Detailed information for compound 307536

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 480.622 | Formula: C26H32N4O3S
  • H donors: 1 H acceptors: 3 LogP: 4.34 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=C)c1ccccc1)NCCc1ccc(cc1)S(=O)(=O)N1CCN(C1=N)C1CCCCC1
  • InChi: 1S/C26H32N4O3S/c1-20(22-8-4-2-5-9-22)25(31)28-17-16-21-12-14-24(15-13-21)34(32,33)30-19-18-29(26(30)27)23-10-6-3-7-11-23/h2,4-5,8-9,12-15,23,27H,1,3,6-7,10-11,16-19H2,(H,28,31)
  • InChiKey: NYYQBFGHZJRAML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide s receptor 0.0453 0.5654 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1418 0.2491
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0531
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.008
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0025 0.0161 0.0755
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0197 0.0256
Brugia malayi Pre-SET motif family protein 0.006 0.0609 0.0816
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Loa Loa (eye worm) hypothetical protein 0.0019 0.0084 0.0105
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0205 0.247 0.5862
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0105
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0596 0.4274
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0032 0.0043
Entamoeba histolytica hypothetical protein 0.0223 0.2706 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0025 0.0161 0.0755
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0057 0.0431
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0466 0.2985
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Schistosoma mansoni thyroid hormone receptor 0.0328 0.4047 0.9663
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0025 0.0161 0.227
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0324 0.0453
Onchocerca volvulus 0.0038 0.0324 0.0484
Schistosoma mansoni nuclear receptor 0.0097 0.1081 0.2515
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0681 0.1551
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0108 0.123 0.2873
Brugia malayi Ets-domain containing protein 0.0076 0.0818 0.1095
Toxoplasma gondii thioredoxin reductase 0.0049 0.0466 0.6692
Echinococcus granulosus mothers against decapentaplegic 5 0.0034 0.0281 0.0476
Onchocerca volvulus 0.0099 0.111 0.1816
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0038 0.0042
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0081 0.0068
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0097 0.1081 0.107
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0115 0.1318 0.1763
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0025 0.0161 0.0819
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0596 0.1346
Brugia malayi ecdysone receptor 0.0097 0.1081 0.1447
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0025 0.0161 0.0755
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0324 0.4266
Echinococcus granulosus dna polymerase kappa 0.0019 0.0083 0.0124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0205 0.247 0.3306
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0038 0.0025
Echinococcus multilocularis GPCR, family 2 0.0033 0.0258 0.0246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0205 0.247 0.3306
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0258 0.0337
Schistosoma mansoni slit 0.0023 0.0141 0.025
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0025 0.0161 0.0819
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0025 0.0161 0.0755
Brugia malayi MH1 domain containing protein 0.0019 0.0084 0.0113
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1318 1
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0466 0.668
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Giardia lamblia DINP protein human, muc B family 0.0019 0.0083 0.0927
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0324 0.4266
Trichomonas vaginalis adenylate cyclase, putative 0.0038 0.0324 0.0453
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0081 0.0105
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0088 0.0967 0.0955
Echinococcus multilocularis netrin receptor unc 5 0.0029 0.0211 0.0198
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0025 0.0161 0.0819
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0495 0.0655
Brugia malayi cytochrome P450 0.0025 0.0161 0.0215
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0205 0.247 0.4355
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Onchocerca volvulus 0.0476 0.5941 1
Schistosoma mansoni cell polarity protein 0.0023 0.0141 0.025
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0038 0.0324 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0108 0.123 0.2873
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0108 0.123 0.1218
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0466 0.0615
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0115 0.1318 0.9214
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0495 0.7015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1132 0.1984
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0258 0.0346
Brugia malayi nuclear receptor RXR 0.0097 0.1081 0.1447
Brugia malayi orphan nuclear receptor NR2E1 0.0097 0.1081 0.1447
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0205 0.247 0.33
