Detailed information for compound 307771

Basic information

Technical information
  • TDR Targets ID: 307771
  • Name: (3Z)-5-bromo-3-[[3-bromo-4-hydroxy-5-(2-metho xyphenyl)phenyl]methylidene]-1H-pyrrolo[2,3-b ]pyridin-2-one
  • MW: 502.155 | Formula: C21H14Br2N2O3
  • H donors: 2 H acceptors: 3 LogP: 4.78 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1c1cc(cc(c1O)Br)/C=C/1\C(=O)Nc2c1cc(Br)cn2
  • InChi: 1S/C21H14Br2N2O3/c1-28-18-5-3-2-4-13(18)14-6-11(8-17(23)19(14)26)7-16-15-9-12(22)10-24-20(15)25-21(16)27/h2-10,26H,1H3,(H,24,25,27)/b16-7-
  • InChiKey: RIJBDOXTEPVDPJ-APSNUPSMSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (3Z)-5-bromo-3-[[3-bromo-4-hydroxy-5-(2-methoxyphenyl)phenyl]methylene]-1H-pyrrolo[2,3-b]pyridin-2-one
  • (3Z)-5-bromo-3-[3-bromo-4-hydroxy-5-(2-methoxyphenyl)benzylidene]-1H-pyrrolo[2,3-b]pyridin-2-one
  • (3Z)-5-bromo-3-[[3-bromo-4-hydroxy-5-(2-methoxyphenyl)phenyl]methylidene]-1H-pyrrolo[5,4-b]pyridin-2-one
  • (3Z)-5-bromo-3-[[3-bromo-4-hydroxy-5-(2-methoxyphenyl)phenyl]methylene]-1H-pyrrolo[5,4-b]pyridin-2-one
  • (3Z)-5-bromo-3-[3-bromo-4-hydroxy-5-(2-methoxyphenyl)benzylidene]-1H-pyrrolo[5,4-b]pyridin-2-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin A1 Starlite/ChEMBL References
Renilla reniformis Renilla-luciferin 2-monooxygenase Starlite/ChEMBL No references
Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL References
Homo sapiens cyclin A2 References
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) TKL/RAF/RAF protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) Get druggable targets OG5_158622 All targets in OG5_158622
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Mycobacterium ulcerans haloalkane dehalogenase Get druggable targets OG5_158622 All targets in OG5_158622
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Raf kinase Get druggable targets OG5_130459 All targets in OG5_130459
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis raf serine:threonine protein kinase Get druggable targets OG5_130459 All targets in OG5_130459
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative Get druggable targets OG5_130459 All targets in OG5_130459
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium ulcerans epoxide hydrolase EphE Renilla-luciferin 2-monooxygenase   311 aa 289 aa 21.1 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Loa Loa (eye worm) protein phosphatase methylesterase 1 Renilla-luciferin 2-monooxygenase   311 aa 278 aa 20.1 %
Mycobacterium tuberculosis Possible epoxide hydrolase EphE (epoxide hydratase) (arene-oxide hydratase) Renilla-luciferin 2-monooxygenase   311 aa 284 aa 21.1 %
Mycobacterium leprae POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) Renilla-luciferin 2-monooxygenase   311 aa 289 aa 20.8 %
Onchocerca volvulus Renilla-luciferin 2-monooxygenase   311 aa 278 aa 19.4 %
Brugia malayi protein phosphatase methylesterase 1 Renilla-luciferin 2-monooxygenase   311 aa 315 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cyclin B 0.009 0.0504 0.1162
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0242 0.0242
Brugia malayi SRC-1 0.0048 0.0242 0.1581
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0089 0.1185
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0014 0.0033 0.0055
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0178 0.3537
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0151 0.0883 0.5643
Echinococcus granulosus tumor protein p63 0.0328 0.1985 0.458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0048
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0008 0.0103
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0048
Echinococcus granulosus Protein kinase C brain isozyme 0.001 0.0004 0.0008
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Brugia malayi C1-like domain containing protein 0.001 0.0004 0.0023
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.009 0.1791
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0008 0.0007
Loa Loa (eye worm) cyclin domain-containing protein 0.0038 0.0177 0.113
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0044 0.0215 0.0495
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0187 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Echinococcus multilocularis pyruvate kinase 0.0053 0.0274 0.0274
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1448 0.1447
Onchocerca volvulus 0.0049 0.025 0.346
Echinococcus granulosus c src tyrosine kinase 0.0013 0.0023 0.0053
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0242 0.0242
Echinococcus multilocularis tyrosine protein kinase Abl 0.0013 0.0023 0.0023
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Echinococcus multilocularis 0.0014 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.009 0.0504 0.3218
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0268 0.4985
Entamoeba histolytica cyclin family protein 0.0038 0.0177 0.351
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0008 0.0049
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0504 0.3288
Schistosoma mansoni cyclin B3 0.0038 0.0177 0.0408
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0029 0.0065
Onchocerca volvulus Huntingtin homolog 0.0125 0.0723 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.009 0.0094
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0014 0.0033 0.0055
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0014 0.0033 0.0055
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0236 0.4675
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0362 0.2365
Echinococcus granulosus raf serine:threonine protein kinase 0.0264 0.1589 0.3666
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0008 0.0017
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0017
Giardia lamblia Hypothetical protein 0.0038 0.0177 0.0536
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.001 0.0004 0.0008
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0242 0.0559
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0362 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0014 0.0029 0.0028
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.016 0.016
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Schistosoma mansoni microtubule-associated protein tau 0.0705 0.4333 1
Brugia malayi hypothetical protein 0.0037 0.0172 0.1123
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0362 0.6995
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0013 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Echinococcus multilocularis protein kinase c iota type 0.001 0.0004 0.0003
Schistosoma mansoni bromodomain containing protein 0.0061 0.0326 0.0751
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.009 0.0148
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Schistosoma mansoni tyrosine kinase 0.0013 0.0023 0.0053
Schistosoma mansoni pyruvate kinase 0.0067 0.0362 0.0836
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.009 0.0148
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Brugia malayi nuclear receptor NHR-88 0.001 0.0008 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0089 0.0568
Schistosoma mansoni coup transcription factor 0.001 0.0008 0.0017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0008 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Schistosoma mansoni hypothetical protein 0.0015 0.0036 0.0082
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0014 0.0029 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0017
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0268 0.1711
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0069 0.0371 0.2367
Echinococcus multilocularis protein kinase c epsilon type 0.001 0.0004 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0008 0.0049
Loa Loa (eye worm) TK protein kinase 0.0044 0.0215 0.1372
Schistosoma mansoni atypical protein kinase C 0.001 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0047 0.0236 0.1505
Brugia malayi PHD-finger family protein 0.0024 0.0094 0.0611
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.001 0.0004 0.0023
