Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis lupus familiaris | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Chorion peroxidase homolog | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.3726 | 0.796 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0252 | 0.9549 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0148 | 0.4682 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0048 | 0 | 0.5 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.9495 | 0.9943 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.4682 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.3726 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0148 | 0.4682 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0048 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0252 | 0.9549 | 0.9549 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.3726 | 0.796 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0252 | 0.9549 | 0.9549 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 115 ng hr ml-1 | AUC (Area Under Plasma concentration-time curve) of the compound was after oral administration at 5 mg/kg | ChEMBL. | 14684306 |
C24 (ADMET) | = 4 ng ml-1 | C24 of the compound was determined after oral administration at 5 mg/kg | ChEMBL. | 14684306 |
Cmax (ADMET) | = 42 ng ml-1 | Cmax (Maximum (Peak) plasma drug concentration) of the compound was after oral administration at 5 mg/kg | ChEMBL. | 14684306 |
IC50 (binding) | = 0.3 uM | In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. | ChEMBL. | 14684306 |
IC50 (binding) | = 0.3 uM | In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. | ChEMBL. | 14684306 |
IC50 (binding) | > 50 uM | In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. | ChEMBL. | 14684306 |
IC50 (binding) | > 50 uM | In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. | ChEMBL. | 14684306 |
Ratio (binding) | > 167 | Ratio of IC50 of COX-1 to that of COX-2. | ChEMBL. | 14684306 |
T max (ADMET) | = 0.8 hr | Tmax (time to reach maximum concentration) of the compound was after oral administration at 5 mg/kg | ChEMBL. | 14684306 |
T1/2 (ADMET) | = 2.6 hr | T1/2 (Half-life) of the compound was after oral administration at 5 mg/kg | ChEMBL. | 14684306 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.