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0205 0.247 0.5862
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0223 0.2706 0.2697
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0324 0.0453
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0223 0.2706 0.4775
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0681 0.0912
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0681 0.1185
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0081 0.0105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0181
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0681 0.0904
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.1114
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0681 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0405
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0081 0.0068
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0038 0.0044
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0596 0.3938
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.1114
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0038 0.0324 0.0453
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0205 0.247 0.33
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0596 0.4274
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Echinococcus granulosus aryl hydrocarbon receptor 0.0038 0.0324 0.0551
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Loa Loa (eye worm) transcription factor SMAD2 0.0504 0.6303 0.8434
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.0111
Schistosoma mansoni hypothetical protein 0.0223 0.2706 0.6432
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0108 0.123 0.1639
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0097 0.1081 0.2515
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0025 0.0161 0.0755
Echinococcus granulosus dna polymerase eta 0.0019 0.0083 0.0124
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0025 0.0161 0.0819
Brugia malayi hypothetical protein 0.0125 0.1449 0.1939
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0742 0.0994
Brugia malayi ecdysteroid receptor 0.0205 0.247 0.3306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0226
Echinococcus multilocularis transfer RNA-Lys 0.0107 0.1215 0.1204
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0681 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0038 0.0324 0.0311
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0081 0.0121
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2772 0.3705
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0081 0.0109
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0097 0.1081 0.1893
Loa Loa (eye worm) hypothetical protein 0.0099 0.111 0.1478
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0324 0.0453
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0083 0.0124
Echinococcus granulosus thyroid hormone receptor alpha 0.0097 0.1081 0.1893
Echinococcus multilocularis thyroid hormone receptor alpha 0.0328 0.4047 0.4039
Loa Loa (eye worm) hypothetical protein 0.0029 0.0211 0.0274
Toxoplasma gondii exonuclease III APE 0.0038 0.033 0.4616
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0141 0.0189
Brugia malayi Nuclear hormone receptor E75 0.0097 0.1081 0.1447
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0083 0.0201
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0038 0.0044
Loa Loa (eye worm) steroid hormone receptor 0.0205 0.247 0.33
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.1266 0.8837
Echinococcus multilocularis dna polymerase eta 0.0019 0.0083 0.007
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0435
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0205 0.247 0.4355
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0205 0.247 0.33
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0097 0.1081 0.1447
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0081 0.0105
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0148 0.1736 0.1726
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0083 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0081 0.0105
Schistosoma mansoni hypothetical protein 0.005 0.0484 0.1076
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0081 0.0121
Loa Loa (eye worm) hypothetical protein 0.0108 0.123 0.1639
Loa Loa (eye worm) RecQ helicase 0.0022 0.0123 0.0156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0681 0.0669
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Trypanosoma brucei cytochrome P450, putative 0.0051 0.0495 0.7235
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0105
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.033 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0038 0.0324 0.0311
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0115 0.1318 1
Schistosoma mansoni hypothetical protein 0.0123 0.1418 0.3327
Onchocerca volvulus Netrin receptor homolog 0.0029 0.0211 0.0293
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0081 0.01
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0205 0.247 0.246
Brugia malayi conserved hypotetical protein 0.0097 0.1081 0.1447
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0609 0.0597
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0081 0.0109
Brugia malayi Cytochrome P450 family protein 0.0051 0.0495 0.0663
Schistosoma mansoni hypothetical protein 0.0047 0.0441 0.0971