Toxoplasma gondii hypothetical protein 0.0028 0.0121 0.3324
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0008 0.0017
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0191 0.044
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0049
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0154 0.0198
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0008 0.0007
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0242 0.0242
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0014 0.0033 0.0055
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0362 0.6995
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0268 0.0618
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0068 0.0433
Trichomonas vaginalis cyclins, putative 0.0062 0.0327 0.4577
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0518 0.338
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0017
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0178 0.0411
Trichomonas vaginalis cyclin A, putative 0.009 0.0504 1
Toxoplasma gondii pyruvate kinase PyKII 0.0035 0.0158 0.4369
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0242 0.0242
Brugia malayi Variant SH3 domain containing protein 0.0014 0.0029 0.0185
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Echinococcus multilocularis tumor protein p63 0.0328 0.1985 0.1984
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0362 0.5675
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0178 0.0293
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1448 0.334
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0046 0.0107
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0107
Schistosoma mansoni tyrosine kinase 0.0048 0.0242 0.0559
Brugia malayi Cyclin, N-terminal domain containing protein 0.0038 0.0177 0.1154
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0362 0.2365
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Loa Loa (eye worm) raf kinase 0.026 0.1565 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0008 0.0049
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0242 0.0559
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Onchocerca volvulus Huntingtin homolog 0.0125 0.0723 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0008 0.0017
Echinococcus granulosus FTZ F1 alpha 0.001 0.0008 0.0017
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0242 0.0559
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0242 0.0558
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0048
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0049
Brugia malayi Cytochrome P450 family protein 0.0023 0.0089 0.0581
Brugia malayi protein kinase C3,putative 0.001 0.0004 0.0023
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0304 0.0304
Trypanosoma brucei cdc2-related kinase 3 0.0052 0.0268 0.4985
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0362 0.0595
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.005 0.0319
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0014 0.0033 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0518 0.0518
Schistosoma mansoni zinc finger protein 0.0019 0.0062 0.0142
Echinococcus multilocularis cyclin dependent kinase 0.0052 0.0268 0.0268
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0052 0.0268 0.4985
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 0.1791
Brugia malayi Protein kinase domain containing protein 0.0052 0.0268 0.1748
Leishmania major pyruvate kinase 0.0067 0.0362 0.6995
Brugia malayi Bromodomain containing protein 0.0073 0.0396 0.2587
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.009 0.1732
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0362 0.6995
Echinococcus granulosus pyruvate kinase 0.0067 0.0362 0.0836
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0014 0.0033 0.0055
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0052 0.0268 0.1711
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0518 0.1195
Echinococcus granulosus cyclin dependent kinase 5 0.0052 0.0268 0.0618
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0007
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Loa Loa (eye worm) hypothetical protein 0.004 0.0189 0.121
Echinococcus granulosus tyrosine protein kinase Blk 0.0044 0.0215 0.0495
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0077
Trypanosoma cruzi ISWI complex protein 0.0015 0.0036 0.0051
Brugia malayi protein-tyrosine kinase 0.0044 0.0215 0.1401
Echinococcus multilocularis microtubule associated protein 2 0.0705 0.4333 0.4333
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0268 0.3169
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0008 0.0049
Onchocerca volvulus 0.001 0.0008 0.0103
Schistosoma mansoni pyruvate kinase 0.0067 0.0362 0.0836
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0049
Brugia malayi Cytochrome P450 family protein 0.0023 0.0089 0.0581
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0236 0.1505
Entamoeba histolytica protein kinase, putative 0.0039 0.0187 0.37
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0191 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0008 0.0017
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0041 0.0201 0.1283
Echinococcus multilocularis cyclin dependent kinase 5 0.0052 0.0268 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0049
Loa Loa (eye worm) TK protein kinase 0.0039 0.0187 0.1191
Brugia malayi ecdysteroid receptor 0.001 0.0008 0.0049
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0518 0.1195
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0038 0.0177 0.0177
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0046 0.0107
Plasmodium falciparum cyclin 0.0038 0.0177 0.4002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.009 0.0148
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.008 0.0183
Chlamydia trachomatis pyruvate kinase 0.0067 0.0362 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0014 0.0029 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0008 0.0007
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0362 0.5675
Loa Loa (eye worm) hypothetical protein 0.0052 0.027 0.1725
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus multilocularis tyrosine protein kinase Blk 0.0044 0.0215 0.0215
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0053 0.0087
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0268 0.5316
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0154 0.3656
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0008 0.0049
Leishmania major cytochrome p450-like protein 0.0023 0.0089 0.1185
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0014 0.0033 0.0055
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Brugia malayi Inositol-1 0.0038 0.0178 0.1163
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0008 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0008 0.0103
Brugia malayi Protein kinase domain containing protein 0.001 0.0004 0.0023
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.008 0.0183
Echinococcus granulosus geminin 0.0173 0.1021 0.2357
Giardia lamblia Cyclin A 0.0038 0.0177 0.0536
Trypanosoma cruzi cdc2-related kinase 3 0.0052 0.0268 0.4985
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0052 0.0268 0.0618
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0518 0.3309
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0008 0.0048
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Schistosoma mansoni hypothetical protein 0.0173 0.1021 0.2357
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0107
Trypanosoma brucei ISWI complex protein 0.0015 0.0036 0.0051
Echinococcus granulosus pyruvate kinase 0.0035 0.0158 0.0365
Mycobacterium ulcerans haloalkane dehalogenase 0.0987 0.6093 1
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0268 0.4985
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0155 0.0988
Loa Loa (eye worm) inositol-1 0.0038 0.0178 0.1138
Schistosoma mansoni protein kinase C mu 0.001 0.0004 0.0008
