TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 302.227 | Formula: C9H15N6O4P
H donors: 4 H acceptors: 8 LogP: -1.46 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Nc1nc(O)c2c(n1)n(CCCCCP(=O)(O)O)nn2
InChi: 1S/C9H15N6O4P/c10-9-11-7-6(8(16)12-9)13-14-15(7)4-2-1-3-5-20(17,18)19/h1-5H2,(H2,17,18,19)(H3,10,11,12,16)
InChiKey: BLMANVQMJUPUCT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purine nucleoside phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	Purine nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128114	All targets in OG5_128114
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma japonicum	ko:K03783 purine-nucleoside phosphorylase, putative	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus granulosus	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114
Echinococcus multilocularis	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Schistosoma mansoni	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium ulcerans	purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Candida albicans	similar to human purine nucleoside phosphorylase	Get druggable targets OG5_128114	All targets in OG5_128114
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	Get druggable targets OG5_128114	All targets in OG5_128114

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	purine nucleoside phosphorylase	289 aa	255 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	glutathione reductase, putative	0.0046	0.1366	1
Treponema pallidum	pfs protein (pfs)	0.0032	0.0729	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0914	0.099
Entamoeba histolytica	hypothetical protein	0.0032	0.0729	0.7622
Trypanosoma brucei	trypanothione reductase	0.0046	0.1366	0.1579
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1541	0.167
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Mycobacterium tuberculosis	Conserved protein	0.0024	0.0364	0.058
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0637	0.1019
Plasmodium falciparum	purine nucleoside phosphorylase	0.0032	0.0729	0.5331
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0007	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.8641	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0007	0.0044
Plasmodium falciparum	glutathione reductase	0.0016	0.0007	0.0044
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0007	0.0007
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Leishmania major	trypanothione reductase	0.0046	0.1366	0.1579
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.1366	0.148
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.7622
Plasmodium falciparum	thioredoxin reductase	0.0046	0.1366	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.403	0.6446
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Trypanosoma brucei	methylthioadenosine phosphorylase, putative	0.0032	0.0729	0.0842
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0024	0.0364	0.0357
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0007	0.0008
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0001	0.0001
Entamoeba histolytica	hypothetical protein	0.0036	0.0914	1
Brugia malayi	Ets-domain containing protein	0.0072	0.2562	0.2776
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.403	0.6446
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.7622
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0002
Entamoeba histolytica	MTA/SAH nucleosidase, putative	0.0032	0.0729	0.7622
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0007	0.0007
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0208	0.87	0.9425
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	methylthioadenosine phosphorylase	0.0032	0.0729	0.1166
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0002
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0587	0.0939
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0032	0.0729	0.1164
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0135	0.0146
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0007	0.0011
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0007	0.0044
Plasmodium vivax	SET domain protein, putative	0.003	0.0637	0.4657
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4808	0.7693
Loa Loa (eye worm)	hypothetical protein	0.005	0.1541	0.167
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0007	0.0007
Chlamydia trachomatis	AMP nucleosidase	0.0032	0.0729	1
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0914	0.099
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0024	0.0364	0.058
Brugia malayi	uridine phosphorylase family protein	0.0032	0.0729	0.0789
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0729	0.0842
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0007	0.5
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0135	0.0215
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Echinococcus multilocularis	methylthioadenosine phosphorylase	0.0032	0.0729	0.1166
Loa Loa (eye worm)	fli-1 protein	0.022	0.923	1
Brugia malayi	Ets-domain containing protein	0.0072	0.2562	0.2776
Mycobacterium ulcerans	bifunctional Mta/Sah nucleosidase Mtn	0.0032	0.0729	0.1156
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0007	0.0044
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0729	0.0789
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0135	0.0155
Trichomonas vaginalis	set domain proteins, putative	0.0237	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.2087	0.2261
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0001	0.0001
Trypanosoma brucei	uridine phosphorylase	0.0032	0.0729	0.0842