Echinococcus multilocularis smad 0.0034 0.0281 0.0269
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0025 0.0161 0.0819
Brugia malayi hypothetical protein 0.0097 0.1081 0.1447
Trichomonas vaginalis set domain proteins, putative 0.0475 0.5938 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0531
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0681 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.033 1
Brugia malayi MH2 domain containing protein 0.0015 0.0038 0.0051
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0141 0.0129
Echinococcus multilocularis pikachurin 0.0023 0.0141 0.0129
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.123 0.1646
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0081 0.0121
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.033 0.0318
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0081 0.0121
Leishmania major protein kinase, putative 0.0038 0.0324 0.2112
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0089 0.05
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1132 0.2638
Loa Loa (eye worm) hypothetical protein 0.0015 0.0038 0.0042
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0081 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0405
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.1266 0.8837
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.1081 0.107
Schistosoma mansoni ap endonuclease 0.0038 0.033 0.0705
Brugia malayi EGF-like domain containing protein 0.0023 0.0141 0.0189
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0025 0.0161 0.0819
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0083 0.1114
Brugia malayi MH1 domain containing protein 0.0034 0.0281 0.0376
Mycobacterium ulcerans putative regulatory protein 0.0107 0.1215 0.9189
Echinococcus multilocularis geminin 0.0339 0.4187 0.4179
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0025 0.0161 0.0755
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.033 0.1995
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0141 0.0189
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0025 0.0161 0.0755
Brugia malayi nuclear hormone receptor 0.0205 0.247 0.3306
Leishmania major DNA polymerase kappa, putative 0.0019 0.0083 0.0201
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0025 0.0161 0.0819
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0025 0.0161 0.0755
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0466 0.0453
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2772 0.371
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1318 0.1306
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0088 0.0967 0.1691
Entamoeba histolytica hypothetical protein 0.0223 0.2706 1
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0038 0.0324 0.0425
Brugia malayi Protein kinase domain containing protein 0.0029 0.0211 0.0282
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0917 0.122
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0161 0.1654
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0258 0.0246
Plasmodium falciparum glutathione reductase 0.0049 0.0466 0.6543
Leishmania major cytochrome p450-like protein 0.0025 0.0161 0.0819
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0057 0.0398
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0205 0.247 0.5862
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.1266 0.8837
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Toxoplasma gondii cytochrome p450 superfamily protein 0.0025 0.0161 0.2014
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.116 0.1552
Onchocerca volvulus 0.0028 0.0197 0.027
Schistosoma mansoni hypothetical protein 0.0025 0.0161 0.0296
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0107 0.1218 0.1623
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.033 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0057 0.0045
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0025 0.0161 0.0819
Loa Loa (eye worm) hypothetical protein 0.0108 0.123 0.1639
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0057 0.0738
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0818 0.0806
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0681 0.0669
Echinococcus multilocularis lamin dm0 0.0028 0.0197 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0205 0.247 0.33
Brugia malayi MH1 domain containing protein 0.0034 0.0281 0.0376
Schistosoma mansoni ets-related 0.0231 0.2807 0.6674
Echinococcus multilocularis slit 2 protein 0.0023 0.0141 0.0129
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0057 0.0398
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0102
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0025 0.0161 0.0755
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0081 0.0068
Brugia malayi MH2 domain containing protein 0.0504 0.6303 0.8435
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0141 0.025
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0038 0.0324 0.4266
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0083 0.0201
Brugia malayi nuclear receptor RXR 0.0108 0.123 0.1646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0101 0.1132 0.1984
Loa Loa (eye worm) hypothetical protein 0.0099 0.1113 0.1482
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0205 0.247 0.3306
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1132 0.2638