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0013 0.0023 0.0053
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.025 0.1632
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.008 0.0079
Echinococcus multilocularis Protein kinase C, brain isozyme 0.001 0.0004 0.0003
Plasmodium vivax pyruvate kinase 2, putative 0.0035 0.0158 0.3403
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0046 0.0107
Plasmodium falciparum protein kinase 5 0.0052 0.0268 0.6943
Entamoeba histolytica cyclin, putative 0.0038 0.0177 0.351
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0008 0.0007
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0089 0.0568
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0052 0.0268 0.739
Entamoeba histolytica cyclin family protein 0.0038 0.0177 0.351
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0362 0.0543
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0987 0.6093 1
Trypanosoma cruzi cyclin 6, putative 0.009 0.0504 1
Echinococcus granulosus cyclin b3 0.0038 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Loa Loa (eye worm) CAMK/PKD protein kinase 0.001 0.0004 0.0022
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0032 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0008 0.0049
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.001 0.0004 0.0022
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0008 0.0103
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0014 0.0033 0.0055
Leishmania major pyruvate kinase 0.0067 0.0362 0.6995
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0172 0.0397
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0033 0.0917
Echinococcus multilocularis geminin 0.0173 0.1021 0.1021
Echinococcus granulosus cyclin B 0.009 0.0504 0.1162
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0008 0.0017
Schistosoma mansoni tyrosine kinase 0.0013 0.0023 0.0053
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0362 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0178 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0178 0.0041
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0178 0.4917
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Loa Loa (eye worm) hypothetical protein 0.0048 0.0242 0.1546
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.009 0.1732
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0008 0.0017
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0014 0.0033 0.0055
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0172 0.0397
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0008 0.0017
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0014 0.0033 0.0055
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0008 0.0017
Brugia malayi hypothetical protein 0.0125 0.0723 0.4717
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0014 0.0033 0.0055
Echinococcus granulosus protein kinase c iota type 0.001 0.0004 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0008 0.0007
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.007 0.0457
Echinococcus granulosus zinc finger protein 0.0019 0.0062 0.0142
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0008 0.0048
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.0504 1
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0362 0.2315
Schistosoma mansoni zinc finger protein 0.0015 0.0036 0.0082
Loa Loa (eye worm) hypothetical protein 0.0242 0.1448 0.925
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0049 0.025 0.0577
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0008 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.0125 0.0723 0.4617
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0089 0.0146
Trypanosoma cruzi cdc2-related kinase 1 0.0052 0.0268 0.4985
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0268 0.0618
Echinococcus multilocularis raf serine:threonine protein kinase 0.0264 0.1589 0.1589
Trypanosoma brucei mitotic cyclin 6 0.009 0.0504 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0008 0.0017
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.009 0.0148
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 0.1791
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0037 0.0175 0.1118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0008 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0304 0.0701
Giardia lamblia Pyruvate kinase 0.0067 0.0362 0.5907
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Entamoeba histolytica cyclin, putative 0.009 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0362 0.2315
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0014 0.0033 0.0055
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0014 0.0029 0.0181
Onchocerca volvulus 0.0048 0.0242 0.3349
Echinococcus granulosus cyclins 0.0038 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0576
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0038 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Schistosoma mansoni thyroid hormone receptor 0.001 0.0008 0.0017
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0008 0.0049
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0089 0.1185
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0178 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0046 0.0107
Brugia malayi Protein kinase c protein 2 0.001 0.0004 0.0023
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus multilocularis pyruvate kinase 0.0067 0.0362 0.0362
Brugia malayi RhoGAP domain containing protein 0.0014 0.0029 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0264 0.1589 0.3666
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0242 0.0242
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0242 0.0559
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0014 0.0033 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0008 0.0048
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0589
Plasmodium falciparum pyruvate kinase 0.0067 0.0362 1
Loa Loa (eye worm) cytochrome P450 0.0014 0.0033 0.0212
Brugia malayi cell division control protein 2 homolog 0.0052 0.0268 0.1748
Schistosoma mansoni pyruvate kinase 0.0035 0.0158 0.0365
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.001 0.0004 0.0022
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0246 0.0567
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Schistosoma mansoni inositol monophosphatase 0.0038 0.0178 0.0411
Plasmodium vivax protein kinase Crk2 0.0052 0.0268 0.6943
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0052 0.0268 0.4985
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Echinococcus granulosus cyclin dependent kinase 1 0.0052 0.0268 0.0618
Brugia malayi Tyrosine-protein kinase abl-1 0.0013 0.0023 0.015
Trypanosoma cruzi cyclin, putative 0.009 0.0504 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.0504 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0008 0.0048
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0044 0.0215 0.0215
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.001 0.0004 0.0003
Brugia malayi nuclear hormone receptor 0.001 0.0008 0.0049
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Echinococcus multilocularis pyruvate kinase 0.0067 0.0362 0.0362
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0089 0.0568
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0362 0.5014
Brugia malayi pyruvate kinase 0.0014 0.0032 0.0205
Echinococcus multilocularis pyruvate kinase 0.0035 0.0158 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Schistosoma mansoni cyclins 0.0038 0.0177 0.0408
Trypanosoma cruzi cyclin, putative 0.009 0.0504 1
Brugia malayi Cytochrome P450 family protein 0.0014 0.0033 0.0217
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Entamoeba histolytica cell division protein kinase 2, putative 0.0052 0.0268 0.5316
Schistosoma mansoni hypothetical protein 0.0037 0.0172 0.0397
Trypanosoma cruzi ISWI complex protein 0.0015 0.0036 0.0051
Brugia malayi cytochrome P450 0.0014 0.0033 0.0217
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0125 0.0723 0.4617
