0.003 0.0025 0.0096
Echinococcus multilocularis orexin receptor type 2 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Onchocerca volvulus 0.0433 0.0944 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0087 0.0329
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.0098 0.0295
Onchocerca volvulus 0.0035 0.0036 0.0385
Leishmania major DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Schistosoma mansoni histone deacetylase 1 2 3 0.0038 0.0042 0.0128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.025 0.0942
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0043 0.0054 0.02
Brugia malayi Melatonin receptor type 1A 0.004 0.0048 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0193 0.0601
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.0098 0.0367
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0043 0.0054 0.02
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0119 0.0451
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0109
Schistosoma mansoni nuclear receptor 0.003 0.0025 0.0076
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.001 0.0037
Schistosoma mansoni neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus granulosus nuclear receptor nhr 48 0.003 0.0025 0.0076
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0048 0.018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0129 0.025 0.0942
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Brugia malayi hypothetical protein 0.0051 0.0073 0.0278
Loa Loa (eye worm) transcription factor SMAD2 0.0628 0.1388 0.5251
Trypanosoma brucei heat shock protein 84, putative 0.0027 0.0017 0.0062
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0107 0.0321
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Brugia malayi hypothetical protein 0.0079 0.0138 0.0521
Plasmodium vivax endoplasmin, putative 0.0065 0.0105 0.0394
Toxoplasma gondii thioredoxin reductase 0.0041 0.005 0.0185
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0043 0.0158
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Plasmodium falciparum glutathione reductase 0.0041 0.005 0.0185
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0167
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0098 0.0367
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0274 0.0581 0.0581
Brugia malayi Calcitonin receptor-like protein seb-1 0.0316 0.0678 0.2564
Brugia malayi tailless protein 0.003 0.0025 0.0096
Loa Loa (eye worm) G-protein coupled receptor 0.004 0.0048 0.018
Schistosoma mansoni amine GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0193 0.0727
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0105 0.0394
Loa Loa (eye worm) TAR-binding protein 0.0202 0.0416 0.1575
Mycobacterium ulcerans beta-lactamase 0.0035 0.0036 0.0134
Toxoplasma gondii histone deacetylase HDAC2 0.0132 0.0258 0.0971
Plasmodium falciparum histone deacetylase 2 0.0125 0.0242 0.0913
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.0098 0.0098
Schistosoma mansoni smad 0.0043 0.0054 0.0163
Onchocerca volvulus 0.004 0.0048 0.0505
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0043 0.0158
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0107 0.0321
Loa Loa (eye worm) CYP4Cod1 0.0023 0.001 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1178 0.2644 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Brugia malayi Latrophilin receptor protein 2 0.01 0.0185 0.0699
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.004 0.0048 0.018
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0048 0.0048
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0038 0.0043 0.0158
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0043 0.0054 0.02
Toxoplasma gondii adenosylhomocysteinase, putative 0.1178 0.2644 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.004 0.0048 0.0048
Loa Loa (eye worm) follicle stimulating hormone receptor 0.004 0.0048 0.018
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0075 0.0279
Echinococcus multilocularis solute carrier family 5 0.0274 0.0581 0.0581
Echinococcus multilocularis Zinc carboxypeptidase family protein 0.0043 0.0054 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Brugia malayi gonadotropin-releasing hormone receptor 2 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Schistosoma mansoni high-affinity choline transporter 0.007 0.0116 0.0349
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0087 0.0087
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0105 0.0394
Echinococcus multilocularis allatostatin A receptor 0.004 0.0048 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0185 0.0185
Loa Loa (eye worm) zinc carboxypeptidase 0.0043 0.0054 0.0204
Onchocerca volvulus 0.0043 0.0054 0.0571
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0416 0.1255
Loa Loa (eye worm) nuclear hormone receptor 0.003 0.0025 0.0096
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0176 0.0359 0.1237
Echinococcus granulosus Smad4 0.0043 0.0054 0.0163
Echinococcus multilocularis thymidylate synthase 0.0433 0.0944 0.0944
Mycobacterium ulcerans acetyl-CoA synthetase 0.0038 0.0043 0.0158
Schistosoma mansoni hypothetical protein 0.0039 0.0045 0.0136
Echinococcus granulosus histone deacetylase 8 0.0038 0.0042 0.0128
Schistosoma mansoni biogenic amine receptor 0.004 0.0048 0.0144
Onchocerca volvulus 0.004 0.0048 0.0505
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0091 0.0343
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0001 0.0004
Onchocerca volvulus Neuropeptide F receptor homolog 0.004 0.0048 0.0505
Brugia malayi Hsp90 protein 0.0027 0.0017 0.0065
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0038 0.0038
Toxoplasma gondii heat shock protein 90, putative 0.0065 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0127
Giardia lamblia Fructose-bisphosphate aldolase 0.0304 0.0649 1
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Onchocerca volvulus 0.004 0.0048 0.0505
Schistosoma mansoni cpg binding protein 0.0033 0.0031 0.0092
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Brugia malayi hypothetical protein 0.0034 0.0034 0.0127
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0048 0.0144
Brugia malayi Cytochrome P450 family protein 0.0023 0.001 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0051 0.0051
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0102 0.0309
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0064 0.0102 0.0309
Leishmania major cytochrome p450-like protein 0.0023 0.001 0.0033
Echinococcus granulosus tachykinin peptides receptor 99D 0.004 0.0048 0.0144
Echinococcus granulosus neuropeptides capa receptor 0.004 0.0048 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0073 0.0272