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0324 0.0453
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0197 0.0256
Schistosoma mansoni netrin receptor unc5 0.0029 0.0211 0.0418
Onchocerca volvulus 0.0047 0.0441 0.0683
Echinococcus granulosus ecdysone induced protein 78C 0.0205 0.247 0.4355
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0681 1
Mycobacterium leprae Possible regulatory protein 0.0038 0.0324 0.1289
Brugia malayi hypothetical protein 0.0229 0.2782 0.3723
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2782 0.4908
Schistosoma mansoni single-minded 0.0145 0.1698 0.4002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0205 0.247 0.4355
Brugia malayi Nuclear hormone receptor E75 0.0097 0.1081 0.1447
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0038 0.0324 0.0453
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0596 0.4274
Loa Loa (eye worm) fli-1 protein 0.0231 0.2807 0.3751
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1425 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Brugia malayi hypothetical protein 0.0148 0.1734 0.2321
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0083 0.0185
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0681 0.0669
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0081 0.01
Schistosoma mansoni intermediate filament proteins 0.0028 0.0197 0.0384
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0211 0.0274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0681 0.0669
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0205 0.247 0.246
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0205 0.247 0.4355
Brugia malayi glutathione reductase 0.0049 0.0466 0.0623
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.1266 0.8837
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.0752 0.1722
Onchocerca volvulus 0.0097 0.1081 0.1767
Brugia malayi Fli-1 protein 0.0231 0.2807 0.3757
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0081 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0258 0.0346
Echinococcus multilocularis Smad4 0.0034 0.0281 0.0269
Onchocerca volvulus 0.0097 0.1081 0.1767
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0115 0.1318 0.2313
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.1081 0.107
Schistosoma mansoni DNA polymerase eta 0.0019 0.0083 0.0108
Brugia malayi Cytochrome P450 family protein 0.0051 0.0495 0.0663
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0034 0.0281 0.0587
Loa Loa (eye worm) CYP4Cod1 0.0051 0.0495 0.0655
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0025 0.0161 0.0819
Onchocerca volvulus 0.0028 0.0197 0.027
Echinococcus multilocularis ecdysone induced protein 78C 0.0205 0.247 0.246
Echinococcus granulosus lamin dm0 0.0028 0.0197 0.0327
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1425 1
Echinococcus granulosus expressed protein 0.0365 0.4517 0.7985
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0081 0.01
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0967 0.2239
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0081 0.0068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.033 0.4373
Echinococcus multilocularis mothers against decapentaplegic 5 0.0034 0.0281 0.0269
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Echinococcus multilocularis musashi 0.0028 0.0197 0.0185
Brugia malayi Smad1 0.0034 0.0281 0.0376
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0025 0.0161 0.1654
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0057 0.0079
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0081 0.01
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.1081 0.1893
Echinococcus granulosus geminin 0.0339 0.4187 0.7399
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0123 0.011
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0025 0.0161 0.0819
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1425 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0681 0.0669
Brugia malayi hypothetical protein 0.0097 0.1081 0.1447
Echinococcus multilocularis lamin 0.0028 0.0197 0.0185
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0025 0.0161 0.0819
Brugia malayi bHLH-PAS transcription factor 0.0107 0.1215 0.1627
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0596 0.1034
Brugia malayi Cytochrome P450 family protein 0.0084 0.0917 0.1227
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0029 0.0214 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0609 0.1378
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0205 0.247 0.3306
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0064 0.0062
Echinococcus granulosus cytochrome P450 2K1 0.0025 0.0161 0.0262
Brugia malayi laminin alpha chain 0.0023 0.0141 0.0189
Schistosoma mansoni lamin 0.0028 0.0197 0.0384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1132 0.1121
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0495 0.0655
Echinococcus multilocularis 0.0025 0.0161 0.0148
Schistosoma mansoni nuclear receptor 0.0097 0.1081 0.2515
Schistosoma mansoni hypothetical protein 0.0339 0.4187 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0038 0.0051
Echinococcus granulosus nuclear factor of activated T cells 5 0.0148 0.1736 0.3055
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0038 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0181
