Detailed information for compound 307961

Basic information

Technical information
  • TDR Targets ID: 307961
  • Name: 6-(4-methylphenyl)sulfanyl-7H-purine
  • MW: 242.3 | Formula: C12H10N4S
  • H donors: 1 H acceptors: 3 LogP: 2.59 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Sc1[nH]cnc2c1ncn2
  • InChi: 1S/C12H10N4S/c1-8-2-4-9(5-3-8)17-12-10-11(14-6-13-10)15-7-16-12/h2-7H,1H3,(H,13,14,15,16)
  • InChiKey: PVQBKEDASIBTAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(p-tolylsulfanyl)-7H-purine
  • 6-(p-tolylthio)-7H-purine
  • 6-[(4-methylphenyl)thio]-7H-purine
  • 5444-08-6
  • Purine, 6-(p-tolylthio)
  • Purine, 6-(p-tolylthio)-
  • NSC19489
  • AIDS-021861
  • AIDS021861

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0072 0.0072
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0215 0.009
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1149 0.15
Echinococcus multilocularis neuropeptide receptor A26 0.0435 1 1
Schistosoma mansoni ap endonuclease 0.002 0.0215 0.0235
Schistosoma mansoni hypothetical protein 0.0049 0.0896 0.0976
Schistosoma mansoni thyroid hormone receptor 0.0143 0.3117 0.3396
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.3866 0.56
Onchocerca volvulus 0.0028 0.0417 0.0742
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0359 0.0307
Echinococcus multilocularis neutral alpha glucosidase AB 0.0069 0.1384 0.1384
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0547 0.3188
Schistosoma mansoni lamin 0.0028 0.0417 0.0455
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.092 0.2985
Onchocerca volvulus 0.0028 0.0417 0.0742
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0896 0.0896
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0215 0.0488
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.5703 0.8013
Toxoplasma gondii exonuclease III APE 0.002 0.0215 0.0488
Schistosoma mansoni thyroid hormone receptor 0.0143 0.3117 0.3396
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0359 0.1653
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0547 0.0596
Schistosoma mansoni cpg binding protein 0.003 0.045 0.049
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Onchocerca volvulus 0.0045 0.0819 0.1455
Brugia malayi RNA recognition motif domain containing protein 0.006 0.1154 0.1621
Echinococcus multilocularis lamin 0.0028 0.0417 0.0417
Onchocerca volvulus 0.025 0.5628 1
Onchocerca volvulus 0.0028 0.0412 0.0732
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.2718 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0215 0.0215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0069 0.1384 0.1945
Loa Loa (eye worm) hypothetical protein 0.0049 0.0896 0.1259
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Brugia malayi TAR-binding protein 0.006 0.1154 0.1621
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0503 0.0548
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0547 0.3188
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0215 0.0303
Brugia malayi Thioredoxin reductase 0.005 0.092 0.1293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0503 0.0548
Schistosoma mansoni alpha-glucosidase 0.0269 0.6091 0.6636
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.1384 1
Echinococcus granulosus lamin dm0 0.0028 0.0417 0.0417
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.1384 0.1855
Trichomonas vaginalis sucrase-isomaltase, putative 0.0069 0.1384 0.1855
Mycobacterium tuberculosis Probable reductase 0.0113 0.242 0.8837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1181 0.1287
Loa Loa (eye worm) hypothetical protein 0.0222 0.4991 0.7014
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.242 0.8837
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0155 0.0169
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0215 0.009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0101
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0215 0.0234
Brugia malayi Calcitonin receptor-like protein seb-1 0.0154 0.3371 0.4737
Brugia malayi glutaminase DH11.1 0.0298 0.6782 0.9529
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1149 0.1149
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.092 0.092
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0359 0.1225
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0547 0.0547
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.1384 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0896 0.1259
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.2866 0.2866
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0219 0.4917 0.6909
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0503 0.0503
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0215 1
Echinococcus granulosus dnaJ subfamily B 0.04 0.9178 0.9178
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0048 0.0067
Loa Loa (eye worm) hypothetical protein 0.0028 0.0405 0.0569
Schistosoma mansoni hypothetical protein 0.0049 0.0896 0.0976
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0072 0.0072
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0215 0.0488
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0155 0.0218
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0547 0.5123
Echinococcus multilocularis geminin 0.0166 0.3656 0.3656
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0896 0.0896
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0069 0.1384 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Loa Loa (eye worm) thioredoxin reductase 0.005 0.092 0.1293
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0417 0.0587
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0215 0.009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0155 0.0155
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0503 0.0503
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0154 0.3371 0.4737
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.1384 0.1855