Brugia malayi Thioredoxin reductase 0.0041 0.005 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Trichomonas vaginalis heat shock protein, putative 0.0065 0.0105 0.0394
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0048 0.0144
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.003 0.0025 0.0096
Echinococcus granulosus 7tm_1 domain containing protein 0.004 0.0048 0.0144
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0087 0.0087
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Brugia malayi Dopamine receptor protein 2 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus hypothetical protein 0.004 0.0048 0.0144
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0025 0.0025
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0054 0.0204
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1178 0.2644 1
Echinococcus granulosus subfamily M14A unassigned peptidase 0.0249 0.0525 0.158
Onchocerca volvulus 0.003 0.0025 0.0268
Toxoplasma gondii histone deacetylase HDAC1 0.0125 0.0242 0.0913
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0064 0.0102 0.0102
Loa Loa (eye worm) oxidoreductase 0.0038 0.0043 0.0161
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0064 0.0102 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Brugia malayi nuclear receptor RXR 0.0034 0.0034 0.0127
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0107 0.0107
Echinococcus granulosus Zinc carboxypeptidase family protein 0.0043 0.0054 0.0162
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0027 0.0017 0.0052
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.1178 0.2644 1
Echinococcus granulosus orexin receptor type 2 0.004 0.0048 0.0144
Echinococcus granulosus smad 0.0043 0.0054 0.0163
Brugia malayi CXXC zinc finger family protein 0.0031 0.0027 0.0101
Echinococcus granulosus fmrfamide receptor 0.004 0.0048 0.0144
Brugia malayi thymidylate synthase 0.0433 0.0944 0.3569
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Trypanosoma cruzi heat shock protein 90, putative 0.0065 0.0105 0.0394
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0193 0.0727
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0048 0.0144
Schistosoma mansoni carboxypeptidase N (M14 family) 0.0043 0.0054 0.0162
Brugia malayi hypothetical protein 0.0723 0.1605 0.6072
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0021 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0064 0.0102 0.0102
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0064 0.0102 0.0309
Schistosoma mansoni histamine h1 receptor 0.004 0.0048 0.0144
Schistosoma mansoni myosin xvIII 0.004 0.0048 0.0144
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.007 0.0116 0.0349
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0202 0.0416 0.1575
Schistosoma mansoni hypothetical protein 0.01 0.0185 0.0556
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.009 0.0162 0.061
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0025 0.0268
Brugia malayi Dopamine receptor protein 1 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0129 0.025 0.0946
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0127
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.025 0.0942
Brugia malayi Dopamine receptor 0.004 0.0048 0.018
Echinococcus granulosus tar DNA binding protein 0.0202 0.0416 0.1255
Plasmodium falciparum acyl-CoA synthetase 0.0096 0.0176 0.0662
Schistosoma mansoni heat shock protein 0.0065 0.0105 0.0316
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis histone deacetylase 7 0.0125 0.0242 0.0242
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0096 0.0176 0.0662
Loa Loa (eye worm) nuclear factor I 0.0024 0.001 0.0039
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Echinococcus granulosus cpg binding protein 0.0033 0.0031 0.0092
Schistosoma mansoni patched 1 0.0051 0.0073 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0416 0.1255
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0009 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0048 0.0144
Schistosoma mansoni inositol transporter 0.0274 0.0581 0.175
Mycobacterium tuberculosis Probable reductase 0.0093 0.0169 0.0637
Echinococcus granulosus sodium:glucose cotransporter 0.0274 0.0581 0.175
Echinococcus multilocularis neuropeptide receptor 0.004 0.0048 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus dna polymerase kappa 0.0057 0.0087 0.0262
Echinococcus granulosus high affinity choline transporter 1 0.007 0.0116 0.0349
Echinococcus multilocularis microtubule associated protein 2 0.1474 0.3319 0.3319
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.004 0.0048 0.0144
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.01 0.0376
Echinococcus multilocularis neuropeptide FF receptor 2 0.004 0.0048 0.0048
Onchocerca volvulus Subfamily M14A unassigned peptidase homolog 0.0249 0.0525 0.5558
Trypanosoma cruzi zinc carboxypeptidase, putative 0.0043 0.0054 0.02
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0045 0.0136
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Toxoplasma gondii histone deacetylase HDAC4 0.0038 0.0042 0.0157
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.004 0.0048 0.0144
Brugia malayi nuclear receptor NHR-67 0.003 0.0025 0.0096
Trypanosoma cruzi heat shock protein, putative 0.0027 0.0017 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) zinc carboxypeptidase 0.0043 0.0054 0.0204
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.0098 0.0367
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1178 0.2644 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0001 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.004 0.0048 0.018
Loa Loa (eye worm) histone deacetylase 11 0.0038 0.0042 0.016
Schistosoma mansoni peptidase 0.0043 0.0054 0.0162
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0102 0.0309
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.005 0.0185
Schistosoma mansoni metallocarboxypeptidase D peptidase unit 2 (M14 family) 0.0043 0.0054 0.0162
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0025 0.0076
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0043 0.0161
Schistosoma mansoni neuropeptide f receptor 76f 0.004 0.0048 0.0144
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Loa Loa (eye worm) hypothetical protein 0.0316 0.0678 0.2564
Echinococcus multilocularis g protein coupled receptor 0.004 0.0048 0.0048
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0038 0.0043 0.0158
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0087 0.0262
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0036 0.0134
Leishmania major histone deacetylase, putative 0.0125 0.0242 0.0913
Echinococcus granulosus sodium:myo inositol cotransporter 0.0274 0.0581 0.175