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0596 0.4274
Loa Loa (eye worm) hypothetical protein 0.0033 0.0258 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0205 0.247 0.3306
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.033 0.0464
Schistosoma mansoni smad1 5 8 and 0.0034 0.0281 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0025 0.0161 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0081 0.0121
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0596 0.8691
Echinococcus granulosus TGF beta signal transducer SmadC 0.0034 0.0281 0.0476
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0097 0.1081 0.144
Echinococcus granulosus slit 2 protein 0.0023 0.0141 0.0228
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0057 0.0738
Schistosoma mansoni Smad4 0.0034 0.0281 0.0587
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0083 0.0108
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0083 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0205 0.247 0.3306
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0205 0.247 0.3306
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0324 0.0453
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0324 0.0453
Trypanosoma brucei unspecified product 0.0019 0.0083 0.1114
Schistosoma mansoni steroid hormone receptor ad4bp 0.0205 0.247 0.5862
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0418 0.5198 0.6954
Loa Loa (eye worm) hypothetical protein 0.0038 0.0324 0.0425
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0246
Loa Loa (eye worm) hypothetical protein 0.0029 0.0214 0.0278
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.033 0.4789
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0197 0.0256
Echinococcus granulosus pikachurin 0.0023 0.0141 0.0228
Schistosoma mansoni smad 0.0034 0.0281 0.0587
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0081 0.0121
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0141 0.0181
Echinococcus granulosus Nuclear hormone receptor HR96 0.0097 0.1081 0.1893
Onchocerca volvulus 0.0205 0.247 0.412
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0025 0.0161 0.0755
Brugia malayi small heat shock protein 0.0595 0.7472 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0025 0.0161 0.0755
Brugia malayi PAS domain containing protein 0.0145 0.1698 0.2273
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0025 0.0161 0.0819
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0609 0.1057
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0205 0.247 0.246
Echinococcus granulosus Ankyrin 0.0029 0.0214 0.0357
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0081 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.0205 0.247 0.3306
Loa Loa (eye worm) hypothetical protein 0.0103 0.116 0.1545
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0081 0.0105
Brugia malayi tailless protein 0.0097 0.1081 0.1447
Loa Loa (eye worm) hypothetical protein 0.0148 0.1734 0.2314
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0083 0.0102
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0205 0.247 0.33
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0057 0.0077
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0681 1
Brugia malayi Uncoordinated protein 44 0.0029 0.0211 0.0282
Onchocerca volvulus Protein ultraspiracle homolog 0.0205 0.247 0.412
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0205 0.247 0.246
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0097 0.1081 0.1767
Echinococcus granulosus lamin 0.0028 0.0197 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Onchocerca volvulus 0.0099 0.111 0.1816
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0681 0.4562
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0057 0.0431
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0211 0.0351
Loa Loa (eye worm) hypothetical protein 0.006 0.0609 0.0808
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.033 0.4373
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0205 0.247 0.3306
Schistosoma mansoni ap endonuclease 0.0038 0.033 0.0705
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.5654 0.5649
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0081 0.0068
Echinococcus granulosus smad 0.0034 0.0281 0.0476
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0081 0.0109
Brugia malayi Pre-SET motif family protein 0.0418 0.5198 0.6957
Onchocerca volvulus 0.0107 0.1215 0.1995
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0081 0.0068
Loa Loa (eye worm) Smad1 0.0034 0.0281 0.0368
Brugia malayi hypothetical protein 0.0223 0.2706 0.3622
Loa Loa (eye worm) hypothetical protein 0.0108 0.123 0.1639
Brugia malayi PXA domain containing protein 0.0019 0.0081 0.0109
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0097 0.1081 0.107
Brugia malayi nuclear receptor NHR-88 0.0205 0.247 0.3306
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0025 0.0161 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0205 0.247 0.3306
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0081 0.0105
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0258 0.0435
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.033 0.0442
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0211 0.0198
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0123 0.0111