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0547 0.0547
Brugia malayi Pre-SET motif family protein 0.0219 0.4917 0.6909
Loa Loa (eye worm) glutaminase 0.0298 0.6782 0.9529
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0026 0.0359 0.0637
Echinococcus granulosus survival motor neuron protein 1 0.0222 0.4991 0.4991
Schistosoma mansoni ap endonuclease 0.002 0.0215 0.0235
Echinococcus multilocularis lysosomal alpha glucosidase 0.0313 0.7117 0.7117
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.1384 0.1855
Schistosoma mansoni tar DNA-binding protein 0.006 0.1154 0.1257
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.2718 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.1384 0.1855
Schistosoma mansoni hypothetical protein 0.0045 0.0819 0.0892
Brugia malayi Glycosyl hydrolases family 31 protein 0.0313 0.7117 1
Schistosoma mansoni cpg binding protein 0.003 0.045 0.049
Echinococcus granulosus cpg binding protein 0.003 0.045 0.045
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2225 0.3127
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Brugia malayi isocitrate dehydrogenase 0.0034 0.0547 0.0769
Echinococcus multilocularis survival motor neuron protein 1 0.0222 0.4991 0.4991
Loa Loa (eye worm) hypothetical protein 0.0105 0.2225 0.3127
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0547 0.0547
Schistosoma mansoni tar DNA-binding protein 0.006 0.1154 0.1257
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.3117 0.3117
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0359 0.0307
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0215 1
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.3656 0.6495
Plasmodium vivax thioredoxin reductase, putative 0.005 0.092 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0359 0.0307
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0547 0.0547
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.242 0.8837
Brugia malayi Glycosyl hydrolases family 31 protein 0.0069 0.1384 0.1945
Trichomonas vaginalis set domain proteins, putative 0.025 0.5628 0.826
Echinococcus granulosus neutral alpha glucosidase AB 0.0069 0.1384 0.1384
Onchocerca volvulus 0.0032 0.0503 0.0894
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0048 0.0067
Loa Loa (eye worm) RNA binding protein 0.006 0.1154 0.1621
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.2718 1
Echinococcus multilocularis tar DNA binding protein 0.006 0.1154 0.1154
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0503 0.0548
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0896 0.1259
Schistosoma mansoni hypothetical protein 0.0166 0.3656 0.3983
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1149 0.8087
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0359 0.0307
Schistosoma mansoni glutaminase 0.0298 0.6782 0.7389
Schistosoma mansoni tar DNA-binding protein 0.006 0.1154 0.1257
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0503 0.283
Brugia malayi glutathione reductase 0.005 0.092 0.1293
Echinococcus granulosus neuropeptide receptor A26 0.0435 1 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1031 0.7125
Schistosoma mansoni cpg binding protein 0.0028 0.0412 0.0449
Leishmania major alpha glucosidase II subunit, putative 0.0069 0.1384 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0069 0.1384 0.1855
Echinococcus granulosus lysosomal alpha glucosidase 0.0313 0.7117 0.7117
Loa Loa (eye worm) glutaminase 2 0.0298 0.6782 0.9529
Leishmania major trypanothione reductase 0.005 0.092 0.6224
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.2718 1
Schistosoma mansoni hypothetical protein 0.0132 0.2866 0.3123
Loa Loa (eye worm) TAR-binding protein 0.006 0.1154 0.1621
Echinococcus granulosus GPCR family 2 0.0049 0.0896 0.0896
Schistosoma mansoni intermediate filament proteins 0.0028 0.0417 0.0455
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0359 0.0307
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0412 0.0579
Trichomonas vaginalis glutaminase, putative 0.0298 0.6782 1
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0417 0.0587
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Trypanosoma brucei glucosidase, putative 0.0069 0.1384 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.1154 0.1621
Echinococcus multilocularis neuropeptide s receptor 0.0435 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0503 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Echinococcus multilocularis lamin dm0 0.0028 0.0417 0.0417
Echinococcus multilocularis GPCR, family 2 0.0049 0.0896 0.0896
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0896 0.0896
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0359 0.0504
Trypanosoma brucei glycosyl hydrolase-like protein 0.0026 0.0359 0.1653
Schistosoma mansoni tar DNA-binding protein 0.006 0.1154 0.1257
Schistosoma mansoni survival motor neuron protein 0.0045 0.0819 0.0892
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0547 0.0547
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.2866 0.2866
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0215 0.0488
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1149 0.1252
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1149 0.1252
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1149 0.3879
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0547 0.0547
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.092 0.6224
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0462 0.0462
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0359 0.0307
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0359 0.1653
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0107 0.0151
Echinococcus multilocularis lysosomal alpha glucosidase 0.0313 0.7117 0.7117
Mycobacterium ulcerans glutaminase 0.0298 0.6782 1
Brugia malayi intermediate filament protein 0.0028 0.0417 0.0587
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.242 0.8837
