Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1118 | 1 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0794 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0794 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 0.5207 | 0.8793 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1118 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 0.5207 | 0.8793 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0324 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1118 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0378 | 0.068 | 0.5 |
Onchocerca volvulus | 0.0737 | 0.5207 | 0.6031 | |
Schistosoma mansoni | amine GPCR | 0.0333 | 0.0116 | 0.0196 |
Brugia malayi | thymidylate synthase | 0.0794 | 0.5922 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0794 | 0.5922 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0794 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0378 | 0.068 | 0.1148 |
Onchocerca volvulus | 0.0794 | 0.5922 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1118 | 1 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0737 | 0.5207 | 0.8793 |
Echinococcus multilocularis | thymidylate synthase | 0.0794 | 0.5922 | 1 |
Brugia malayi | Trypsin family protein | 0.0737 | 0.5207 | 0.8793 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0737 | 0.5207 | 0.8793 |
Brugia malayi | hypothetical protein | 0.0378 | 0.068 | 0.1148 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0794 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0794 | 0.5922 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.4 mg kg-1 | In vivo inhibition of phenyl-1,4-benzoquinone(PBQ) -induced writhing in mice (sc) | ChEMBL. | 3361582 |
ED50 (functional) | = 0.5 mg kg-1 | In vivo inhibition of Acetic acid-induced writhing in mice (sc) | ChEMBL. | 3361582 |
ED50 (functional) | = 9.7 mg kg-1 | Effective dose of the compound was measured in hot plate test. | ChEMBL. | 3361582 |
GPI (functional) | = 7.5 nM | In vitro opioid activity of compound in the GPI (guinea pig ileum) by determination of inhibition of electrically induced contractions | ChEMBL. | 3361582 |
logD | = 0.39 | log P value determined between 1-butanol and 50 mM phosphate buffer, pH 7.4 | ChEMBL. | 3361582 |
Ratio (functional) | = 3.9 | Dose ratio in the presence / absence of N-methylnalorphine (11.5 mg/kg) in acetic acid (AA) writhing | ChEMBL. | 3361582 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.