Loa Loa (eye worm) heat shock protein 75 0.0027 0.0017 0.0065
Leishmania major heat shock protein, putative 0.0027 0.0017 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0098 0.0295
Brugia malayi G protein-coupled receptor 0.004 0.0048 0.018
Echinococcus multilocularis histone deacetylase 6 0.0125 0.0242 0.0242
Brugia malayi ecdysteroid receptor 0.0064 0.0102 0.0387
Trichomonas vaginalis STE family protein kinase 0.009 0.0162 0.061
Trypanosoma brucei protein kinase, putative 0.0062 0.0098 0.0367
Onchocerca volvulus 0.0249 0.0525 0.5558
Brugia malayi nuclear hormone receptor family member nhr-6 0.003 0.0025 0.0096
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.004 0.0048 0.0048
Trichomonas vaginalis esterase, putative 0.0035 0.0036 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0102 0.0387
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0034 0.0101
Onchocerca volvulus 0.0249 0.0525 0.5558
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) zinc carboxypeptidase 0.0043 0.0054 0.0204
Schistosoma mansoni adenoreceptor 0.004 0.0048 0.0144
Onchocerca volvulus 0.0031 0.0027 0.0283
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0064 0.0102 0.0309
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0036 0.0134
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.003 0.0025 0.0076
Giardia lamblia Heat shock protein HSP 90-alpha 0.0065 0.0105 0.1605
Echinococcus granulosus dihydrofolate reductase 0.0176 0.0359 0.1081
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14 0.0043 0.0054 0.02
Plasmodium vivax importin-beta 2, putative 0.0028 0.0021 0.0076
Plasmodium vivax histone deacetylase, putative 0.0125 0.0242 0.0913
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0665
Echinococcus multilocularis dnaJ subfamily B 0.0439 0.0957 0.0957
Schistosoma mansoni neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0048 0.0048
Trypanosoma brucei histone deacetylase, putative 0.0125 0.0242 0.0913
Echinococcus granulosus endoplasmin 0.0052 0.0075 0.0225
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0043 0.0158
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0144
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis adenosylhomocysteinase 0.1178 0.2644 0.2644
Onchocerca volvulus 0.004 0.0048 0.0505
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Plasmodium falciparum importin beta, putative 0.0028 0.0021 0.0076
Giardia lamblia Histone deacetylase 0.0132 0.0258 0.3962
Onchocerca volvulus 0.004 0.0048 0.0505
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0107 0.04
Brugia malayi Nuclear hormone receptor E75 0.003 0.0025 0.0096
Echinococcus granulosus sodium:glucose cotransporter 2 0.0274 0.0581 0.175
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Brugia malayi ecdysone receptor 0.003 0.0025 0.0096
Toxoplasma gondii histone deacetylase HDAC3 0.0132 0.0258 0.0971
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0054 0.0163
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0034 0.0101
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0102 0.0309
Echinococcus multilocularis geminin 0.1414 0.3182 0.3182
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.004 0.0048 0.0144
Schistosoma mansoni nuclear hormone receptor 0.003 0.0025 0.0076
Echinococcus multilocularis heat shock protein 90 0.0065 0.0105 0.0105
Echinococcus multilocularis subfamily M14A unassigned peptidase 0.0249 0.0525 0.0525
Echinococcus multilocularis alpha 1A adrenergic receptor 0.004 0.0048 0.0048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0064 0.0102 0.0309
Schistosoma mansoni histone deacetylase 4 5 0.0125 0.0242 0.073
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus granulosus allatostatin A receptor 0.004 0.0048 0.0144
Schistosoma mansoni hypothetical protein 0.0216 0.045 0.1355
Brugia malayi Nuclear hormone receptor E75 0.003 0.0025 0.0096
Onchocerca volvulus Bile acid receptor homolog 0.0064 0.0102 0.1086
Echinococcus granulosus dro:myosuppressin receptor 0.004 0.0048 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Mycobacterium ulcerans heat shock protein 90 0.0052 0.0075 0.0279
Echinococcus multilocularis endoplasmin 0.0052 0.0075 0.0075
Trypanosoma brucei metallo-peptidase, Clan MC, Family M14, putative 0.0043 0.0054 0.02
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0043 0.0158
Leishmania major trypanothione reductase 0.0041 0.005 0.0185
Loa Loa (eye worm) glutathione reductase 0.0041 0.005 0.0188
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0119 0.036
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0134
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0048 0.0144
Schistosoma mansoni dihydrofolate reductase 0.0176 0.0359 0.1081
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0048 0.0144
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0416 0.1255
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0433 0.0944 0.348
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0009 0.003
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0045 0.0136
Trichomonas vaginalis heat shock protein, putative 0.004 0.0048 0.0176
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0107 0.04
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0051 0.0153
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0038 0.0043 0.0128
Loa Loa (eye worm) hypothetical protein 0.0216 0.045 0.1701
Loa Loa (eye worm) hypothetical protein 0.0079 0.0138 0.0521
Brugia malayi Smad1 0.0043 0.0054 0.0204
Schistosoma mansoni survival motor neuron protein 0.0147 0.0293 0.0882
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0043 0.0054 0.0818
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Trypanosoma brucei Heat shock protein 83, putative 0.0065 0.0105 0.0394
Echinococcus granulosus expressed conserved protein 0.0112 0.0211 0.0636
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0105 0.0394
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0119 0.036
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0036 0.0134
Echinococcus multilocularis dihydrofolate reductase 0.0176 0.0359 0.0359
Onchocerca volvulus 0.0035 0.0036 0.0385
Echinococcus multilocularis cpg binding protein 0.0033 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.004 0.0048 0.0505
Onchocerca volvulus 0.0327 0.0702 0.7435
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.0098 0.1499
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Leishmania major histone deacetylase, putative 0.0125 0.0242 0.0913
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0001 0.0001
Brugia malayi GnHR receptor homolog 0.004 0.0048 0.018
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.009 0.0162 0.0613
Plasmodium falciparum thioredoxin reductase 0.0041 0.005 0.0185