Echinococcus multilocularis expressed protein 0.0365 0.4517 0.451
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.5654 0.5649
Schistosoma mansoni nuclear receptor nhr-48 0.0097 0.1081 0.2515
Schistosoma mansoni hypothetical protein 0.0029 0.0211 0.0418
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0083 0.0405
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.1266 0.8837
Loa Loa (eye worm) hypothetical protein 0.007 0.0742 0.0986
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Brugia malayi Ets-domain containing protein 0.0076 0.0818 0.1095
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.033 0.0949
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0141 0.025
Echinococcus multilocularis nuclear receptor nhr 48 0.0097 0.1081 0.107
Trypanosoma brucei trypanothione reductase 0.0049 0.0466 0.6798
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0057 0.0738
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0088 0.0967 0.2239
Schistosoma mansoni retinoic acid receptor RXR 0.0205 0.247 0.5862
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0034 0.0281 0.0269
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0083 0.0043
Brugia malayi hypothetical protein 0.0019 0.0081 0.0109
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.033 0.2165
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0596 0.1346
Plasmodium falciparum thioredoxin reductase 0.0049 0.0466 0.6543
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.033 0.0434
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0083 0.0006
Echinococcus multilocularis muscleblind protein 1 0.0154 0.1814 0.1804
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.033 0.4597
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0324 0.2112
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0025 0.0161 0.0819
Entamoeba histolytica hypothetical protein 0.0223 0.2706 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0581 0.1007
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0081 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0101 0.1132 0.2638
Entamoeba histolytica hypothetical protein 0.0223 0.2706 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0025 0.0161 0.0755
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0025 0.0161 0.0819
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0051 0.0495 0.3473
Loa Loa (eye worm) DR-78 0.0097 0.1081 0.144
Loa Loa (eye worm) hypothetical protein 0.0154 0.1814 0.2422
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.1266 0.8742
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0025 0.0161 0.0755
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0081 0.0121
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0097 0.1081 0.1767
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0057 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0205 0.247 0.3306
Echinococcus granulosus bloom syndrome protein 0.0022 0.0123 0.0195
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.033 0.0563
Brugia malayi nuclear receptor NHR-88 0.0097 0.1081 0.1447
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0197 0.0264
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0025 0.0161 0.0819
Schistosoma mansoni survival motor neuron protein 0.0047 0.0441 0.0971
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0025 0.0161 0.0819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0205 0.247 0.33
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0205 0.247 0.412
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0596 0.0584
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0038 0.0324 0.0453
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0025 0.0161 0.0755
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0081 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0108 0.123 0.1646
Brugia malayi Nuclear hormone receptor-like 1 0.0205 0.247 0.3306
Loa Loa (eye worm) nuclear factor I 0.0019 0.0084 0.0105
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0441 0.059
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0081 0.0105
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0101 0.1132 0.1508
Onchocerca volvulus Bile acid receptor homolog 0.0205 0.247 0.412
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0141 0.0228
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0038 0.0324 0.4266
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0081 0.0121
Schistosoma mansoni nuclear hormone receptor 0.0097 0.1081 0.2515
Schistosoma mansoni thyroid hormone receptor 0.0328 0.4047 0.9663
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0083 0.0043
Brugia malayi SET domain containing protein 0.0013 0.0012 0.0016
Leishmania major protein kinase, putative 0.0038 0.0324 0.2112
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0009
Onchocerca volvulus 0.0071 0.0752 0.121
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Echinococcus multilocularis muscleblind protein 0.0154 0.1814 0.1804
Schistosoma mansoni zinc finger protein 0.0097 0.1081 0.2515
Loa Loa (eye worm) hypothetical protein 0.0027 0.0191 0.0247
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0081 0.0105
Brugia malayi Steroid receptor seven-up type 2 0.0205 0.247 0.3306
Loa Loa (eye worm) hypoxia-induced factor 1 0.0448 0.5589 0.7477
Echinococcus granulosus intermediate filament protein 0.0028 0.0197 0.0327