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0135	0.0155
Mycobacterium tuberculosis	Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase	0.0032	0.0729	0.1164
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0135	0.0155
Onchocerca volvulus	Purine nucleoside phosphorylase homolog	0.0154	0.625	0.5995
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0032	0.0729	0.1156
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Leishmania major	hypothetical protein, conserved	0.0207	0.8641	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.4686	0.5077
Schistosoma mansoni	hypothetical protein	0.0034	0.0828	0.0897
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1541	0.167
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0364	0.042
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0914	0.1462
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Echinococcus granulosus	dna polymerase eta	0.0019	0.0135	0.0216
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0.0729	0.0842
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0135	0.0215
Trichomonas vaginalis	purine nucleoside phosphorylase I, putative	0.0154	0.625	0.6248
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0135	0.0216
Giardia lamblia	5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase	0.0032	0.0729	0.1156
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0637	0.069
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0116	0.4559	0.7293
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0135	0.0205
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.625	0.6772
Echinococcus multilocularis	GA binding protein alpha chain	0.0072	0.2562	0.4099
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0007	0.0011
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0024	0.0364	0.0571
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0007	0.5
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0637	0.4657
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0135	0.0128
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0002
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0135	0.0128
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Schistosoma mansoni	uridine phosphorylase	0.0032	0.0729	0.0789
Giardia lamblia	Purine nucleoside phosphorylase lateral transfer candidate	0.0154	0.625	1
Brugia malayi	MTAP	0.0032	0.0729	0.0789
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0135	0.0155
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0364	0.042
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0007	0.0044
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0135	0.0205
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Schistosoma mansoni	ets-related	0.022	0.923	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1541	0.167
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Giardia lamblia	UPL-1	0.0032	0.0729	0.1156
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0135	0.0146
Mycobacterium leprae	Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP)	0.0154	0.625	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Toxoplasma gondii	phosphorylase family protein	0.0032	0.0729	0.5331
Entamoeba histolytica	hypothetical protein	0.0036	0.0914	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0122	0.4808	0.7693
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.1366	0.2185
Leishmania major	DNA polymerase eta, putative	0.0019	0.0135	0.0155
Toxoplasma gondii	thioredoxin reductase	0.0046	0.1366	1
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Toxoplasma gondii	Purine nucleoside phosphorylase	0.0032	0.0729	0.5331
Brugia malayi	Fli-1 protein	0.022	0.923	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.1366	0.2184
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.1366	1
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0024	0.0364	0.042
Trypanosoma brucei	unspecified product	0.0019	0.0135	0.0155
Trypanosoma brucei	hypothetical protein, conserved	0.0207	0.8641	1
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0135	0.0216
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0637	0.1019
Loa Loa (eye worm)	hypothetical protein	0.003	0.0637	0.069
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0135	0.0146
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0001	0.0001
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.403	0.6446
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0135	0.0146
Brugia malayi	Thioredoxin reductase	0.0046	0.1366	0.148
Echinococcus granulosus	citrate lyase subunit beta protein	0.0024	0.0364	0.0582
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.403	0.6446
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0007	0.0044
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0729	0.0789
Plasmodium vivax	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.5331
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0024	0.0364	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0122	0.4808	0.5209
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0637	0.069
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0135	0.0146
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0154	0.625	0.6772
Brugia malayi	Pre-SET motif family protein	0.003	0.0637	0.069
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0072	0.2562	0.2776
Brugia malayi	glutathione reductase	0.0046	0.1366	0.148
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0135	0.0216
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Schistosoma mansoni	gabp alpha	0.0072	0.2562	0.2776
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Schistosoma mansoni	uridine phosphorylase	0.0032	0.0729	0.0789