Echinococcus multilocularis cpg binding protein 0.003 0.045 0.045
Brugia malayi Pre-SET motif family protein 0.0032 0.0503 0.0707
Schistosoma mansoni hypothetical protein 0.04 0.9178 1
Schistosoma mansoni lamin 0.0028 0.0417 0.0455
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0547 0.3188
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1149 0.8087
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0215 0.0488
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.1384 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0215 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0503 0.0548
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0547 0.3188
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0215 0.0784
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0547 0.3188
Echinococcus granulosus tar DNA binding protein 0.006 0.1154 0.1154
Brugia malayi hypothetical protein 0.0222 0.4991 0.7014
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0155 0.0155
Echinococcus multilocularis musashi 0.0028 0.0417 0.0417
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0359 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0359 0.0504
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.1384 0.1855
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1149 0.15
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1149 0.1149
Trypanosoma brucei trypanothione reductase 0.005 0.092 0.6224
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0215 0.0303
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0547 0.5123
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0503 0.0503
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0359 0.0307
Leishmania major glycosyl hydrolase-like protein 0.0026 0.0359 0.1653
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.1384 0.1855
Schistosoma mansoni alpha-glucosidase 0.0269 0.6091 0.6636
Schistosoma mansoni tar DNA-binding protein 0.006 0.1154 0.1257
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.1384 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0896 0.1259
Echinococcus granulosus lamin 0.0028 0.0417 0.0417
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0896 0.0896
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.0084
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0547 0.3188
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1149 0.15
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0547 0.1529
Schistosoma mansoni hypothetical protein 0.0105 0.2225 0.2425
Loa Loa (eye worm) glutathione reductase 0.005 0.092 0.1293
Plasmodium falciparum glutathione reductase 0.005 0.092 1
Echinococcus granulosus geminin 0.0166 0.3656 0.3656
Loa Loa (eye worm) hypothetical protein 0.0154 0.3371 0.4737
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0107 0.0151
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.5703 0.8013
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0155 0.5
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0547 0.0769
Schistosoma mansoni alpha glucosidase 0.0069 0.1384 0.1508
Echinococcus multilocularis dnaJ subfamily B 0.04 0.9178 0.9178
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0547 0.3188
Echinococcus granulosus intermediate filament protein 0.0028 0.0417 0.0417
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0215 0.0215
Plasmodium vivax SET domain protein, putative 0.0032 0.0503 0.4547
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.3866 0.56
Plasmodium falciparum thioredoxin reductase 0.005 0.092 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0417 0.0587
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0313 0.7117 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0045 0.0819 0.1151
Onchocerca volvulus 0.0181 0.4011 0.7126
Toxoplasma gondii thioredoxin reductase 0.005 0.092 0.6224
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.242 0.8837
Schistosoma mansoni hypothetical protein 0.0049 0.0896 0.0976
Schistosoma mansoni hypothetical protein 0.0166 0.3656 0.3983
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.242 0.8837
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0547 0.0769
Brugia malayi CXXC zinc finger family protein 0.0028 0.0412 0.0579
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.092 0.092
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.1384 0.1855
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.3656 0.5283
Brugia malayi RNA binding protein 0.006 0.1154 0.1621
Plasmodium vivax glutathione reductase, putative 0.005 0.092 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.5703 0.8372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0154 0.3371 0.4737
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0417 0.0587
Schistosoma mansoni hypothetical protein 0.0049 0.0896 0.0976
Loa Loa (eye worm) hypothetical protein 0.0013 0.006 0.0084
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0215 0.0784

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 65 % Percent inhibitory activity of the compound against Mycobacterium tuberculosis (Mtb) H37Rv Strain at 12.25 ug/mL ChEMBL. 14695841
Inhibition (functional) = 65 % Percent inhibitory activity of the compound against Mycobacterium tuberculosis (Mtb) H37Rv Strain at 12.25 ug/mL ChEMBL. 14695841
MIC (functional) > 12.8 ug ml-1 Inhibitory activity of the compound against growth of Mycobacterium tuberculosis (Mtb) H37Ra Strain ChEMBL. 14695841
MIC (functional) > 12.8 ug ml-1 Inhibitory activity of the compound against growth of Mycobacterium tuberculosis (Mtb) H37Ra Strain ChEMBL. 14695841
MIC90 (functional) > 12.5 ug ml-1 Inhibitory activity against growth of Mycobacterium tuberculosis H37Rv Strain ChEMBL. 14695841
MIC90 (functional) > 12.5 ug ml-1 Inhibitory activity against growth of Mycobacterium tuberculosis H37Rv Strain ChEMBL. 14695841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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