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis nuclear receptor nhr 48 0.003 0.0025 0.0025
Giardia lamblia DINP protein human, muc B family 0.0057 0.0087 0.1329
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Giardia lamblia Grp94/Hsp90 0.0052 0.0075 0.1138
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0165 0.0625
Trypanosoma brucei unspecified product 0.0057 0.0087 0.0326
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0433 0.0944 0.3567
Plasmodium falciparum heat shock protein 90 0.0065 0.0105 0.0394
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0036 0.0134
Mycobacterium tuberculosis Hypothetical protein 0.0206 0.0426 0.1608
Onchocerca volvulus Histone deacetylase 10 homolog 0.0038 0.0042 0.0449
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0043 0.0158
Echinococcus granulosus survival motor neuron protein 1 0.0723 0.1605 0.4837
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0134
Leishmania major zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 0.0043 0.0054 0.02
Echinococcus granulosus biogenic amine 5HT receptor 0.004 0.0048 0.0144
Plasmodium vivax heat shock protein 90, putative 0.0027 0.0017 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.025 0.0942
Echinococcus multilocularis somatostatin receptor 0.004 0.0048 0.0048
Mycobacterium ulcerans hypothetical protein 0.0129 0.025 0.0942
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0054 0.02
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0169 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0064 0.0102 0.0387
Loa Loa (eye worm) histone deacetylase 1 0.0132 0.0258 0.0975
Schistosoma mansoni hypothetical protein 0.0049 0.0069 0.0207
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0185 0.0556
Brugia malayi GH02984p 0.007 0.0116 0.0438
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.001 0.0033
Schistosoma mansoni smad1 5 8 and 0.0043 0.0054 0.0163
Schistosoma mansoni amine GPCR 0.004 0.0048 0.0144
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0087 0.0326
Trypanosoma cruzi heat shock protein 85, putative 0.0065 0.0105 0.0394
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0144
Brugia malayi hypothetical protein 0.0327 0.0702 0.2654
Brugia malayi steroid hormone receptor 0.0064 0.0102 0.0387
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus granulosus sex peptide receptor 0.004 0.0048 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0064 0.0102 0.0102
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0102 0.0387
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.004 0.0048 0.0048
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0043 0.0054 0.0818
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0038 0.0043 0.0158
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0169 0.0637
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0228 0.0858
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0127
Schistosoma mansoni hypothetical protein 0.01 0.0185 0.0556
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0043 0.0158
Brugia malayi latrophilin 2 splice variant baaae 0.0216 0.045 0.1701
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0038 0.0043 0.0158
Trypanosoma cruzi histone deacetylase 1, putative 0.0132 0.0258 0.0971
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0144
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0048 0.0144
Schistosoma mansoni biogenic amine receptor 0.004 0.0048 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0098 0.0367
Echinococcus granulosus histone deacetylase 1 0.0132 0.0258 0.0776
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0438
Onchocerca volvulus 0.0249 0.0525 0.5558
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0107 0.04
Echinococcus granulosus histone deacetylase 6 0.0125 0.0242 0.073
Echinococcus granulosus histone deacetylase 3 0.0132 0.0258 0.0776
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0169 0.051
Echinococcus multilocularis GPCR, family 2 0.01 0.0185 0.0185
Loa Loa (eye worm) adenosylhomocysteinase 0.1178 0.2644 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.0098 0.0367
Brugia malayi heat shock protein 90 0.0065 0.0105 0.0397
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.007 0.0116 0.0434
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0609 0.1346 0.509
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0036 0.0109
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0036 0.0134
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1178 0.2644 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Echinococcus granulosus ecdysone induced protein 78C 0.0064 0.0102 0.0309
Echinococcus granulosus dual specificity mitogen activated protein 0.009 0.0162 0.0489
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0027 0.0017 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Mycobacterium ulcerans lipase LipD 0.0035 0.0036 0.0134
Schistosoma mansoni amine GPCR 0.004 0.0048 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0025 0.0076
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Schistosoma mansoni nuclear hormone receptor 0.003 0.0025 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0087 0.0326
Trypanosoma cruzi histone deacetylase 1, putative 0.0132 0.0258 0.0971
Toxoplasma gondii Hsp90 domain-containing protein 0.0027 0.0017 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0164 0.0616
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Brugia malayi Carboxypeptidase A2 precursor 0.0043 0.0054 0.0204
Onchocerca volvulus 0.004 0.0048 0.0505
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0054 0.0204
Entamoeba histolytica adenosylhomocysteinase, putative 0.1178 0.2644 1
Trypanosoma brucei heat shock protein 90, putative 0.0065 0.0105 0.0394
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.0295 0.1111
Loa Loa (eye worm) hypothetical protein 0.0057 0.0087 0.0329
Brugia malayi follicle stimulating hormone receptor 0.004 0.0048 0.018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0036 0.0137
Brugia malayi glutathione reductase 0.0041 0.005 0.0188
Onchocerca volvulus 0.0038 0.0043 0.0452
Echinococcus granulosus adenosylhomocysteinase 0.1178 0.2644 0.7966
Schistosoma mansoni neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0064 0.0102 0.0309
Echinococcus granulosus g protein coupled receptor 0.004 0.0048 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.01 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0127
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0064 0.0102 0.0387
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0138 0.0517
Brugia malayi MAP kinase sur-1 0.0062 0.0098 0.0371
