Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0423 | 0.4555 | 0.4468 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0896 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0896 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0168 | 0.1624 | 0.1489 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0896 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0896 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0896 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0423 | 0.4555 | 0.4468 |
Brugia malayi | ecdysone receptor | 0.0423 | 0.4555 | 0.4555 |
Onchocerca volvulus | 0.0896 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0896 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0473 | 0.5138 | 0.5138 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0896 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0896 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0896 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0423 | 0.4555 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0473 | 0.5138 | 0.506 |
Brugia malayi | nuclear hormone receptor | 0.0896 | 1 | 1 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.0395 | 0.0395 |
Brugia malayi | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0896 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0423 | 0.4555 | 0.4468 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.0395 | 0.0395 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0896 | 1 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.031 | 0.0154 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0896 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0211 | 0.2123 | 0.1996 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.3108 |
Brugia malayi | Muscleblind-like protein | 0.0168 | 0.1624 | 0.1624 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0159 | 0.0457 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0473 | 0.5138 | 0.5138 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0423 | 0.4555 | 0.4555 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0896 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0168 | 0.1624 | 0.1489 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.016 | 0.1539 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0423 | 0.4555 | 0.4468 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.3108 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0054 | 0.031 | 0.0154 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0159 | 0.0457 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0896 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0423 | 0.4555 | 0.4555 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.0395 | 0.0241 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0423 | 0.4555 | 0.4468 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0423 | 0.4555 | 0.4468 |
Schistosoma mansoni | nuclear hormone receptor | 0.0896 | 1 | 1 |
Plasmodium falciparum | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0046 | 0.0217 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Brugia malayi | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.031 | 0.031 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0046 | 0.0217 | 0.0217 |
Schistosoma mansoni | thyroid hormone receptor | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0896 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0896 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.0325 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0896 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0896 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.0395 | 0.0241 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0423 | 0.4555 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0473 | 0.5138 | 0.5138 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0423 | 0.4555 | 0.4468 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0329 | 0.3472 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0896 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0896 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | nuclear hormone receptor | 0.0423 | 0.4555 | 0.4468 |
Schistosoma mansoni | thyroid hormone receptor | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0896 | 1 | 1 |
Echinococcus multilocularis | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0046 | 0.0217 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0423 | 0.4555 | 0.4555 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0896 | 1 | 1 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0046 | 0.0217 | 0.0217 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.0478 | 0.0325 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0896 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0217 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0159 | 0.0457 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.031 | 0.031 |
Brugia malayi | Mitochondrial import inner membrane translocase subunit Tim17 family protein | 0.0046 | 0.0217 | 0.0217 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0473 | 0.5138 | 0.506 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0167 | 0.0167 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0423 | 0.4555 | 0.4468 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0473 | 0.5138 | 0.506 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0896 | 1 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0054 | 0.031 | 0.0154 |
Onchocerca volvulus | 0.0423 | 0.4555 | 0.4555 | |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0054 | 0.031 | 0.0154 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0896 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.0325 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.0395 | 0.0241 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.0395 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0473 | 0.5138 | 0.5138 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0423 | 0.4555 | 0.4468 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0473 | 0.5138 | 0.506 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.0478 | 1 |
Brugia malayi | steroid hormone receptor | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0217 | 0.0217 |
Onchocerca volvulus | 0.0423 | 0.4555 | 0.4555 | |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0423 | 0.4555 | 0.4468 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0896 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0423 | 0.4555 | 0.4468 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0211 | 0.2123 | 0.1996 |
Brugia malayi | mbt repeat family protein | 0.0054 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0423 | 0.4555 | 0.4468 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0896 | 1 | 1 |
Brugia malayi | tailless protein | 0.0423 | 0.4555 | 0.4555 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0054 | 0.031 | 0.0154 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0896 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.004 | 0.0159 | 0.0159 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0896 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | coup transcription factor | 0.0896 | 1 | 1 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0054 | 0.031 | 0.0154 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.3108 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0896 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0896 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0168 | 0.1624 | 0.1489 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0423 | 0.4555 | 0.4555 |
Brugia malayi | hypothetical protein | 0.0041 | 0.0167 | 0.0167 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0896 | 1 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.0478 | 0.0325 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0054 | 0.031 | 0.031 |
Onchocerca volvulus | 0.0054 | 0.031 | 0.031 | |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0159 | 0.0457 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0054 | 0.031 | 0.0154 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0896 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0423 | 0.4555 | 0.4468 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0896 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.016 | 0.1539 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0423 | 0.4555 | 0.4555 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0423 | 0.4555 | 0.4468 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.0478 | 0.3108 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0896 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Brugia malayi | nuclear receptor RXR | 0.0423 | 0.4555 | 0.4555 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0896 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0896 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Plasmodium vivax | mitochondrial import inner membrane translocase subunit TIM23, putative | 0.0046 | 0.0217 | 0.5 |
Loa Loa (eye worm) | DR-78 | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0423 | 0.4555 | 0.4555 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.016 | 0.1539 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0395 | 0.0395 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0896 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0423 | 0.4555 | 0.4468 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0896 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0329 | 0.3472 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Brugia malayi | nuclear hormone receptor | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 0.5138 | 0.5138 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0054 | 0.031 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0896 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | hypothetical protein | 0.0326 | 0.3442 | 0.3336 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0329 | 0.3472 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0423 | 0.4555 | 0.4468 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0423 | 0.4555 | 0.4468 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0423 | 0.4555 | 0.4555 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0423 | 0.4555 | 0.4555 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.0395 | 0.0241 |
Loa Loa (eye worm) | hypothetical protein | 0.0423 | 0.4555 | 0.4555 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA | ChEMBL. | 6205151 |
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA | ChEMBL. | 6205151 |
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein | ChEMBL. | 6205151 |
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells asayed by the incorporation of radioactive thymidine into DNA | ChEMBL. | 6205151 |
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive uridine into RNA | ChEMBL. | 6205151 |
IC50 (functional) | > 100 uM | Inhibition of macromolecular synthesis in HeLa cells assayed by the incorporation of radioactive leucine into protein | ChEMBL. | 6205151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.