Brugia malayi MH1 domain containing protein 0.0019 0.0084 0.0113
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0081 0.0109
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0115 0.1318 1
Schistosoma mansoni cytochrome P450 0.0025 0.0161 0.0296
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.033 0.2165
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.0281 0.0368
Schistosoma mansoni coup transcription factor 0.0205 0.247 0.5862
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0681 1
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0211 0.0418
Echinococcus granulosus nuclear receptor nhr 48 0.0097 0.1081 0.1893
Brugia malayi Death domain containing protein 0.0029 0.0211 0.0282
Loa Loa (eye worm) hypothetical protein 0.0486 0.6071 0.8124
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0681 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0405
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0205 0.247 0.3306
Mycobacterium tuberculosis Probable reductase 0.0111 0.1266 0.8837
Loa Loa (eye worm) hypothetical protein 0.0108 0.123 0.1639
Loa Loa (eye worm) hypothetical protein 0.0065 0.0676 0.0897
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0097 0.1081 0.2515
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0081 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0205 0.247 0.4355
Plasmodium vivax SET domain protein, putative 0.006 0.0609 0.8891
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0025 0.0161 0.0819
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0025 0.0161 0.1654
Loa Loa (eye worm) nuclear receptor NHR-67 0.0097 0.1081 0.144
Brugia malayi MH2 domain containing protein 0.0034 0.0281 0.0376
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.01
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.1081 0.1893
Loa Loa (eye worm) hypothetical protein 0.0108 0.123 0.1639
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0205 0.247 0.5862
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0123 0.0164
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.033 0.4373
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0057 0.0738
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0205 0.247 0.4355
Loa Loa (eye worm) glutathione reductase 0.0049 0.0466 0.0615
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0205 0.247 0.33
Leishmania major cytochrome p450-like protein 0.0025 0.0161 0.0819
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0681 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.0281 0.0368
Plasmodium vivax glutathione reductase, putative 0.0049 0.0466 0.668
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0466 0.0803
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.033 0.0464
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0081 0.0109
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0081 0.0109
Onchocerca volvulus 0.0148 0.1734 0.2873
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0025 0.0161 0.0819
Echinococcus granulosus death domain containing protein 0.0029 0.0211 0.0351
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0818 0.1087
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0081 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0205 0.247 0.5862
Schistosoma mansoni hypothetical protein 0.007 0.0742 0.1698
Schistosoma mansoni transcription factor LCR-F1 0.0223 0.2706 0.6432
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0324 0.4266
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0205 0.247 0.3306
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0818 0.1427
Schistosoma mansoni RAR-like nuclear receptor 0.0205 0.247 0.5862
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0032 0.0034
Brugia malayi nuclear hormone receptor 0.0097 0.1081 0.1447
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0083 0.0201
Leishmania major cytochrome p450-like protein 0.0051 0.0495 0.3473
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0205 0.247 0.5862
Echinococcus granulosus GPCR family 2 0.0033 0.0258 0.0435
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0531
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0609 0.0597
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0101 0.1132 0.1121
Loa Loa (eye worm) hypothetical protein 0.0023 0.0141 0.0181
Echinococcus granulosus Smad4 0.0034 0.0281 0.0476
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0025 0.0161 0.0755
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0025 0.0161 0.0755
Echinococcus granulosus single minded 2 0.0107 0.1215 0.2132
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0466 0.6543
Loa Loa (eye worm) cytochrome P450 0.0025 0.0161 0.0207
Loa Loa (eye worm) MH2 domain-containing protein 0.0504 0.6303 0.8434
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.116 0.1545
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0081 0.01
Schistosoma mansoni smad1 5 8 and 0.0034 0.0281 0.0587
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0205 0.247 0.4355
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0083 0.0185
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0083 0.1114
Loa Loa (eye worm) nuclear hormone receptor 0.0097 0.1081 0.144
Schistosoma mansoni hypothetical protein 0.0033 0.0258 0.0531
Schistosoma mansoni aryl hydrocarbon receptor 0.0145 0.1698 0.4002