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Treponema pallidum fructose-bisphosphate aldolase 0.0304 0.0649 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Onchocerca volvulus Carboxypeptidase D homolog 0.0043 0.0054 0.0571
Brugia malayi Cytochrome P450 family protein 0.0059 0.0091 0.0343
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0138 0.0517
Schistosoma mansoni coup transcription factor 0.0064 0.0102 0.0309
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Brugia malayi sulfakinin receptor protein 0.004 0.0048 0.018
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0344 0.1037
Plasmodium vivax heat shock protein, putative 0.0027 0.0017 0.0062
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0052 0.0075 0.0225
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0107 0.0403
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Echinococcus multilocularis fmrfamide receptor 0.004 0.0048 0.0048
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0021 0.0076
Schistosoma mansoni adenosylhomocysteinase 0.0729 0.162 0.4879
Brugia malayi putative neuropeptide receptor NPR1 0.004 0.0048 0.018
Plasmodium falciparum heat shock protein 90, putative 0.0027 0.0017 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0165 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0165 0.0498
Schistosoma mansoni tar DNA-binding protein 0.0202 0.0416 0.1255
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.003 0.0025 0.0025
Echinococcus multilocularis expressed conserved protein 0.0112 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0723 0.1605 0.6072
Chlamydia trachomatis dihydrofolate reductase 0.0176 0.0359 1
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0344 0.0344
Brugia malayi AMP-binding enzyme family protein 0.0129 0.025 0.0946
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.001 0.0033
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Schistosoma mansoni thyroid hormone receptor 0.0064 0.0102 0.0309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0064 0.0102 0.0387
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0036 0.0134
Echinococcus multilocularis fmrfamide receptor 0.004 0.0048 0.0048
Echinococcus multilocularis neuropeptide receptor A26 0.004 0.0048 0.0048
Brugia malayi AKH receptor 0.004 0.0048 0.018
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0038 0.0043 0.0158
Echinococcus multilocularis histone deacetylase 6 0.0125 0.0242 0.0242
Schistosoma mansoni acetyl-CoA synthetase 0.0038 0.0043 0.0128
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0119 0.0448
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0073 0.0219
Loa Loa (eye worm) hypothetical protein 0.0051 0.0073 0.0275
Onchocerca volvulus 0.0129 0.025 0.265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0137
Trypanosoma brucei heat shock protein, putative 0.0065 0.0105 0.0394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.004 0.0048 0.018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0232 0.0698
Brugia malayi conserved hypotetical protein 0.003 0.0025 0.0096
Loa Loa (eye worm) neuropeptide F receptor 0.004 0.0048 0.018
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.004 0.0048 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0064 0.0102 0.0387
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Toxoplasma gondii histone deacetylase HDAC5 0.0038 0.0042 0.0157
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0665
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0009 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Schistosoma mansoni steroid hormone receptor ad4bp 0.0064 0.0102 0.0309
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Trypanosoma cruzi metallo-peptidase, Clan MC, Family M14, putative 0.0043 0.0054 0.02
Loa Loa (eye worm) hypothetical protein 0.0064 0.0102 0.0387
Brugia malayi G-protein coupled receptor 0.004 0.0048 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.025 0.0942
Loa Loa (eye worm) hypothetical protein 0.0028 0.0021 0.008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0185 0.0185
Echinococcus granulosus peptide allatostatin:somatostatin 0.004 0.0048 0.0144
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0064 0.0102 0.0102
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Echinococcus granulosus cytosolic carboxypeptidase protein 5 0.0043 0.0054 0.0162
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Brugia malayi neuropeptide F receptor 0.004 0.0048 0.018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.01 0.0376
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0185 0.0699
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.007 0.0116 0.0438
Brugia malayi hypothetical protein 0.0206 0.0426 0.1611
Brugia malayi MH2 domain containing protein 0.0628 0.1388 0.5251
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.003 0.0025 0.0268
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Schistosoma mansoni zinc finger protein 0.003 0.0025 0.0076
Brugia malayi MH1 domain containing protein 0.0043 0.0054 0.0204
Schistosoma mansoni hypothetical protein 0.0049 0.0069 0.0207
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0098 0.0367
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0043 0.0054 0.02
Loa Loa (eye worm) hypothetical protein 0.0034 0.0034 0.0127
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0043 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0064 0.0102 0.0387
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0054 0.0054
Echinococcus multilocularis neuropeptide s receptor 0.004 0.0048 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0164 0.0616
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0051 0.0051
Schistosoma mansoni endoplasmin 0.0065 0.0105 0.0316
Schistosoma mansoni adenosylhomocysteinase 0.0729 0.162 0.4879
Brugia malayi nuclear hormone receptor 0.003 0.0025 0.0096
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.005 0.0185
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0075 0.0279
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Brugia malayi RE15519p 0.004 0.0048 0.018
Mycobacterium ulcerans thymidylate synthase 0.0433 0.0944 0.3567
Loa Loa (eye worm) Smad1 0.0043 0.0054 0.0204
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0107 0.0107
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0087 0.0326
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.1178 0.2644 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0134
Echinococcus multilocularis cytosolic carboxypeptidase protein 5 0.0043 0.0054 0.0054
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0036 0.0134
Brugia malayi nuclear hormone receptor 0.0064 0.0102 0.0387
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0316 0.0678 0.2564
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.01 0.0185 0.0556