Brugia malayi steroid hormone receptor 0.001 0.0008 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0518 0.1195
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0032 0.0201
Echinococcus multilocularis cyclins 0.0038 0.0177 0.0177
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0178 0.3081
Echinococcus multilocularis tyrosine protein kinase Srms 0.0044 0.0215 0.0215
Brugia malayi protein kinase C II. 0.001 0.0004 0.0023
Onchocerca volvulus 0.0024 0.009 0.1248
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Brugia malayi Cytochrome P450 family protein 0.0034 0.0155 0.1009
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0014 0.0033 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0008 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0242 0.0242
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0052 0.0268 0.1711
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.009 0.0094
Leishmania major cyclin 0.009 0.0504 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.0339
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0014 0.0033 0.0055
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0008 0.0017
Schistosoma mansoni inositol monophosphatase 0.0038 0.0178 0.0411
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0008 0.0049
Schistosoma mansoni hypothetical protein 0.0173 0.1021 0.2357
Echinococcus granulosus microtubule associated protein 2 0.0705 0.4333 1
Schistosoma mansoni tyrosine kinase 0.0048 0.0242 0.0559
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0178 0.0178
Brugia malayi Raf kinase 0.0255 0.1532 1
Trichomonas vaginalis cyclin B, putative 0.009 0.0504 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0178 0.0041
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0242 0.0559
Plasmodium falciparum pyruvate kinase 2 0.0035 0.0158 0.3403
Schistosoma mansoni hypothetical protein 0.002 0.0068 0.0157
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0362 1
Echinococcus granulosus cyclin dependent kinase 0.0052 0.0268 0.0618
Trichomonas vaginalis cyclins, putative 0.009 0.0504 1
Echinococcus granulosus N chimaerin 0.0014 0.0029 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0008 0.0017
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0148
Brugia malayi hypothetical protein 0.0242 0.1448 0.9449
Echinococcus granulosus tyrosine kinase 0.0044 0.0215 0.0495
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0008 0.0017
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0504 0.3288
Echinococcus multilocularis zinc finger protein 0.0019 0.0062 0.0061
Echinococcus multilocularis N chimaerin 0.0014 0.0029 0.0028
Echinococcus granulosus protein kinase c epsilon type 0.001 0.0004 0.0008
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0014 0.0033 0.0055
Giardia lamblia Kinase, CMGC CDK 0.0052 0.0268 0.3169
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0089 0.1185
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0014 0.0033 0.0055
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0362 0.6995
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0046 0.0046
Echinococcus granulosus pyruvate kinase 0.0067 0.0362 0.0836
Echinococcus multilocularis cyclin B3 1 0.0038 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.009 0.0504 0.3218
Schistosoma mansoni survival motor neuron protein 0.0049 0.025 0.0577
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.016 0.037
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0268 0.2782
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Echinococcus multilocularis c src tyrosine kinase 0.0013 0.0023 0.0023
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0008 0.0049
Echinococcus multilocularis cyclin b3 0.0038 0.0177 0.0177
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0268 0.0268
Loa Loa (eye worm) SRC-1 0.0048 0.0242 0.1548
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0046 0.0046
Schistosoma mansoni vav2 0.0014 0.0029 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0172 0.0172
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0013 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.001 0.0008 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.1211
Echinococcus granulosus cyclin B3 1 0.0038 0.0177 0.0408
Loa Loa (eye worm) hypothetical protein 0.0017 0.0046 0.0295
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0242 0.0242
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0187 0.043
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.0504 1
Entamoeba histolytica hypothetical protein 0.0037 0.0172 0.3416
Schistosoma mansoni cytochrome P450 0.0014 0.0033 0.0077
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0014 0.0033 0.0055
Echinococcus multilocularis cyclin B 0.009 0.0504 0.0504
Trypanosoma brucei cdc2-related kinase 1 0.0052 0.0268 0.4985
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0053 0.0033
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0008 0.0017
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0014 0.0033 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0264 0.1689
Schistosoma mansoni serine/threonine protein kinase 0.001 0.0004 0.0008
Onchocerca volvulus 0.009 0.0504 0.697
Brugia malayi Bromodomain containing protein 0.0037 0.0175 0.1139
Echinococcus multilocularis cyclin dependent kinase 1 0.0052 0.0268 0.0268

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 8.191 uM GSK_PKIS: Inhibition of Sea Pansy Luciferase (Data from PubChem: AID 652015) [NIH NCATS] ChEMBL. No reference
AC50 (binding) = 41.0523 uM GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS] ChEMBL. No reference
IC50 (binding) = 0.008 uM Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor) ChEMBL. 15013000
IC50 (binding) = 0.008 uM Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor) ChEMBL. 15013000
IC50 (binding) = 0.7 uM Inhibition of c-Raf1 kinase ChEMBL. 15013000
IC50 (binding) = 0.7 uM Inhibition of c-Raf1 kinase ChEMBL. 15013000
IC50 (binding) = 10.4 uM Inhibition of Cyclin-dependent kinase 2 cyclin A ChEMBL. 15013000
IC50 (binding) = 10.4 uM Inhibition of Cyclin-dependent kinase 2 cyclin A ChEMBL. 15013000
Inhibition (binding) = -9.49 % GSK_PKIS: CRAF mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -9.46 % GSK_PKIS: AXL mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -6.64 % GSK_PKIS: PAK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -6.56 % GSK_PKIS: SYK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5.9 % GSK_PKIS: TYK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5.55 % GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5.25 % GSK_PKIS: SRPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -5.01 % GSK_PKIS: PI4K-beta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -4.15 % GSK_PKIS: ERBB2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -4 % GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = -3.29 % GSK_PKIS: PASK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.56 % GSK_PKIS: MRCKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.44 % GSK_PKIS: SPHK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2.27 % GSK_PKIS: SRPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -2 % GSK_PKIS: IKK-beta % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = -2 % GSK_PKIS: Mer Kinase % inhibition at 10 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = -1.67 % GSK_PKIS: PIM3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.54 % GSK_PKIS: PIM3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.52 % GSK_PKIS: PASK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.51 % GSK_PKIS: AXL mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.47 % GSK_PKIS: CDK2/cyclinA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.24 % GSK_PKIS: PAK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -1.22 % GSK_PKIS: TYK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.96 % GSK_PKIS: PAR-1Balpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.96 % GSK_PKIS: SYK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.86 % GSK_PKIS: FGFR4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.76 % GSK_PKIS: EGFR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.74 % GSK_PKIS: EGFR (L858R mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.72 % GSK_PKIS: MRCKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.66 % GSK_PKIS: MRCKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.61 % GSK_PKIS: PKC-gamma mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.48 % GSK_PKIS: IKKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.31 % GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.23 % GSK_PKIS: RSK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.19 % GSK_PKIS: JAK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.19 % GSK_PKIS: CRAF mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.07 % GSK_PKIS: YES mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.06 % GSK_PKIS: MRCKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.06 % GSK_PKIS: PIM2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = -0.04 % GSK_PKIS: MSSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0 % GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 0.04 % GSK_PKIS: NEK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.08 % GSK_PKIS: RSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.1 % GSK_PKIS: CAMK1D mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.1 % GSK_PKIS: PIM2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.1 % GSK_PKIS: SPHK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.14 % GSK_PKIS: PIM1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.15 % GSK_PKIS: P38delta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.15 % GSK_PKIS: AKT1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.16 % GSK_PKIS: PRKX mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.16 % GSK_PKIS: RSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.16 % GSK_PKIS: PRKX mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.16 % GSK_PKIS: SGK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.19 % GSK_PKIS: IKKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.21 % GSK_PKIS: ROCK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.26 % GSK_PKIS: PKC-beta1 (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.29 % GSK_PKIS: PAK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.39 % GSK_PKIS: NEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.42 % GSK_PKIS: MAP4K2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.44 % GSK_PKIS: RSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.44 % GSK_PKIS: PAK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.5 % GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.51 % GSK_PKIS: JAK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.53 % GSK_PKIS: TBK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.6 % GSK_PKIS: HIPK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.6 % GSK_PKIS: PTK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.61 % GSK_PKIS: AKT3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.61 % GSK_PKIS: EGFR (L858R mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.64 % GSK_PKIS: PKC-iota mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.66 % GSK_PKIS: TNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.67 % GSK_PKIS: AKT1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.67 % GSK_PKIS: PRAK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.71 % GSK_PKIS: IKKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.74 % GSK_PKIS: HIPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.75 % GSK_PKIS: BMX mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.8 % GSK_PKIS: SPHK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.81 % GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.82 % GSK_PKIS: PKC-alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.85 % GSK_PKIS: DCAMKL2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.86 % GSK_PKIS: CAMK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.86 % GSK_PKIS: DYRK1B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.86 % GSK_PKIS: MSSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.89 % GSK_PKIS: IGF1R mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 0.98 % GSK_PKIS: DAPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.02 % GSK_PKIS: IRR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.04 % GSK_PKIS: TNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.05 % GSK_PKIS: PKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.08 % GSK_PKIS: CDK6/cyclinD3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.08 % GSK_PKIS: ITK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.11 % GSK_PKIS: CDK3/cyclinE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.14 % GSK_PKIS: ERBB2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.15 % GSK_PKIS: RSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.21 % GSK_PKIS: DCAMKL2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.24 % GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.27 % GSK_PKIS: MARK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.35 % GSK_PKIS: PRAK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.5 % GSK_PKIS: BTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.52 % GSK_PKIS: RSK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.53 % GSK_PKIS: EGFR (T790M mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.57 % GSK_PKIS: MET mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.58 % GSK_PKIS: KIT (V560G mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.59 % GSK_PKIS: CK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.61 % GSK_PKIS: PKC-theta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.62 % GSK_PKIS: PKC-eta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.63 % GSK_PKIS: CLK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.66 % GSK_PKIS: JAK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.67 % GSK_PKIS: CAMK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.69 % GSK_PKIS: MAPKAPK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.71 % GSK_PKIS: FER mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.73 % GSK_PKIS: PRKG2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.73 % GSK_PKIS: PKC-alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.73 % GSK_PKIS: PKC-theta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.73 % GSK_PKIS: CAMK1D mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.75 % GSK_PKIS: EPHA2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.75 % GSK_PKIS: MSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.76 % GSK_PKIS: MSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.76 % GSK_PKIS: EPHB4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.8 % GSK_PKIS: FLT4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.81 % GSK_PKIS: MAPKAPK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.82 % GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.83 % GSK_PKIS: PKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.85 % GSK_PKIS: IRAK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.87 % GSK_PKIS: KIT (D816V mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.88 % GSK_PKIS: EGFR (T790M mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.89 % GSK_PKIS: ROCK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.91 % GSK_PKIS: TSSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.92 % GSK_PKIS: PAK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.93 % GSK_PKIS: AKT3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.96 % GSK_PKIS: AKT2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.97 % GSK_PKIS: FGFR4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 1.98 % GSK_PKIS: MUSK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.01 % GSK_PKIS: PRKG1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.01 % GSK_PKIS: MARK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.05 % GSK_PKIS: RSK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.06 % GSK_PKIS: PKC-eta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.07 % GSK_PKIS: BTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.08 % GSK_PKIS: EGFR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.09 % GSK_PKIS: PDK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.09 % GSK_PKIS: IGF1R mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.12 % GSK_PKIS: PTK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.15 % GSK_PKIS: ROCK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.16 % GSK_PKIS: SRMS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.22 % GSK_PKIS: PAR-1Balpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.23 % GSK_PKIS: RET mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.24 % GSK_PKIS: PKC-beta2 (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.3 % GSK_PKIS: MAPK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.31 % GSK_PKIS: SPHK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.31 % GSK_PKIS: ROCK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.35 % GSK_PKIS: CLK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.36 % GSK_PKIS: AKT2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.4 % GSK_PKIS: IRAK4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.43 % GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.43 % GSK_PKIS: ZAP70 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.44 % GSK_PKIS: CHEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.46 % GSK_PKIS: IRR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.46 % GSK_PKIS: LCK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.48 % GSK_PKIS: RON mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.48 % GSK_PKIS: PAK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.49 % GSK_PKIS: P38gamma mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.49 % GSK_PKIS: BLK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.5 % GSK_PKIS: TSSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.51 % GSK_PKIS: p70s6K1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.51 % GSK_PKIS: DYRK1A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.52 % GSK_PKIS: PDK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.55 % GSK_PKIS: MST4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.55 % GSK_PKIS: JAK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.57 % GSK_PKIS: PKC-iota mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.58 % GSK_PKIS: SGK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.62 % GSK_PKIS: ALK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.67 % GSK_PKIS: NEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.7 % GSK_PKIS: FGR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.73 % GSK_PKIS: P38alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.75 % GSK_PKIS: DDR2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.75 % GSK_PKIS: p70s6K1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.82 % GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.84 % GSK_PKIS: CDK2/cyclinA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.91 % GSK_PKIS: CK1a mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.98 % GSK_PKIS: PKC-gamma mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 2.99 % GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.05 % GSK_PKIS: TXK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.09 % GSK_PKIS: SNF1LK (SIK) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.14 % GSK_PKIS: CK1-g2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.18 % GSK_PKIS: PIM1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.18 % GSK_PKIS: EPHA2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.2 % GSK_PKIS: JAK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.21 % GSK_PKIS: CSK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.21 % GSK_PKIS: KIT (T6701 mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.23 % GSK_PKIS: SGK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.24 % GSK_PKIS: FES mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.26 % GSK_PKIS: MAPK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.28 % GSK_PKIS: MER mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.32 % GSK_PKIS: FLT1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.34 % GSK_PKIS: MARK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.37 % GSK_PKIS: CK1-g3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.41 % GSK_PKIS: TYRO3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.42 % GSK_PKIS: MSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.43 % GSK_PKIS: MARK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.44 % GSK_PKIS: JNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.44 % GSK_PKIS: NEK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.44 % GSK_PKIS: ARG mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.53 % GSK_PKIS: CDK1/cyclinB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.53 % GSK_PKIS: NEK9 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.57 % GSK_PKIS: PRKD1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.58 % GSK_PKIS: PHKG1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.62 % GSK_PKIS: NEK7 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.65 % GSK_PKIS: CSK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.68 % GSK_PKIS: DYRK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.72 % GSK_PKIS: INSR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.73 % GSK_PKIS: NEK9 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.83 % GSK_PKIS: CK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.84 % GSK_PKIS: CHEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.85 % GSK_PKIS: FGFR1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.85 % GSK_PKIS: RSK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.85 % GSK_PKIS: PHKG2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.88 % GSK_PKIS: FMS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.92 % GSK_PKIS: KIT (T6701 mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.92 % GSK_PKIS: BRK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.94 % GSK_PKIS: LTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 3.95 % GSK_PKIS: ITK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4 % GSK_PKIS: IKK-alpha % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 4.01 % GSK_PKIS: P38gamma mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.03 % GSK_PKIS: MAPK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.03 % GSK_PKIS: MET mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.08 % GSK_PKIS: CK1-g3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.1 % GSK_PKIS: ARK5 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.16 % GSK_PKIS: CAMK2A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.16 % GSK_PKIS: DYRK1B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.19 % GSK_PKIS: PLK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.21 % GSK_PKIS: MKNK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.24 % GSK_PKIS: TSSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.26 % GSK_PKIS: EPHB4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.28 % GSK_PKIS: FLT4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.29 % GSK_PKIS: EGFR (L861Q mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.31 % GSK_PKIS: KIT (V560G mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.33 % GSK_PKIS: MELK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.36 % GSK_PKIS: FLT3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.41 % GSK_PKIS: TEC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.41 % GSK_PKIS: FES mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.42 % GSK_PKIS: TIE2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.45 % GSK_PKIS: EPHA3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.46 % GSK_PKIS: SGK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.47 % GSK_PKIS: SGK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.48 % GSK_PKIS: EGFR (T790M-L858R mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.55 % GSK_PKIS: PAK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.58 % GSK_PKIS: LYN B (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.6 % GSK_PKIS: DAPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.63 % GSK_PKIS: ABL1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.68 % GSK_PKIS: MAPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.72 % GSK_PKIS: BRSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.73 % GSK_PKIS: BRSK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.73 % GSK_PKIS: GSK3A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.73 % GSK_PKIS: FLT1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.73 % GSK_PKIS: FLT3 (D835Y mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.74 % GSK_PKIS: PRKD2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.79 % GSK_PKIS: DYRK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.82 % GSK_PKIS: CHEK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.84 % GSK_PKIS: CDK5/p35 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.84 % GSK_PKIS: KIT (D816V mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.85 % GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.86 % GSK_PKIS: CAMK2D mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.87 % GSK_PKIS: PHKG2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.87 % GSK_PKIS: SRC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 4.91 % GSK_PKIS: CDK5/p35 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.02 % GSK_PKIS: PRKD3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.05 % GSK_PKIS: CK1-g1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.08 % GSK_PKIS: CDK4/cyclinD mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.09 % GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.09 % GSK_PKIS: CLK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.17 % GSK_PKIS: GSK3B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.18 % GSK_PKIS: MARK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.22 % GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.3 % GSK_PKIS: PRKG1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.31 % GSK_PKIS: MAPKAPK3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.31 % GSK_PKIS: CDK1/cyclinB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.34 % GSK_PKIS: MAP4K2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.35 % GSK_PKIS: GRK6 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.35 % GSK_PKIS: FYN mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.35 % GSK_PKIS: PAK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.39 % GSK_PKIS: ABL1 (T315I mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.39 % GSK_PKIS: JAK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.41 % GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.44 % GSK_PKIS: CK1-g1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.49 % GSK_PKIS: LOK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.49 % GSK_PKIS: EPHA3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.53 % GSK_PKIS: SGK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.58 % GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.58 % GSK_PKIS: IKKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.59 % GSK_PKIS: P38beta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.59 % GSK_PKIS: EPHB3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.65 % GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.66 % GSK_PKIS: CK1a mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.69 % GSK_PKIS: LTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.7 % GSK_PKIS: MAP4K4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.7 % GSK_PKIS: MEK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.71 % GSK_PKIS: MINK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.73 % GSK_PKIS: P38beta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.76 % GSK_PKIS: CDK3/cyclinE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.82 % GSK_PKIS: BRSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.88 % GSK_PKIS: BRK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.9 % GSK_PKIS: MUSK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.91 % GSK_PKIS: CAMK2A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.97 % GSK_PKIS: BRSK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.97 % GSK_PKIS: PRKG2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 5.99 % GSK_PKIS: LOK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6 % GSK_PKIS: LYN A (splice variant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.05 % GSK_PKIS: EPHB2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.07 % GSK_PKIS: TBK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.09 % GSK_PKIS: ARK5 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.09 % GSK_PKIS: TSSK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.14 % GSK_PKIS: TIE2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.16 % GSK_PKIS: NEK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.17 % GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.21 % GSK_PKIS: PRKD3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.23 % GSK_PKIS: PAK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.3 % GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.3 % GSK_PKIS: MSK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.33 % GSK_PKIS: MAPKAPK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.34 % GSK_PKIS: CK1-g2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.4 % GSK_PKIS: EPHA4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.41 % GSK_PKIS: MST1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.42 % GSK_PKIS: PRKD1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.47 % GSK_PKIS: ALK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.48 % GSK_PKIS: PDGFRB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.48 % GSK_PKIS: PRKD2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.48 % GSK_PKIS: BMX mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.49 % GSK_PKIS: KDR mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.5 % GSK_PKIS: NEK7 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.54 % GSK_PKIS: MEK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.58 % GSK_PKIS: BRAF mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.62 % GSK_PKIS: FLT3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.64 % GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.65 % GSK_PKIS: TXK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.66 % GSK_PKIS: FGFR2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.67 % GSK_PKIS: ZAP70 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.7 % GSK_PKIS: PAK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.73 % GSK_PKIS: CHEK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.8 % GSK_PKIS: NEK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 6.87 % GSK_PKIS: INSR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7 % GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 7.04 % GSK_PKIS: PHKG1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.13 % GSK_PKIS: PI4K-beta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.16 % GSK_PKIS: FMS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.22 % GSK_PKIS: MARK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.25 % GSK_PKIS: BRAF (V599E mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.31 % GSK_PKIS: Aurora-C mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.41 % GSK_PKIS: LRRK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.42 % GSK_PKIS: CAMK2D mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.45 % GSK_PKIS: PI3K-delta mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.47 % GSK_PKIS: TYRO3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.53 % GSK_PKIS: HIPK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.61 % GSK_PKIS: MNK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.62 % GSK_PKIS: CDK4/cyclinD mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.63 % GSK_PKIS: RON mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.67 % GSK_PKIS: HCK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.77 % GSK_PKIS: MER mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.78 % GSK_PKIS: MST2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.78 % GSK_PKIS: EPHB2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.88 % GSK_PKIS: AMPKA2 (A2B1G1) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.89 % GSK_PKIS: CDK2/cyclinE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 7.94 % GSK_PKIS: ROS mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.02 % GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.03 % GSK_PKIS: EPHB3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.04 % GSK_PKIS: BRAF (V599E mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.06 % GSK_PKIS: KIT mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.09 % GSK_PKIS: MST2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.19 % GSK_PKIS: MST1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.21 % GSK_PKIS: MELK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.22 % GSK_PKIS: LCK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.24 % GSK_PKIS: PI3K-alpha mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.24 % GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.54 % GSK_PKIS: JNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.55 % GSK_PKIS: FGFR3 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.56 % GSK_PKIS: KDR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 8.88 % GSK_PKIS: GSK3B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.01 % GSK_PKIS: SNF1LK (SIK) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.04 % GSK_PKIS: PLK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.18 % GSK_PKIS: P38delta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.25 % GSK_PKIS: RET (V804L mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.31 % GSK_PKIS: FER mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.34 % GSK_PKIS: CDK2/cyclinE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.43 % GSK_PKIS: TRKA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.46 % GSK_PKIS: LYN B (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.58 % GSK_PKIS: EPHA4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.85 % GSK_PKIS: AMPKA1 (A1B1G1) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.88 % GSK_PKIS: CLK3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 9.88 % GSK_PKIS: TTK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10 % GSK_PKIS: IKK-epsilon % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 10.03 % GSK_PKIS: GSK3A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.27 % GSK_PKIS: TEC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.45 % GSK_PKIS: SNF1LK2 (QIK) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.53 % GSK_PKIS: BRAF mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.57 % GSK_PKIS: DDR2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.7 % GSK_PKIS: BLK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.87 % GSK_PKIS: IKKE mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 10.93 % GSK_PKIS: HIPK4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.1 % GSK_PKIS: RET mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.16 % GSK_PKIS: ERBB4 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.22 % GSK_PKIS: DYRK1A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.27 % GSK_PKIS: P38alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.57 % GSK_PKIS: PDGFRA mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.57 % GSK_PKIS: PDGFRB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.62 % GSK_PKIS: FGR mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.73 % GSK_PKIS: MKNK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 11.99 % GSK_PKIS: RET (V804L mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.39 % GSK_PKIS: Aurora-B mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.5 % GSK_PKIS: IKKE mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.52 % GSK_PKIS: HCK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.58 % GSK_PKIS: RET (Y791F mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.71 % GSK_PKIS: TTK mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 12.93 % GSK_PKIS: YES mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.18 % GSK_PKIS: RET (Y791F mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.31 % GSK_PKIS: MINK mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.43 % GSK_PKIS: Aurora-A mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.49 % GSK_PKIS: MST4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.52 % GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.86 % GSK_PKIS: PI3K-delta mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.97 % GSK_PKIS: MAP4K4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 13.98 % GSK_PKIS: FGFR1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.01 % GSK_PKIS: FGFR3 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.36 % GSK_PKIS: LYN A (splice variant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 14.66 % GSK_PKIS: SRMS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15 % GSK_PKIS: TBK1 % inhibition at 1 uM [UNC Frye lab] ChEMBL. No reference
Inhibition (binding) = 15.11 % GSK_PKIS: ARG mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.25 % GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 15.6 % GSK_PKIS: PYK2 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 16.94 % GSK_PKIS: PDGFRA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.09 % GSK_PKIS: SRC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.55 % GSK_PKIS: LRRK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.72 % GSK_PKIS: ERBB4 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 17.98 % GSK_PKIS: FGFR2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 18.61 % GSK_PKIS: PI3K-alpha mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.78 % GSK_PKIS: ABL1 (M351T mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 19.98 % GSK_PKIS: ABL1 (Y253F mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 20.49 % GSK_PKIS: ABL1 (Q252H mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 21.95 % GSK_PKIS: ABL1 (H396P mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 22.3 % GSK_PKIS: ABL1 (E255K mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.15 % GSK_PKIS: ROS mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 26.27 % GSK_PKIS: FYN mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 27.9 % GSK_PKIS: KIT mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 27.92 % GSK_PKIS: ABL1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 28.74 % GSK_PKIS: GRK7 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 30.3 % GSK_PKIS: GRK6 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 38.72 % GSK_PKIS: TRKB mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 39.1 % GSK_PKIS: PYK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.12 % GSK_PKIS: MNK2 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 40.2 % GSK_PKIS: TNK1 mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 41.67 % GSK_PKIS: TRKC mean inhibition at 0.1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 55.32 % GSK_PKIS: LRRK2 (G2019S mutant) mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 57.19 % GSK_PKIS: GRK7 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 57.24 % GSK_PKIS: Aurora-B mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 61.66 % GSK_PKIS: TRKA mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 80.4 % GSK_PKIS: TNK1 mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 87.54 % GSK_PKIS: Aurora-C mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 89.24 % GSK_PKIS: TRKB mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 93.04 % GSK_PKIS: Aurora-A mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference
Inhibition (binding) = 93.93 % GSK_PKIS: TRKC mean inhibition at 1 uM [Nanosyn] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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