Brugia malayi isocitrate dehydrogenase 0.0066 0.0681 0.0912
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Echinococcus multilocularis FTZ F1 alpha 0.0205 0.247 0.246
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0205 0.247 0.246
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0211 0.0282
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0205 0.247 0.246
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0083 0.0111
Brugia malayi intermediate filament protein 0.0028 0.0197 0.0264
Brugia malayi hypothetical protein 0.0108 0.123 0.1646
Leishmania major DNA polymerase eta, putative 0.0019 0.0083 0.0201
Brugia malayi hypothetical protein 0.0108 0.123 0.1646
Echinococcus granulosus FTZ F1 alpha 0.0205 0.247 0.4355
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.5654 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0038 0.0025
Schistosoma mansoni lamin 0.0028 0.0197 0.0384
Schistosoma mansoni hypothetical protein 0.0339 0.4187 1
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0025 0.0161 0.0819
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0108 0.123 0.2157
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0025 0.0161 0.0755
Brugia malayi hypothetical protein 0.0486 0.6071 0.8125
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0205 0.247 0.3306
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0097 0.1081 0.107
Brugia malayi steroid hormone receptor 0.0205 0.247 0.3306
Brugia malayi hypoxia-induced factor 1 0.0448 0.5589 0.748
Brugia malayi hypothetical protein 0.0099 0.1113 0.1489
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0115 0.1318 0.3085
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0609 0.8895
Brugia malayi nuclear hormone receptor family member nhr-6 0.0097 0.1081 0.1447
Trypanosoma cruzi cytochrome P450, putative 0.0051 0.0495 0.7015
Brugia malayi M-phase phosphoprotein, mpp8 0.0099 0.111 0.1485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0609 0.1378
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0081 0.0121
Brugia malayi nuclear hormone receptor family member odr-7 0.0097 0.1081 0.1447
Leishmania major trypanothione reductase 0.0049 0.0466 0.324
Brugia malayi Thioredoxin reductase 0.0049 0.0466 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0083 0.1114
Brugia malayi nuclear receptor NHR-67 0.0097 0.1081 0.1447
Loa Loa (eye worm) hypothetical protein 0.0595 0.7472 1
Schistosoma mansoni nuclear hormone receptor 0.0097 0.1081 0.2515
Loa Loa (eye worm) hypothetical protein 0.0154 0.1814 0.2422
Brugia malayi MH2 domain containing protein 0.0034 0.0281 0.0376
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0609 0.1378
Brugia malayi hypothetical protein 0.0019 0.0081 0.0109
Echinococcus granulosus muscleblind protein 0.0154 0.1814 0.3194
Brugia malayi PXA domain containing protein 0.0019 0.0081 0.0109
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Loa Loa (eye worm) hypothetical protein 0.0229 0.2782 0.3717
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0025 0.0161 0.0755
Echinococcus granulosus netrin receptor unc 5 0.0029 0.0211 0.0351
Trichomonas vaginalis guanylate cyclase, putative 0.0038 0.0324 0.0453
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0083 0.0405
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Echinococcus multilocularis Ankyrin 0.0029 0.0214 0.0202
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0205 0.247 0.5862
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0081 0.0105
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0038 0.0324 0.0551
Schistosoma mansoni smad1 5 8 and 0.0034 0.0281 0.0587
Loa Loa (eye worm) hypothetical protein 0.0205 0.247 0.33
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1418 0.1407
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0081 0.0068
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0101 0.1132 0.1515
Brugia malayi Cytochrome P450 family protein 0.0025 0.0161 0.0215
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0025 0.0161 0.0755
Schistosoma mansoni gabp alpha 0.0076 0.0818 0.188
Loa Loa (eye worm) hypothetical protein 0.0327 0.4032 0.5392
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.0324 0.4266
Loa Loa (eye worm) hypothetical protein 0.0097 0.1081 0.144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0681 0.4951
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0025 0.0161 0.0755
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2782 0.2772
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.116 0.1552
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0081 0.0068
Brugia malayi Muscleblind-like protein 0.0154 0.1814 0.2428
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0123 0.0111

Activities

Activity type Activity value Assay description Source Reference
ED20 (functional) = 0.014 mM kg-1 Hypoglycemic activity by lowering blood glucose in normal rats by 20% after oral administration. ChEMBL. 6864736
ED20 (functional) = 0.96 mM kg-1 Hypoglycemic activity by lowering blood glucose in streptozotocin-diabetic rats by 20% after oral administration. ChEMBL. 6864736
ED50 (functional) = 0.048 mM kg-1 Hypoglycemic activity by lowering blood glucose in normal rats by 50% after oral administration. ChEMBL. 6864736

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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