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0043 0.0158
Onchocerca volvulus 0.007 0.0116 0.1226
Schistosoma mansoni heat shock protein 0.0065 0.0105 0.0316
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0087 0.0326
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.1178 0.2644 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0064 0.0102 0.1086
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.01 0.0376
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0102 0.0102
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.0098 0.0371
Loa Loa (eye worm) hypothetical protein 0.0132 0.0258 0.0975
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0052 0.0075 1
Giardia lamblia Nuclear ATP/GTP-binding protein 0.0043 0.0054 0.0818
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Brugia malayi histone deacetylase 1 (HD1) 0.0132 0.0258 0.0975
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0102 0.0102
Onchocerca volvulus 0.0038 0.0043 0.0452
Schistosoma mansoni neuropeptide F-like receptor 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0609 0.1346 0.509
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0228 0.0861
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.0098 0.0367
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0038 0.0043 0.0158
Brugia malayi nuclear receptor NHR-88 0.003 0.0025 0.0096
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.004 0.0048 0.0144
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus multilocularis high affinity choline transporter 1 0.007 0.0116 0.0116
Echinococcus multilocularis tar DNA binding protein 0.0202 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0087 0.0326
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0001 0.0004
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0088 0.0156 0.0591
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.009 0.0335
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0038 0.0043 0.0158
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0107 0.04
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0087 0.0329
Echinococcus multilocularis neuropeptides capa receptor 0.004 0.0048 0.0048
Schistosoma mansoni histone deacetylase 4 5 0.0125 0.0242 0.073
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0052 0.0075 0.0147
Echinococcus granulosus neuropeptide Y receptor 0.004 0.0048 0.0144
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Brugia malayi Tachykinin-like peptides receptor 99D 0.004 0.0048 0.018
Brugia malayi Histone deacetylase 1 0.0132 0.0258 0.0975
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0064 0.0102 0.0309
Echinococcus multilocularis g protein coupled receptor 0.004 0.0048 0.0048
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0047 0.0172
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni RAR-like nuclear receptor 0.0064 0.0102 0.0309
Schistosoma mansoni heat shock protein 0.0027 0.0017 0.0052
Brugia malayi Histone deacetylase family protein 0.0125 0.0242 0.0916
Schistosoma mansoni adenosylhomocysteinase 0.1178 0.2644 0.7966
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0043 0.0161
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0132 0.0258 0.0971
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) hypothetical protein 0.0206 0.0427 0.1615
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0038 0.0043 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0064 0.0102 0.0387
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.004 0.0048 0.0144
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.0098 0.0367
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0038 0.0043 0.0158
Brugia malayi putative neuropeptide receptor 0.004 0.0048 0.018
Echinococcus multilocularis histone deacetylase 1 0.0132 0.0258 0.0258
Schistosoma mansoni peptidase 0.0043 0.0054 0.0162
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0609 0.1346 0.509
Echinococcus granulosus heat shock protein 90 0.0065 0.0105 0.0316
Schistosoma mansoni protease m14 carboxypeptidase 0.0043 0.0054 0.0162
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0185 0.0556
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0105 0.0394
Schistosoma mansoni Smad4 0.0043 0.0054 0.0163
Echinococcus granulosus tm gpcr rhodopsin 0.004 0.0048 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.001 0.0037
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0138 0.0517
Brugia malayi larval opioid receptor 0.004 0.0048 0.018
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0107 0.0403
Echinococcus granulosus neuropeptide s receptor 0.004 0.0048 0.0144
Loa Loa (eye worm) hypothetical protein 0.0112 0.0211 0.0798
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0665
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.005 0.0185
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0274 0.0581 0.0581
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0165 0.0498
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0064 0.0102 0.0387
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus multilocularis serotonin receptor 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Loa Loa (eye worm) histone deacetylase 0.0125 0.0242 0.0916
Echinococcus multilocularis heat shock protein 90 0.0052 0.0075 0.0075
Echinococcus granulosus histone deacetylase 0.0125 0.0242 0.073
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0052 0.0075 0.0279
Trichomonas vaginalis conserved hypothetical protein 0.0206 0.0426 0.1608
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.025 0.0942
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.0647 0.2449
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0098 0.0367
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.009 0.0162 0.061
Schistosoma mansoni retinoic acid receptor RXR 0.0064 0.0102 0.0309
Mycobacterium ulcerans hypothetical protein 0.0035 0.0036 0.0134
Loa Loa (eye worm) dihydrofolate reductase 0.0176 0.0359 0.1358
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0087 0.0262
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.1178 0.2644 1
Schistosoma mansoni hypothetical protein 0.004 0.0048 0.0144
Loa Loa (eye worm) endoplasmin 0.0065 0.0105 0.0397
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni amine GPCR 0.004 0.0048 0.0144
Schistosoma mansoni biogenic amine (dopamine) receptor 0.004 0.0048 0.0144
Echinococcus granulosus serotonin receptor 0.004 0.0048 0.0144
Echinococcus multilocularis dna polymerase eta 0.0057 0.0087 0.0087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0129 0.025 0.0942
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0165 0.0165
Schistosoma mansoni protein kinase 0.009 0.0162 0.0489