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.1366	0.1579
Entamoeba histolytica	hypothetical protein	0.0036	0.0914	1
Echinococcus multilocularis	uridine phosphorylase 1	0.0032	0.0729	0.1166
Mycobacterium tuberculosis	Probable oxidoreductase	0.0116	0.4559	0.7293
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.403	0.6446
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0007	0.0007
Leishmania major	methylthioadenosine phosphorylase, putative	0.0032	0.0729	0.0842
Treponema pallidum	uridine phosphorylase (udp)	0.0032	0.0729	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.7622
Trichomonas vaginalis	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.0722
Brugia malayi	hypothetical protein	0.0036	0.0914	0.099
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0637	0.069
Plasmodium falciparum	glutathione reductase	0.0046	0.1366	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0154	0.625	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Loa Loa (eye worm)	S-methyl-5'-thioadenosine phosphorylase MTAP	0.0032	0.0729	0.0789
Mycobacterium tuberculosis	Probable reductase	0.0105	0.403	0.6446
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0637	0.1019
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0135	0.0146
Trypanosoma cruzi	methylthioadenosine phosphorylase, putative	0.0032	0.0729	0.0842
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0001	0.0002
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0007	0.0007
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0007	0.0007
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0024	0.0364	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0828	0.0897
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0001	0.0002
Brugia malayi	Pre-SET motif family protein	0.0208	0.87	0.9425
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0135	0.0155
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0001	0.0001
Schistosoma mansoni	methylthioadenosine phosphorylase	0.0032	0.0729	0.0789
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0007	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0135	0.0146
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0364	0.0571
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0007	0.0007
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.7622
Brugia malayi	MH2 domain containing protein	0.0119	0.4686	0.5077
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0116	0.4559	0.6936
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0729	0.0722
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0001	0.0002
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0007	0.001
Echinococcus granulosus	uridine phosphorylase 1	0.0032	0.0729	0.1166
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0729	0.0842
Loa Loa (eye worm)	uridine phosphorylase	0.0032	0.0729	0.0789
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0116	0.4559	0.7293
Toxoplasma gondii	phosphorylase family protein	0.0032	0.0729	0.5331
Treponema pallidum	purine nucleoside phosphorylase (deoD)	0.0032	0.0729	1
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0135	0.0205
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Mycobacterium ulcerans	5'-methylthioadenosine phosphorylase	0.0032	0.0729	0.1156
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0024	0.0364	0.0571
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0122	0.4808	0.7693
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0637	0.069
Mycobacterium tuberculosis	Hypothetical protein	0.0032	0.0729	0.1164
Mycobacterium ulcerans	purine nucleoside phosphorylase	0.0154	0.625	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0007	0.0044
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0135	0.0216
Trypanosoma cruzi	nucleoside phosphorylase, putative	0.0032	0.0729	0.0842
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0914	0.1462
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0135	0.0155
Echinococcus granulosus	GA binding protein alpha chain	0.0072	0.2562	0.4099
Entamoeba histolytica	hypothetical protein	0.0036	0.0914	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0007	0.0044
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0007	0.0007
Schistosoma mansoni	purine nucleoside phosphorylase	0.0154	0.625	0.6772
Loa Loa (eye worm)	glutathione reductase	0.0046	0.1366	0.148
Trichomonas vaginalis	conserved hypothetical protein	0.0032	0.0729	0.0722
Echinococcus granulosus	purine nucleoside phosphorylase	0.0154	0.625	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0135	0.0216
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0364	0.0571
Entamoeba histolytica	purine nucleoside phosphorylase, putative	0.0032	0.0729	0.7622
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.1366	0.2185
Mycobacterium tuberculosis	Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP)	0.0154	0.625	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.403	0.5978
Trypanosoma cruzi	hypothetical protein, conserved	0.0207	0.8641	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.4686	0.5077
Leishmania major	nucleoside phosphorylase-like protein	0.0032	0.0729	0.0842
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0828	0.0897
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0007	0.0007

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.065 uM	In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.	ChEMBL.	8632418
Ki (binding)	= 0.065 uM	In vitro inhibition of purine nucleoside phosphorylase isolated from human erythrocytes.	ChEMBL.	8632418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 307949