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0134
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Trypanosoma brucei histone deacetylase 3 0.0125 0.0242 0.0913
Schistosoma mansoni family M14 non-peptidase homologue (M14 family) 0.0043 0.0054 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0138 0.0517
Echinococcus granulosus heat shock protein 0.0065 0.0105 0.0316
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0228 0.0686
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0036 0.0109
Trypanosoma brucei unspecified product 0.0039 0.0047 0.0172
Echinococcus multilocularis protein dispatched 1 0.0058 0.0089 0.0089
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0107 0.0107
Brugia malayi G-protein coupled receptor 0.004 0.0048 0.018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0087 0.0262
Echinococcus multilocularis dual specificity mitogen activated protein 0.009 0.0162 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0064 0.0102 0.0387
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Onchocerca volvulus 0.004 0.0048 0.0505
Brugia malayi hypothetical protein 0.003 0.0025 0.0096
Trypanosoma cruzi histone deacetylase, putative 0.0125 0.0242 0.0913
Schistosoma mansoni opsin-like receptor 0.004 0.0048 0.0144
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0087 0.0326
Onchocerca volvulus 0.004 0.0048 0.0505
Brugia malayi dihydrofolate reductase family protein 0.0176 0.0359 0.1358
Echinococcus multilocularis Smad4 0.0043 0.0054 0.0054
Echinococcus granulosus microtubule associated protein 2 0.1474 0.3319 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0064 0.0102 0.0387
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.004 0.0048 0.018
Schistosoma mansoni hypothetical protein 0.0049 0.0069 0.0207
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0034 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0087 0.0326
Echinococcus multilocularis snurportin 1 0.0303 0.0647 0.0647
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0036 0.0134
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.004 0.0048 0.0048
Echinococcus granulosus heat shock protein 90 0.0052 0.0075 0.0225
Echinococcus granulosus thyroid hormone receptor alpha 0.003 0.0025 0.0076
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.004 0.0048 0.0144
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0107 0.04
Echinococcus granulosus neuropeptide receptor 0.004 0.0048 0.0144
Echinococcus multilocularis sex peptide receptor 0.004 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Schistosoma mansoni peptidase 0.0043 0.0054 0.0162
Toxoplasma gondii heat shock protein 75, putative 0.0027 0.0017 0.0062
Trichomonas vaginalis STE family protein kinase 0.009 0.0162 0.061
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0176 0.0359 0.1355
Brugia malayi TAR-binding protein 0.0202 0.0416 0.1575
Toxoplasma gondii zinc carboxypeptidase, putative 0.0043 0.0054 0.02
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0119 0.0448
Schistosoma mansoni opsin-like receptor 0.004 0.0048 0.0144
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0185 0.0699
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0043 0.0158
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0075 0.1138
Entamoeba histolytica heat shock protein 90, putative 0.0065 0.0105 0.0394
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0087 0.0326
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0193 0.0727
Schistosoma mansoni microtubule-associated protein tau 0.1474 0.3319 1
Trypanosoma cruzi histone deacetylase, putative 0.0125 0.0242 0.0913
Giardia lamblia Kinase, STE STE20 0.009 0.0162 0.2489
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.005 0.0188
Trypanosoma brucei histone deacetylase 1 0.0132 0.0258 0.0971
Plasmodium falciparum endoplasmin, putative 0.004 0.0048 0.0176
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0119 0.0448
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0064 0.0102 0.0387
Echinococcus multilocularis survival motor neuron protein 1 0.0723 0.1605 0.1605
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0043 0.0024
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0038 0.0114
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0087 0.0329
Trichomonas vaginalis Clan MC, family M14, Zinc carboxypeptidase-like metallopeptidase 0.0043 0.0054 0.02
Onchocerca volvulus Protein ultraspiracle homolog 0.0064 0.0102 0.1086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0064 0.0102 0.0102
Schistosoma mansoni adenosylhomocysteinase 0.0729 0.162 0.4879
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.025 0.082
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0033 0.0031 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0105 0.0318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0147 0.0293 0.1107
Echinococcus granulosus cytosolic carboxypeptidase 1 0.0043 0.0054 0.0162
Trypanosoma brucei cytochrome P450, putative 0.0023 0.001 0.0033
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0038 0.0043 0.0158
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0167
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0064 0.0102 0.0309
Echinococcus granulosus G protein coupled receptor 139 0.004 0.0048 0.0144
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0316 0.0678 0.2564
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0176 0.0359 0.1355
Onchocerca volvulus 0.0043 0.0054 0.0571
Schistosoma mansoni hypothetical protein 0.0049 0.0069 0.0207
Loa Loa (eye worm) histone deacetylase 7A 0.0125 0.0242 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0064 0.0102 0.0387
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.01 0.0376
Leishmania major 4-coumarate:coa ligase-like protein 0.0129 0.025 0.0942
Echinococcus multilocularis histone deacetylase 3 0.0132 0.0258 0.0258
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.01 0.0302
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0017 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.0043 0.0161
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.009 0.0162 0.061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0129 0.025 0.082
Echinococcus multilocularis rhodopsin orphan GPCR 0.004 0.0048 0.0048
Brugia malayi orphan nuclear receptor NR2E1 0.003 0.0025 0.0096
Schistosoma mansoni ap endonuclease 0.002 0.0001 0.0003
Loa Loa (eye worm) thymidylate synthase 0.0433 0.0944 0.3569
Schistosoma mansoni amine GPCR 0.004 0.0048 0.0144
Echinococcus granulosus geminin 0.1414 0.3182 0.9588
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.025 0.0942
Mycobacterium ulcerans acyl-CoA synthetase 0.0129 0.025 0.0942
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Brugia malayi Adenosylhomocysteinase 0.1178 0.2644 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.004 0.0048 0.0144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0064 0.0102 0.0309
Leishmania major S-adenosylhomocysteine hydrolase 0.1178 0.2644 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.004 0.0048 0.0144
Echinococcus multilocularis neuropeptide Y receptor 0.004 0.0048 0.0048
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.004 0.0048 0.018
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Onchocerca volvulus 0.0064 0.0102 0.1086
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0036 0.0036
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0132 0.0258 0.0971
Trichomonas vaginalis histone deacetylase, putative 0.0132 0.0258 0.0971
Brugia malayi Steroid receptor seven-up type 2 0.0064 0.0102 0.0387
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.004 0.0048 0.0048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.0467 0.1764
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.0098 0.0367
Brugia malayi Sodium:solute symporter family protein 0.007 0.0116 0.0438
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0165 0.0165
Echinococcus granulosus snurportin 1 0.0303 0.0647 0.1951
Echinococcus granulosus Nuclear hormone receptor HR96 0.003 0.0025 0.0076
Brugia malayi Endoplasmin precursor 0.0065 0.0105 0.0397
Loa Loa (eye worm) hypothetical protein 0.0043 0.0054 0.0204
Loa Loa (eye worm) nuclear receptor NHR-67 0.003 0.0025 0.0096
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0038 0.0043 0.0158
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0096
Schistosoma mansoni histone deacetylase 0.0132 0.0258 0.0776
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Brugia malayi MH2 domain containing protein 0.0043 0.0054 0.0204
Brugia malayi hypothetical protein 0.0034 0.0034 0.0127
Onchocerca volvulus 0.004 0.0048 0.0505
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0112 0.0211 0.0798
Schistosoma mansoni subfamily M14A unassigned peptidase (M14 family) 0.0249 0.0525 0.158
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0138 0.0517
Echinococcus granulosus histone deacetylase 7 0.0125 0.0242 0.073
Schistosoma mansoni biogenic amine receptor 0.004 0.0048 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0064 0.0102 0.0387
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0609 0.1346 0.509
Schistosoma mansoni biogenic amine (5HT) receptor 0.004 0.0048 0.0144
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0304 0.0649 0.2451
Loa Loa (eye worm) hypothetical protein 0.0096 0.0176 0.0665
Loa Loa (eye worm) beta-lactamase 0.0035 0.0036 0.0137
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.004 0.0048 0.0144
Plasmodium vivax acyl-CoA synthetase, putative 0.0096 0.0176 0.0662
Brugia malayi hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus solute carrier family 5 0.0274 0.0581 0.175
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0096 0.0176 0.0662
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0075 0.0279
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.0098 0.0098
Entamoeba histolytica hypothetical protein 0.0039 0.0045 0.0167
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0119 0.0451
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0034 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0036 0.0134
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0043 0.0158
Schistosoma mansoni sodium/solute symporter 0.007 0.0116 0.0349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0064 0.0102 0.0387
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.004 0.0048 0.0048
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0038 0.0043 0.0158
Schistosoma mansoni nuclear receptor 0.003 0.0025 0.0076
Mycobacterium tuberculosis Conserved protein 0.0035 0.0036 0.0134
Loa Loa (eye worm) RNA binding protein 0.0202 0.0416 0.1575
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0034 0.0127
Onchocerca volvulus 0.004 0.0048 0.0505
Echinococcus multilocularis smad 0.0043 0.0054 0.0054
Echinococcus multilocularis 0.0043 0.0054 0.0054
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0107 0.04
Trypanosoma brucei DNA polymerase eta, putative 0.0057 0.0087 0.0326
Schistosoma mansoni DNA polymerase eta 0.0057 0.0087 0.0262
Loa Loa (eye worm) hypothetical protein 0.0129 0.025 0.0946
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0027 0.0017 0.0017
Schistosoma mansoni histone deacetylase hda2 0.0125 0.0242 0.073
Echinococcus multilocularis protein patched 0.0051 0.0073 0.0073
Schistosoma mansoni endoplasmin 0.0065 0.0105 0.0316
Echinococcus granulosus g-protein coupled receptor 0.004 0.0048 0.0144
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0087 0.0326
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.018
Echinococcus granulosus rhodopsin orphan GPCR 0.004 0.0048 0.0144
Toxoplasma gondii zinc carboxypeptidase superfamily protein 0.0043 0.0054 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0091 0.0164 0.0616
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0433 0.0944 0.2843
Onchocerca volvulus 0.003 0.0025 0.0268
Plasmodium vivax histone deacetylase 2, putative 0.0125 0.0242 0.0913
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.003 0.0025 0.0076
Schistosoma mansoni histone deacetylase hda2 0.0038 0.0042 0.0128
Brugia malayi MH1 domain containing protein 0.0024 0.001 0.0039
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Brugia malayi Zinc carboxypeptidase family protein 0.0043 0.0054 0.0204
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0169 0.0637
Onchocerca volvulus 0.004 0.0048 0.0505
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0165 0.0498
Brugia malayi nuclear hormone receptor family member odr-7 0.003 0.0025 0.0096
Schistosoma mansoni smad1 5 8 and 0.0043 0.0054 0.0163
Toxoplasma gondii flagellar/basal body protein 0.0043 0.0054 0.02
Onchocerca volvulus 0.0147 0.0293 0.3102
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.1178 0.2644 1
Loa Loa (eye worm) steroid hormone receptor 0.0064 0.0102 0.0387
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0043 0.0158
Leishmania major heat shock protein 83-1 0.0065 0.0105 0.0394

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 5 % Inhibitory activity against 3'-processing by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against strand transfer by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against 3'-processing by HIV-1 Integrase at 100 microM ChEMBL. 8568830
Inhibition (binding) < 5 % Inhibitory activity against strand transfer by HIV-1 Integrase at 100 microM ChEMBL. 8568830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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